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Aktivitas Antioksidan Ekstrak Daun Sirsak (Annona muricata L.) Dan Antiaging Melalui Koleganisasi Dan Gambaran Histopatologi Kulit Tikus Yang Terpapar Sinar Ultraviolet B Mujihad, Andi; Pratama, Irza Haicha; Siregar, Lisdawaty
JURNAL PENELITIAN PENDIDIKAN, PSIKOLOGI DAN KESEHATAN (J-P3K) Vol 6, No 2 (2025): J-P3K
Publisher : Yayasan Mata Pena Madani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51849/j-p3k.v6i2.614

Penelitian ini bertujuan untuk mengevaluasi aktivitas antioksidan ekstrak daun sirsak (Annona muricata L.) dan efek anti-aging melalui kolagenisasi serta gambaran histopatologi kulit tikus yang terpapar sinar ultraviolet B (UVB). Paparan sinar UVB dapat menyebabkan stres oksidatif dan mempercepat penuaan kulit. Daun sirsak diketahui mengandung senyawa antioksidan yang kuat yang dapat membantu melindungi kulit dari kerusakan akibat sinar UVB. Penelitian ini melibatkan perlakuan tikus dengan ekstrak daun sirsak dan paparan sinar UVB, diikuti dengan penilaian kadar antioksidan, produksi kolagen, dan perubahan histopatologi pada kulit. Hasil penelitian menunjukkan bahwa ekstrak daun sirsak menunjukkan aktivitas antioksidan yang signifikan dan mendukung sintesis kolagen, yang membantu mengurangi kerusakan kulit akibat paparan UVB. Analisis histopatologi menunjukkan perbaikan pada struktur kulit, yang mengindikasikan potensi ekstrak daun sirsak sebagai agen anti-aging alami.

Pengaruh Pemberian Ekstrak Daun Sirsak (Annona Muricata L.) Terhadap Kadar Kolesterol Total, Trigliserida Dan Histopatologi Hati Tikus Putih Galur Wistar Jantan Yang Mengalami Diabetes Melitus Anugrah, Hary Try; Pratama, Irza Haicha; Siregar, Lisdawaty
JURNAL PENELITIAN PENDIDIKAN, PSIKOLOGI DAN KESEHATAN (J-P3K) Vol 6, No 2 (2025): J-P3K
Publisher : Yayasan Mata Pena Madani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51849/j-p3k.v6i2.683

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak daun sirsak (Annona muricata L.) terhadap kadar kolesterol total, trigliserida, dan histopatologi hati pada tikus putih galur Wistar jantan yang mengalami diabetes melitus. Diabetes melitus yang tidak terkontrol dapat menyebabkan peningkatan kadar kolesterol dan trigliserida serta kerusakan pada organ hati. Dalam penelitian ini, 24 tikus Wistar jantan dibagi menjadi empat kelompok: kelompok kontrol normal, kelompok diabetes tanpa perlakuan, kelompok diabetes yang diberi ekstrak daun sirsak dosis rendah, dan kelompok diabetes yang diberi ekstrak daun sirsak dosis tinggi. Pemberian ekstrak daun sirsak dilakukan selama 28 hari. Pengukuran kadar kolesterol total dan trigliserida dilakukan menggunakan metode enzimatik, sedangkan pemeriksaan histopatologi hati dilakukan dengan pewarnaan Hematoxylin-Eosin (HE). Hasil penelitian menunjukkan bahwa pemberian ekstrak daun sirsak dosis tinggi dapat menurunkan kadar kolesterol total dan trigliserida serta memperbaiki kerusakan histopatologi hati pada tikus yang mengalami diabetes melitus. Penurunan kadar kolesterol dan trigliserida serta perbaikan histopatologi hati menunjukkan bahwa ekstrak daun sirsak memiliki potensi sebagai terapi adjuvan dalam pengelolaan diabetes melitus.

Pengaruh Pemberian Ekstrak Daun Sirsak (Annona Muricata L.) Terhadap Fungsi Pankreas Dan Gambaran Histopatologi Pankreas Tikus Putih Galur Wistar Jantan yang Mengalami Diabetes Melitus Nazar, Hasrul; Loren, Jeff; Siregar, Lisdawaty
JURNAL PENELITIAN PENDIDIKAN, PSIKOLOGI DAN KESEHATAN (J-P3K) Vol 6, No 2 (2025): J-P3K
Publisher : Yayasan Mata Pena Madani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51849/j-p3k.v6i2.759

Penelitian ini bertujuan untuk menyelidiki pengaruh pemberian ekstrak daun sirsak (Annona muricata L.) terhadap fungsi pankreas dan gambaran histopatologi pankreas pada tikus putih galur Wistar jantan yang menderita diabetes melitus. Diabetes diinduksi dengan pemberian alloksan, dan tikus dibagi menjadi beberapa kelompok: kelompok kontrol, kelompok diabetes, dan kelompok perlakuan yang menerima dosis ekstrak daun sirsak yang berbeda. Fungsi pankreas dievaluasi melalui pengukuran kadar glukosa darah, dan pemeriksaan histopatologi pankreas dilakukan menggunakan pewarnaan hematoksilin dan eosin. Hasil penelitian menunjukkan bahwa pemberian ekstrak daun sirsak secara signifikan menurunkan kadar glukosa darah dan memperbaiki gambaran histopatologi pankreas, yang menunjukkan adanya efek protektif terhadap fungsi pankreas pada tikus diabetes. Hal ini menunjukkan bahwa ekstrak daun sirsak berpotensi memiliki manfaat terapeutik dalam pengelolaan diabetes melitus.

Factors influencing family planning acceptors' use of IUD contraception in the working area of Medan Amplas District Abdullah, Armelia Adel; Kaban, Lenni Apriani; Novianti, Desi; Hidayat, Andri; Ongko, Nicholas Xavier; Rosar, Naufal; Marpaung, Hans Hotma Haposan; Siregar, Lisdawaty; Sherliana, Ferra; Lizar, Budi Septhian; Angkasa, Celvin
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.7437

Indonesia's high population growth rate is a big problem and needs serious handling from all parties of society and government The family planning movement is carried out to build a prosperous family in order to create optimal human resources. The family planning program is one of the most effective ways to improve family resilience, health, and safety of mothers, children, and women. Descriptive quantitative research, where this study aims to determine the factors that influence family planning acceptors on the use of IUD contraceptives in the Medan Amplas working area in 2024 using a cross-sectional design where the independent variable and the dependent variable are identified at the same time. The results of this study are There is an influence of education (P<0.05), mileage (P<0.05), knowledge (P<0.05), attitude (P,0.05), attitude (P<0.05), husband support (P<0.05), health worker support (P<0.05), The most dominant factor affecting the use of IUD contraceptives is the variable Husband support Exp (B) = 2.50 means that if there is husband's support for the use of IUD contraceptives then there are 2.5 times the mother wants to participate as an acceptor of IUD contraceptives. It is expected to Improve the Awareness Campaign Program by holding campaigns that target husbands and other family members, explaining the importance of their support in the use of contraceptives.

The Effect Of Sanitary Pads Use On The Incidence Of Pruritus Vulva In Students Of Prima Indonesia University Margolang, Salsabila Armenia; Siregar, Lisdawaty; Sumantri, Ade Arhamni
Jurnal Ners Vol. 9 No. 4 (2025): OKTOBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i4.51206

Menstruation is a physiological process, but improper use of sanitary pads and poor vulvar hygiene can cause health problems such as vulvar pruritus. This study aimed to determine the frequency of sanitary pad replacement, the effect of disposable sanitary pad use on the incidence of vulvar pruritus, and vulvar hygiene behavior among female students at Prima University, Medan. This study used an analytical observational design with a cross-sectional approach involving 68 female medical students from the 2022 cohort selected through purposive sampling. Data were collected using a questionnaire and analyzed using the Chi-Square test. The results showed that most female students used disposable sanitary pads and the majority experienced mild vulvar pruritus. Data analysis found a statistically significant relationship between the type of sanitary napkin, frequency of replacement, cleanliness of use, and duration of sanitary napkin use with the incidence of vulvar pruritus. It was concluded that sanitary napkin use practices and vulvar hygiene behaviors strongly influence the incidence of vulvar pruritus in female students. It is hoped that female students can better maintain genital hygiene and replace sanitary napkins.

Factors influencing family planning acceptors' use of IUD contraception in the working area of Medan Amplas District Abdullah, Armelia Adel; Kaban, Lenni Apriani; Novianti, Desi; Hidayat, Andri; Ongko, Nicholas Xavier; Rosar, Naufal; Marpaung, Hans Hotma Haposan; Siregar, Lisdawaty; Sherliana, Ferra; Lizar, Budi Septhian; Angkasa, Celvin
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.7437

Indonesia's high population growth rate is a big problem and needs serious handling from all parties of society and government The family planning movement is carried out to build a prosperous family in order to create optimal human resources. The family planning program is one of the most effective ways to improve family resilience, health, and safety of mothers, children, and women. Descriptive quantitative research, where this study aims to determine the factors that influence family planning acceptors on the use of IUD contraceptives in the Medan Amplas working area in 2024 using a cross-sectional design where the independent variable and the dependent variable are identified at the same time. The results of this study are There is an influence of education (P<0.05), mileage (P<0.05), knowledge (P<0.05), attitude (P,0.05), attitude (P<0.05), husband support (P<0.05), health worker support (P<0.05), The most dominant factor affecting the use of IUD contraceptives is the variable Husband support Exp (B) = 2.50 means that if there is husband's support for the use of IUD contraceptives then there are 2.5 times the mother wants to participate as an acceptor of IUD contraceptives. It is expected to Improve the Awareness Campaign Program by holding campaigns that target husbands and other family members, explaining the importance of their support in the use of contraceptives.

The Relationship Between Chronic Kidney Disease and the Severity of Pruritus in Patients Undergoing Hemodialysis at Royal Prima General Hospital in Medan Fazriani, Popy; Arhamni, Ade; Siregar, Lisdawaty
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.483

Chronic kidney disease-associated pruritus represents a prevalent complication that significantly impairs hemodialysis patient quality of life. This study examined the relationship between hemodialysis duration and uremic pruritus severity. An analytical cross-sectional design enrolled 34 chronic kidney disease patients receiving maintenance hemodialysis at Royal Prima General Hospital, Medan. Data collection utilized questionnaires and medical records; purposive sampling identified meeting participants inclusion criteria. Univariate analysis described demographic and clinical characteristics using frequency distributions. Bivariate chi-square analysis tested associations between hemodialysis duration (categorized as less than 6 to 12 months, 13 to 24 months, and greater than 24 months) and pruritus severity (mild, moderate, severe) using IBM SPSS Statistics software. Results demonstrated a highly significant association between dialysis duration and pruritus severity (χ² = 17.661, p = 0.000), with severe pruritus occurring in 0% of early-stage dialysis patients, 16.7% of intermediate-duration patients, and 82.4% of long-term recipients. Extended hemodialysis exposure correlates directly with progressive pruritus escalation through cumulative uremic toxin accumulation and inflammatory activation. These findings substantially systematic pruritus screening and multimodal management implementation for all dialysis patients, particularly targeting long-term recipients experiencing substantial symptom burden.

Efficacy Test of Lemon Juice (Citrus Limon) on Acne to Inhibit the Growth of Propionibacterium Acnes 2025 Nurhidayah, Nurhidayah; Siregar, Lisdawaty; Arhamni , Ade
Journal of Social Research Vol. 4 No. 12 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i12.2887

Acne (Acne Vulgaris) has now developed into a very annoying skin disease that can even leave scars (acne scar). Records from Indonesian cosmetic dermatology continue to increase, namely 60% of acne vulgaris sufferers in 2006, 80% in 2007 and 90% in 2009. Propionibecterium acnes is one of the pathogenic bacteria that plays a role in the onset of acne vulgaris and inflammatory diseases. Lemon water (Citrus limon) is known to contain limonene and quercetin, which are able to act as anti-inflammatory and inhibit the growth of P.acnes. The purpose of this study is to determine the effectiveness of adding lemon water extract to face toner preparations to inhibit the growth of P. acnes. The extraction method used was maceration using ethanol and methanol solvents and was carried out for 24 hours, 48 hours and 72 hours, in this study using 5 days (120 hours). The concentration of extracts used is 20%, 40%, 60%, 80% and 100%. The bacterial test method used is the diffusion of paper disk or nutrient agar with observations carried out every 12 hours. The results of the one-way-ANOVA statistical test showed no significant difference in the change in the concentration of lemon peel extract in the face toner preparation to the diameter of the P. acnes growth inhibition zone (p > 0.05). Based on research conducted for 120 hours, maceration has the highest quercetin content with methanol solvent, but the best antibacterial activity is face toner with lemon water extract content with ethanol solvent. The addition of 1% lemon water extract already had bacterial activity, but P. acnes was able to resist faster compared to higher concentrations.

The Relationship Between Stress Levels And The Severity of Acne Vulgaris In Medical Students At Prima Indonesia University Class of 2022 Mudhia Putri, Tarisa; Arhamni, Ade; Siregar, Lisdawaty
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.484

Acne vulgaris is a chronic skin disease of the pilosebaceous follicle with multifactorial etiology. Psychological stress represents one significant etiological factor, as stress activates the hypothalamic-pituitary-adrenal axis, stimulating corticotropin-releasing hormone, which plays an important role in acne vulgaris development. Medical students experience high academic burdens that potentially cause stress, making them more susceptible to acne vulgaris with varying severity degrees. This cross-sectional analytic observational study investigated the relationship between stress levels and acne vulgaris severity among medical students at Universitas Prima Indonesia, class of 2022. A total of 35 respondents were selected through stratified random sampling. Data were collected using the Depression Anxiety Stress Scale-42 to measure stress levels and the Lehmann Acne Grading System to assess acne severity. Results showed that 60.0% of respondents experienced moderate stress, while 45.7% exhibited mild acne vulgaris. Chi-Square testing revealed a statistically significant relationship between stress levels and acne severity (p = 0.000). A clear dose-response pattern emerged, with mild stress predominantly associated with mild acne, moderate stress with moderate acne, and severe stress universally manifesting as moderate-to-severe acne manifestations. This investigation concludes that a significant correlation exists between stress levels and acne vulgaris severity in this population, necessitating stress management interventions and mental health education programs to reduce acne severity risk among medical students.

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