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All Journal Jurnal Riset Kefarmasian Indonesia Indonesian Journal of Science and Pharmacy
Nasution, M Pandapotan
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Antibacterial Activity of Reduced Silver Leaf Extract of Ketumpang Air (Peperomia pellucida (L.) Kunth) Against Staphylococcus aureus Efendi, Tania Tiara; Miswanda, Dikki; Nasution, M Pandapotan; Lubis, Minda Sari; Hermanto, Bambang
Indonesian Journal of Science and Pharmacy Vol. 1 No. 2 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i2.24

Abstract

Silver particles are widely applied in various medical fields, one of which is as an antibacterial. The advantage of silver particles is their small particle size, which increases their antibacterial effect. One of the environmentally friendly methods that can be used to synthesize silver particles is by utilizing extract of daun ketumpang air (Peperomia pellucida (L.) Kunth) through a reduction reaction. The aim of this research was to determine the antibacterial activity of silver particles made using water ketumpang leaf extract against Staphylococcus aureus bacteria. Silver particles were synthesized using the green synthesis method from extract of daun ketumpang air (Peperomia pellucida (L.) Kunth) which acts as a bioreductant. Silver reduction using water ketumpang leaf extract was carried out with varying concentrations of AgNO3 solution of 1 mM, 2 mM, 5 mM, and 10 mM with a ratio between the extract and AgNO3 solution of 1:40. The resulting silver particles were characterized using a Uv-Vis spectrophotometer and particle size analysis using PSA. The antibacterial activity test of the reduced silver particles was carried out against Staphylococcus aureus bacteria using the Kirby-Bauer method. The results of the research showed the formation of silver particles in the form of a change in the color of the solution from yellow to brownish. Analysis using a UV-Vis spectrophotometer showed a maximum wavelength of 423 nm, which indicated that silver particles were formed. The results of PSA analysis show the size of silver particles, where the smallest size of silver is 0.41 μm for a concentration variation of 10 mM. The antibacterial activity test showed strong antibacterial activity against Staphylococcus aureus bacteria with an average diameter of the inhibition zone of 11.48 mm. This shows that ketumpang water leaf extract can be used as a bioreductant in reducing silver particles and the silver particles produced have the potential to be antibacterial.
UJI AKTIVITAS ANTIBAKTERI NANOPARTIKEL EKSTRAK ETANOL DAUN MATOA (Pometia pinnata J.R. Forst & G. Forst) TERHADAP BAKTERI Streptococcus mutans Fahira, Nelsa; Rahayu, Yayuk Putri; Nasution, Haris Munandar; Nasution, M Pandapotan
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 1 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i1.327

Abstract

Streptococcus mutans is one of the bacteria that plays an important role in the formation of dental caries. One of the plants known to have antibacterial compounds are matoa leaves (Pometia pinnata J.R. Forst & G. Forst) family Sapindaceae. The objective of this research was to determine the antibacterial activity of matoa leaves ethanolic extract nanoparticles is better than matoa leaves ethanolic extract against S. mutans bacteria. The research method was carried out experimentally. Free variables, namely the concentration of matoa leaf ethanol extract (KEDM 25% ; KEDM 50%; and KEDM 75%) and the concentration of nanoparticles of matoa leaf ethanol extract (KNDM 2.5%; KNDM 5%; and KNDM 7.5%). Bound variables are antibacterial activity of ethanol extract and nanoparticles of matoa leaf ethanol extract against S. mutans bacteria. The nanoparticle size of the extract was characterized using a Particle Size Analyzer (PSA). Test of antibacterial activity of ethanol extract and matoa leaf ethanol extract nanoparticles against S. mutans using the diffusion method to Kirby Bauer. The result of the extract nanoparticle size characterization was 324.97 nm. Zone of Inhibition (ZOI) values of antibacterial ethanol extract of matoa leaves against S. mutans were 12.00 mm (KEDM 25%), 12.50 mm (KEDM 50%), and 12.60 mm (KEDM 75%). The antibacterial ZOI values of matoa leaf ethanol extract nanoparticles against S. mutans were 8.00 mm (KNDM 2.5%), 9.06 mm (KNDM 5%), and 10.10 mm (KNDM 7.5%). The conclusion is that ethanol extract of matoa leaves can be used as extract nanoparticles, where the extract nanoparticle concentration of 7.5% already has the ability of antibacterial activity that is close to the concentration of 25% ethanol extract, so that it can be said that the extract nanoparticle preparation can reduce the dose of a drug even though it is in the resistant category compared to Amoxicillin 25 g with the susceptible category.
UJI AKTIVITAS ANTIBAKTERI NANOPARTIKEL EKSTRAK ETANOL DAUN MATOA (Pometia pinnata J.R. Forst & G. Forst) TERHADAP BAKTERI Escherichia coli Siregar, Huzeila Nisa; Rahayu, Yayuk Putri; Nasution, Haris Munandar; Nasution, M Pandapotan
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 1 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i1.329

Abstract

Escherichia coli was one of the bacteria that causes diarrhea. Matoa leaves (Pometia pinnata J.R. Forst & G. Forst) ) is a plant from the Sapindaceae family and is known to have antibacterial compounds. This study aims to make ethanol extract of matoa leaves into extract nanoparticles and to determine the antibacterial activity of ethanol extract nanoparticles better than ethanol extract of matoa leaves against E. coli bacteria. This research was conducted experimentally with free variables, namely the concentration of matoa leaf ethanol extract (KEDM 25%; KEDM 50%; and KEDM 75%), and the nanoparticle concentration of matoa leaf ethanol extract (KNDM 2.5%; KNDM 5%; and KNDM 7.5%). The bound variable was the antibacterial activity of ethanol extract and nanoparticles of ethanol extract of matoa leaves against E. coli bacteria. Nanoparticle manufacturing uses the ionic glassing method with chitosan 0.1% and Na-TPP 0.1% (1:1). The nanoparticle size characterization of the extract used a Particle Size Analyzer (PSA). Antibacterial activity test using the diffusion method of Kirby Bauer's agar. The result of the characterization of the extract nanoparticles obtained a size of 324.97 nm. The value of the antibacterial Zone Of Inhibition (ZOI) of matoa leaf ethanol extract was 13.9 mm (KEDM 25%); 14.6 mm (KEDM 50%); and 18 mm (KEDM 75%). The antibacterial ZOI value of the ethanol extract nanoparticles was 6.6 mm (KNDM 2.5%); 7.2 mm (KNDM 5%); and 7.7 mm (KNDM 7.5%). The conclusion of this research was that matoa leaf ethanol extract can be used as an extract nanoparticle, where with a concentration of 2.5% extract nanoparticles already has antibacterial activity capability which is equivalent to half the dose of 25% ethanol extract concentration of matoa leaves, so it can be said that the extract nanoparticle preparation can reduce the dose of a drug by up to half the dose, even though it is in the resistant category compared to Tetracycline 30 μg.
Co-Authors Bambang Hermanto Dikki Miswanda Efendi, Tania Tiara Fahira, Nelsa Haris Munandar Nasution Lubis, Minda Sari Siregar, Huzeila Nisa Yayuk Putri Rahayu