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All Journal Indonesian Journal of Pharmacology and Therapy Indonesian Journal of Health Research Innovation
Nurkomariah Zulhijjah
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Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Effect of essential oil of black cumin (Nigella sativa) on hematological profiles and total cholesterol levels of Wistar rats exposed by cigarette smoke Rakhmawatie, Maya Dian; Muhammad Adzanta Al Afghani; Nurkomariah Zulhijjah; Andra Novitasari; Arief Tajally Adhiatma
Indonesian Journal of Pharmacology and Therapy Vol 1 No 1 (2020)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.495

Abstract

Cigarette smoke contains toxic substances such as carbon monoxide, lead, cadmium, tar and hydrogen cyanide which can triggeroxidative stress and causeerythrocyte membrane damage and hemoglobin oxidation. In addition, it also contains nicotine which can increase the total cholesterol levels. Black cumin containing thymoquinone has been known for its antioxidant and anticholesterol activities. This study aimed to investigate the effect of black cumin extract on hematological profiles and total cholesterol levels of Wistar rats exposed by cigarette smoke. It was an experimental study with randomized posttest only control group design. Twenty Wistar rats (Rattus norvegicus) that divided into four groups were used in this study.The normal control group (N) was provided with standard feed,the negative control group (C) was exposed to the cigarette smoke with two pieces of cigarettes/day for 14 days, the treated groups were given black cumin extract 200mg/kg (T1) and 400mg/kg (T2) and exposed by cigarette smoke two pieces of cigarettes/day for 14 days. On day 15, blood samples from the rats were taken through the sinus orbitalis and then the erythrocyte, the hemoglobin and the total cholesterol levels were examined. Data were analyzed using the one-way ANOVA test and continued by the post-hoc test. The results showed the number of erythrocytes and hemoglobin levels of the T2 group was significantly higher than those of the C group (p<0.05). Although, total cholesterol levels of the T2 group was lower than that of other groups, however it was not significantly different (p>0.05). In conclusion, the administration of black cumin extract at 400mg/kg significantly increases the erythrocytes numbers and the hemoglobin levels in Wistar rats exposed by cigarette smoke.
HUBUNGAN KNOWLEDGE, ATTITUDE, PRACTICE PERNIKAHAN DINI DENGAN KESEHATAN REPRODUKSI REMAJA PUTRI DI DESA GELANGSAR Luthfiyyah Asri Cahyani; Sabrina Intan Zoraya; Nurkomariah Zulhijjah; Dany Karmila
Indonesian Journal of Health Research Innovation Vol. 3 No. 1 (2026): Indonesian Journal of Health Research Innovation
Publisher : Yayasan Menawan Cerdas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64094/xe60e261

Abstract

Kesehatan reproduksi remaja merupakan aspek penting dalam menentukan kualitas kesehatan di masa depan, namun masih menghadapi berbagai permasalahan, termasuk pernikahan dini. Pernikahan dini dapat meningkatkan risiko gangguan kesehatan reproduksi karena kondisi fisik dan psikologis remaja yang belum matang. Penelitian ini bertujuan untuk mengetahui hubungan knowledge, attitude, dan practice mengenai pernikahan dini dengan status kesehatan reproduksi remaja putri di Desa Gelangsar. Penelitian ini merupakan penelitian observasional analitik dengan desain cross-sectional yang dilaksanakan pada bulan Desember 2023. Sampel sebanyak 74 remaja putri dipilih menggunakan teknik multistage random sampling. Data dikumpulkan menggunakan kuesioner terstruktur dan dianalisis menggunakan uji Chi-square dengan tingkat kepercayaan 95%. Hasil penelitian menunjukkan bahwa responden dengan knowledge kurang baik memiliki proporsi gangguan kesehatan reproduksi lebih tinggi (33,8%) dibandingkan dengan knowledge baik (9,5%) dengan nilai p=0,004. Responden dengan attitude kurang baik memiliki proporsi gangguan kesehatan reproduksi sebesar 32,4% dibandingkan attitude baik (10,8%) dengan nilai p=0,006. Responden yang melakukan pernikahan dini memiliki proporsi gangguan kesehatan reproduksi lebih tinggi (24,3%) dibandingkan yang tidak menikah dini (18,9%) dengan nilai p=0,001. Penelitian ini menunjukkan bahwa knowledge, attitude, dan practice mengenai pernikahan dini berhubungan secara signifikan dengan status kesehatan reproduksi remaja putri. Peningkatan edukasi kesehatan reproduksi dan pencegahan pernikahan dini diperlukan untuk menurunkan risiko gangguan kesehatan reproduksi pada remaja.
Co-Authors Andra Novitasari Arief Tajally Adhiatma Dany Karmila Luthfiyyah Asri Cahyani Maya Dian Rakhmawatie Muhammad Adzanta Al Afghani Sabrina Intan Zoraya