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All Journal Indonesian Journal of Pharmaceutical Science and Technology Veterinary Biomedical and Clinical Journal ULIN: Jurnal Hutan Tropis Buletin LOUPE (Laporan Umum Penelitian) Prosiding Konferensi Nasional PKM-CSR
Herawati, Elisa
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

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Prospective Anti-Aging Benefits of Mackerel Scad Collagen Peptides Through Anti-Hyaluronidase Activity Herawati, Elisa; Agnesia, Pipin
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.56450

Abstract

The increased activity of the hyaluronidase enzymes speeds up the degradation of hyaluronic acid in the skin, leading to reduced elasticity and the formation of fine wrinkles, eventually contributing to skin aging. Mackerel scad (Decapterus macarellus) is a promising candidate as a skin anti-aging substance due to its particular amino acid composition. Native collagen and collagen peptides from mackerel scad skin were extracted using pepsine soluble collagen and hydrolysis with collagenase II enzyme. The amino acid profile of collagen was determined using HPLC analysis. An anti-hyaluronidase activity test was done using the spectrophotometry assay to express the content of N-acetyl glucosaminoglycan, and IC50 was calculated. Results showed that mackerel scad collagen contains 17 amino acids, with the highest content of glutamic acid, 8.20%; aspartic acid, 6.70%; glycine, 5.37%; arginine, 4.24%; and proline, 3.84%. The collagen from the extraction results had relatively low anti-hyaluronidase activity (IC50 326.05 ± 6.77 ppm). However, when it was broken down into smaller collagen peptides, the anti-hyaluronidase activity increased to IC50 100.78 ± 0.17 ppm. This indicated that the hydrolysis of collagen into collagen peptides with a smaller molecular weight increased its capacity to inhibit hyaluronidase. These findings suggest that D. macarellus collagen peptides have the potential to inhibit skin aging by inhibiting hyaluronidase enzyme activity.
Co-Authors Agnesia, Pipin Agustina Murniyati Avi, Salsabilla El Djatmiko, Rudi Dwi Septi Amalia Fathiah H.R, La Ode Muh. Asdiq Herijanto Thamrin Kardika, Adelia Juli M, Masrudy M. Fadjeri Malaysia, Emi Murniyati, Agustina Noorhamsyah Nurrahmah, Alfhiya Sadam, Muhamad Shanti Listyawati TETRI WIDIYANI Yelis Tria Monica