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All Journal Jurnal Penelitian Pendidikan, Psikologi Dan Kesehatan (J-P3K) Buletin Kedokteran dan Kesehatan Prima
Angkasa, Celvin
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Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences

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Pengaruh Ekstrak Daun Sirsak (Annona Muricata L.) terhadap Fungsi Ginjal dan Histopatologi Tikus Putih Wistar Jantan Penderita Diabetes Melitus Usiana, Gusti Nyoman Bagus; Yumardika, Deza; Angkasa, Celvin
JURNAL PENELITIAN PENDIDIKAN, PSIKOLOGI DAN KESEHATAN (J-P3K) Vol 6, No 2 (2025): J-P3K
Publisher : Yayasan Mata Pena Madani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51849/j-p3k.v6i2.758

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak daun sirsak (Annona muricata L.) terhadap fungsi ginjal dan gambaran histopatologi ginjal pada tikus putih jantan galur Wistar yang menderita diabetes melitus. Induksi diabetes melitus dilakukan dengan pemberian aloksan dan tikus dibagi menjadi beberapa kelompok, yaitu kelompok kontrol, kelompok diabetes, dan kelompok perlakuan yang diberi ekstrak daun sirsak dengan dosis yang berbeda-beda. Fungsi ginjal dinilai melalui kadar nitrogen urea darah (BUN), kreatinin serum, dan asam urat. Pemeriksaan histopatologi ginjal dilakukan dengan pewarnaan hematoksilin dan eosin. Hasil penelitian menunjukkan bahwa pemberian ekstrak daun sirsak secara signifikan memperbaiki fungsi ginjal dengan menurunkan kadar BUN, kreatinin serum, dan asam urat. Selain itu, analisis histopatologi menunjukkan adanya penurunan kerusakan jaringan ginjal akibat diabetes. Temuan ini menunjukkan bahwa ekstrak daun sirsak memiliki potensi efek terapeutik dalam memperbaiki fungsi ginjal dan mengurangi kerusakan ginjal pada tikus diabetes.
Factors influencing family planning acceptors' use of IUD contraception in the working area of Medan Amplas District Abdullah, Armelia Adel; Kaban, Lenni Apriani; Novianti, Desi; Hidayat, Andri; Ongko, Nicholas Xavier; Rosar, Naufal; Marpaung, Hans Hotma Haposan; Siregar, Lisdawaty; Sherliana, Ferra; Lizar, Budi Septhian; Angkasa, Celvin
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.7437

Abstract

Indonesia's high population growth rate is a big problem and needs serious handling from all parties of society and government The family planning movement is carried out to build a prosperous family in order to create optimal human resources. The family planning program is one of the most effective ways to improve family resilience, health, and safety of mothers, children, and women. Descriptive quantitative research, where this study aims to determine the factors that influence family planning acceptors on the use of IUD contraceptives in the Medan Amplas working area in 2024 using a cross-sectional design where the independent variable and the dependent variable are identified at the same time. The results of this study are There is an influence of education (P<0.05), mileage (P<0.05), knowledge (P<0.05), attitude (P,0.05), attitude (P<0.05), husband support (P<0.05), health worker support (P<0.05), The most dominant factor affecting the use of IUD contraceptives is the variable Husband support Exp (B) = 2.50 means that if there is husband's support for the use of IUD contraceptives then there are 2.5 times the mother wants to participate as an acceptor of IUD contraceptives. It is expected to Improve the Awareness Campaign Program by holding campaigns that target husbands and other family members, explaining the importance of their support in the use of contraceptives.
Co-Authors Abdullah, Armelia Adel Andri Hidayat, Andri Kaban, Lenni Apriani Lizar, Budi Septhian Marpaung, Hans Hotma Haposan Novianti, Desi Ongko, Nicholas Xavier Rosar, Naufal Sherliana, Ferra Siregar, Lisdawaty Usiana, Gusti Nyoman Bagus Yumardika, Deza