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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Indonesian Journal of Tropical and Infectious Disease HIGEIA (Journal of Public Health Research and Development) Jurnal Pengabdian Masyarakat Medika
Satria, Yohanes Aditya Adhi
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Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Faktor-Faktor yang Dapat Memengaruhi Keseimbangan Th17/Treg: Review Article Prakoeswa, Flora Ramona Sigit; Hidayat, Saiful; Satria, Yohanes Aditya Adhi; Awanis, Ghina Shabrina
HIGEIA (Journal of Public Health Research and Development) Vol 6 No 1 (2022): HIGEIA: January 2022
Publisher : Jurusan Ilmu Kesehatan Masyarakat, Fakultas Ilmu Keolahragaan, Universitas Negeri Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/higeia.v6i1.50196

Abstract

Abstrak Sistem imun manusia terdiri dari sistem imun alami dan adaptif. Sistem imun alami berperan sebagai pertahanan pertama tubuh terhadap pathogen, sedangkan sistem imun adaptif berperan dalam menjalankan respon imun spesifik. Di antara berbagai efektor sistem imun adaptif, Th17 yang bertugas melawan pathogen dapat menimbulkan terjadinya autoimun dan inflamasi ketika jumlahnya berlebih. Sebaliknya, Treg yang bertugas menjaga homeostasis imun dapat menyebabkan terjadinya autoimun ketika jumahnya menurun. Ketidakseimbangan antara Th17 dan Treg berperan penting dalam patogenesis berbagai penyakit autoimun, seperti systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), inflammatory bowel disease (IBD), multiple sclerosis (MS), dan psoriasis. Artikel ini dibuat untuk mengevaluasi faktor-faktor yang dapat memengaruhi keseimbangan Th17 dan Treg sehingga dapat digunakan sebagai pendekatan terapeutik tambahan dalam merawat pasien-pasien autoimun. Beberapa hal yang dapat dilakukan untuk mengembalikan keseimbangan Th17 dan Treg di antaranya adalah pemberian suplemen vitamin D, paparan terhadap sinar matahari, paparan terhadap mikrobiota, dan pengaturan diet. Abstract The human immune system consists of the innate and adaptive immune systems. The innate immune system acts as the body's first defense against pathogens, while the adaptive immune system plays a role in carrying out specific immune responses. Among the various effects of the adaptive immune system, Th17 which is in charge of fighting pathogens can induce inflammation and autoimmune when there is an excessive amount of them. On the other hand, Tregs that maintain immune homeostasis can lead to autoimmunity when their amount is low. The imbalance between Th17 and Tregs plays an important role in the pathogenesis of various autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), inflammatory bowel disease (IBD), multiple sclerosis (MS), and psoriasis. This article is aimed to evaluate factors that can affect Th17 and Treg balance so that they can be used as an adjuvant treatment for autoimmune patients. Some things that can be done to restore the balance of Th17 and Tregs include supplementation of vitamin D, exposure to sunlight, exposure to microbiota, and dietary regulation. Keywords: autoimmune, Th17/Treg balance, therapy
Genital Tract Infection during Pregnancy and its Association with Preterm Delivery Susilawati, Tri Nugraha; Satria, Yohanes Aditya Adhi
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 1 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v8i3.11460

Abstract

Genital tract infection (GTI) remains a significant health concern. It is estimated that in 2016, there were 370 million people who suffer from chlamydia, gonorrhea, and trichomoniasis; and 708 million others suffer from genital herpes and condyloma acuminatum. It has been reported that in pregnant women, GTI is associated with preterm delivery. The mechanisms of GTI-associated preterm delivery need to be further understood to prevent neonatal mortality and morbidity that could be the risk factor for neonates' growth and development disorders. This article aims to describe various types of GTI and the associated pathogenesis causing preterm birth. A literature search was conducted to retrieve recent articles published in English from online databases including Pubmed, ScienceDirect, and Google Scholar. This literature study found that GTI evokes inflammatory responses that trigger several mechanisms leading to preterm delivery. The inflammatory responses in GTI include the production of proinflammatory cytokines and robust activation of neutrophils. The key mechanisms that stimulate preterm delivery in GTI include the events of early uterine contraction, preterm premature rupture of membranes, and induction of cervical ripening; which are under normal circumstances in a full-term pregnancy, those mechanisms are regulated by progesterone and prostaglandin levels along with suppression of the inflammatory responses. In conclusion, this paper has described the underlying mechanisms of preterm delivery in pregnant women with ISG. However, such mechanisms remain unclear in candida and gonococcal infection; thus, prompting the need for further studies. 
BEDAH BUKU SEBAGAI UPAYA PENINGKATAN PENGETAHUAN TATA LAKSANA TERKINI ULKUS PLANTAR KRONIS PADA PENDERITA KUSTA: Book Review as an Effort to Improve the Knowledge of the Latest Management on Chronic Plantar Ulcus in Leprosy Prakoeswa, Flora Ramona Sigit; Satria, Yohanes Aditya Adhi; Dewi, Listiana Masyita
Jurnal Pengabdian Masyarakat Medika Vol 3. No. 1, Maret 2023
Publisher : Universitas Muhamamdiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jpmmedika.v3i1.474

Abstract

ABSTRAK Penyakit kusta masih menjadi masalah kesehatan di negara endemis, termasuk Indonesia. Di antara komplikasi penyakit kusta, ulkus plantar kronis meningkatkan morbiditas dan stigma terhadap kusta. Terapi konvensional untuk ulkus plantar pada pasien kusta tidak menyediakan faktor pertumbuhan yang cukup dan terkait dengan proses penyembuhan luka yang lama. Studi terdahulu melaporkan bahwa implementasi panduan atau konsep baru pada praktik klinis memerlukan waktu yang bervariasi, dari 12 bulan hingga 17 tahun. Oleh karena itu, kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan pengetahuan di antara mahasiswa Fakultas Kedokteran Universitas Muhammadiyah Surakarta mengenai situasi kusta di Indonesia dan prinsip tata laksana ulkus plantar kronis pada pasien kusta. Kegiatan pengabdian masyarakat ini dilakukan melalui acara bedah buku. Pengetahuan awal peserta dianalisis dengan pretest. Hasil pretest menunjukkan variabilitas pada tingkat pengethuan peserta pada beberapa aspek. Untuk aspek situasi terkini kusta, pengetahuan peserta cukup baik, dibuktikan dengan persentase jawaban benar pada pretest terkait aspek tersebut mencapai 66,7% dan 80,7%. Pengetahuan mengenai ulkus kusta di antara peserta masih kurang. Hal ini terlihat dari persentase jawaban benar yang hanya 43,9%. Pada awal acara, peserta yang memahami mengenai prinsip penatalaksanaan ulkus plantar hanya mencapai 36,8%. Selanjutnya pendekatan kualitatif oleh persepsi pemateri digunakan untuk menilai tingkat pengetahuan peserta selama dan setelah acara bedah buku.  Setelah dilakukan bedah buku, diamati adanya peningkatan pengetahuan peserta mengenai situasi kusta di Indonesia dan terutama mengenai prinsip tata laksana ulkus plantar kronis pada pasien kusta. ABSTRACT Leprosy remains major health problem in endemic countries, including Indonesia. Amongst the complication of leprosy is the chronic plantar ulcer which add to the disease morbidity and stigma. Standard treatment for chronic plantar in leprosy did not provide enough growth factor and was associated with prolonged healing process. Previous studies reported variety in implementing new guideline or new concept into clinical practice, from 12 months to 17 years. Thus, this community service aimed to increase awareness and understanding amongst medical student of Universitas Muhammadiyah Surakarta in regards to leprosy epidemiology in Indonesia and especially principal management of chronic plantar ulcers in leprosy. The community service activity was carried out by delivering a book review. Participants’ prior knowledge were assessed using pretest. Pretest results showed variability in participants' knowledge. For current situation of leprosy, the result was good with the score were ranging from 66.7% to 80.7%. However, there are lack of understanding on leprosy ulcer and the basis of plantar ulcer treatment in leprosy, as the pretest score showed 43.9% and 36.8%, respectively for each aspect. A qualitative approach was then used to assess participants’ comprehension during and after the book review. The results showed that the book review increased participants' understanding of leprosy situation in Indonesia and especially about principal management of chronic plantar ulcers in leprosy.
Topical anti-aging agents: state-of-the-art review Prakoeswa, Flora Ramona Sigit; Maharani, Faradiba; Satria, Yohanes Aditya Adhi; Awanis, Ghina Shabrina; Febrianty, Astrida Fesky
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 4 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005504202310

Abstract

Skin aging can be divided into intrinsic and extrinsic aging. Even though it is inevitable, symptoms of skin aging are a common concern for patients. As a result, there is a surge in the making of anti-aging cosmeceuticals. However, there is a lack of evidence-based data to support the usage of topical preparations as anti-aging treatments. Therefore, further studies are needed to explore topical treatment options for skin aging. This literature review discusses the mechanism of commonly used topical anti-aging agents and their adverse reactions.
Co-Authors Awanis, Ghina Shabrina Febrianty, Astrida Fesky Flora Ramona Sigit Prakoeswa Listiana Masyita Dewi Maharani, Faradiba Saiful Hidayat Tri Nugraha Susilawati