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All Journal Biomedical Journal of Indonesia Medica Hospitalia
Azhar, Abu
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Relationship between Prostate Volume and International Prostate Symptom Score (IPSS) Degree of Tamed Prostate Enlargement on Transabdominal Ultrasonography (TAUS) and Transrectal Ultrasonography (TRUS) Examination Azhar, Abu; Eriawan Agung Nugroho; Ezra Endria Gunadi
Biomedical Journal of Indonesia Vol. 7 No. 1 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i1.259

Abstract

A B S T R A C TIntroduction: IPSS is the gold standard in measuring clinical symptoms of BPH. 1Prostate volume has been said to have a close relationship with the development ofBPH. 9 The aim of this study was to determine the relationship between prostate volumeas measured by transabdominal ultrasonography (TAUS) and transrectal (TRUS) to thedegree of IPSS. Methods: An analytic observational study with a cross sectional designwas carried out on 303 BPH patients at the General Hospital of Kariadi Hospital,Semarang. The data obtained from the TAUS, TRUS and IPSS prostate volume wereobtained from medical records for the period 2015 - 2020. The data were then analyzedby using the chi square test. Results: Patients with BPH have a TAUS prostate volumein classification I of 0 people 0%, classification II of 16 people (5.3%), classification IIIof 96 people (31.7%), classification IV of 102 people (33.7%) and classification V of 89people (29.4%). While TRUS in classification I was 0% (0 people), classification II was11 people (3.6%), classification III was 92 people (30.4%), classification IV was 110people (36.3%) and classification V of 90 people (29.7%). IPSS obtained severe IPSSdegrees, namely 192 people (63.4%), moderate degrees of 111 people (36.6%), and milddegrees 0% (0 people). The results of the Chi Square test obtained a p-value of 0.000(p <0.05), indicating that there was a significant relationship between prostate volume,whether examined by transabdominal or transrectal ultrasound, and the degree ofIPSS. The correlation coefficient r = 0.925 indicates a very strong relationship betweenprostate volume as measured by both transabdominal and transrectal ultrasound withthe degree of IPSS, a positive result shows that the increase in prostate volume, thedegree of IPSS will also increase. Conclusion: There is a significant relationshipbetween prostate volume as measured by both TAUS and TRUS and the degree of IPSS.
Antioxidant and Anti-inflammatory effect of Graptophyllum pictum (L.) Griff extract Study on SOD and COX-2 serum of experimental hemorrhoids Azhar, Abu; Riwanto, Ignatius; Nugroho, Eriawan Agung; Susilaningsih, Neni; Prajoko, Yan Wisnu; Budiono, Parish; Prasetyo, Sigit Adi
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.539 KB) | DOI: 10.36408/mhjcm.v7i2.515

Abstract

Background The 1st, 2nd and small 3rd degree hemorrhoids are non-operatively treated by using anti-inflammatory and plebotonic medicines, high fiber diet and changing lifestyle. Graptophyllum pictum (L.) Griff (GP) is potential to be a hemorrhoid medicine (anti-inflammatory and plebotonic medicine) since its anti-inflammatory effect may be related to antioxidant property. ObjectiveTo elaborate the anti-inflammatory and anti-oxidant effect of GP on experimental hemorrhoid in male Wistar rats. MethodsA Randomized Controlled Trial Post-test only design in hemorrhoid-like rats using croton oil induced into the anus for 30 seconds each day for 3 consecutive days. 14 Wistar rats were randomly allocated into 2 groups. Group 1 got normal saline solution, while group 2 treated with GPE 100mg/Kg bw for 5 consecutive days. On the 9th experimental day, the blood was drawn for Elisa examination of COX-2 and SOD levels. As COX-2 and SOD normally distributed, pool t-test and product moment correlation was used for statistical analysis. Results All of Wistar rats were still alive. COX-2 levels (ng/ml) in the GPE group was 266.28±158.47, was significantly lower compared to control (595.21±68.92) (p=0.000). Serum SOD levels (ng/ml) in the GPE was 77.00±11.0, and was significantly higher than the control 28.00±4.00 (p=0.02). Correlation between COX-2 and SOD serum level was significantly strong negative correlation (p=0,000 and r=-0.842) Conclusions GPE at a dose of 100 mg/kg bw has antioxidant and anti-inflammatory effects on artificial hemorrhoids through decreased COX-2 levels, and elevated SOD levels. There is a strong negative correlation between SOD and COX-2 serum level. KeywordsGraptophyllum pictum, hemorrhoids, Croton oil, COX-2, SOD.
Co-Authors Eriawan Agung Nugroho Eriawan Agung Nugroho, Eriawan Agung Ezra Endria Gunadi Ignatius Riwanto, Ignatius Neni Susilaningsih Parish Budiono Sigit Adi Prasetyo, Sigit Adi Yan Wisnu Prajoko