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ANTIOXIDANT POTENTIAL OF TEMULAWAK (CURCUMA XANTHORRHIZA) EXTRACT GEL AS A CANDIDATE FOR WOUND HEALING Malau, Reghita Claudia; Nasution, Sri Wahyuni; Nasution, Ali Napiah; Widowati, Wahyu; Salfa Nindya, Faradhina; Kusuma, Hanna Sari Widya
Journal of Vocational Health Studies Vol. 7 No. 3 (2024): March 2024 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V7.I3.2024.166-174

Background: The complete treatment of chronic wounds remains a significant unmet medical need. To expedite the healing of chronic wounds, numerous studies have begun to utilize gels, including hydrogels or sol-gels, which incorporate a combination of antioxidant properties. Curcuma xanthorrhiza is known to contain polyphenolic compounds, which include flavonoids acting as an antioxidant. Purpose: Examine the potential of C. xanthorrhiza extract (CXE) gel as a candidate for wound-healing by measuring its antioxidant activity. Method: Three CXE gel formulas were prepared from different concentrations of CMC-Na (3, 4, and 5%). Each formula consisted of 5% CXE, 15% propylene Glycol, 10% Glycerin, 0.25% Methylparaben, and distilled water. The quality of the CXE gel was tested through homogeneity, spreadability, pH, and viscosity tests. The antioxidant activity was measured by 2,2-Diphenyl-1-picrylhydrazil (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS)-reducing activity assay in a gel formula that was close the standards. The measurement results were then used in the calculation of antioxidant activity to determine the IC50 value. Result: Formulas 1, 2, and 3 meet the requirements by yielding a homogeneous gel with a spreadability of 5.37 – 5.93 cm, a pH level of 5.87 – 6.10, and a viscosity of 8.800 – 9296.67 cps. The highest DPPH and ABTS percentages were 34.04% and 5.28%, respectively. The IC50 values of CXE gel in DPPH and ABTS were 1973.38 Î¼g/mL and 700.65 Î¼g/mL, respectively. Conclusion: The CXE 1, 2, and 3 gel formula meets the requirements and has the potential to be used as a wound healing therapy through its antioxidant properties.

Factors related to the quality of health services at Rambung Community Health Center Tebing Tinggi City Purba, Arna Fransisca Millyanti; Harahap, Yuri Warda; Atmadja, Linda Stefanie; Djamin, Djamin; Silalahi, Todung Donald Aposan; Malau, Reghita Claudia; Br Bukit, Rosmeri; Iskandar, Dalmy; Zubaidah, Siti; Pakpahan, Enni Halimatussa'diyah
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.7450

Service activites in an organization that the main activitiy is as service’s provider has a very strategic role. The facility that can support health service’s realization through Community Health Center (PUSKESMAS). Minister of Health Regulation number 43 of 2019 concerning Puskesmas states that Puskesmas is health service that doing public health means and first level individual health, by prioritizing promotive and preventive in their working areas. This study aims to determinate the factors relating to quality of health’s service in Puskesmas Rambung at Tebing Tinggi City. This type of research is quantitative with a cross-sectional approach. With population of average monthly patitent who come for treatment of 68 samples. Sampling method used purposive sampling.The results showed that the variables that relating to health service’s quality at Puskesmas Rambung Tebing Tinggi City are tangibles (p=0,004), responsiveness (p=0,0001), assurance (p=0,0001), and empathy (p=0,0001). Puskesmas health workers must improving reliability through the attitude of officers towards patients, maintaining the cleanliness of the puskesmas environment so that patients who come for treatment feel comfortable and it is health workers considered to improve their performance so that they will be even better in the future.

Factors related to the quality of health services at Rambung Community Health Center Tebing Tinggi City Purba, Arna Fransisca Millyanti; Harahap, Yuri Warda; Atmadja, Linda Stefanie; Djamin, Djamin; Silalahi, Todung Donald Aposan; Malau, Reghita Claudia; Br Bukit, Rosmeri; Iskandar, Dalmy; Zubaidah, Siti; Pakpahan, Enni Halimatussa'diyah
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.7450

Service activites in an organization that the main activitiy is as service’s provider has a very strategic role. The facility that can support health service’s realization through Community Health Center (PUSKESMAS). Minister of Health Regulation number 43 of 2019 concerning Puskesmas states that Puskesmas is health service that doing public health means and first level individual health, by prioritizing promotive and preventive in their working areas. This study aims to determinate the factors relating to quality of health’s service in Puskesmas Rambung at Tebing Tinggi City. This type of research is quantitative with a cross-sectional approach. With population of average monthly patitent who come for treatment of 68 samples. Sampling method used purposive sampling.The results showed that the variables that relating to health service’s quality at Puskesmas Rambung Tebing Tinggi City are tangibles (p=0,004), responsiveness (p=0,0001), assurance (p=0,0001), and empathy (p=0,0001). Puskesmas health workers must improving reliability through the attitude of officers towards patients, maintaining the cleanliness of the puskesmas environment so that patients who come for treatment feel comfortable and it is health workers considered to improve their performance so that they will be even better in the future.

Risk factors associated with dengue hemorrhagic fever incidence in the Belawan II Community Health Center Sari, Juwita Purnama; Ginting, Rapael; Sihotang, Widya Yanti; Fioni, Fioni; Tarigan, Antje Irmella; Malau, Reghita Claudia; Angkasa, Alexander; Lizar, Budi Septhian
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7813

Dengue Hemorrhagic Fever (DHF) remains a major public health concern in tropical regions such as Indonesia, where environmental and behavioural factors play crucial roles in its transmission. This study aimed to analyse the factors associated with the incidence of DHF in the working area of the Belawan II Community Health Centre in Medan. A quantitative approach with a cross-sectional design was employed. A sample of 110 housewives was selected via purposive sampling from a population of 150 housewives in the area. Data were collected through questionnaires and observation, then analysed using univariate, bivariate (Chi-Square test), and multivariate (logistic regression) methods. Bivariate analysis revealed significant associations between DHF incidence and the following factors: education level (p=0.001), housewives' knowledge (p=0.000), 3M Plus behaviour (p=0.000), health promotion services (p=0.000), and the presence of mosquito larvae (p=0.000). In contrast, variables for age (p=0.161) and occupation (p=0.898) showed no significant association. Multivariate analysis identified health promotion services as the dominant factor associated with DHF incidence (OR=0.029; 95% CI=0.010-0.084; p=0.000), with housewives' knowledge serving as a supporting factor. In conclusion, DHF prevention efforts in the Belawan II area should prioritise enhancing the quality and coverage of effective health promotion services, complemented by improving household-level knowledge and preventive practices, alongside sustainable control of mosquito breeding sites.

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