Article Per Year (5 Year)
p-Index From 2020 - 2025
1.945
P-Index
This Author published in this journals
All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Jurnal Kreativitas PKM Indonesian Journal of Community Services Medica Hospitalia Journal of Holistics and Health Sciences (JHHS) Jurnal Pengabdian Masyarakat Kedokteran International Journal of Cell and Biomedical Science
Minidian Fasitasari
Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA) Semarang Jl. Raya Kaligawe KM. 4 PO BOX 1054 Semarang Central Java Indonesia, Phone (+6224) 65833584, Fax. (+6224) 6594366.
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

Published : 12 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 12 Documents
Search

 1   2 
Effects of Propolis Extract Supplementation during Pregnancy on Stress Oxidative and Pregnancy Outcome: Levels of Malondialdehyde, 8-Oxo-2′-Deoxogunosine, Maternal Body Weight, and Number of Fetuses Wibowo, Joko Wahyu; Fasitasari, Minidian; Zulaikhah, Siti Thomas
Jurnal Kedokteran Brawijaya Vol 31, No 3 (2021)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2021.031.03.5

Abstract

Oxidative stress is related to pregnancy complications that could increase maternal and infant mortality. This study aimed to determine the effect of propolis extract supplementation during pregnancy on oxidative stress level and pregnancy outcomes utilizing Malonedealdehyde (MDA) and 8-Oxo-2′-Deoxogunosine (8-OHdG) levels, maternal body weight, and the average number of fetuses as the parameters. The study was conducted by using a posttest only control group design on 24 pregnant Wistar rats, which were divided into four groups. Group I was control, Group II-IV were the treatment groups given propolis extract of 1.8mg, 3.6mg, and 7.2mg/200gBW/day, respectively. The standard feed given was AIN93G dose of 20g/day and distilled water ad libitum. Propolis extract was given using a gastric feeding tube every morning for 20 days. At the end of the treatment, body weight was meisured and blood collected for assessed MDA and 8-OHdG levels  by ELISA method  and then we performed abdominal surgery to count number of fetuses. The result are there were decreasing level of MDA and 8-OHDG by administration of propolis significantly (p<0.05) group: I: 2,04±0,091, II: 1,55±0,067, III: 1,05±0,176, IV: 0,73±0,075 (mmol/mL) (p=0.001); 8 OHdG level (ng/mL) group I: 10,02±0,403, II: 8,60±0,078, III: 7,89±0,051, IV: 7,53±0,063 (p=0,001). Average of maternal body weight (g) were increased: group I: 228,33±3,93, II: 237,17±4,36, III: 244,83±4,02, IV: 248,00±5,76 (p=0,001) and Average number of fetuses tend to increased as well, group I : 8,5±0,05, II: 7,8±0,41, III: 9,5±1,05, IV: 9,6±0,52 (p=0,02). The conclusion of this research are supplementation of propolis extract in pregnant rats can reduce oxidative stress and improve pregnancy outcomes.
Physical Activity Correlates to Body Mass Index among Medical Students Vikawati, Nura Eky; Sarosa, Hadi; Makarim, Fadli Rizal; Fasitasari, Minidian
Jurnal Kedokteran Brawijaya Vol 31, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2020.031.02.8

Abstract

Physical activity (PA) has a positive effect on preventing risk on cardiovascular and metabolic syndrome, including obesity. Learning behavior that tends to be sedentary causes medical students to tend to be physically inactive. This present study aimed to associate the physical activity (PA) level with blood pressure, body mass index, and non-fasting blood glucose level (NFBG) among medical students. This cross-sectional study was conducted from February to March in 2019 on the first-year medical students at Sultan Agung Islamic University (UNISSULA). A total of 167 medical students (64.7% female and 35.3% male) were enrolled in this study. The international physical activity questionnaire (IPAQ)-short form was used to measure the PA level. The activity level was classified into low, moderate, and high. Blood pressure and glucose level were measured using a digital sphygmomanometer and NFBG dipstick. The association between PA level and Body Mass Index (BMI), Blood Pressure (BP), and NFBG level were analyzed using Spearman's correlation test. Chi square test was done to analyse the difference of PA level between male and female groups. The majority of the respondents had a low PA level (64.7%). A positive association was shown between PA level and BMI (p<0.05, r=0.192). Female medical students tend to be physically inactive than males (OR 2.004, 95% CI (1.038-3.8690)). Female students need to be encouraged to do more physical activity. The university's policies that promote physical outdoor activity need to be suggested.  
Aplikasi Berbasis Mobile untuk Diabetisi dalam Menunjang Ibadah Puasa, Haji dan Umroh Kerja Sama Persadia Unit RSI Sultan Agung Sri Mulyono; Nur Anna Chalimah Sadyah; Minidian Fasitasari
Indonesian Journal of Community Services Vol 3, No 1 (2021): May 2021
Publisher : Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijocs.3.1.73-84

Abstract

Dari data Kementerian Kesehatan dari Sampel Registration Survey 2014 menyebutkan bahwa diabetes telah menjadi penyebab kematian terbesar nomor 3 di Indonesia, dengan presentase sebesar 6,7%, setelah stroke (21,1%) dan penyakit jantung koroner (12,9%), Berdasarkan data Riskesdas 2013 (Kemenkes RI, 2013), 90% dari total kasus diabetes merupakan diabetes tipe 2, yang umumnya terjadi pada orang dewasa. Namun beberapa tahun terakhir makin banyak ditemukan pada usia dewasa muda kurang dari 30 tahun bahkan pada anak-anak dan remaja. Indonesia merupakan negara muslim terbesar di dunia. Jumlah penduduk Indonesia 258 juta 87,2% adalah warga muslim. Sebagai warga muslim disyariatkan untuk melaksanakan berbagai ibadah antara lain ibadah puasa di bulan ramadan, haji dan umroh. Pada saat puasa pasien diabetes tidak makan selama siang hari yang berpeluang menimbulkan kecenderungan makan berlebih pada malam hari. Hal ini berpotensi menyebabkan pasien 5 kali lebih berisiko mengalami hiperglikemia dan sebanyak 7 kali lebih berisiko mengalami hipoglikemia. Kegiatan edukasi program aplikasi berbasis mobile untuk diabetesi sebagai bekal dalam menjalankan ibadah puasa haji dan umroh telah dilaksanakan dengan yang diikuti oleh 348 peserta dengan berbagai unsur peserta antara lain dokter, mahasiswa kesehatan, perawat dan ibu rumah tangga. Aplikasi juga telah didistribusikan di google playstore sehingga masyarakat luas akan lebih mudah mengunduh, memasang dan memakai aplikasi tersebut dimana saja, kapan saja dengan melalui koneksi internet.Data from the Ministry of Health from the 2014 Sample Registration Survey states that diabetes has become the 3rd largest cause of death in Indonesia, with a percentage of 6.7%, after stroke (21.1%) and coronary heart disease (12.9%). Data from Riskesdas 2013 (Kemenkes RI, 2013), 90% of total diabetes cases are type 2 diabetes, which generally occurs in adults. However, in recent years, it is increasingly found in adults less than 30 years, even in children and adolescents. Indonesia is the largest Muslim country in the world. The total population of Indonesia 258 million 87.2% are Muslims. As Muslim citizens, they are obliged to carry out various acts of worship, including fasting in the month of Ramadan, Hajj and Umrah. During fasting, diabetic patients do not eat during the day which may lead to a tendency to overeat at night. This puts the patient 5 times more likely to develop hyperglycemia and 7 times more likely to develop hypoglycemia. Educational activities for mobile-based application programs for diabetes as a provision for carrying out the Hajj and Umrah fasting services have been carried out by 348 participants with various participants including doctors, health students, nurses and housewives. Applications have also been distributed on the Google Play Store so that the wider community will find it easier to download, install and use the application anywhere, anytime via an internet connection.
Peningkatan Kesadaran Masyarakat untuk Berolahraga melalui Kegiatan Jalan Sehat dan Penyuluhan Kesehatan pada Kelompok Pra Lansia dan Lansia Dasa Wisma Flamboyan 2 Kelurahan Tlogosari Kulon Masfiyah Masfiyah; Minidian Fasitasari; Rahayu Rahayu
Jurnal Pengabdian Masyarakat Kedokteran Vol 2, No 1 (2023): Januari
Publisher : Fakultas Kedokteran, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/abdimasku.2.1.30-36

Abstract

Latar Belakang: Prevalensi obesitas meningkat di berbagai negara. Obesitas merupakan faktor risiko berbagai macam penyakit. Pencegahan dibutuhkan dengan pola hidup sehat dan berolahraga. Jalan kaki merupakan olah raga yang murah dan sehat. Pengabdian ini bertujuan meningkatkan kesadaran masyarakat untuk berolahraga melalui kegiatan jalan sehat dan penyuluhan kesehatan.Metode: Pengabdian diikuti oleh ibu-ibu lansia dan pra lansia di kelompok dasa wisma Flamboyan 2. Kegiatan dimulai dengan berolah raga jalan kaki selama 30 menit, dilaksanakan pada pagi hari. Kegiatan dilanjutkan dengan penyuluhan kesehatan, dan pengukuran data antropometri. Kegiatan dilaksanakan rutin setiap bulan.Hasil: Data BMI kelompok normal 22,2%, kelompok BB lebih dengan risiko 11,1%, Kelompok Obesitas satu 44,4%, dan kelompok obesitas dua 22,2%. Kehadiran meningkat dari 54,5 % bulan Juni, menjadi 63,64% bulan Juli dan Agustus, serta 72,73% pada bulan September.Kesimpulan: Terjadi peningkatan kesadaran masyarakat untuk berolah raga melalui kegiatan jalan sehat. Background: The prevalence of obesity is increasing in various countries. Obesity is a risk factor for various diseases. Prevention is needed with a healthy lifestyle and exercise. Walking is an inexpensive and healthy exercise. This service aims to increase public awareness to exercise through healthy walks and health education.Methods: This service was attended by elderly and pre-elderly mothers in the Flamboyan 2 dasa wisma group. The activity began with walking for 30 minutes, carried out in the morning. The activity was continued with health education, and anthropometric data measurement. Activities are carried out regularly every month.Results: BMI data for the normal group was 22.2%, the overweight group was 11.1% at risk, the first obesity group was 44.4%, and the second obesity group was 22.2%. Attendance increased from 54.5% in June, to 63.64% in July and August, and 72.73% in September.Conclusion: There is an increase in public awareness to exercise through healthy walking activities.
The Correlation of Exercise and Range of Motion (ROM) on Elderly Knee Observasional Study on Elderly People in Pedurungan Semarang Widyantoro, Adhitya Putra; Rosdiana, Ika; Fasitasari, Minidian
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 1 (2012): Januari-Juni 2012
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (139.675 KB) | DOI: 10.30659/sainsmed.v4i1.383

Abstract

Background: In aging process, decreasing of musculosceletal capabilities will reduce physical activity and excercise, as well as Range Of Motion (ROM). In order to maintain the normality of ROM, joints and muscles should be moved regularly. However many elderly people are still less physically active, due to lack of knowledge, no free time for physical activity, and lack of support from the social environment. This study aimed to determine the correlation of excercise on ROM of knee in the elderly in Pedurungan District, Semarang.Design and Method: Observastional study with a cross sectional design 80 elderly men and women were divided into 2 groups: gymnastics group in the Social Rehabilitation Unit Of Pucang Gading (n=40) and unexcercises group in the Penggaron village (n=40). In both groups, the degree of ROM of knee was assessed using the Goniometer. To evaluate the value of its significance, the data were analyzed using the Mann Withney test followed by Spearmann’s rho test.Result: ROM for gymnastic(exercised group) and unexercised group were 115.50°±11.591°, 95.38°±12.780° respectively with p<0. 001. Resuts showed that doing exercise was useful for maintaining ROM of knee in elderly people. Spearmann’s rho test resulted in a strong correlation between ROM and exercise with r value of 0.652.Conclusion: exercise correlates with ROM of knee in elderly (Sains Medika, 4(1):39-45).
Nutrition Therapy in Elderly with Chronic Obstructive Pulmonary Disease (COPD) Fasitasari, Minidian
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 5, No 1 (2013): January-June 2013
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (748.08 KB) | DOI: 10.30659/sainsmed.v5i1.366

Abstract

Nutrition is an important health element for elderly people and influence aging process. Malnutrition prevalence is increasing in this population. Chronic Obstructive Pulmonary Disease (COPD) is one of the chronic diseases in elderly that is related to malnutrition. The association between malnutrition and pulmonary disease (including COPD) has been known for a long time. Malnutrition has negative impacts on pulmonary structure, elasticity, and function, strength and endurance of respiratory muscles, pulmonary immunity defense mechanism, and breath control. Inversely, pulmonary disease (including COPD) will increase energy need and may reduce dietary intake. Nutrition intervention in COPD patient is intended for regulating anorexia, improving pulmonary function, and controlling weight loss. Nutrient requirements will be calculated according to the results of nutrition assessment. This article will discuss about nutrition therapy in elderly with COPD. It describes respiratory system in aging, association COPD and nutrition, and nutrition assessment, as well as nutrition intervention in elderly people with COPD.
Efektivitas Terapi Metode Wim Hoff Terhadap Respirasi, Denyut Jantung, Dan SpO2 Pada Pasien Covid – 19 Di Rumah Sakit Islam Sultan Agung Semarang Syaifulloh, Moh; Susanto, Mujib Akhis; Fasitasari, Minidian; Aziz, Muhammad; Pudjowati, Saras; Yasin, Muhammad Fatah; Setianto, Rochady
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 1A (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (279.796 KB) | DOI: 10.36408/mhjcm.v7i1A.482

Abstract

Latar belakang : Metode Wim Hoff merupakan kombinasi dari paparan dingin, tekhnik pernafasan, dan meditasi. Kombinasi antara terapi konvensional medis dengan terapi non farmakologis seperti pada Metode Wim Hoff yang berusaha mengkombinasikan antara yoga dengan pengaturan nafas sehingga memberi kesempatan pada peningkatan volume/kapasitas tidal paru menjadi stabil. Ada banyak variasi dari metode Wim Hoff meliputi mengontrol pernafasan, menahan nafas, dan memulai pernafasan, ketiga fase tersebut dapat diulang dalam kurun waktu tiga kali secara berturut – turut atau lebih. Dengan dilakukan terus menerus sangat membantu peningkatkan sel darah merah, meningkatkan kapasitas tidal paru, meningkatkan sirkulasi, dan dapat dibuktikan secara klinis. Penelitian ini bertujuan untuk mengetahui pengaruh Metode Wim Hoff terhadap pola nafas, denyut jantung, dan SpO2 pasien Covid – 19 yang dirawat di Rumah Sakit Islam Sultan Agung Semarang. Metode : Metode yang digunakan dalam penelitian ini adalah quasi experiment dengan desain pre dan post test tanpa kelompok kontrol. Sampel pada penelitian ini dipilih secara consecutive, dan terdiri dari 25 responden dengan rincian 9 laki – laki dan 16 perempuan. Ditemukan hasil bermakna antara intervensi sebelum dan sesudah terhadap pola nafas, dan SpO2, selanjutnya data diolah menggunakan uji paired T test dampak komparatif Wim Hoff dengan perbandingan respirasi, denyut jantung, SpO2 dan uji Wilcoxon signed rank test pada kelompok perlakuan didapatkan P = 0,0014 < ? = 0,05, sehingga H0 ditolak. Pada kelompok kontrol didapatkan P = 1,000 > ? = 0,05 sehingga H0 diterima, artinya bahwa ada pengaruh terhadap kemandirian responden kelompok perlakuan. Hasil : Hasil uji statistik adalah p value 0,000 pada pola nafas dan SpO2, akan tetapi terhadap denyut jantung didapatkan p value 0,447. Simpulan : Metode Wim Hoff mampu menstabilkan pola nafas dan SpO2, akan tetapi tidak untuk denyut jantung. Kata kunci : Wim Hoff, Pola nafas, SpO2, Denyut jantung Background : Wim Hof Method (WHM) is combination of frequent cold exposure, breathing techniques and meditation. The combination of conventional medical therapy with non-pharmacological therapies such as the Wim Hoff Method which seeks to combine yoga with breath control so as to provide an opportunity for the increase in lung tidal volume / capacity to become stable.There are many types of breathing method including Controlled breathing, Breath retention, and Recovery. these three phases may be repeated for three or more consecutive rounds. By being done continuously it really helps increase red blood cells, increase lung tidal capacity, improve circulation, and can be proven clinically. This research aimed to explore the effect of Wim Hoff Method on respiration rate, heart rate, and SpO2 among Covid – 19 patients at Islamic Sultan Agung Hospital Semarang. Methods : Quasi experiment used in this study was pre and post test design without control group. Sampel were recruited using consecutive sampling. The samples of this study consists of 25 Covid – 19 patients including 9 male and 16 female. The study found significant result between pre and post test intervention for respiration rate and SpO2. A meaningful result between the before and after intervention of the breath pattern, and the SpO2, subsequently the data was processed using a test paired T comparative impact of Wim Hoff with a ratio of respiration, heart rate, SpO2 and a test of Wilcoxon signed rank test on the treatment group obtained P = 0.0014 < ? = 0.05, so that H0 rejected. In the control group acquired P = 1.000 > ? = 0.05 so that H0 was accepted, meaning that there was an influence on the self-reliance of the group treatment. Result : The statistical test result was p value 0,000 for respiration rate and SpO2 but for the heart rate p value 0,447. Conclusion : Wim Hoff Method was effective on stabilizing respiration rate and increasing SpO2 but not for heart rate. Keyword : Wim Hoff Method, Respiration rate, SpO2, Heart rate.
Hubungan Status Gizi dengan Derajat Trombositopenia pada Anak dengan Demam Berdarah Dengue: Relationship Between Nutritional Status and Degree of Thrombocytopenia in Children with Dengue Hemorrhagic Fever Fasitasari, Minidian; Pertiwi, Danis; Wibowo, Joko Wahyu; Indrayani, Ulfah Dian; Athatsaniya, Mazaya Denta
Journal of Holistics and Health Sciences Vol. 6 No. 1 (2024): Journal of Holistics and Health Sciences (JHHS), Maret
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/jhhs.v6i1.399

Abstract

Dengue haemorrhagic fever (DHF) is still the most common infectious disease in children aged <5 years and the mortality rate were quite high in Indonesia. The body's immune response to pathogens could be influenced by nutritional status. DHF patients show laboratory results in the form of a decrease in the number of platelets or thrombocytopenia. The aim of this study was to determine whether nutritional status correlates with the degree of thrombocytopenia in children suffering from dengue haemorrhagic fever. A cross sectional study was conducted at Rumah Sakit Islam Sultan Agung (RSI-SA), a teaching hospital in Semarang. The subjects were 90 children under 5 years who hospitalized during 2019 – 2023 by using total sampling technique. Nutritional status indicator was weight-for-age z score (WAZ), and the degree of thrombocytopenia was classified according to platelets count in the second day of hospitalization. The data was analysed using the Spearmen's Rank correlation test with a significance level of 0.05. Average of WAZ was -0.963±1.146 SD with 80% of children had normal nutritional status, while the mean platelet count was 77,622 ± 34,931/µl with 47.8% of the subjects were moderate thrombocytopenia. The p value of correlation test was 0.292. There was no correlation between nutritional status and the degree of thrombocytopenia in children with dengue haemorrhagic fever at a teaching hospital in Semarang.   ABSTRAK Demam berdarah dengue (DBD) masih menjadi penyakit infeksi terbanyak pada anak usia <5 tahun dan mortalitasnya cukup tinggi di Kota Semarang. Respon imun tubuh terhadap pathogen dipengaruhi beberapa faktor, salah satunya adalah status gizi. Pada pasien DBD menunjukkan gambaran hasil laboratorium berupa penurunan jumlah trombosit atau trombositopenia. Tujuan dari penelitian ini adalah untuk mengetahui apakah status gizi berkorelasi dengan derajat trombositopenia pada anak-anak yang menderita demam berdarah dengue. Penelitian observasional analitik dengan desain cross sectional dilakukan di RS Islam Sultan Agung (RSISA) Semarang. Sampel penelitian sebanyak 90 subyek yang diambil dengan teknik total sampling berupa pasien anak usia <5 tahun dan memiliki data rekam medis lengkap periode 2019 – 2023. Penelitian dilakukan dari bulan Agustus hingga Oktober 2023. Data yang diambil berupa status gizi (BB/U) dan jumlah trombosit hari kedua rawat inap. Data tersebut dianalisis menggunakan uji korelasi Rank Spearmen dengan tingkat signifkansi (α) 0,05 atau 5%. Rerata Z score status gizi (WAZ) yaitu – 0,963 ± 1,146 SD dengan 80% status gizi anak normal, sedangkan rerata jumlah trombosit (trombositopenia) yaitu 77.622 ± 34.931/µl dengan 47,8% anak dengan trombositopenia sedang. Penelitian ini menunjukkan tidak ada hubungan yang bermakna antara status gizi dengan derajat trombositopenia (P=0,292). Tidak terdapat hubungan antara status gizi dengan derajat trombositopenia pada anak dengan demam berdarah dengue di Rumah Sakit Islam Sultan Agung (RSISA) Semarang.
Pengukuran Antropometri dan Komposisi Tubuh pada Masyarakat di Perumahan Sembungharjo Permai Semarang Fasitasari, Minidian; Suparmi, Suparmi; Latifah, Fadzil
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 7, No 4 (2024): Volume 7 No 4 2024
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v7i4.13968

Abstract

ABSTRAK Kegiatan ini berawal dari permasalahan yang dialami masyarakat di Perumahan Sembungharjo Semarang yang (1) sebagian di antara mereka merasakan kegemukan di usia yang semakin bertambah, (2) ketidaktahuan masyarakat tentang pentingnya pengukuran antropometri dan komposisi tubuh, dan (3) kurangnya ketrampilan masyarakat dalam menjaga kesehatan dengan memonitor antopometri tubuhnya masing-masing. Tujuan: (1) meningkatkan pengetahuan masyarakat tentang pentingnya pengukuran antopometri dan komposisi tubuh, (2) meningkatkan ketrampilan masyarakat dalam memonitor antropometri tubuhnya masing-masing, dan (3) meningkatkan self-efficacy masyarakat untuk memperbaiki status gizinya dengan self-monitoring antropometri. Kegiatan yang dilakukan antara lain: (1) Pengukuran antropometri tubuh, (2) Sosialisasi tentang penentuan status gizi menggunakan data antropometri, (3) Pengukuran komposisi tubuh, (4) Penyukuhan tentang pentingnya pengukuran antropometri dan komposisi tubuh dikaitkan dengan risiko penyakit, (5) Pelatihan melakukan pengukuran lingkar perut, dan (6) Diskusi dan konsultasi tentang kesehatan dan obat. Terdapat 70 orang berusia 15 – 74 tahun yang berpartisipasi pada kegiatan ini, namun hanya 53 orang yang mengembalikan kuesioner untuk menilai tingat pengetahuan tentang pengukuran antopometri dan komposisi tubuh. Sebagian besar (>60%) dapat menjawab pertanyaan dengan benar. Hasil antropometi didapatkan rerata IMT 26,1 ± 4,0 kg/m2 dan lebih dari 60% obesitas dengan massa lemak yang lebih tinggi dari normal. Pengetahuan masyarakat tentang antropometri dan komposisi tubuh cukup baik. Status gizi masyarakat sebagian besar obesitas dan obesits sentral dengan massa lemak tergolong sangat tinggi. Kata Kunci: Antropometri, Status Gizi, Komposisi Tubuh, Massa Lemak  ABSTRACT This activities began with the problems experienced by the community in the Sembungharjo Housing Complex, Semarang, e.g. (1) some of them felt obese as they got older, (2) the public's ignorance about the importance of anthropometric and body composition measurements , and (3) lack of community skills in maintaining health by monitoring the anthropometry of their respective bodies. (1) increase community knowledge about the importance of anthropometric measurements and body composition, (2) increase community skills in monitoring the anthropometry of their own bodies, and (3) increase community self-efficacy to improve their nutritional status by self-monitoring anthropometry. Activities carried out include: (1) Anthropometric body measurements, (2) Socialization about determining nutritional status using anthropometric data, (3) Body composition measurements, (4) Education about the importance of anthropometric measurements and body composition in relation to disease risk, (5) Training in measuring abdominal circumference, and (6) Discussion and consultation about health and medicine. There were 70 people aged 15 – 74 years who participated in this activity, but only 53 people returned questionnaires to assess their level of knowledge about anthropometric measurements and body composition. Most (>60%) were able to answer the questions correctly. Anthropometric results showed a mean BMI of 26.1 ± 4.0 kg/m2 and more than 60% obesity with a fat mass higher than normal. The knowledge about anthropometry and body composition was quite good. The nutritional status of the majority of people was obese and central obese with very high fat body mass. Keywords: Anthropometry, Nutritional Status, Body Composition, Fat Mass
The Effect of Celery Extract on Caspase-3 and TNF-α Gene Expression in Lead Poisoning-Induced Renal Injury in Rats Purwaningsih, Hesti; Sumarawati, Titiek; Chodidjah, Chodidjah; Putra, Agung; Priyantini, Sri; Fasitasari, Minidian; Ibrahim, Sugeng; Amalina, Nur Dina
International Journal of Cell and Biomedical Science Vol 2 No 6 (2023)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v2i6.42

Abstract

Background To determine the effect of Apium graveolens L (Celery) extract in the TNF-α and caspase-3 gene expression on the lead poisoning-induced renal injury rats’ model. Methods This study is experimental research with post test only control group design. Twenty male Wistar rats were randomly allocated into four groups (n=5). The control group was orally administrated with distillate water. The second group received lead acetate 200mg/kg body weight orally for 14 days, the third group were orally administered lead acetate 200 mg lead acetate/kg body weight and vitamin E 50IU/kg body weight for 14 days. The fourth group was administrated with leas acetate like second group and celery extract 300mg/kg body weight for 14 days. The TNF-a and caspase-3 gene expression was analyses under qRT-PCR. Results The phytochemical analysis of APE indicated the presence of alkaloids, flavonoids, tannins, saponins, and steroids. Leads acetate increased the TNF-α (3.87±0.09) and caspase-3 (7.95±0.23) gene expression. The celery extract was significantly decrease in the TNF-α (3.13±0.34) and caspase-3 (2.48±1.23) gene expression. Conclusion: In conclusion, the presence of celery extract inhibited the renal injury-induced lead acetate toxicity by inhibition of TNF-α proinflammation protein and caspase-3 proapoptosis protein
Co-Authors Adhitya Putra Widyantoro, Adhitya Putra Agung Putra Amalina, Nur Dina Aryani, Rini Athatsaniya, Mazaya Denta Chodidjah Chodidjah Danis Pertiwi Fadzil Latifah, Fadzil Hadi Sarosa Ibrahim, Sugeng Ika Rosdiana Joko Wahyu Wibowo Makarim, Fadli Rizal Masfiyah Masfiyah Muhammad Aziz Nur Anna Chalimah Sadyah Pudjowati, Saras Purwaningsih, Hesti Rahayu Rochady Setianto Samsudin Samsudin Siti Thomas Zulaikhah Sri Mulyono Sri Priyantini Suparmi Suparmi Susanto, Mujib Akhis Syaifulloh, Moh Tanry, Selvina Titiek Sumarawati Ulfah Dian Indrayani Vikawati, Nura Eky Yasin, Muhammad Fatah Yuniarti, Heny