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All Journal Journal of Halal Science and Research Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Ayumuyas, Nur Palestin
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Evaluating fondaparinux vs bovine-derived enoxaparin as halal anticoagulants in East Java Provincial Haji Hospital Samlan, Karima; Ayumuyas, Nur Palestin; Ramdani, Dewi; Zulfiana, Risa; Sari, Annisa Kartika; Isnaeni, Isnaeni
Journal of Halal Science and Research Vol. 6 No. 2 (2025): September
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jhsr.v6i2.12277

Abstract

This study evaluated the effectiveness of two halal anti-coagulant therapies used in patients at East Java Provincial Haji Hospital. The research design was a retrospective, comparative, observational study spanning the last three years. The study population consisted of patients assigned to anti-coagulant therapy, divided into two groups based on the use of two halal anti-coagulants: bovine enoxaparin and fondaparinux. Participation in this study is voluntary, and all patient data will be kept confidential in accordance with data protection laws. Inclusion criteria were patients with diagnoses requiring anticoagulants, such as atrial fibrillation, while exclusion criteria included patients with conditions that could affect drug metabolism or response to therapy. The main variables to be assessed in this study were length of stay, which is one of the key indicators of anticoagulant effectiveness. In addition, this study also compared the cost-effectiveness of hospital care. This data will be collected through electronic medical records, followed by rigorous statistical analysis. Independent t-test and chi-square by which quantitative data, while multivariate analysis was applied to control potential confounding variables. Two anticoagulant groups were used as samples containing fondaparinux and bovine enoxaparin, respectively. Based on the observational results showed that the average length of stay for patients using the group fondaparinux was shorter than bovine enoxaparin. The bovine enoxaparin group has a lower price per dose, but based on the LOS, the fondaparinux group can reduce total hospital costs, because it has a shorter length of stay. The expectation of this research will provide insight into the effectiveness of halal anti-coagulant drugs in muslim patients, which will also assist in clinical decision making. Hopefully, the results of this research will be useful in Indonesia and other countries with large muslim populations, and can provide the scientific confirmation needed to validate the use of halal medicines. Keywords: Anticoagulant, Effectiveness, Enoxaparin, Fondaparinux, Halal pharmaceuticals.
Studi Penggunaan Asam Traneksamat pada Penderita Tuberkulosis dengan Hemoptisis di Instalasi Rawat Jalan Rumah Sakit Umum Haji Surabaya Yuni, Santi Eka; Hasmono, Didik; Kasih, Elisabeth; Ayumuyas, Nur Palestin
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 5 No. 1 (2018)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v5i1.2051

Abstract

Tuberculosis is one of the world's health problems, especially in developing countries with coughing in the form of blood (hemoptysis) as a sign of this disease. Tranexamic acid can be used as one of the treatments for hemoptysis. Tranexamic acid is a synthesis derivative of aminolenic acid which provides antifibrinolytic effects through reversible blocking of lysine binding sites on plasminogen molecules and inhibits plasmin. This study aims to analyze the pattern of use of tranexamic acid in tuberculosis patients with hemoptysis including dosage, frequency and duration of use in the Outpatient Installation of Surabaya Haji General Hospital. The study was conducted observationally with a retrospective method on medical records of patients diagnosed with tuberculosis with hemoptysis and received treatment for tranexamic acid, then analyzed descriptively. Sampling was done by purposive sampling, from January 1, 2016 to December 31, 2017. From the results of the study, the use of tranexamic acid single dose (3x500mg) as many as 2 patients (67%), 500 mg intravenously as many as 1 patient (33%) and combination with Vitamin K as many as 3 patients. The highest duration of use was 3 days in 11 patients (56%). The use of tranexamic acid in hemoptysis patients related to dose, frequency and duration of use is in accordance with the existing literature.
Co-Authors Annisa Kartika Sari Didik Hasmono Elisabeth Kasih Isnaeni Isnaeni Ramdani, Dewi Samlan, Karima Yuni, Santi Eka Zulfiana, Risa