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All Journal PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Prima Medika Sains Buletin Kedokteran dan Kesehatan Prima International Journal of Health and Pharmaceutical (IJHP)
Djamin, Djamin
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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The Effect of Giving Aloe Vera Gel on Collagen Growth in Wistar Rats (Rattus Norvegicus) with Exposure to Ultra Violet-B Light Fitria , Inola; Djamin, Djamin; Samin, Buter
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 4 (2023): November 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i4.310

Abstract

Exposure to UV rays can cause photochemical damage to the DNA of cells in the body, triggering cancer formation, especially skin cancer in humans. The skin may lose elasticity. Research is needed to ensure that currently, we are still looking for plants or foods that contain collagen, which can prevent wrinkles. This research is an original experiment carried out in a laboratory. Two types of variables play a role in this research: independent variables and dependent variables. In this experiment, aloe vera gel was used as an independent variable as a substitute for UVB light exposure. Collagen development, measured in mouse skin, is the dependent variable here. This study found that the standard control group had no collagen growth and was stable. This was because the typical control treatment was not exposed to UVB rays; hence, collagen formation was stable. The group administered 15% aloe vera extract gel had a more substantial effect on rat skin tissue collagen development after UVB light exposure than the 5% and 10% groups. This is because a higher dose of aloe vera extract includes more chemical components that promote mouse skin collagen formation.
Effect of gotu kola leaf extract cream on collagenization and histopathological picture of rat skin exposed to Ultraviolet B light Al Hamid, Muhammad; Novita, Cut Elvira; Wijaya, Johanna Fransiska; Djamin, Djamin
Jurnal Prima Medika Sains Vol. 6 No. 2 (2024): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i2.5743

Abstract

Changes due to genetic conditions (internal and chronological aging) overlap with aging symptoms triggered by environmental conditions (extrinsic aging). Until recently, exposure to the sun's ultraviolet (UV) radiation was considered the leading cause of extrinsic skin aging; both UVB (290-320 nm) and UVA (320-400 nm) caused photoaging, and due to their physical properties, UVB radiation was especially harmful to the skin condition. This study aims to analyze and test the effect of administering gotu kola leaf extract cream (Ceentella asiatica) on collagenization in Wistar rats (Rattus norvegicus) exposed to ultraviolet-B light. This study uses a posttest-only control group design, where only observations are made to the control group and treatment after the treatment is given. The research results show that gotu kola leaf extract contains phytochemicals that can be used as an antioxidant and anti-inflammatory ingredient because they contain flavonoids, saponins, tannins, and phenolic compounds. This research concludes that pegagan leaf extract contains phytochemicals that can be used as medicinal ingredients because it contains high antioxidant and anti-inflammatory compounds. The average percentage of collagen growth in the control group compared to treatment groups P1, P2, and P3 after exposure to UVB light was very high, and the group control of collagen growth was not significant and tended to be stable.
PENGARUH PEMBERIAN GEL EKSTRAK KULIT KAYU MANIS (CINNAMOMUM BURMANNII) DALAM MENINGKATKAN KOLAGEN PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG MENGALAMI LUKA BAKAR Fathona, Zenia; Djamin, Djamin; Setiawan, Deni
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 1 (2025): APRIL 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i1.41180

Abstract

Tubuh manusia adalah mesin biologis yang terbuat dari sistem tubuh; kelompok organ yang bekerja sama untuk menghasilkan dan mempertahankan kehidupan. Sistem integumen adalah sekumpulan organ yang membentuk lapisan luar tubuh. Sistem ini meliputi kulit, pelengkap kulit, kelenjar keringat, dan reseptor sensorik. Kulit terbagi menjadi tiga lapisan, epidermis, dermis, dan hypodermis. Lapisan epidermis merupakan lapisan terluar kulit. Sel utamanya adalah keratinosit (95% dari sel). Melanosit, sel Langerhans, dan sel Merkel merupakan 5% sisanya. Tujuan penelitian in iuntuk menguji dan menganalisis pengaruh pemberian gel ekstrak kulit kayu manis (Cinnamomum burmannii) dalam meningkatkan kolagen pada tikus putih (Rattus norvegicus) jantan galur wistar yang mengalami luka bakar. Penelitian ini menggunakan post-test only control group design untuk mengetahui dan menganalisis efek pemberian ekstrak kulit kayu manis dalam mempercepat penyembuhan luka dan meningkatkan kolagen pada tikus putih (Rattus norvegicus) galur wistar yang mengalami luka bakar. Ekstrak kulit kayu manis mengandung senyawa fitokimia yaitu flavonoid, saponin, tannin, alkaloid, dan triterpenoid yang memiliki efek antioksidan, antimikroba, dan antiinflamasi dan berperan pada proses penyembuhan luka bakar dan kolagenisasi. Krim ekstrak kulit kayu manis dengan konsentrasi 10% paling efektif dalam mempercepat penyembuhan luka, yaitu dalam 12 hari. Hasil pengamatan gambaran histopatologi jaringan kulit menunjukkan kelompok perlakuan 3 dengan pemberian krim ekstrak kulit kayu manis dengan konsentrasi 10% memiliki kepadatan kolagen yang masuk dalam kategori rapat.
Factors related to the quality of health services at Rambung Community Health Center Tebing Tinggi City Purba, Arna Fransisca Millyanti; Harahap, Yuri Warda; Atmadja, Linda Stefanie; Djamin, Djamin; Silalahi, Todung Donald Aposan; Malau, Reghita Claudia; Br Bukit, Rosmeri; Iskandar, Dalmy; Zubaidah, Siti; Pakpahan, Enni Halimatussa'diyah
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.7450

Abstract

Service activites in an organization that the main activitiy is as service’s provider has a very strategic role. The facility that can support health service’s realization through Community Health Center  (PUSKESMAS). Minister of Health Regulation number 43 of 2019 concerning Puskesmas states that Puskesmas is health service that doing public health means and first level individual health, by prioritizing promotive and preventive in their working areas. This study aims to determinate the factors relating to quality of health’s service in Puskesmas Rambung at Tebing Tinggi City. This type of research is quantitative with a cross-sectional approach. With population of average monthly patitent who come for treatment of 68 samples. Sampling method used purposive sampling.The results showed that the variables that relating to health service’s quality at Puskesmas Rambung Tebing Tinggi City are tangibles (p=0,004), responsiveness (p=0,0001), assurance (p=0,0001), and empathy (p=0,0001). Puskesmas health workers must improving reliability through the attitude of officers towards patients, maintaining the cleanliness of the puskesmas environment so that patients who come for treatment feel comfortable and it is health workers considered to improve their performance so that they will be even better in the future.
Co-Authors Al Hamid, Muhammad Atmadja, Linda Stefanie Br Bukit, Rosmeri DENI SETIAWAN Fathona, Zenia Fitria , Inola Harahap, Yuri Warda Iskandar, Dalmy Malau, Reghita Claudia Novita, Cut Elvira Pakpahan, Enni Halimatussa'diyah Purba, Arna Fransisca Millyanti Samin, Buter Siti Zubaidah Todung Donald Aposan Silalahi Wijaya, Johanna Fransiska