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All Journal Jurnal Prima Medika Sains JOURNAL LA MEDIHEALTICO Journal of Multidisciplinary Applied Natural Science Buletin Kedokteran dan Kesehatan Prima Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE)
Wijaya, Johanna Fransiska
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Pemberian ASI eksklusif dan faktor-faktor pendukungnya Nur, Fauziah Yasmin; Milano, Tri Adi; Amir, Widya Pasca; Wijaya, Johanna Fransiska; Isnanta, Rahmad; Katarino, Djamin
Buletin Kedokteran & Kesehatan Prima Vol. 1 No. 1 (2022): Maret
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (56.358 KB)

Abstract

Pemberian ASI eksklusif merupakan salah satu tujuan dari MDGs yaitu untuk mengurangi tingkat kematian anak dan meningkatkan kesehatan ibu. Target pencapaian Pemberian ASI eksklusif di Indonesia masih jauh belum tercapai. Tujuan penelitian ini adalah untuk megetahui hubungan pengetahuan, sikap dan dukungan suami terhadap pemberian ASI eksklusif. Jenis penelitian ini adalah penelitian observasional dengan rancangan penelitian cross sectional. Jumlah sampel dalam penelitian ini sebanyak 91 responden dengan teknik pengambilan sampel yang digunakan simple random sampling. Analisis data menggunakan uji Chi Square dengan derajat kepercayaan sebesar 95%. Hasil penelitian menunjukkan ada hubungan antara sikap (0,000) dan dukungan suami (0,000) terhadap pemberian ASI esklusif. Sementara itu pengetahuan tidak berhubungan dengan pemberian ASI eksklusif (0,06).
Tingkat pendidikan ibu hamil dan keteraturan pemeriksaan ANC Wijaya, Johanna Fransiska; Tanamal, Claudia; Arif, Julio; Syahputri, Febrianti
Jurnal Prima Medika Sains Vol. 4 No. 2 (2022): Desember
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v4i2.2960

Abstract

Kehamilan merupakan kondisi terdapat janin pada tubuh seorang perempuan. Selama kehamilan, perempuan memiliki risiko besar terkena gangguan atau komplikasi yang mungkin ditimbulkan saat kehamilan. Oleh karena itu, selama kehamilan ibu yang sedang hamil perlu untuk melakukan kunjungan pemeriksaan Antenatal Care pada pusat layanan kesehatan. Antenatal Care adalah pemeriksaan kepada ibu hamil yang mencakup pemantauan terhadap janin, mendeteksi gangguan atau kelainan selama kehamilan, serta mempersiapkan fisik dan psikologis ibu hamil dalam melakukan persalinan. Penelitian ini bertujuan untuk mengetahui hubungan antara tingkat pendidikan ibu hamil dengan keteraturan pemeriksaan Antenatal Care di Puskesmas Helvetia. Penelitian ini menggunakan desain penelitian observasional analitik dengan pendekatan cross-sectional study dan analisa data dengan menggunakan uji Chi Square. Sampel yang diambil pada penelitian ini sebanyak 83 ibu hamil. Dari hasil penelitian yang telah dilakukan, mayoritas tingkat pendidikan ibu hamil pada penelitian ini adalah tingkat pendidikan SMA dengan presentase sebesar 57,8%. Sebesar 60,2% dari total sampel teratur dalam melakukan kunjungan pemeriksaan Antenatal Care. Dari hasil uji statistik yang dilakukan, didapatkan nilai P atau p value 0,028 yang lebih kecil dari nilai uji signifikan 0,05. Sehingga dapat disimpulkan bahwa terdapat hubungan antara tingkat pendidikan ibu hamil dengan keteraturan pemeriksaan Antenatal Care.
Comparison of the Effectiveness of Dermapen Using Plasma from Platelets with Dermapen on Pockmarked Skin Surface of Female Wistar Rats (Rattus Norvegicus) Nila, Endang Dwi Wulansari Roh; Wijaya, Johanna Fransiska; Edison, Rizki Edmi
Journal La Medihealtico Vol. 5 No. 1 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i1.1090

Abstract

Various treatments can cure pockmarks. First, you have to know the cause of the pockmarks and the strength of the pockmarked skin, making it easier to choose the treatment, one of which is dermapen, which uses Plasma from platelets. Test and compare the effectiveness of the derma pen action using Plasma from platelets with the derma pen action on the pockmarked skin surface of female Wistar rats (Rattus Copernicus). This research is a laboratory experiment to compare the effectiveness of the dermapen action using Plasma from platelets with the dermapen action on the pockmarked skin surface of female Wistar rats (Rattus novergicus) using a post-test with control group design or control samples based on treatment groups to analyze the dermapen action using Plasma from platelets with dermapenic action on the surface of rat skin pockmarks. The results showed that the dermapen treatment group with Plasma from platelets at a dose of 10% was more effective in healing cut wounds in white mice than the dermapen treatment group using Plasma from platelets at doses of 2.5% and 5%, respectively. This is because, at a concentration of 10%, blood plasma metabolite compounds from platelets that are applied to wounds already affect the wound. The effect only inhibits microorganisms at small doses, making it less effective in healing wounds. It is recommended that the minimum dose be 10% so that the metabolite compounds in the Plasma from platelets have a healing effect on wounds.
Effect of gotu kola leaf extract cream on collagenization and histopathological picture of rat skin exposed to Ultraviolet B light Al Hamid, Muhammad; Novita, Cut Elvira; Wijaya, Johanna Fransiska; Djamin, Djamin
Jurnal Prima Medika Sains Vol. 6 No. 2 (2024): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i2.5743

Abstract

Changes due to genetic conditions (internal and chronological aging) overlap with aging symptoms triggered by environmental conditions (extrinsic aging). Until recently, exposure to the sun's ultraviolet (UV) radiation was considered the leading cause of extrinsic skin aging; both UVB (290-320 nm) and UVA (320-400 nm) caused photoaging, and due to their physical properties, UVB radiation was especially harmful to the skin condition. This study aims to analyze and test the effect of administering gotu kola leaf extract cream (Ceentella asiatica) on collagenization in Wistar rats (Rattus norvegicus) exposed to ultraviolet-B light. This study uses a posttest-only control group design, where only observations are made to the control group and treatment after the treatment is given. The research results show that gotu kola leaf extract contains phytochemicals that can be used as an antioxidant and anti-inflammatory ingredient because they contain flavonoids, saponins, tannins, and phenolic compounds. This research concludes that pegagan leaf extract contains phytochemicals that can be used as medicinal ingredients because it contains high antioxidant and anti-inflammatory compounds. The average percentage of collagen growth in the control group compared to treatment groups P1, P2, and P3 after exposure to UVB light was very high, and the group control of collagen growth was not significant and tended to be stable.
Investigation of Potential Molecular Targets of Zanthoxylum acanthopodium in Ovarian Cancer Using Network Pharmacology Assessments Wijaya, Johanna Fransiska; Chiuman, Linda; Syahputra, Hariyadi Dharmawan; Kaban, Vera Estefania; Razoki, Razoki; Ginting, Chrismis Novalinda; Iksen, Iksen
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.268

Abstract

Ovarian cancer is a serious disease that affects the ovaries, and its early detection is challenging due to vague symptoms often dismissed as minor ailments. Currently, natural sources have gained attention for their potential role in anticancer treatment. This study aimed to utilize network pharmacology to explore the potential targets and mechanisms of Zanthoxylum acanthopodium in the treatment of ovarian cancer. This study utilized the KNApSAcK and Swiss Target Prediction to identify active compounds and target genes. Additionally, ovarian cancer-specific target genes were sourced from the GEO database. To identify possible key target genes, the network interaction between protein-protein using the STRING database and visualized them in Cytoscape. Subsequent analysis using Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enabled us to focus on primary therapeutic targets. Our investigation into Zanthoxylum acanthopodium revealed 10 active compounds that pass Lipinski rule of five and oral bioavailability with acceptable pharmacokinetic profiles, 88 therapeutic targets, and identified 5 hub genes: SRC, CCNB2, MMP9, PTGS2, and PTPRC, which are strongly associated with ovarian cancer progression. Pathway enrichment analysis highlighted several pathways significantly related to the pathogenesis of ovarian cancer. This study elucidates the therapeutic potential and mechanisms of action of Z. acanthopodium as a promising candidate for ovarian cancer treatment. However, further research, including both in vitro and in vivo studies, is necessary to understand its molecular mechanisms comprehensively.
Hubungan Karakteristik, Pengetahuan Ibu, dan Dukungan Keluarga terhadap Keberhasilan ASI Eksklusif pada Bayi Harahap, Maulana Muhammad Yusuf Zakaria; Wijaya, Johanna Fransiska
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 2 (2025): Agustus : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i2.6265

Abstract

Exclusive breastfeeding plays a crucial role in reducing neonatal mortality rates, preventing growth disorders, and enhancing immunological resilience. However, adherence to exclusive breastfeeding practices remains below the targeted level. This study aims to analyze the relationship between maternal characteristics, knowledge, and family support with the success of exclusive breastfeeding in infants. A cross-sectional design was used, conducted at the UPTD Sawang Health Center, South Aceh Regency, during February–March 2025. The population consisted of all mothers with infants aged 7–12 months visiting the health center, totaling 120 individuals. A sample of 97 respondents was selected using purposive sampling. Data were collected through a structured questionnaire, followed by data processing that included response completeness checks, variable coding, and data entry. Data analysis comprised univariate analysis to present the frequency distribution of maternal characteristics and knowledge, and bivariate analysis using the Chi-Square (χ²) test with a significance level of α=0.05 to test the hypotheses. The results showed that maternal employment was significantly associated with the success of exclusive breastfeeding (p < 0.001), whereas maternal education (p = 0.566), income (p = 0.915), maternal knowledge (p = 0.351), and family support (p = 0.252) were not significantly related. In conclusion, maternal employment has a significant relationship with exclusive breastfeeding success
Co-Authors Al Hamid, Muhammad Amir, Widya Pasca Arif, Julio Chiuman, Linda Djamin, Djamin Edison, Rizki Edmi Ginting, Chrismis Novalinda Harahap, Maulana Muhammad Yusuf Zakaria Iksen, Iksen Katarino, Djamin Milano, Tri Adi Nila, Endang Dwi Wulansari Roh Novita, Cut Elvira Nur, Fauziah Yasmin Rahmad Isnanta, Rahmad Razoki, Razoki Syahputra, Hariyadi Dharmawan Syahputri, Febrianti Tanamal, Claudia Vera Estefania Kaban