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All Journal Heart Science Journal
Rahimah, Anna Fuji
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Health Professions Immunology & microbiology Medicine & Pharmacology

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The Role of Antioxidants and Anti-Inflammatory Agents in Cardiometabolic Disease Aryanugraha, Teguh; Sargowo, Djanggan; Rahimah, Anna Fuji; Tjahjono, Cholid Tri
Heart Science Journal Vol. 5 No. 1 (2024): Inflammation and Cardiovascular Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub/hsj.2024.005.01.3

Abstract

Cardiovascular diseases remain a major cause of morbidity and mortality worldwide. Cardiovascular diseases associated with metabolic disorders are collectively referred to as Cardiometabolic Diseases (CMDs). Oxidative stress and inflammation are key contributors to the development and progression of CMDs. Antioxidants and anti-inflammatory agents have garnered significant attention as potential therapeutic strategies for preventing and managing cardiovascular disorders. To better understand the complex interactions between oxidative stress, inflammation, and cardiovascular health, this review paper will focus on the mechanisms of action and potential advantages of antioxidants and anti-inflammatory drugs in reducing the risk factors associated with CVDs and enhancing cardiovascular health in general.
A case of cardiac myxoma with obstructive symptoms: Recognizing key early signs for improved diagnosis Filano, Marco; Kuhn, Corinna Maria; Zhao, Zihan; Laukkanen, Noora Julia; Rahimah, Anna Fuji; Karolina, Wella; Prasetya, Indra; Rohman, Mohammad Saifur
Heart Science Journal Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Pa
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.01.21

Abstract

Background: LA myxoma is the most common primary cardiac tumor, often presenting with obstructive symptoms when the tumor prolapses into the mitral valve during diastole. On the other hand, rheumatic MS leads to fixed obstruction of the mitral valve. The coexistence of both conditions is extremely rare and can exacerbate the severity of mitral inflow obstruction. Early recognition of this dual pathology through careful clinical evaluation and echocardiographic assessment is crucial for timely and effective management. Case Presentations: A 66-year-old female patient presented with progressive dyspnea. Transthoracic echocardiography detected a mobile mass in the left atrium and later identified it as a cardiac myxoma. Further evaluation revealed severe rheumatic mitral stenosis (MS) with a mitral valve area (MVA) measured by planimetry at 1.23 cm², restricting the mass from slipping into the left ventricle during the diastolic phase. Based on the conference decision, tumor resection was performed, and the histopathological examination revealed a left atrial (LA) myxoma. The dual obstruction caused by mitral valve stenosis and a left atrial myxoma resulted in life-threatening symptoms due to diastolic obstruction of mitral inflow. In isolated LA myxoma, the tumor pushes into the mitral valve opening during the heart's relaxation phase, blocking blood flow from the left atrium to the left ventricle and raising pressure in the atrium and lungs. When significant MS is present, the narrowed valve further worsens this obstruction, leading to higher atrial pressure and more severe heart failure symptoms. Both conditions commonly present with early symptoms such as exertional dyspnea, palpitations, signs of heart failure like edema and pulmonary crackles, diastolic murmur, and sometimes syncope caused by reduced cardiac output. Conclusions: This case highlights the critical importance of identifying early obstructive symptoms indicative of cardiac myxoma. Timely identification of these clinical manifestations can facilitate earlier diagnosis, improve patient outcomes, and prevent potentially fatal complications.
Assessing left atrial function in acute decompensated heart failure: Insights from echocardiography Niazta, Nisa Amnifolia; Karolina, Wella; Rahimah, Anna Fuji; Prasetya, Indra
Heart Science Journal Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.02.2

Abstract

Acute heart failure remains a major cause hospitalization, especially in older adults and is associated with mortality and frequent readmissions. Several factors associated with heart failure outcomes include left ventricular dysfuction, left atrial dysfunction, and LA enlargement. LA enlargement has been recognized as a dependable imaging marker, closely tied to adverse outcomes such as heart failure, stroke, atrial fibrillation, and mortality. LA is not merely a passive conduit for transport. LA plays an active role and responds to distension by releasing atrial natriuretic peptides. LA enlargement has been shown to correlate with poor cardiovascular prognosis. In patients experiencing acute heart failure, fluid overload and its reduction can alter LA mechanical performance. Decongestive treatment has been associated with improved LA reservoir function, which can be assessed through parameters like LA reservoir strain rate also peak atrial longitudinal strain. In more advanced heart failure—characterized by reduced left ventricular ejection fraction, increased filling pressures, then diminished cardiac output—both PALS and strain rate are often markedly impaired, reflecting significant dysfunction in LA reservoir. Evaluating left atrial function via echocardiographic techniques is proving to be a vital tool in predicting outcomes for individuals with acute decompensated heart failure. As the understanding of LA physiology evolves, its role is increasingly seen as dynamic rather than passive. Echocardiography is showing potential imaging biomarker for risk stratification and therapeutic guidance in heart failure management.
Co-Authors Adi, Andi Wahjono Akbar, Akita Rukmana Alfata, Fandy Hazzy Anjarwani, Setyasih Arif Wicaksono Aryanugraha, Teguh Astiawati, Tri Cholid Tri Tjahjono Djanggan Sargowo Dwigustiningrum, Nur Kaputrin Emil Fathoni, Emil Filano, Marco Galuh, Lukitasari Ayu Haryati, Lina Indra Prasetya Karolina, Wella Kuhn, Corinna Maria Kurnianingsih, Novi Laitupa, Fitranti Suciati Laukkanen, Noora Julia Martini, Henny Martini, Heny Mohammad Saifur Rohman Niazta, Nisa Amnifolia Noverike, Nikhen Nugraha, Krishna Ari Nurudinulloh, Akhmad Isna Putri, Valerinna Yogibuana Swastika Rizal, Ardian Saputri, Vemmy Lian Saskia Dyah Handari Satrijo, Budi Suprayoga, Imam Mi'raj Widito, Sasmojo Wikananda, Adhika Prastya Yoga Waranugraha Yogibuana, Valerinna Zhao, Zihan zunardi, Lutfi hafiz