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All Journal Medicinus : Jurnal Kedokteran Journal of General Procedural Dermatology and Venereology Indonesia
Wardianti, Flora Asri
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Medicine & Pharmacology Public Health

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Combination of 1064 nm QS Nd:YAG Photoacoustic Technology and Exosome for Facial Rejuvenation Setiawan, Stanley; Putranto, Samuel Septrian; Linata, Angela Maria; Salim, Stephanie; Mertosono, Novia Sari Andriati; Nobel, Shelly; Wardianti, Flora Asri; Anggraini, Ita; Rahmawati, Zulaikha Rizqina
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 9, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Facial rejuvenation has become a global trend in cosmetic and aesthetic dermatology to restore youthful skin. The combination of 1064 nm Q-Switched Neodymium:Yttrium Aluminum Garnet (QS Nd:YAG) laser and exosomes as a facial rejuvenation procedure restores youthfulness by increasing collagen and elastin. Case Illustration: This case series evaluated the effectiveness of 1064 nm QS Nd:YAG laser with and without human amniotic fluid stem cell-derived exosomes (hAFSC-exo) for facial rejuvenation in six adults aged 24–39 years with Fitzpatrick skin types III-IV. Participants were randomized to receive either laser treatment alone or combined with intradermal hAFSC-exo injections every two weeks for three sessions, with outcomes assessed through blinded objective and subjective evaluations. Objective assessments using a skin analyzer showed improvements for both groups, with consistently greater improvement in the combination therapy group. Meanwhile, subjective evaluations using the GAIS scale indicated that combination therapy recipients experienced “very much improved” outcomes, minimal side effects, and good overall tolerance. Discussion: Facial rejuvenation using 1064 nm QS Nd:YAG laser and hAFSC-exo was evaluated in this case series. Both treatments improved skin quality, but combination therapy demonstrated superior results. However, improvements in pigmentation were limited, and subjective assessments may have been influenced by response bias. The short follow-up period limited the evaluation of long-term skin changes; extended studies are warranted to assess sustained outcomes. Conclusion: Combination therapy of 1064 nm QS Nd:YAG laser and exosomes has a favorable result for facial rejuvenation.
The Role of Dermatovenereology in the Diagnosis and Management of Bacterial Vaginosis: A Systematic Review Eldy; Amalia, Shania Rizky; Wardianti, Flora Asri; Sitanggang, Mega Rahmani; Hakiki, Nadhira Permata
Medicinus Vol. 13 No. 1 (2023): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i1.10784

Abstract

Background: Bacterial vaginosis (BV) is a prevalent, recurrent cause of abnormal vaginal discharge with important sexual and reproductive health implications. Because symptoms overlap with candidiasis, trichomoniasis, cervicitis/STIs, and vulvar dermatoses, dermatovenereology services are central to accurate diagnosis and comprehensive care. Methods: A PRISMA-compliant systematic review searched PubMed, EMBASE, and Scopus from inception to September 1, 2023, using controlled vocabulary and keywords related to BV, diagnostic modalities (Amsel, Nugent/Gram stain, microscopy, molecular assays), and dermatovenereology/sexual health services. Screening, full-text eligibility, and narrative synthesis were performed; risk of bias was assessed using the Newcastle–Ottawa Scale. Result: From 729 records, 8 studies were included after deduplication, screening, and eligibility assessment. Studies consistently highlighted the value of objective diagnosis particularly in recurrent, atypical, or post-treatment presentations. NAAT-based testing was used mainly in referral settings and facilitated concurrent STI testing. First-line antibiotics (metronidazole or clindamycin) achieved short-term response, but recurrence was common; suppressive intravaginal metronidazole and newer recurrence-prevention approaches (e.g., astodrimer gel, Lactin-V) reduced relapse in selected populations. Conclusions: Dermatovenereology-led pathways that integrate objective testing, careful differential diagnosis, STI screening, and counseling can improve diagnostic precision and reduce BV recurrence.
Co-Authors Amalia, Shania Rizky Anggraini, Ita Eldy Hakiki, Nadhira Permata Linata, Angela Maria Mertosono, Novia Sari Andriati Nobel, Shelly Putranto, Samuel Septrian Rahmawati, Zulaikha Rizqina Salim, Stephanie Setiawan, Stanley Sitanggang, Mega Rahmani