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Factors Influencing the Decision of Parents to LP in Pediatric with CNS Infection Dessy Dian Antarini; Dimyati, Yazid; Rosdiana, Nelly; Fujiati, Isti Ilmiati; Destariani, Cynthea Prima
Sumatera Medical Journal Vol. 2 No. 3 (2019): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v2i3.1262

Lumbal Puncture (LP) is a procedure that can help to diagnosed CNS infection in children. The procedure of LP is a common invasive procedure, but sometimes it had refused by the parents. Furthermore, it can cause a delayed in the diagnosis and affected the prognosis. The subject was the parents of pediatric patients with CNS infection. We have a questionnaire and using Chi-square and Fisher exact test to analyze factors that influenced the parent’s decision of LP procedure. From the parents of 50 children with CNS infection, 19 parents (38%) were refused the LP procedure. Father’s education was related to the refusal of LP procedure with PR 6.64 (95%CI; 8.95-788.08). Mother’s education was related to the refusal of LP procedure with PR 7.69 (95%CI; 3.19-16.24). There was the significant result of the parent's education with the decision of LP procedure.

Peranan Mikronutrien terhadap Perkembangan Otak Siregar, Gursal Rai Gandra; Saing, Johannes Harlan; Dimyati, Yazid; Destariani, Cynthea Prima
Cermin Dunia Kedokteran Vol 46, No 3 (2019): Nutrisi
Publisher : PT. Kalbe Farma Tbk.

Perkembangan otak dimulai saat konsepsi sampai masa dewasa muda. Nutrisi berperan penting dalam perkembangan saraf, mulai dari neurulasi sampai mielinasi. Penelitian telah menunjukkan hubungan antara kadar mikronutrien dengan perkembangan otak, baik bersifat sementara maupun permanen dan dalam jangka pendek maupun jangka panjang.Brain development begin from conception through young adult period. Nutrition plays a main role in the brain development from neurulation until myelination process. Studies showed the relationship between micronutrient status and brain development.

Kejang Demam sebagai Faktor Predisposisi Epilepsi pada Anak Hasibuan, Dede Khairina; Dimyati, Yazid
Cermin Dunia Kedokteran Vol 47, No 11 (2020): Infeksi
Publisher : PT. Kalbe Farma Tbk.

Kejang demam adalah bangkitan kejang pada anak berumur 6 bulan sampai 5 tahun yang mengalami kenaikan suhu tubuh (di atas 38Â°C dengan metode pengukuran suhu apapun) yang tidak disebabkan oleh proses intrakranial. Faktor-faktor risiko kejang demam berkembang menjadi epilepsi adalah kelainan neurologis atau perkembangan yang jelas sebelum kejang demam pertama, kejang demam kompleks (KDK), riwayat epilepsi pada orangtua atau saudara kandung, dan kejang demam sederhana (KDS) berulang 4 episode atau lebih dalam satu tahun. Kombinasi faktor risiko tersebut akan lebih meningkatkan risiko epilepsi. Pemberian obat rumatan kejang demam belum terbukti dapat mencegah epilepsi di kemudian hari.Febrile seizure is a seizure episode in children aged 6 months to 5 years preceded with an increase in body temperature (above 38Â° C with any measurement method) not caused by intracranial process. Risk factors to epilepsy are neurological or developmental abnormalities before the first febrile seizure, complex febrile seizures, history of epilepsy in parents or siblings, and simple febrile seizures 4 episodes or more in one year. Combination of these risk factors will increase the likelihood of epilepsy. Febrile seizure prophylaxis medication has not been proven to prevent epilepsy.

Peran Vitamin D pada Epilepsi Anak Batubara, Ratna Suwita; Saing, Johannes Harlan; Sianturi, Pertin; Dimyati, Yazid; Destariani, Cynthea Prima
Cermin Dunia Kedokteran Vol 46, No 10 (2019): Farmasi
Publisher : PT. Kalbe Farma Tbk.

Vitamin D memiliki peran penting selama perkembangan otak, proliferasi, diferensiasi, neurotrofik dan neuroprotektif. Bentuk aktif vitamin D menekan inflamasi dan mengubah keseimbangan antara sitokin inhibitor dan sitokin eksitasi. Bentuk aktif vitamin D menunjukkan efek imunomodulator dan secara efektif dapat menekan inflamasi sehingga mempunyai efek antikonvulsan. Penderita epilepsi anak berisiko tinggi defisiensi vitamin D.Pemakaian obat antiepilepsi sebagai politerapi dihubungkan dengan penurunan kadar vitamin D yang lebih besar dibandingkan obat antieepilepsi sebagai monoterapi. Pemberian vitamin D harus cukup untuk mempertahankan kadar normal 25(OH)D (â‰¥30 ng/mL). Pemberian vitamin D pada epilepsi dapat meningkatkan batas ambang kejang secara signifikan dan mengurangi keparahan kejang.Vitamin D has an important role during brain development, proliferation, differentiation, neurotrophic and neuroprotection. The active form of vitamin D suppresses inflammation and changes the balance between inhibitory cytokines and excitatory cytokines. The active form of vitamin D shows an immunomodulatory effect and can effectively suppress inflammation so that it has an anticonvulsant effect. Epileptic children are in high risk of vitamin D deficiency. Antiepileptic polytherapy is associated with a greater reduction in vitamin D levels than in monotherapy. Vitamin D supplementation must be sufficient to maintain normal level of 25(OH)D (â‰¥30 ng/mL. Vitamin D can significantly increase the seizure threshold and reduce the severity of seizure.Â

Analisis Gas Darah dan Laktat Darah Tali Pusat sebagai Parameter Metabolik pada Asfiksia Perinatal Sitanggang, Fitri Parinda; Lubis, Bugis Mardina; Dimyati, Yazid; Tjipta, Guslihan Dasa; Syofiani, Beby; Sianturi, Pertin; Lubis, Syamsidah; Wahyuni, Fera
Cermin Dunia Kedokteran Vol 46, No 9 (2019): Neuropati
Publisher : PT. Kalbe Farma Tbk.

Asfiksia masih merupakan salah satu penyebab utama kematian neonatus per tahun. Skor Apgar dapat memberikan informasi vitalitas neonatus namun memiliki beberapa keterbatasan. Asfiksia perinatal dapat muncul dari berbagai risiko intrapartum dan postpartum yang mengakibatkan terhentinya pertukaran gas pada fetus. Metabolisme anaerob akan menyebabkan akumulasi laktat dan penurunan pH. Analisis asam-basa dan laktat darah tali pusat dapat memberikan penilaian objektif terhadap status metabolik neonatus.Asphyxia still remain a major causes of neonatal death per year. Apgar score provides information on neonatal vitality but has several limitations. Perinatal asphyxia can arise from a variety of intrapartum and postpartum risks which result in cessation of gas exchange. Anaerobic metabolism will cause lactate accumulation and pH decrease. Analysis of acid-base and lactate in cord blood can provide an objective assessment of the metabolic status of the neonate.Â

Factors associated with feeding problems in children with cerebral palsy: A cross-sectional study from Indonesia Maulidia, Dwi S.; Sembiring, Tiangsa; Dimyati, Yazid; Tanjung, Ika CD.; Wahyuni, Arlinda S.; Pratita, Winra; Nasution, Halida R.; Alharbi, Olayan; Pasaribu, Ayodhia P.
Narra X Vol. 2 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v2i3.163

Children with cerebral palsy are at high risk for feeding difficulties and malnutrition due to motor impairments and associated conditions. The aim of this study was to evaluate the prevalence and types of feeding problems and their association with malnutrition in children with cerebral palsy. A cross-sectional study was conducted involving 54 children under five years old with cerebral palsy. Participants were classified into spastic cerebral palsy subtypes such as quadriplegic, hemiplegic, diplegic, or triplegic. Feeding problems were categorized as inappropriate feeding practices, reduced food intake, parental misperception, and food preferences using the Pediatric Symptom Checklist-17. Nutritional status was assessed using weight-for-age percentiles based on WHO growth charts. History of constipation and dysphagia were also recorded. Data analysis included Chi-square and Mann-Whitney U tests. Among the participants, 38.9% had hemiplegia, 33.3% diplegia, and 25.9% quadriplegia. Feeding problems were prevalent, with inappropriate feeding practices being the most common (70.4%). Malnutrition was identified in 59.3% of the children. However, no significant associations were observed between CP subtype or demographic variables and the types of feeding problems. Similarly, the type of feeding problem was not significantly associated with malnutrition. Constipation and dysphagia were reported in 31.5% and 37.0% of participants, respectively, and were significantly associated with nutritional status (p<0.001). In conclusion, feeding problems and malnutrition are common in children with cerebral palsy, with inappropriate feeding practices being the most prevalent issue. Although no significant associations were found between CP subtypes or the types of feeding problems and malnutrition, the findings emphasize the multifactorial nature of feeding challenges.

Factors associated with feeding problems in children with cerebral palsy: A cross-sectional study from Indonesia Maulidia, Dwi S.; Sembiring, Tiangsa; Dimyati, Yazid; Tanjung, Ika CD.; Wahyuni, Arlinda S.; Pratita, Winra; Nasution, Halida R.; Alharbi, Olayan; Pasaribu, Ayodhia P.
Narra X Vol. 2 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v2i3.163

Children with cerebral palsy are at high risk for feeding difficulties and malnutrition due to motor impairments and associated conditions. The aim of this study was to evaluate the prevalence and types of feeding problems and their association with malnutrition in children with cerebral palsy. A cross-sectional study was conducted involving 54 children under five years old with cerebral palsy. Participants were classified into spastic cerebral palsy subtypes such as quadriplegic, hemiplegic, diplegic, or triplegic. Feeding problems were categorized as inappropriate feeding practices, reduced food intake, parental misperception, and food preferences using the Pediatric Symptom Checklist-17. Nutritional status was assessed using weight-for-age percentiles based on WHO growth charts. History of constipation and dysphagia were also recorded. Data analysis included Chi-square and Mann-Whitney U tests. Among the participants, 38.9% had hemiplegia, 33.3% diplegia, and 25.9% quadriplegia. Feeding problems were prevalent, with inappropriate feeding practices being the most common (70.4%). Malnutrition was identified in 59.3% of the children. However, no significant associations were observed between CP subtype or demographic variables and the types of feeding problems. Similarly, the type of feeding problem was not significantly associated with malnutrition. Constipation and dysphagia were reported in 31.5% and 37.0% of participants, respectively, and were significantly associated with nutritional status (p<0.001). In conclusion, feeding problems and malnutrition are common in children with cerebral palsy, with inappropriate feeding practices being the most prevalent issue. Although no significant associations were found between CP subtypes or the types of feeding problems and malnutrition, the findings emphasize the multifactorial nature of feeding challenges.

Associations between seizure management and sleep disorders in children with epilepsy: A cross-sectional study in Medan, Indonesia Suistaya, Novi A.; Dimyati, Yazid; Siregar, Olga R.; Harahap, Juliandi; Dewi, Ika C.; Lubis, Mahrani; Mukhtar, Fatima AS.; Alharbi, Olayan
Narra X Vol. 3 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v3i1.168

Sleep disorders are prevalent in children, particularly those with chronic illnesses such as epilepsy, where they disrupt sleep quantity, quality, or timing. The aim of this study was to analyze factors associated with sleep disorder among epileptic children admitted to Haji Adam Malik General Hospital, Medan, Indonesia. The study employed cross sectional design, recruiting 49 children (4–10 years old) with epilepsy at Haji Adam Malik General Hospital from February to June 2024. Data collection was carried out using the Children's Sleep Habit Questionnaire (CSHQ) questionnaire. Further, data on Anti-Epileptic Drugs (AED) intake and history and type of seizures were collected. Pearson’s Chi-square test was employed to analyze the association of the demographic, seizure characteristics, and AED with sleeping disorder. The findings suggest that sleep disorder in children with epilepsy was prevalent (n=26, 53.1%), mostly occurring in boys (32.7%) and those receiving valproic acid (n=9, 34.6%) and its combination with levetiracetam (n=8, 30.8%). Chi-square test results showed that seizure history intake (p<0.001), AEDs intake (p<0.001), and type of AED (p=0.010) were significantly associated with sleep disorder. In conclusion, seizure management strategies and AED regimens can influence sleep disorders in children with epilepsy. Therefore, revisiting and modifying AED treatments may be required to improve both seizure control and sleep quality in affected patients.

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