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All Journal Journal of General Procedural Dermatology and Venereology Indonesia Journal of Medicine and Health
Nobel, Shelly
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Medicine & Pharmacology Public Health

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Studi Kasus: Optimalisasi Regenerasi Kulit Pasca Prosdeur Estetik dengan Perawatan Kulit Dermo-kosmetik Setiawan, Stanley; Darmawan, Hari; Putranto, Samuel S; Linata, Angela M; Salim, Stephanie; Nobel, Shelly
Journal of Medicine and Health Vol 6 No 2 (2024)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v6i2.8269

Abstract

The use of ecobiology-based dermocosmetics containing Antalgicine™ can expedite the optimization of skin regeneration post-aesthetic procedures. The aim of this case study assess the clinical benefit of Antalgicine™ post-aesthetic procedures. Six patients were recruited into this case study which utilizes subjective and objective measurements. Antalgicine™ was applied using a split-face study method. Subjective evaluation is graded by patients using a 1-5 Likert scale, along with objective evaluation, was performed by a blinded dermatologist. Results showed an objective reduction in post-aesthetic procedure on day 7, namely 40% for microneedling, 32% for fractional radiofrequency, and 29% for picosecond laser, as well as subjective reductions in every post-aesthetic procedure sensation, specifically pain, pruritus, tightness, and burning sensation at 67%, 75%, 67%, 33% for microneedling, 71%, 67%, 67%, 50% for fractional radiofrequency, and 67%, 75%, 78%, 60% for picosecond laser, respectively. As a conclusion, Antalgicine™ can reduce post-aesthetic procedure effects for optimizing skin regeneration.
Combination of 1064 nm QS Nd:YAG Photoacoustic Technology and Exosome for Facial Rejuvenation Setiawan, Stanley; Putranto, Samuel Septrian; Linata, Angela Maria; Salim, Stephanie; Mertosono, Novia Sari Andriati; Nobel, Shelly; Wardianti, Flora Asri; Anggraini, Ita; Rahmawati, Zulaikha Rizqina
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 9, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Facial rejuvenation has become a global trend in cosmetic and aesthetic dermatology to restore youthful skin. The combination of 1064 nm Q-Switched Neodymium:Yttrium Aluminum Garnet (QS Nd:YAG) laser and exosomes as a facial rejuvenation procedure restores youthfulness by increasing collagen and elastin. Case Illustration: This case series evaluated the effectiveness of 1064 nm QS Nd:YAG laser with and without human amniotic fluid stem cell-derived exosomes (hAFSC-exo) for facial rejuvenation in six adults aged 24–39 years with Fitzpatrick skin types III-IV. Participants were randomized to receive either laser treatment alone or combined with intradermal hAFSC-exo injections every two weeks for three sessions, with outcomes assessed through blinded objective and subjective evaluations. Objective assessments using a skin analyzer showed improvements for both groups, with consistently greater improvement in the combination therapy group. Meanwhile, subjective evaluations using the GAIS scale indicated that combination therapy recipients experienced “very much improved” outcomes, minimal side effects, and good overall tolerance. Discussion: Facial rejuvenation using 1064 nm QS Nd:YAG laser and hAFSC-exo was evaluated in this case series. Both treatments improved skin quality, but combination therapy demonstrated superior results. However, improvements in pigmentation were limited, and subjective assessments may have been influenced by response bias. The short follow-up period limited the evaluation of long-term skin changes; extended studies are warranted to assess sustained outcomes. Conclusion: Combination therapy of 1064 nm QS Nd:YAG laser and exosomes has a favorable result for facial rejuvenation.
Co-Authors Anggraini, Ita Hari Darmawan Linata, Angela M Linata, Angela Maria Mertosono, Novia Sari Andriati Putranto, Samuel S Putranto, Samuel Septrian Rahmawati, Zulaikha Rizqina Salim, Stephanie Setiawan, Stanley Wardianti, Flora Asri