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ANTIOXIDANT POTENTIAL OF TEMULAWAK (CURCUMA XANTHORRHIZA) EXTRACT GEL AS A CANDIDATE FOR WOUND HEALING Malau, Reghita Claudia; Nasution, Sri Wahyuni; Nasution, Ali Napiah; Widowati, Wahyu; Salfa Nindya, Faradhina; Kusuma, Hanna Sari Widya
Journal of Vocational Health Studies Vol. 7 No. 3 (2024): March 2024 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V7.I3.2024.166-174

Background: The complete treatment of chronic wounds remains a significant unmet medical need. To expedite the healing of chronic wounds, numerous studies have begun to utilize gels, including hydrogels or sol-gels, which incorporate a combination of antioxidant properties. Curcuma xanthorrhiza is known to contain polyphenolic compounds, which include flavonoids acting as an antioxidant. Purpose: Examine the potential of C. xanthorrhiza extract (CXE) gel as a candidate for wound-healing by measuring its antioxidant activity. Method: Three CXE gel formulas were prepared from different concentrations of CMC-Na (3, 4, and 5%). Each formula consisted of 5% CXE, 15% propylene Glycol, 10% Glycerin, 0.25% Methylparaben, and distilled water. The quality of the CXE gel was tested through homogeneity, spreadability, pH, and viscosity tests. The antioxidant activity was measured by 2,2-Diphenyl-1-picrylhydrazil (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS)-reducing activity assay in a gel formula that was close the standards. The measurement results were then used in the calculation of antioxidant activity to determine the IC50 value. Result: Formulas 1, 2, and 3 meet the requirements by yielding a homogeneous gel with a spreadability of 5.37 – 5.93 cm, a pH level of 5.87 – 6.10, and a viscosity of 8.800 – 9296.67 cps. The highest DPPH and ABTS percentages were 34.04% and 5.28%, respectively. The IC50 values of CXE gel in DPPH and ABTS were 1973.38 Î¼g/mL and 700.65 Î¼g/mL, respectively. Conclusion: The CXE 1, 2, and 3 gel formula meets the requirements and has the potential to be used as a wound healing therapy through its antioxidant properties.

Factors related to the quality of health services at Rambung Community Health Center Tebing Tinggi City Purba, Arna Fransisca Millyanti; Harahap, Yuri Warda; Atmadja, Linda Stefanie; Djamin, Djamin; Silalahi, Todung Donald Aposan; Malau, Reghita Claudia; Br Bukit, Rosmeri; Iskandar, Dalmy; Zubaidah, Siti; Pakpahan, Enni Halimatussa'diyah
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.7450

Service activites in an organization that the main activitiy is as service’s provider has a very strategic role. The facility that can support health service’s realization through Community Health Center (PUSKESMAS). Minister of Health Regulation number 43 of 2019 concerning Puskesmas states that Puskesmas is health service that doing public health means and first level individual health, by prioritizing promotive and preventive in their working areas. This study aims to determinate the factors relating to quality of health’s service in Puskesmas Rambung at Tebing Tinggi City. This type of research is quantitative with a cross-sectional approach. With population of average monthly patitent who come for treatment of 68 samples. Sampling method used purposive sampling.The results showed that the variables that relating to health service’s quality at Puskesmas Rambung Tebing Tinggi City are tangibles (p=0,004), responsiveness (p=0,0001), assurance (p=0,0001), and empathy (p=0,0001). Puskesmas health workers must improving reliability through the attitude of officers towards patients, maintaining the cleanliness of the puskesmas environment so that patients who come for treatment feel comfortable and it is health workers considered to improve their performance so that they will be even better in the future.

Factors related to the quality of health services at Rambung Community Health Center Tebing Tinggi City Purba, Arna Fransisca Millyanti; Harahap, Yuri Warda; Atmadja, Linda Stefanie; Djamin, Djamin; Silalahi, Todung Donald Aposan; Malau, Reghita Claudia; Br Bukit, Rosmeri; Iskandar, Dalmy; Zubaidah, Siti; Pakpahan, Enni Halimatussa'diyah
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.7450

Service activites in an organization that the main activitiy is as service’s provider has a very strategic role. The facility that can support health service’s realization through Community Health Center (PUSKESMAS). Minister of Health Regulation number 43 of 2019 concerning Puskesmas states that Puskesmas is health service that doing public health means and first level individual health, by prioritizing promotive and preventive in their working areas. This study aims to determinate the factors relating to quality of health’s service in Puskesmas Rambung at Tebing Tinggi City. This type of research is quantitative with a cross-sectional approach. With population of average monthly patitent who come for treatment of 68 samples. Sampling method used purposive sampling.The results showed that the variables that relating to health service’s quality at Puskesmas Rambung Tebing Tinggi City are tangibles (p=0,004), responsiveness (p=0,0001), assurance (p=0,0001), and empathy (p=0,0001). Puskesmas health workers must improving reliability through the attitude of officers towards patients, maintaining the cleanliness of the puskesmas environment so that patients who come for treatment feel comfortable and it is health workers considered to improve their performance so that they will be even better in the future.

Risk factors associated with dengue hemorrhagic fever incidence in the Belawan II Community Health Center Sari, Juwita Purnama; Ginting, Rapael; Sihotang, Widya Yanti; Fioni, Fioni; Tarigan, Antje Irmella; Malau, Reghita Claudia; Angkasa, Alexander; Lizar, Budi Septhian
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7813

Dengue Hemorrhagic Fever (DHF) remains a major public health concern in tropical regions such as Indonesia, where environmental and behavioural factors play crucial roles in its transmission. This study aimed to analyse the factors associated with the incidence of DHF in the working area of the Belawan II Community Health Centre in Medan. A quantitative approach with a cross-sectional design was employed. A sample of 110 housewives was selected via purposive sampling from a population of 150 housewives in the area. Data were collected through questionnaires and observation, then analysed using univariate, bivariate (Chi-Square test), and multivariate (logistic regression) methods. Bivariate analysis revealed significant associations between DHF incidence and the following factors: education level (p=0.001), housewives' knowledge (p=0.000), 3M Plus behaviour (p=0.000), health promotion services (p=0.000), and the presence of mosquito larvae (p=0.000). In contrast, variables for age (p=0.161) and occupation (p=0.898) showed no significant association. Multivariate analysis identified health promotion services as the dominant factor associated with DHF incidence (OR=0.029; 95% CI=0.010-0.084; p=0.000), with housewives' knowledge serving as a supporting factor. In conclusion, DHF prevention efforts in the Belawan II area should prioritise enhancing the quality and coverage of effective health promotion services, complemented by improving household-level knowledge and preventive practices, alongside sustainable control of mosquito breeding sites.

The Effect of Giving Coffee Pulp Extract Cream on the Healing of Cut Wounds in Wistar Rats Anggun Juita; Refi Ikhtiari; Erny Tandanu; Reghita Claudia Malau
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 1 (2025): February 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i1.409

Humans need skin to protect their internal organs, such as muscles, nerves, and bones, from disease. This study examines the effect of coffee grounds extract cream on wound healing in Wistar rats. This study is an experimental laboratory study. The research design used a post-test with a control group design or control on samples based on treatment groups to analyze the effect of coffee grounds extract on wound healing and skin histopathology in male Wistar white rats. According to the results of the study, coffee grounds extract accelerated wound healing in Wistar white rats, as shown by the average differences of 2.5%, 5%, and 10%. This study shows that coffee grounds extract contains saponins, alkaloids, flavonoids, and tannins. Research on skin histopathology on the best fibroblast tissue found that 10% coffee grounds extract cream was the most helpful in developing connective tissue in injured skin. The findings of this study are expected to help other researchers explore the effects of coffee grounds extract on skin collagen formation.

An Effect Of Methanol Extract Sunkist Orange Peel (Citrus Sinensis (L.) Osbeck) On Blood Sugar And Cholesterol Levels Wistar Rats (Rattus Norvegicus) Induced By Aloxan Yolanda Eliza Putri Lubis; Reghita Claudia Malau; Rahmi Arianti; Maya Sari Mutia
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 2 (2023): May 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i3.117

Insulin resistance is a condition with damage to target organs that generally respond to the activity of the hormone insulin. About 10% of the population in big cities in Indonesia suffer from insulin resistance. At the cellular level, insulin resistance can result from damage to the pre-receptor, receptor, or post-receptor. The most common cause of insulin resistance is post-receptor damage, namely disruption and damage to insulin signaling pathways. To find out that the methanol extract of Sunkist orange peel can reduce blood sugar levels in Wistar rats. This research uses the experimental laboratory method in vivo with the chosen research design form, namely True Experimental Pre Test and Post Test Control. The Kruskal Wallis test showed that the Sunkist Orange Peel Methanol Extract resulted in a significant decrease in blood sugar levels of Wistar rats with a p-value <0.05, and also the Anova test showed that the Sunkist Orange Peel Methanol Extract resulted in a decrease in blood sugar levels of Wistar rats, which is significant with p-value <0.05. All doses tested affect lowering blood sugar levels, namely, 300 mg/kg BW, 450 mg/kg BW, and 600 mg/kg BW.

Hubungan Stres Akademik dengan Pola Tidur dan Indeks Massa Tubuh pada Mahasiswa Pendidikan Kedokteran Nabila Dwi Atiqa; Reghita Claudia Malau; Andrico Napolin Lumban Tobing
GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Vol. 5 No. 4 (2026): GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh - Agustus 20
Publisher : Program Studi Kedokteran Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/jkkmm.v5i4.29640

Mahasiswa kedokteran menghadapi tuntutan akademik yang intens sehingga rentan mengalami stres psikologis yang dapat berdampak pada kesehatan fisik, termasuk kualitas tidur dan perubahan berat badan. Penelitian ini bertujuan untuk menganalisis hubungan antara stres akademik dengan pola tidur dan Indeks Massa Tubuh (IMT) pada mahasiswa tahap preklinik di Fakultas Kedokteran Universitas Prima Indonesia. Penelitian ini menggunakan desain analitik observasional dengan pendekatan cross-sectional. Sebanyak 89 responden dipilih melalui teknik simple random sampling. Data stres akademik diukur menggunakan instrumen Academic Stress Scale (ASS), pola tidur dievaluasi menggunakan Pittsburgh Sleep Quality Index (PSQI), dan IMT dihitung berdasarkan pengukuran antropometri. Analisis data dilakukan menggunakan uji korelasi Spearman. Hasil penelitian menunjukkan bahwa mayoritas responden adalah perempuan (76,4%) dengan usia rata-rata 19 tahun. Terdapat hubungan positif yang signifikan secara statistik antara stres akademik dengan pola tidur (p<0,001;r=0,638) serta antara stres akademik dengan IMT (p<0,001; r=0,463). Semakin tinggi tingkat stres akademik, semakin buruk pola tidur mahasiswa dan semakin besar peluang terjadinya peningkatan IMT (kelebihan berat badan). Penelitian ini menyimpulkan bahwa stres akademik merupakan prediktor yang signifikan terhadap disrupsi pola tidur dan perubahan status gizi mahasiswa kedokteran, sehingga institusi pendidikan perlu mengintegrasikan program manajemen stres ke dalam kurikulum pembinaan mahasiswa.

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