Article Per Year (5 Year)
p-Index From 2020 - 2025
1.288
P-Index
This Author published in this journals
All Journal Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Pengabdian Kepada Masyarakat Sisthana Bencoolen Journal of Pharmacy Science and Community Pharmacy Journal
Sa’adah, Anifatus
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 7 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 7 Documents
Search

 1 
PENGARUH PEMBERIAN METFORMIN KOMBINASI EKSTRAK ETANOL DAUN KELOR (Moringa oleifera L.) TERHADAP PENURUNAN KADAR GLUKOSA DARAH TIKUS YANG DIINDUKSI ALOKSAN Ovikariani; Sa’adah, Anifatus
BENCOOLEN JOURNAL OF PHARMACY Vol. 4 No. 1 (2024): April
Publisher : UNIB PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/bjp.v4i1.34207

Abstract

Abstrak: Diabetes adalah masalah kesehatan yang masih menjadi beban kesehatan Dunia karena angka prevelensi yang sangat tinggi yaitu, mencapai ½ miliar individu menderita Diabetes Melitus (DM) tipe 2. Daun Kelor adalah tanaman yang sering dimanfaatkan oleh masyarakat sebagai bahan makanan. Kandungan senyawa yang ada di dalam daun kelor memiliki peran sebagai anti-hipergkilemia. Ekstrak etanol daun kelor mengandung flavonoid. Flavonoid memiliki mekanisme menghambatan fosfodiesterase sehingga kadar cAMP dalam sel beta pankreas menjadi tinggi. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian metformin kombinasi ekstrak etanol daun kelor terhadap penurunan kadar glukosa darah tikus putih yang diinduksi aloksan. Penelitian ini merupakan penelitian ekperimental laboratorium, dengan rancangan Posttest-only Control Group Design yang menggunakan binatang percobaan yaitu tikus putih (Rattus norvegicus) . Menggunakan 4 kelompok hewan uji yaitu kelompok 1 (CMC-Na), kelompok 2 (Ekstrak dosis 100 mg/KgBB), kelompok 3 (Metformin dosis 12,5 mg/KgBB TIkus), kelompok 4 (kombinasi ekstrak dan metformin). Hasil penelitian menunjukkan penurunan glukosa darah tikus paling tinggi terjadi pada kelompok perlakuan Ekstrak daun kelor 100 mg/kg BB . Penurunan glukosa darah terjadi karena ekstrak daun kelor mengandung flavonoid yang dapat meningkatkan ekspresi GLUT 4 pada otot dan meningkatkan ambila glukosa oleh otot soleus melalui jalur PI3K dan PKC pada tikus. Kata Kunci: Daun kelor; Metformin; Glukosa Darah
Pengaruh Variasi Konsentrasi Bahan Pengikat Terhadap Formulasi dan Stabilitas Fisik Tablet Detergen Effervescent Ekstrak Daun Serai Dapur (Cymbopogon citratus) Girsang, Valentina; Kusuma Dewi, Liestyani; Rustaman, Heri; Sa’adah, Anifatus; Wibowo, Anisa Devi Kharisma
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p10-19

Abstract

Lemongrass leaves (Cymbopogon citratus) contain saponins that can form foam in water so that they are used as natural compounds that produce foam used in industry. The purpose of this study was to provide the effect of variations in PVP concentrations of 2%, 3% and 4% on the physical characteristics, physical stability and detergenation ability of effervescent detergent tablets of lemongrass leaf extract (Cymbopogon citratus). This study used the maceration extraction method with 96% ethanol and the manufacture of effervescent tablets by the wet granulation method. The results of the characterization and stability study of effervescent tablets of lemongrass leaf extract with variations in PVP concentration showed that the tablets met the requirements for characterization testing of effervescent tablets before and after stability. Based on the results of the foam height test on effervescent tablets before and after stability did not affect the high foam with the results of F1, F2, F3 after stability of 86.56 ± 0.34; 86.56 ± 0.34; 88.20 ± 2.28. This study shows that PVP affects the characteristics and stability of tablets but does not affect the detergent ability of effervescent detergent tablets.
Total Flavonoid Content (TFC) and Antioxidant Activity of Carrot Extract Isolate (Daucus carota L.) Nadiya Nihlatunnaja; Kalsum, Ummi; Sa’adah, Anifatus
Science and Community Pharmacy Journal Vol. 2 No. 1 (2023): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v2i1.356

Abstract

Antioxidants are antiradical compounds that can neutralize reactive free radicals into non-reactive ones that are relatively more stable so as to protect cells from the harmful effects of free radicals. Carrots have antioxidant activity due to the presence of carotenoid compounds. This study aims to determine the antioxidant activity of carrots. Extraction research method with maceration method. Isolation of flavonoids by column chromatography method. Antioxidant activity test using FRAP method. The results of research conducted from 60 extract fractions obtained 10 flavonoid fractions with a %TFC value 5,332%; 5,242%; 6,742%; 7,475%; 6,829%; 5,896%; 5,282%; 6,191%; 5,450%; and 5,498%. IC50 3,920; 1,960; 2,096; 2,065; 1,846; 0,867; 3,517; 1,179; 3,383; dan 3,570 ppm. In conclusion, the antioxidant activity of the ten fractions was very strong (<50 g/mL).
Stability Testing Occurred On Piroxicam Cream Preparation By Using Stearic Acid And Triethanolamine As Emulsifying Agents Aldila, Silvy; Girsang, Valentina; Rahmawati, Ina Sonia; Maharai, Daniel; Sa’adah, Anifatus
Science and Community Pharmacy Journal Vol. 2 No. 2 (2023): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v2i2.482

Abstract

Preface: Piroxicam is classified as a Class 2 product in the Biopharmaceutic Classification System due to its limited solubility in water. The cream preparations underwent optimisation of the stearic acid and triethanolamine concentrations. The optimisation results indicate that the most favourable amounts of stearic acid and triethanolamine (TEA) are 16% and 4% respectively. The physical attributes test yielded positive findings for the formula, indicating a successful cream formulation that satisfied the specified criteria. Purpose: The cream formulation is thereafter submitted to a stability assessment. The purpose of the stability test is to ascertain the long-lasting quality of the preparation when subjected to various storage circumstances. Procedure: Stability tests were conducted over 6 cycles at temperatures of 4° C and 40° C. During the testing phase, various characteristics of the cream preparation were assessed, including organoleptic properties, homogeneity, viscosity, adhesive power, spreadability, and pH. Result: The formulated solution successfully fulfils the criteria of the physical characteristics test, with the following parameter values: pH of 6.8, viscosity of 11010 Cps, spreading power of 6.8 cm, adhesive power of 2.6 seconds, and protective power of 6.5 seconds. Conclusion: The t-test findings conducted before and after assessing the stability of the preparation indicated a p-value greater than 0.05, indicating the absence of a significant difference.
BROCCOLI (Brassica oleracea L) ETHANOL EXTRACT: A MOISTURIZER AND ITS EVALUATION IN ASPECTS OF PHYSICAL CHARACTERISTICS Aldila, Silvy; Puruhita, Ranatri; Uliana, Syahkhirotul Exma; Sa’adah, Anifatus; Gloria, Fransisca
Science and Community Pharmacy Journal Vol. 3 No. 1 (2024): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v3i1.545

Abstract

Skin disorders that are dry, dull, scaly, and not fresh affect everyone. Moisturizing cream is a cosmetic product that effectively hydrates and improves dry skin. Broccoli, scientifically known as Brassica oleracea L, is rich in vitamin C components, vitamin E (α-tocopherol), and flavonoids, which act as natural antioxidants and provide moisturizing properties for the skin. Producing extracts by the maceration process. Broccoli extract is utilized in the formulation of four moisturizing cream preparation compositions, each with a concentration of F1 (0%), F2 (2%), F3 (3%), and F4 (4%). The moisturizing cream formulation is assessed for its physical properties. Conducting tests to evaluate the dosage characteristics of moisturizing creams, includes organoleptic testing, homogeneity testing, pH testing, dispersion testing, adhesion testing, and viscosity testing. The concentration of broccoli extract in the four moisturizing cream preparation formulations is as follows: F1 (0%), F2 (2%), F3 (3%), and F4 (4%). The moisturizing cream formulation is assessed for its physical properties. Conducting tests to evaluate the dosage properties of moisturizing creams, including sensory evaluation, uniformity assessment, pH measurement, dispersion analysis, adhesion examination, and viscosity measurement
PEMANFAATAN LILIN AROMATERAPI DALAM UPAYA MENGATASI FATIGUE DAN GANGGUAN TIDUR PADA PASIEN HEMODIALISA DENGAN BERBASIS HUMANIS ETIS Danny Putri Sulistyaningrum; Noer'aini, I'ien; Sa’adah, Anifatus
JURNAL PENGABDIAN KEPADA MASYARAKAT SISTHANA Vol. 7 No. 1 (2025): Juni : Jurnal Pengabdian Kepada Masyarakat Sisthana
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/pkmsisthana.v7i1.1981

Abstract

Latar Belakang: Hemodialisa merupakan terapi pengganti ginjal pada pasien gagal ginjal terminal yang dilakukan seumur hidup atau sampai pasien mendapatkan donor ginjal. Terapi ini dapat menimbulkan berbagai keluhan seperti fatigue dan gangguan tidur. Akibatnya pasien mengalami penurunan konsentrasi dan aktivitas fisik, serta penurunan kualitas hidup. Tujuan: Mengidentifikasi dan menganalisa fatigue dan gangguan tidur pada pasien hemodialisa, serta mengaplikasikan pemanfaatan lilin aromaterapi untuk mengatasi masalah tersebut. Metode: Mengkaji fatigue dan gangguan tidur, memberikan penyuluhan tentang fatigue dan gangguan tidur, serta menerapkan lilin aromaterapi untuk mengatasi fatigue dan gangguan tidur pada pasien hemodialisa. Hasil: Setelah diberikan lilin aromaterapi terdapat penurunan fatigue dari rerata 20.00 menjadi rerata 15.40. serta terdapat penurunan gangguan tidur dari rerata 10.14 menjadi rerata 5.29. Kesimpulan: Lilin aromaterapi mampu dimanfaatkan untuk mengurangi keluhan fatigue dan gangguan tidur pada pasien hemodialisa.
MONITORING SIDE EFFECTS OF ANTITUBERCULOSIS DRUGS (OATS) IN PATIENTS WITH TUBERCULOSIS AT TUGUREJO REGIONAL GENERAL HOSPITAL SEMARANG Yuliasari, Niken; Gloria, Fransisca; Dahliyanti, Novita Dwi; Ovikariani, Ovikariani; Sa’adah, Anifatus; Suwarni, Sri
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p21-25

Abstract

Monitoring of side effects of antituberculosis drugs (OAT) in tuberculosis (TB) patients during the intensive treatment phase. Tuberculosis, caused by Mycobacterium tuberculosis, requires the use of OAT which can cause a variety of side effects. Research shows that common side effects experienced by TB patients include joint pain, nausea, lack of appetite, and dizziness. The high incidence of these side effects has the potential to affect patient compliance in undergoing treatment, which has an impact on the success of TB therapy. The research method used is descriptive observation with a cross-sectional approach. Data was taken from patients undergoing treatment at various hospitals and health centers. The results showed that most patients experienced mild side effects, with frequency varying depending on the week of treatment. In the first week, almost all patients reported side effects, while the frequency tended to decrease over time. Regular monitoring of OAT side effects is essential to improve patient compliance and prevent treatment discontinuation. Health workers are expected to conduct periodic evaluations and provide support to patients to stay motivated. With effective monitoring, the risk of serious side effects can be minimized, and treatment outcomes for TB patients can be improved.
Co-Authors Aldila, Silvy Anisa Devi Kharisma Wibowo Dahliyanti, Novita Dwi Girsang, Valentina Gloria, Fransisca Kusuma Dewi, Liestyani Maharai, Daniel Nadiya Nihlatunnaja Noer'aini, I'ien Ovikariani Ovikariani, Ovikariani Puruhita, Ranatri Rahmawati, Ina Sonia Rustaman, Heri Sri Suwarni Sulistyaningrum, Danny Putri Uliana, Syahkhirotul Exma Ummi Kalsum Yuliasari, Niken