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All Journal Jurnal Farmasi Jurnal Farmasi dan Sains Indonesia (JFSI) Media Farmasi Indonesia Solo International Collaboration and Publication of Social Sciences and Humanities MULTIPLE: Journal of Global and Multidisciplinary Medical Sains : Jurnal Ilmiah Kefarmasian Science and Community Pharmacy Journal
Puruhita, Ranatri
Unknown Affiliation
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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A LITERATURE REVIEW: THE POTENTIAL OF NATURAL INGREDIENTS AS ANTIDEPRESSANTS Ranatri Puruhita; Arifah Sri Wahyuni; Andi Suhendi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.843

Abstract

Changes in mood, physical well-being, and behavior, such as sleep and hunger patterns, psychomotor abilities, concentration, anhedonia, exhaustion, hopelessness, helplessness, and suicidal thoughts, define a mental illness known as depression. Alternative therapies that can be used to avoid these side effects include herbal medicines from several types of plants. This literature review aims to determine the potential of natural ingredients that have antidepressant activity in plant biomarkers, methods of obtaining biomarkers, effective dose, and their mechanisms of action. Article searches use keywords ("Herbal plant" OR "Medicinal plant" OR "Herbal" OR "Plant Extract" OR "Plant Extracts") AND ("Antidepressant" OR "Antidepressive") AND ("Mechanism of antidepressant") using the Science Direct, PubMed, and Google Scholar databases. The final results included eight research articles in the systematic review that met the inclusion criteria. Plants that have antidepressant potential include flowers of Viola odorata L, Crocus sativus, Impatiens glandulifera, and Leptadenia hastata (Pers.) and Alpinia zerumbet, seeds of Nigella sativa, root of Panax ginseng, and Achyranthes aspera. Keywords: Antidepressants, Natural Ingredients, Literature Review
Pengaruh Penyuluhan terhadap Pengetahuan Kategori Penggunaan Obat untuk Ibu Hamil Warga Desa Asinan Kabupaten Semarang Ranatri Puruhita; Firstca Aulia Rahma; Danik Sulistyoningsih; Yovita Dwi Arini; Wahyu Chandi Saputra; Fifi Qolifatul Khasanah
urn:multiple://2988-7828multiple.v3i14
Publisher : Institute of Educational, Research, and Community Service

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Abstract

Penggunaan obat-obatan oleh ibu hamil merupakan hal yang penting karena dapat berdampak pada perkembangan janin. Beberapa penelitian menjelaskan bahwa beberapa obat-obatan mempunyai kemampuan untuk menembus plasenta dan dapat mengganggu pertumbuhan janin. Kegiatan penyuluhan yang dilakukan adalah memberikan informasi kepada ibu hamil tentang berbagai kategori penggunaan obat dengan jumlah peserta 16 orang. Pengetahuan peserta diukur dengan suatu instrumen berbentuk kuisioner. Kuisioner tersebut dibagikan sebelum dan sesudah pelaksanaan pemberian informasi kategori penggunaan obat untuk ibu hamil. Nilai p > 0,05 menunjukkan signifikansi statistik, dan analisis statistik menunjukkan bahwa ada peningkatan pengetahuan sebelum dan sesudan dilakukannya penyuluhan.
BROCCOLI (Brassica oleracea L) ETHANOL EXTRACT: A MOISTURIZER AND ITS EVALUATION IN ASPECTS OF PHYSICAL CHARACTERISTICS Aldila, Silvy; Puruhita, Ranatri; Uliana, Syahkhirotul Exma; Sa’adah, Anifatus; Gloria, Fransisca
Science and Community Pharmacy Journal Vol. 3 No. 1 (2024): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v3i1.545

Abstract

Skin disorders that are dry, dull, scaly, and not fresh affect everyone. Moisturizing cream is a cosmetic product that effectively hydrates and improves dry skin. Broccoli, scientifically known as Brassica oleracea L, is rich in vitamin C components, vitamin E (α-tocopherol), and flavonoids, which act as natural antioxidants and provide moisturizing properties for the skin. Producing extracts by the maceration process. Broccoli extract is utilized in the formulation of four moisturizing cream preparation compositions, each with a concentration of F1 (0%), F2 (2%), F3 (3%), and F4 (4%). The moisturizing cream formulation is assessed for its physical properties. Conducting tests to evaluate the dosage characteristics of moisturizing creams, includes organoleptic testing, homogeneity testing, pH testing, dispersion testing, adhesion testing, and viscosity testing. The concentration of broccoli extract in the four moisturizing cream preparation formulations is as follows: F1 (0%), F2 (2%), F3 (3%), and F4 (4%). The moisturizing cream formulation is assessed for its physical properties. Conducting tests to evaluate the dosage properties of moisturizing creams, including sensory evaluation, uniformity assessment, pH measurement, dispersion analysis, adhesion examination, and viscosity measurement
AN ANALYSIS OF FLAVONOID COMPOUNDS FROM ETHANOL EXTRACT OF MORINGA LEAVES (MORINGA OLEIFERA L.) USING FTIR AND HPLC Puruhita, Ranatri; Sulistyoningsih, Danik; Kristiyanti, Winnie; Aulia Rachma, Firstca
Science and Community Pharmacy Journal Vol. 3 No. 2 (2024): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v3i2.583

Abstract

Moringa leaves contain flavonoids, phenols, tannins, alkaloids, saponins, terpenoids, and steroids. The flavonoid and phenol content has antioxidant activity. This research aimed to determine compounds in the ethanol extract of Moringa leaves To determine the type of flavonoid content using FTIR and HPLC. FTIR analysis shows that Moringa leaves possibly contain compounds from quercetin derivatives, which is supported by HPLC analysis. This quercetin compound is a group of flavonols that are characterized by the presence of a hydroxyl group and a carbonyl group. HPLC analysis was carried out by making a quercetin standard with a concentration of 200 ppm. The resulting wavelength is 254 nm. The results of the quercetin standard chromatogram which contains one main peak obtained from the quercetin standard. This peak shows the retention time at 3 minutes. The results of the standard chromatogram, quercetin has an outer area of ​​44763473 and a sample area of ​​17455781 with 2 times dilution, so the % purity of fraction 9 for quercetin is 77.99 ppm. This HPLC analysis shows that Moringa leaves probably contain quercetin derivatives which are characterized by the same retention time between the sample and the quercetin standard, namely at a retention time of 3 minutes, and have a peak pattern that is almost the same as the quercetin standard.
EFEKTIVITAS PENYEMBUHAN LUKA BAKAR AKIBAT PEMBERIAN GEL ESTRAK ETANOL DAUN CENGKEH (Syzygium aromaticum L.) PADA KELINCI (Oryctolagus cuniculus) Puruhita, Ranatri; Aldila, Silvy; Ariyani, Destiana Putri
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p221-228

Abstract

Burns are damage to the organs that can happen when heat exposure from fire, chemicals, electricity, or radiation damages or destroys skin tissue. For burns, topical treatment can hasten the healing process. Because clove leaves have antiseptic qualities and antibacterial and anti-inflammatory activity, their secondary metabolites—flavonoids, tannins, and saponins—can be used to treat open wounds and stop infection. The purpose of this study is to create a gel formulation using clove leaf extract that will treat burn wounds without causing skin infections. Two formulations of the gel preparation, each with a 10% and 15% concentration, were evaluated on test rabbits. Using a hot iron plate, the rabbits' backs were shaved to cause burns. Clove leaf extract gel was used for the treatment group, Bioplacenton® was used as the positive control, and gel base was used as the negative control. Measurements of the wound's diameter were taken on days 0 and 15, and SPSS was used to analyze the results. Clove leaf extract burn gel is 60.98% effective in formula 1 and 77.16% effective in formula 2. Formula 2 is the gel formulation that works best for treating rabbit burns.
Pengaruh Berat Badan Terhadap Efek Aprodisiaka pada Mencit dengan Pemberian Jus Buah Nanas Madu Puruhita, Ranatri; Hesti Wulan S, A. Ariani; Puspitaningrum, Ika
Jurnal Farmasi (Journal of Pharmacy) Vol. 9 No. 2 (2020): Jurnal Farmasi (Journal of Pharmacy), October 2020
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Afrodisiaka adalah suatu bahan organik, minyak esensial (minyak atsiri), obat, minuman herbal atau bahan yang dapat membangkitkan gairah seksual. Penelitian ini menggunakan jus buah nanas madu (Ananas comosus L.Mer). Parameter yang akan dilihat yaitu pengaruh berat badan dan kemampuan daya aprodisiaka meliputi introduction, climbing, dan coitus. Hewan uji terbagi dalam 5 kelompok perlakuan yaitu kelompok I normal, kelompok II diberikan jamu pasak bumi®, kelompok III diberikan jus buah nanas 30g/KgBB mencit, kelompok IVdiberikan jus buah nanas 45g/KgBB mencit, dan kelompok V diberikan jus buah nanas 67,5g/KgBB mencit. Pemberian dilakukan selama 14 hari secara per oral dengan frekuensi pemberian sehari satu kali pada control positif dan pada kelompok pemberian jus sebanyak dua kali sehari. Pada hari ke-15 dilakukan pengamatan terhadap berat badan, berat testis dan aktifitas aprodisiak meliputi introduction, climbing, dan coitus. Berdasar hasil statistic dosis efektif jus buah nanas madu adalah 45g/KgBB dan tidak terdapat hubungan antara berat badan dan kemampuan aprodisiaka.
Excellent Pharmacist Service Strategy in the Pharmaceutical Community Towards Superior and Progressive Pharmacy Anindya Salsabila; Ranatri Puruhita; Siti Nadhira Indah P.I; Parwati; Siti Sitatul Mar’ah; Muthoifin; Muchammad Taufiq Affandi; Jihan Husna Srifyan; Ishmah Afiyah
Solo International Collaboration and Publication of Social Sciences and Humanities Vol. 1 No. 02 (2023): Solo International Collaboration and Publication of Social Sciences and Humani
Publisher : Walidem Institute and Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61455/sicopus.v1i02.57

Abstract

The purpose of this study is to determine the implementation of good and bad pharmaceutical ethics. The methods used are population and sample, sampling techniques, operational definitions, research instruments, data collection techniques, and data analysis. The results of research related to the implementation of practices based on SPKA as a whole can be used as studies and inputs in addition to the results of supervision from the government so that the government together with IAI professional organizations can support pharmacists in implementing practices according to standards. Decisions can also be taken appropriately by stakeholders in providing guidance, supervision and follow-up on the implementation of standards by pharmacists in pharmacies. Pharmacists can get full support to raise awareness of legal compliance in carrying out responsible practices.
Determination Of Antioxidant Activity And Spf Value Of Purified And Crude Extracts Of Mango Leaves (Mangifera Indica L.) Audrie Agustini Widiawati; Salma Hilmy Rusydi Hashim; La Ode Muhammad Anwar; Ranatri Puruhita
Media Farmasi Indonesia Vol. 21 No. 1 (2026): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v21i1.353

Abstract

Penelitian ini bertujuan untuk menguji perbedaan aktivitas antioksidan dan Sun Protection Factor (SPF) antara ekstrak kasar dan ekstrak murni daun mangga (Mangifera indica L.), dan untuk mengevaluasi peran pemurnian dalam meningkatkan efektivitasnya. Latar belakang penelitian ini terkait dengan meningkatnya permintaan akan senyawa alami dengan potensi ganda sebagai antioksidan dan pelindung UV, mengingat radikal bebas dan paparan ultraviolet merupakan penyebab utama stres oksidatif dan kerusakan kulit. Proses penelitian meliputi beberapa tahap, yaitu penentuan tanaman, persiapan simplisia, ekstraksi maserasi menggunakan etanol 70%, pemurnian dengan n-heksana, skrining fitokimia, evaluasi kualitas, uji antioksidan menggunakan metode DPPH, dan penentuan SPF dengan spektrofotometri. Hasil penelitian menunjukkan bahwa ekstrak murni memiliki profil kualitas yang lebih tinggi dengan rendemen 50%, kadar air 5,78% ± 0,29, dan kadar abu 0,22%. Uji fitokimia menunjukkan adanya flavonoid, alkaloid, tanin, fenolik, dan saponin, dengan flavonoid yang lebih terkonsentrasi dalam ekstrak murni. Uji antioksidan menunjukkan nilai IC₅₀ sebesar 24,64 ± 0,52 µg/mL untuk ekstrak murni dan 48,28 ± 0,61 µg/mL untuk ekstrak kasar, keduanya tergolong sangat kuat. Hasil SPF menunjukkan nilai 44,89 pada 12.000 ppm untuk ekstrak murni dan 30,23 untuk ekstrak kasar. Analisis ANOVA menunjukkan perbedaan yang signifikan (p < 0,05). Temuan ini menyoroti potensi ekstrak daun mangga murni yang menjanjikan sebagai bahan tabir surya herbal.
Co-Authors Andi Suhendi Anindya Salsabila Arifah Sri Wahyuni Ariyani, Destiana Putri Audrie Agustini Widiawati Danik Sulistyoningsih Fifi Qolifatul Khasanah Firstca Aulia Rachma Firstca Aulia Rahma Gloria, Fransisca Hesti Wulan S, A. Ariani Ika Puspitaningrum Ishmah Afiyah Jihan Husna Srifyan Kristiyanti, Winnie La Ode Muhammad Anwar Muchammad Taufiq Affandi Muthoifin Parwati Salma Hilmy Rusydi Hashim Sa’adah, Anifatus Silvy Aldila Siti Nadhira Indah P.I Siti Sitatul Mar’ah Sulistyoningsih, Danik Uliana, Syahkhirotul Exma Wahyu Chandi Saputra Yovita Dwi Arini