Article Per Year (5 Year)
p-Index From 2021 - 2026
0.817
P-Index
This Author published in this journals
All Journal Padjadjaran Journal of Dentistry IJEMS (Indonesian Journal of Environmental Management and Sustainability) Best Journal (Biology Education, Sains and Technology) Jurnal Pengabdian Masyarakat: Humanity and Medicine
Saleh, Muhammad Irsan
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Energy Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

Published : 4 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search

 1 
Pemanfaatan ekstrak air daun karamunting sebagai terapi tambahan pada penderita diabetes mellitus tipe II: edukasi dan pembuatan infusa/ekstrak air karamunting skala rumah tangga Saleh, Muhammad Irsan; Lusiana, Evi; Rofflin, Eddy
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 5 No 2 (2024): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V5I2.139

Abstract

Utilisation of aqueous extract of karamunting leaves as adjunctive therapy in patients with type II diabetes mellitus: education and household-scale production of karamunting water infusion/extracts Diabetes mellitus (DM) is a chronic condition caused by high blood glucose levels due to insulin deficiency or the body's inability to use insulin properly. This community service aims to increase knowledge about Diabetes mellitus and the utilization of herbal plants Karamunting leaves to lower blood sugar. The target of the activity is the community in the working area of the Gandus Palembang Health Center, totaling 30 participants. The method in this service is in the form of socialization of herbal plants of Karamunting leaves to lower blood sugar. The results of this community service are an increase in knowledge and application of herbal plants of Karamunting leaves to reduce blood sugar in the community. The method used was counseling about diabetes mellitus and the benefits of Karamunting leaves, demonstration and assistance in making Karamunting leaf infusion, and evaluation. The results of this community service activity are knowledge about diabetes mellitus increased marked by the activeness of answering questions given and the independent use of Karamunting leaves in handling diabetes mellitus.
Analysis of Water Pollution Levels in Batang Masumai River, Merangin Regency, Jambi Province Astuti, Syurmi; Saleh, Muhammad Irsan; Arita, Susila; Legiran
Indonesian Journal of Environmental Management and Sustainability Vol. 8 No. 4 (2024): December
Publisher : Magister Program of Material Science, Graduate School of Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/ijems.2024.8.4.172-183

Abstract

Water pollution is a pressing environmental issue that adversely affects aquatic ecosystems and the usability of water resources. The Batang Masumai River, located in Merangin Regency, Jambi Province, is an essential water source for local communities but faces escalating pollution challenges due to industrial, agricultural, and residential activities. This study analyzes the pollution levels of the Batang Masumai River by assessing seven key parameters: temperature, pH, Total Dissolved Solids (TDS), Total Suspended Solids (TSS), Dissolved Oxygen (DO), Biochemical Oxygen Demand (BOD), and Chemical Oxygen Demand (COD). A quantitative observational approach was employed, utilizing secondary data collected from 2021 to 2024. The results were evaluated against Class II water quality standards as stipulated in Government Regulation Number 22 of 2021. The findings indicate that while parameters such as temperature and pH generally adhered to acceptable standards, others, notably TSS, BOD, and COD, frequently exceeded the regulatory limits, particularly in 2021. This suggests substantial pollution stemming from untreated wastewater and soil erosion. Although improvements were observed in subsequent years, several parameters remained problematic, posing ongoing risks to aquatic ecosystems and water resource sustainability. These findings underscore the urgent need for enhanced wastewater treatment systems, stricter enforcement of environmental regulations, and the adoption of sustainable watershed management practices to restore and safeguard the ecological health of the river.
Systematic Literature Review Pada Potensi Antidiabetes Rhodomyrtus Tomentosa Arini, Melinda; Saleh, Muhammad Irsan; Harahap, Debby Handayani
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 1 (2025): Juni 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i1.11096

Abstract

Rhodomyrtus tomentosa, yang dikenal sebagai karamunting, menarik perhatian karena potensi perannya dalam pengelolaan diabetes melitus tipe 2 (DMT2), yaitu gangguan metabolik kronis dengan prevalensi yang terus meningkat secara global. Studi ini mengkaji potensi antidiabetes dari R. tomentosa melalui tinjauan pustaka sistematis terhadap artikel ilmiah yang dipublikasikan antara tahun 2013 hingga 2023. Data dikumpulkan dari berbagai basis data terpercaya seperti Google Scholar, PubMed, NCBI, Scopus, dan Elsevier, dengan total 11 studi yang memenuhi kriteria inklusi. Hasil kajian menunjukkan bahwa berbagai ekstrak daun R. tomentosa—etanol, air, infusa, dan mikroemulsi—efektif dalam menurunkan kadar glukosa darah, meningkatkan sekresi insulin, serta memperbaiki jaringan pankreas pada model hewan. Senyawa bioaktif yang berperan antara lain flavonoid, saponin, tanin, fenol, tectoridin, dan engeletin. Mekanisme kerjanya meliputi aktivitas antioksidan, penghambatan enzim α-glukosidase dan α-amilase, serta stimulasi produksi insulin. Meskipun hasil praklinis menjanjikan, diperlukan penelitian klinis lebih lanjut untuk memastikan keamanan dan efektivitas terapeutiknya pada manusia
Biomolecular and bioinformatics characterization of salivary matrix metalloproteinase-9 as oral cancer potential targeted therapy Dewi, Siti Rusdiana Puspa; Saleh, Muhammad Irsan; Murti, Krisna; Parisa, Nita; Rosdah, Ayeshah Augusta; Subandrate, Subandrate; Kumar, Arun
Padjadjaran Journal of Dentistry Vol 38, No 2 (2026): July 2026
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol38no2.70464

Abstract

Introduction: Oral cancer is the 11th most common cancer worldwide. Previous studies have reported that saliva contains biomarkers for oral cancer. MMP-9, found in saliva, is a marker that indicates and facilitates tumor development. However, comprehensive biomolecular and bioinformatics characterization of salivary MMP-9 remains limited. This study aimed to analyze the biomolecular and bioinformatics characteristics of salivary MMP-9 as an oral cancer biomarker and a potential target for therapy because it plays an important role in tumor development and management. Methods: The features of MMP-9 were obtained from the NCBI database (www.ncbi.nlm.nih.gov). Protein analyses were performed using Protparam site, PROTSCALE, TMM application, PEPTIDE CUTTER, NETNGLYC and TARGETTP. The protein model and structure of MMP-9 were evaluated using SWISSMODEL. Results: Based on the study, it showed that MMP-9 is located on 20q13.12. It is involved in extracellular matrix breakdown, and this enzyme degrades type IV and V collagens. Based on the instability index (II), the protein was found to be unstable. The hydrophobicity range of the MMP-9 protein was 0–7654. Among the 20 amino acids analyzed, the hydrophobicity of arginine was -4.500, while isoleucine was 4.500. Transmembrane helix analysis indicated the MMP-9 protein isoform is predominantly located outside of the cell. The predicted N-glycosylation site was at the 28th amino acid. The structural model analysis indicated that the protein model was of good quality. Conclusion: Biomolecular and bioinformatics characterization of salivary MMP-9 demonstrates strong potential as an oral cancer biomarker. The biomolecular and bioinformatics characteristics identified in this study support the potential utility of MMP-9 as an oral cancer biomarker and provide a foundation for future studies investigating its therapeutic relevance.
Co-Authors Arini, Melinda Astuti, Syurmi Ayeshah A Rosdah Evi Lusiana Harahap, Debby Handayani Krisna Murti Kumar, Arun Legiran Legiran Nita Parisa Rofflin, Eddy Siti Rusdiana Puspa Dewi Subandrate Susila Arita