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All Journal Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan SRIWIJAYA JOURNAL OF MEDICINE Sriwijaya Journal of Ophthalmology Jurnal Pengabdian Masyarakat: Humanity and Medicine Conferences of Medical Sciences Dies Natalis Ophthalmologica Indonesiana
Petty Purwanita
Bagian Ilmu Kesehatan Mata, Fakultas Kedokteran, Universitas Sriwijaya
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Studi Diagnostik Menggunakan PCR untuk Mendeteksi Virus Hepatitis C Dalam Cairan Air Mata Pasien Hemodialisis Purwanita, Petty; Natsir, Novia
Sriwijaya Journal of Medicine Vol. 4 No. 1 (2021): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v4i1.186

Abstract

Patients Hepatitis C virus (HCV) is a hepatotropic and lymphotropic virus. Patients infected with HCV might develop at least one extrahepatic manifestation ocular and in the lacrimal sac during the course of their disease. HCV transmission occurs through exposure to blood contaminated with high risk factor in hemodialysis patients about 70%. Detection RNA HCV more sensitive and specific by PCR (Polymerase Chain Reaction). This study evaluated the sensitivity and specificity of PCR hepatitis c virus in tears hemodialysis patients at Mohammad Hoesin Palembang. This is an observational diagnostic study of 25 samples from tears and blood in hemodialysis patients. PCR examined by RT-PCR. The data obtained were analyzed by a diagnostic test. Of 25 samples HCV-RNA was detected by PCR in the tears 11 cases were positive (44%) and 20 cases were found positive (80%) in plasma. The value of the sensitivity of the tears is 72.73% and the specificity was 13.33%. Tears fluid specimen quite sensitive but not specific, therefore PCR examination can be used for screening for hepatitis C virus in hemodialysis patients.
The Effect of Aloe Vera Extract to Extensive Lesion and Expression of Transforming Growth Factor (TGF-β) on Alkaline Chemical Trauma Cornea Model Fahcreza; Elsa Iskandar; Rachmat Hidayat; Petty Purwanita; Anang Tribowo; Riani Erna
Sriwijaya Journal of Ophthalmology Vol. 1 No. 2 (2018): Sriwijaya Journal of Ophthalmology
Publisher : Department of Opthalmology, Faculty of Medicine, Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (236.279 KB) | DOI: 10.37275/sjo.v1i2.36

Abstract

Abstract Background: Chemical trauma to the cornea is an emergency condition of the eye that requires early diagnosis and good treatment. Alkaline have ability to saponify fatty acids in cells and cell membranes which can make penetration into the stroma and destroy proteoglycans and collagen in cells. Aloe vera (AV) contains several active substances that are reported to have anti-inflammatory, immunomodulatory, and wound healing effects. AV has been reported to accelerate the healing process of corneal epithelial defects by increasing fibroblast proliferation, collagen production and growth factor production. This study aims to determine the difference between the effect of aloe vera extract with a concentration of 10%, 20%, 40% and BSS on the healing of extensive corneal lesions in white wistar rats alkaline trauma models. Method: This study was an experimental study with a pre and posttest only with control group design in vivo approach to 30 Wistar white rats which were divided into 5 treatment groups for 3 days. Comparative analysis of effectiveness using the ANNOVA test or the Kruskal Wallis test and continued by the post hoc test. Results: Based on the one way ANOVA test there was a statistically significant difference in effectiveness between the five treatment groups on the percentage of corneal wound healing area and TGF-β expression with an assessment of p = 0,000 each. The administration of alloevera (AV) concentration of 20% had a significant difference in percentage of healing of corneal lesions and TGF-β expression compared with other treatment groups with p = 0,000 each. Large differences in the area of corneal lesions in the 40% AV group were -0.45 in the BBS group, 0.146 in the 10% AV group, 0.493 in the 20% AV group. The difference in the AV group 10% was 0.30 in the BBS group, -064 in the AV group 20%, and -0.14 in the AV group 40%. However, TGFβ expression in the normal control group that did not receive treatment was 54.94 (53.21-56-12). TGFβ levels in the BSS group were 10.44, the 10% aloe vera group was 25.43, 47.99 for the 20% aloe vera group and 37.95 for the 40% aloe vera group. Conclusion: There is a difference between the effect of aloe vera extract with concentrations of 10%, 20%, 40% and BSS on the extensive healing of corneal lesions in white wistar rats with alkaline chemical trauma models.
Comparison of Schirmer and Tear Break Up Time (TBUT) Diagnostic Test of Dry Eye Following Phacoemulsification Cataract Surgery Disty Andryani; Petty Purwanita; Anang Tribowo
Sriwijaya Journal of Ophthalmology Vol. 2 No. 1 (2019): Sriwijaya Journal of Ophthalmology
Publisher : Department of Opthalmology, Faculty of Medicine, Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (243.049 KB) | DOI: 10.37275/sjo.v2i1.41

Abstract

Abstract Background: Phacoemulsification is a technique of modern cataract surgery with smaller corneal incision than conventional techniques but uses various effects on springs that cause dry eye syndrome (DES). DES is a multifactorial defect of tears and ocular surfaces characterized by eye discomfort. Examination of DES can be done by examining Schirmer 1 and Tear Break Up Time (TBUT). Purpose: To determine the accuracy, sensitivity and specificity of the Schirmer test dan TBUT in postoperative patients with phacoemulsification techniques at the Rumah Sakit Khusus Mata Province of South Sumatra. Method: Diagnostic test has been done in order to the accuracy, sensitivity and specificity of the Schirmer test dan TBUT on DES in post operative cataract surgery with phacoemulsification techniques. This study has been conduct Schirmer 1 test and TBUT was done periodically from 1 week, 2 weeks and 1 month after cataract surgery. The data analysis has been done with diagnostic research by SPSS version 20.0 (SPSS, Inc Chicago, Illinois). Result: 40 study samples of post operative cataract surgery with phacoemulsification technique obtained by female sex with 22 out of samples were (55%), with an average age of patients between of 60-70 years.The accuracy of Shirmer 1 and TBUT test was 0,425 and the sensitivity value was 39.5% and also the specificity value was 100%. Conclusion: Schirmer 1 test and TBUT in patients of post cataract surgery with phacoemulsification techniques are specific (100%) but less sensitive (39,5%)
Fortified Fluconazole Eyedrops for Treatment of Culvularia Corneal Ulcer Muhammad Reza Arlas; Petty Purwanita
Sriwijaya Journal of Ophthalmology Vol. 3 No. 2 (2020): Sriwijaya Journal of Ophthalmology
Publisher : Department of Opthalmology, Faculty of Medicine, Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjo.v3i2.45

Abstract

Introduction: Fungal keratitis is less common than bacterial keratitis, generally representing less than 5%–10% of corneal infections in reported clinical series in the United States. But in developing countries (Ghana, India, China) it accounts for more than 90% of the cases. Corneal trauma by plant or vegetative material is the leading risk factor for fungal keratitis. One or more topical antifungals are usually administered with systemic support of oral antifungals. The most common classes of antifungal used for medical therapy include the polyenes, azoles, and the echinocandins. Case presentation: A 47-year-old male presented with a widening white patch on his left eye since 4 days before coming to our hospital. The left eye was injured by wood flakes 3 weeks ago. He felt a sore, red, watery left eye and blurred vision. He washed his eyes with betel leaf water. His left eye visual acuity was 1/60 and not improved with pinhole. There were blepharospasm, ciliary and conjunctival injection. Corneal examination showed a cloudy cornea, a central corneal defect sized 8x6 mm with an irregular margin, 2/3 to stromal depth, infiltrate, satellite lesion, and positive fluorescein staining at the defect margin. KOH examination demonstrated hyphae. The culture test of left corneal discharge identified a fungi species (Curvularia sp). We prescribed fortified fluconazole eye drops in combination with supportive therapy for 2.5 months. This regimen showed a significant increase in visual acuity to 6/30 with pinhole improvement of 6/21 in the left eye. Discussion: Imidazole acts by inhibiting ergosterol biosynthesis of the fungal cell wall, through action on the cytochrome P450-dependent enzyme. This leads to cell membrane destabilization and leakage. Curvularia sp belongs to the family of dematiaceous fungi. Its clinical manifestations include raised lesions and feathery edges; hypopyon rarely occurs, and the prognosis is quite good. Fluconazole (2 mg/ml) is available for injection and is a well-tolerated eye drop. The intravenous injection can be used as a topical treatment and can be given subconjunctivally at the same concentration. Conclusions: Fortified fluconazole eyedrops (2 mg/ml) can become an alternative and additional therapy for deep fungal keratitis, especially for Curvularia sp.
PUBLIC EDUCATION ABOUT EYES DURING THE COVID-19 PANDEMIC Ramzi Amin; Petty Purwanita; Prima Maya Sari
Conferences of Medical Sciences Dies Natalis Vol. 3 No. 1 (2021): Conference of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sri
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.338 KB)

Abstract

In December 2019, a case of pneumonia of unknown etiology first reported in Wuhan, Hubei Province, China. (1) The etiology was finally identified and showed a new type of coronavirus, which was given the tentative name 2019 novel coronavirus (2019-nCoV). On February 11, 2020, the World Health Organization (WHO) announced the name of the new virus, namely Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), and the name of the disease as Coronavirus Disease (COVID-19).Indonesia reported its first two confirmed cases of COVID-19 inMarch 2, 2020. As of September 8, 2020, the number of confirmed cases of COVID-19 in Indonesia was 200,035, with 8,230 deaths (CFR 6.9%).
Studi Diagnostik Menggunakan PCR untuk Mendeteksi Virus Hepatitis C Dalam Cairan Air Mata Pasien Hemodialisis Petty Purwanita; Novia Natsir
Sriwijaya Journal of Medicine Vol. 4 No. 1 (2021): Vol 4, No 1, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v4i1.93

Abstract

Virus hepatitis C (HCV) adalah virus hepatotropik dan limfotropik. Pasien yang terinfeksi HCV setidaknya terdapat satu manifestasi ekstrahepatik okular dan di kantung lakrimal selama perjalanan penyakit mereka. Penularan HCV terjadi melalui paparan darah yang terkontaminasi dengan faktor risiko tinggi pada pasien hemodialisis sekitar 70%. Deteksi RNA HCV lebih sensitif dan spesifik dengan PCR (Reaksi Polymerase Chain). Studi ini mengevaluasi sensitivitas dan spesifisitas virus hepatitis C PCR pada pasien hemodialisis air mata di Mohammad Hoesin Palembang. Dengan menggunakan studi diagnostik observasional dari 25 sampel dari air mata dan darah pada pasien hemodialisis. PCR diperiksa oleh RT-PCR. Data yang diperoleh dianalisis dengan tes diagnostik. Didapatkan hasil dari 25 sampel HCV-RNA terdeteksi oleh PCR dalam air mata 11 kasus positif (44%) dan 20 kasus positif (80%) dalam plasma. Nilai sensitivitas air mata adalah 72,73% dan spesifisitasnya 13,33%. Spesimen air mata cukup sensitif tetapi tidak spesifik, oleh karena itu pemeriksaan PCR dapat digunakan untuk skrining virus hepatitis C pada pasien hemodialisis.
Deteksi dini dan screening ARMD (Age-Related Macular Degeneration) di Puskesmas Palembang Ramzi Amin; Petty Purwanita; Ria Mutiara
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 2 No 1 (2021): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V2I1.36

Abstract

Age-related Macular Degeneration (ARMD) merupakan penyebab utama kebutaan pada negara berkembang, yang menyebabkan gangguan penglihatan sentral yang parah pada satu atau kedua mata. ARMD merupakan degenerasi progresif makula yang timbul pada usia lebih dari 50 tahun, yang ditandai dengan adanya drusen yang merupakan deposit material di antara retinal pigmen epithelium (RPE) dan membran Bruch. Prevalensi ARMD 29,2% unilateral dan 70,8 % bilateral. Pada wet ARMD unilateral, 50% akan berkembang mengenai mata sebelahnya dalam jangka waktu 5 tahun. Diperkirakan pada tahun 2020 sekitar 8 juta orang di Amerika memiliki ARMD karena peningkatan jumlah populasi usia tua. Pada tahap awal ARMD jarang menyebabkan keluhan. Keluhan baru dirasakan apabila telah terjadi drusen, neovaskularisasi koroid, adanya cairan dan darah yang menyebar ke sentral makula atau berpindahnya darah ke ruang vitreus, sehingga dapat menyebabkan gangguan lapang pandang sentral dan penurunan tajam penglihatan yang dapat membuat penderita kehilangan kemandirian dan kemampuan untuk aktivitas sehari-hari. Pengetahuan mengenai pentingnya melakukan skrining pada mata secara rutin dapat mencegah kebutaan 22-70%.
Skrining retinopati hipertensi di layanan kesehatan primer di Palembang Ramzi Amin; Petty Purwanita; Riani Erna; Prima Maya Sari; Eka Rahmadini; vidya hestika
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 1 No 3 (2020): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V1I3.37

Abstract

Hypertension is a condition of blood vessels that have high pressure. Hypertensive retinopathy is a complication of hypertension. The prevalence of hypertensive retinopathy varies between 2% -15%. There was lack of data regarding the prevalence of hypertensive retinopathy in Indonesia. Hypertensive retinopathy identification and diagnosis should be performed by an ophthalmologist. Most ophthalmologists are not assigned to primary health care. So that for cases of hypertension that can be resolved at primary health care such as Puskesmas, the true rate of hypertensive retinopathy is unknown. In addition, the patient's lack of awareness about routine eye examinations also causes the prevalence of hypertensive retinopathy to be unknown. This study aims to examine hypertensive retinopathy in hypertensive patients who are attending Puskesmas in Palembang, namely Puskesmas Dempo and Merdeka. The examination was carried out on 150 hypertensive patients. There were 15,3% patients with hypertensive retinopathy of which 10% had a history of hypertension more than 5 years and 5,3% less than 5 years. It could be argued that there are patients with hypertensive retinopathy who were undiagnosed in the community. The role of the Puskesmas in referring patients with hypertension to an ophthalmologist is very important so that the cases of hypertensive retinopathy could be detected immediately.
Comparison of the Effectiveness of Levofloxacin Eye Drop 0.5% and Povidone-Iodine 2.5% Against Conjunctival Normal Flora Bacterial Colonies in Intraocular Preoperative Procedures Petty Purwanita; Okta Kurniawan Saputra; Erial Bahar; Nurmalia Purnama Sari
Sriwijaya Journal of Ophthalmology Vol. 6 No. 1 (2023): Sriwijaya Journal of Ophthalmology
Publisher : Department of Opthalmology, Faculty of Medicine, Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjo.v7i1.95

Abstract

Introduction: Endophthalmitis is the most severe ocular complication and often causes blindness. The incidence of endophthalmitis varies depending on the type of surgery performed, from 0.082% to 0.32%. The use of povidone-iodine and topical antibiotics on the conjunctiva has been reported to reduce the likelihood of postoperative infection. This study aimed to compare the effectiveness of levofloxacin ED 0.5% with povidone-iodine 2.5% in reducing the normal bacterial flora of the conjunctiva in intraocular preoperative procedures. Methods: Clinical trial experimental studies. A total of 34 research subjects participated in this study. The research subjects were grouped into treatment groups of 0.5% levofloxacin and 2.5% povidone-iodine. Analysis of differences in the number of bacterial colonies was carried out with the help of bivariate SPSS software. Results: Treatment with levofloxacin 0.5% eye drop was able to reduce the number of colonies by 78.11%, while treatment with povidone-iodine 2.5% was able to reduce the number of colonies by 68.57%. Conclusion: Levofloxacin 0.5% eye drop is superior in reducing the number of conjunctival bacterial colonies in intraocular preoperative procedures compared to 2.5% povidone-iodine.
Initial Outcome of Subconjunctival Bevacizumab for Corneal Neovascularization - a Case Series: Poster Presentation - Case Series - Resident DEZCA NINDITA; Anang Tribowo; Petty Purwanita
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/6rgqwz73

Abstract

Introduction : Corneal neovascularization (CNV) has a variety of causes and threatens corneal clarity, thus optimal visual acuity. Conventional medical management includes topical steroids and matrix metalloproteinase inhibitors like doxycycline. Anti-vascular endothelial growth factor (anti-VEGF) agents have demonstrated promise but remain off-label for this indication. Case Illustration : We present three patients with corneal neovascularization varied in etiology who underwent subconjunctival injection of Bevacizumab . Case 1: a-female-69 years old came with blurred vision after had Stephen Johnson Syndrome which affect her cornea. The examination revealed opacification of cornea accompanied by neovascularization at 5 until 9 o’clock position up to edge of pupil in the left. Case 2: a-male-47 years old presented corneal haze with neovascularization almostin all corneal region on background of fungal keratitis. Case 3: a-male-63 years old who underwent penetrating keratoplasty of indication corneal lekoma following an episode of fungal keratitis. There was opacity in all corneal region and neovascularization in 360 degree of limbus. All of these patients showed regression of neovessel after first injection of bevacizumab. Discussion : Corneal neovascularization is a condition caused by disruption homeostasis in which proangiogenic balanced by antiangiogenic, thereby maintaining avascularity. Bevacizumab as VEGF-A-binding proteins could prevent VEGF-A from binding cell surface receptors. Conclusion : Subconjunctival injection of Bevacizumab can be considered as a treatment for corneal neovascularization. It has shown promising effects in recess neovascularization in cornea regardlessthe etiology.
Co-Authors ADRIAN PRATAMA Anang Tribowo Anang Tribowo ANCI WINAS Cicilia, Monica Putri DEZCA NINDITA Disty Andryani Eka Rahmadini Elsa Iskandar Erial Bahar Fahcreza Fanseca Alvarez, Frashad Indri Seta Septadina Muhammad Reza Arlas Natsir, Novia Novia Natsir Nurmalia Purnama Sari Okta Kurniawan Saputra Prima Maya Sari Prima Maya Sari RACHMAT HIDAYAT Ramzi Amin Ramzi Amin Ramzi Amin, Ramzi Ria Mutiara Riani Erna Riani Erna Tribowo, Anang vidya hestika