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All Journal Indonesian Journal of Global Health research Cermin Dunia Kedokteran
Saing, Johannes Harlan
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Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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Peranan Mikronutrien terhadap Perkembangan Otak Siregar, Gursal Rai Gandra; Saing, Johannes Harlan; Dimyati, Yazid; Destariani, Cynthea Prima
Cermin Dunia Kedokteran Vol 46, No 3 (2019): Nutrisi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (610.365 KB) | DOI: 10.55175/cdk.v46i3.504

Abstract

Perkembangan otak dimulai saat konsepsi sampai masa dewasa muda. Nutrisi berperan penting dalam perkembangan saraf, mulai dari neurulasi sampai mielinasi. Penelitian telah menunjukkan hubungan antara kadar mikronutrien dengan perkembangan otak, baik bersifat sementara maupun permanen dan dalam jangka pendek maupun jangka panjang.Brain development begin from conception through young adult period. Nutrition plays a main role in the brain development from neurulation until myelination process. Studies showed the relationship between micronutrient status and brain development.
Peran Vitamin D pada Epilepsi Anak Batubara, Ratna Suwita; Saing, Johannes Harlan; Sianturi, Pertin; Dimyati, Yazid; Destariani, Cynthea Prima
Cermin Dunia Kedokteran Vol 46, No 10 (2019): Farmasi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (694.588 KB) | DOI: 10.55175/cdk.v46i10.432

Abstract

Vitamin D memiliki peran penting selama perkembangan otak, proliferasi, diferensiasi, neurotrofik dan neuroprotektif. Bentuk aktif vitamin D menekan inflamasi dan mengubah keseimbangan antara sitokin inhibitor dan sitokin eksitasi. Bentuk aktif vitamin D menunjukkan efek imunomodulator dan secara efektif dapat menekan inflamasi sehingga mempunyai efek antikonvulsan. Penderita epilepsi anak berisiko tinggi defisiensi vitamin D.Pemakaian obat antiepilepsi sebagai politerapi dihubungkan dengan penurunan kadar vitamin D yang lebih besar dibandingkan obat antieepilepsi sebagai monoterapi. Pemberian vitamin D harus cukup untuk mempertahankan kadar normal 25(OH)D (≥30 ng/mL). Pemberian vitamin D pada epilepsi dapat meningkatkan batas ambang kejang secara signifikan dan mengurangi keparahan kejang.Vitamin D has an important role during brain development, proliferation, differentiation, neurotrophic and neuroprotection. The active form of vitamin D suppresses inflammation and changes the balance between inhibitory cytokines and excitatory cytokines. The active form of vitamin D shows an immunomodulatory effect and can effectively suppress inflammation so that it has an anticonvulsant effect. Epileptic children are in high risk of vitamin D deficiency. Antiepileptic polytherapy is associated with a greater reduction in vitamin D levels than in monotherapy. Vitamin D supplementation must be sufficient to maintain normal level of 25(OH)D (≥30 ng/mL. Vitamin D can significantly increase the seizure threshold and reduce the severity of seizure. 
The Impact of Age on Seizure Severity Characteristics in Children With Drug Resistant Epilepsy Lestari, Tria Diana; Tanjung, Ika Citra Dewi; Lubis, Syamsidah; Harahap, Juliandi; Saing, Johannes Harlan; Dalimunthe, Wisman
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.5890

Abstract

Drug-resistant epilepsy (DRE) is found in up to one-third of individuals with epilepsy who have received appropriate therapy and this condition causes significant child morbidity and mortality. Epilepsy that appears at an early age is at higher risk of developing DRE. Objective to assess the effect of age on the characteristics of seizure severity in children with DRE. This study used a cross-sectional design involving 36 DRE patients aged 2-18 years at the Child Neurology Polyclinic, Adam Malik Hospital Medan, from September to October 2024. Seizure severity characteristics were assessed using the Global Assessment of the Severity of Epilepsy (GASE) questionnaire instrument. The categorical data are presented in the form of proportions and the effect of age on seizure severity characteristics was analyzed using the chi-square test. There were 36 children with DRE in this study, predominantly aged ≥ 10 years. Bivariate analysis showed a significant effect of age in children with drug resistant epilepsy only on the disruption of activity experienced by children with a p value = 0.036 (p <0.05). Most patients aged ≥ 10 years did not experience activity disorders or experienced mild activity disorders (73.9%), while in patients aged <10 years, most patients experienced severe activity disorders (61.5%). The age of children with drug resistant epilepsy have a significant effect on daily activity disorders.
Co-Authors Batubara, Ratna Suwita Destariani, Cynthea Prima Dimyati, Yazid Harahap, Juliandi Lestari, Tria Diana Pertin Sianturi Siregar, Gursal Rai Gandra Syamsidah Lubis, Syamsidah Tanjung, Ika Citra Dewi Wisman Dalimunthe, Wisman