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All Journal Chimica et Natura Acta Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Jurnal Ilmiah Pangan Halal Journal of Bio-molecule Research And Engineering
Saputri, Ratih Dewi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Public Health Other

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DUA ISOMER SENYAWA FLAVONOID DARI BATANG Sesbania grandiflora Tjahjandarie, Tjitjik Srie; Saputri, Ratih Dewi; Putri, Nathasa Aquila; Dewi, Bella Kurniawati; Tanjung, Mulyadi
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol 3, No 1 (2020)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (748.124 KB) | DOI: 10.35799/pmj.3.1.2020.28962

Abstract

ABSTRACTTwo isomer flavonoids, 7,4´-dihydroxyflavanon (1) and 7,4´-dihydroxyisoflavanon (2) were isolatedfrom the bark of Sesbania grandiflora L. Their structures were determined based on spectroscopicdata such as UV, IR, MS, 1D and 2D NMR.Keywords : Sesbania grandiflora L., flavonoid, 7,4´-dihydroxyflavanon, 7,4´-dihydroxyisoflavanonABSTRAKDua isomer senyawa flavonoid, 7,4´-dihidroksiflavanon (1) dan 7,4´-dihidroksiisoflavanon(2) telah berhasil dipisahkan dari batang Sesbania grandiflora L. Kedua struktur senyawaisomer ditetapkan berdasarkan analisis spektroskopi UV, IR, MS, 1D dan 2D NMR.Kata kunci : Sesbania grandiflora L., flavonoid, 7,4´-dihidroksiflavanon, 7,4´-dihidroksiisoflavanon
Elimination of Dengue Virus with Antiviral Compound and Appropriate Technology Farihah, Neni Isna; Wijayanti, Alvia Rachma; Sucipto, Teguh Hari; Putri, Deva Permata; Ihsan, Anaqi Syaddad; Fauziyah, Shifa; Saputri, Ratih Dewi; Damayanti, Mamik
Journal of Bio-Molecule Research and Engineering Vol 2 No 1 (2023)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbiome.v2i1.44803

Abstract

Infection with the dengue virus by the Aedes aegypti mosquito vector is in the form of dengue hemorrhagic fever (DHF), which can cause a decrease in platelets and even death. The parasitic drug niclosamide, which is effective against dengue virus serotype 2 (DENV-2) is used to prevent further dengue virus infection. Many tests were carried out using inhibitors such as doxorubicin (SA-17), glycoside inhibitors in the form of deocynojirimycin (DNJ) and castanospermine (CSP), carbohydrate-binding agents (CBA), and the use of heparan sulfate aimed at inhibition of the adsorption process and replication process, as well as improper protein folding to prevent the conformation of virus merger. The elimination process can also be carried out using antiviral compounds found in the leaves of Psidium guajava and Carica papaya, which have inhibitory activities of 92.6% and 89.5%, respectively; propyl gallate, with a percent inhibition of dengue virus envelope protein serotype 2 of 53-9.85%; isobutyl gallate, with CC50 values of 167.19 g/mL and an inhibitory value (IC50) of 4.45; Cissampelos Pariera Linn methanol extract, with progressive inhibition as the Cipa extract concentration increased with an IC50 value of 6.1μg/ml Preventive methods are also carried out in several ways, namely by utilizing hydrophobic liquid in the form of silicone oil (low-viscosity polydimethylsiloxane, or L-PDMS), the use of eave tubes in home tubes inserted with insecticides, and utilizing ultrasound with a frequency of 100 kHz and 90 dB to repel mosquitoes carrying dengue virus vectors.
Kajian Peningkatan Aktivitas Antioksidan pada Umbi-Umbian Melalui Fermentasi Jusman, Nur Hasanah; Wikandari, Prima Retno; Saputri, Ratih Dewi
Jurnal Ilmiah Pangan Halal Vol. 7 No. 2 (2025): Jurnal Ilmiah Pangan Halal
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/jiph.v7i2.19321

Abstract

Tubers are recognized as local food sources rich in bioactive compounds, particularly phenolics and flavonoids, which function as natural antioxidants. However, in many tubers, phenolic compounds are often bound in glycosidic forms, reducing their antioxidant effectiveness. To enhance their bioactivity, these glycosidic bonds can be hydrolyzed through fermentation, utilizing microorganisms with β-glucosidase activity such as Lactobacillus plantarum. This enzyme breaks glycosidic bonds, releasing glucose and aglycones in free forms that are more biologically active and possess greater antioxidant potential. As a result, the bioavailability and absorption of phenolic compounds in the human body are improved, enhancing their ability to neutralize free radicals. Several types of tubers, including Chinese yam, jicama, and cassava, have shown significant increases in total phenolic and flavonoid content after undergoing fermentation. Studies have demonstrated that fermentation not only boosts antioxidant activity but also supports the development of more nutritious and affordable functional food products derived from tubers. Nonetheless, the success of fermentation depends on several factors, including microbial strains, fermentation duration, environmental conditions, and processing techniques. This review aims to summarize current findings on how fermentation enhances antioxidant properties in tubers and its potential application in functional food innovation.
Cytotoxicity of Chromanone Acid from the Steam Bark of Calophyllum incrassatum against P-388 Leukemia Murine Cells Hasanah, Ulfatun; Andawiyah, Robi’atul; Taqiyah, Barrotut; Saputri, Ratih Dewi; Tjahtjandarie, Tjitjik Srie
Chimica et Natura Acta Vol 13, No 2 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n2.58510

Abstract

Calophyllum incrassatum is one of the plant species of the Calophylloceae family and is found endemic in Kalimantan and Sumatra. This study aims to isolate chromanone acid compounds from the stem bark of C. incrassatum and determine the relationship between structure and activity against murine Leukemia P-388 cells. The extraction method used was maceration using methanol solvent, partitioned with n-hexane and ethyl acetate solvents. Separation and purification of n-hexane and ethyl acetate extracts by vacuum liquid chromatography, pressed column, and radial. Two chromanone acids derivatives, isoapetalic acid (1), and methyl isoapetalic (2), have been successfully isolated from the stem bark of Calophyllum incrassatum. The structures of the two compounds were identified and elucidated using spectroscopic techniques such as UV, IR, and 1D and 2D NMR. The cytotoxic activity against murine leukemia P-388 cells of compounds 1-2 showed IC50 values of 8.51 and 1.47 µg/mL, respectively, and compound (2) exhibited high cytotoxic activity
Co-Authors Andawiyah, Robi’atul DAMAYANTI, MAMIK Dewi, Bella Kurniawati Farihah, Neni Isna Ihsan, Anaqi Syaddad Jusman, Nur Hasanah Mulyadi Tanjung Prima Retno Wikandari Putri, Deva Permata Putri, Nathasa Aquila Shifa Fauziyah Taqiyah, Barrotut Teguh Hari Sucipto, Teguh Hari Tjahtjandarie, Tjitjik Srie Tjitjik Srie Tjahjandarie Ulfatun Hasanah Wijayanti, Alvia Rachma