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All Journal J-HESTECH (Journal Of Health Educational Science And Technology) Jurnal Aisyah : Jurnal Ilmu Kesehatan Green Medical Journal Jurnal Penyakit Dalam Indonesia
Virnanda Amu, Ivan
Program Of Nursing, Universitas Negeri Gorontalo
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Immune Response toward Mycobacterium Tuberculosis Infection Ikram Hasanuddin, Abdi Dzul; Roswita, Nanang; Virnanda Amu, Ivan
Green Medical Journal Vol 2 No 2 August (2020): Green Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/gmj.v2i2.47

Abstract

Understanding the human immune response toward Mycobacterium tuberculosis infection is important for controlling its infection. Its transmission through the air consists of "droplets nuclei" containing TB bacilli. After initial infection, the human body will provide diverse immune responses and will determine different clinico-histopathologic finding. This response starts from innate immunity that consists of phagocytosis by distal alveolar macrophages or nasal microfold cells, then will be continued by dendritic cells to be transferred to mediastinal lymph nodes to induced adaptive immune responses. This response is mediated by cells through IFN- γ signaling which will enhance phagocytosis. If this response is effective, there will be a latent infection with an initial histopathological finding of caseosa granulomas and predominantly followed by chronic granulomas. In a few cases, it can be reactivated via the IL-10 activation pathway and exogenous factors, it will induce a great adaptive immune reaction and provide more severe clinico-histopathological manifestation. The existence of the human body's immune response to Mycobacterium tuberculosis, etiher innate or adaptive immunity will determine the clinical course and pathology that will occur.
Stress Level And Hemodialysis Duration Of Patients With Chronic Kidney Failure Undergoing Hemodialysis Soeli, Yuniar M.; Amu, Ivan Virnanda; Sune, Ziah Anisa
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 6 (2021): Special Issue GINC
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1391.609 KB) | DOI: 10.30604/jika.v6iS1.773

Abstract

Kidney failure is a chronic and irreversible impaired kidney function. End-stage kidney disease requires therapy, namely hemodialysis using a dialysis machine, in which the process takes a long time. Such a duration of therapy can lead to anxiety and stress to the patient. The study aims to determine the relationship between stress level and hemodialysis duration among patients with chronic kidney failure who underwent hemodialysis at Toto Kabila Regional Public Hospital.This research employed a cross-sectional method involving patients suffering from kidney failure and undergoing hemodialysis as the population. Further, the sample consisted of 29 respondents with a total sampling technique. The results showed that one respondent (3.4%) experienced normal stress, eight respondents (27.6%) had mild stress, 15 respondents (51.7%) got moderate stress, and five respondents (17.2%) experienced severe stress. In addition, two respondents underwent hemodialysis therapy for less than 6 months, and 27 respondents (93.1%) were under the therapy for more than 6 months.All in all, stress level relates to hemodialysis therapy of patients with chronic kidney failure who undergo hemodialysis in the aforementioned hospital. The p-value was 0.021 less than 0.05, indicating that Ha is accepted. It is suggested that people think positively and composedly during circumstances to live a better life.
Profil Fitokimia dan Kromatografi Lapis Tipis Kulit Jeruk Nipis (Citrus aurantifolia) dalam Bentuk Ekstrak Maserasi, Rendaman, dan Perasan: Indonesia Mulyadi, Jesica; A. Kasim, Vivien Novarina; Amu, Ivan Virnanda
Journal of Health Educational Science And Technology Vol. 8 No. 2 (2025): J-HESTECH (Journal Of Health Educational Science And Technology)
Publisher : Faculty of Health Sciences , Dr. Soetomo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25139/htc.v8i2.11274

Abstract

Produk jeruk nipis yang kaya akan berbagai senyawa fenolik dan serat makanan, membuat produk jeruk diminati oleh semua kalangan. Dampaknya adalah terdapat sejumlah besar kulit jeruk nipis yang umumnya dibuang sebagai limbah di lingkungan. Limbah lingkungan tersebut ternyata berpotensi sebagai sumber nutraceutical. Metode penelitian true-eksperimen design, Sampel kulit jeruk nipis ekstrak maserasi dengan metanol 3000 terendam selama 3 x 24 jam kemudian dievaporasi sampai terbentuk ekstrak kental. Sampel ekstrak rendaman dari simplisia kulit jeruk nipis dirajang kecil-kecil dilarutkan dalam Ethanol 96% sebanyak 2000 ml terendam sempurna selama 3 x 24 jam dipisahkan antara filtrat dan residu selanjutnya di uapkan. Sampel ekstrak perasan dari jeruk nipis dibelah menjadi dua kemudian diperas dan diambil air perasan selanjutnya diuapkan. Hasil pemeriksaan profil fitokimia dari kulit jeruk nipis, bentuk ekstrak maserasi mengandung 6 senyawa metabolik yaitu alkaloid, flavonoid, saponin, steroid, tanin dan fenol, untuk ekstrak rendaman mengandung 4 senyawa metabolik yaitu alkaloid, flavonoid, steroid, fenol dan bentuk ekstrak perasan mengandung 3 senyawa metabolik yaitu alkaloid, steroid, dan fenol. Hasil Kromatografi lapis tipis menggunakan eluen n-heksan : etil asetat dengan perbandingan 3:2 pada lampu UV 366 nm, didapatkan bahwa ekstrak perasan memiliki empat bercak noda, ekstrak rendaman memiliki empat bercak noda, dan ekstrak maserasi memiliki lima bercak noda. Kesimpulannya ekstrak maserasi kulit jeruk nipis lebih banyak kandungan senyawa metabolik dan menghasilkan lebih banyak senyawa terlarut karena pelarut organik masuk ke jaringan kulit. Pemanfaatan limbah lingkungan kulit jeruk nipis diharapkan dapat sebagai terapi adjuvant yang murah, efesien dan ramah lingkungan.
Faktor Prediktif Post Dialysis Fatigue Sedang pada Pasien yang Menjalani Hemodialisis Reguler Amu, Ivan Virnanda; Marbun, Maruhum Bonar H; Nugroho, Pringgodigdo; Rinaldi, Ikhwan; Shatri, Hamzah; Mardiana, Nunuk; Hidayat, Rudy; Susalit, Endang; Yunihastuti, Evy; Purnamasari, Dyah; Wardoyo, Elizabeth Y
Jurnal Penyakit Dalam Indonesia
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction. Fatigue is often found in patients with CKD-HD. Fatigue serves as an indicator of mortality and may be a viable target in a treatment strategy. Current research has not established the determinants of moderate PDF in individuals with CKD who are undergoing HD. Therefore, this study was conducted to prove the predictor factors of moderate PDF. Methods. A retrospective cohort study in CKD-HD patients at Fatmawati Central General Hospital during the period of November-December 2024. The independent variables of this study are comorbidities, MIS, depression, intradialytic SBPV, dialysis vintage, UFG, IDWG, and anemia status. Primary data from the PDF Scale, MIS, and BDI II questionnaire were collected through patient interviews during the eighth hemodialysis session. Demographic and clinical information of the patients was obtained from medical records. Intradialytic SBPV was determined by the ARV. All variables were examined using the chi-square test, except for the depression variable, which failed to fulfil the requirements and was assessed using the Fisher exact test. A logistic regression analysis was performed to identify the most significant association among the predictor variables of moderate PDF. Results. A total of 135 research subjects were included in the study. Based on the results of the bivariate analysis, MIS, depression, and the type of dialysis were significantly linked to moderate post dialysis fatigue (p < 0.05). From the results of the multivariate analysis, inflammatory malnutrition (RR 1.580; 95% CI 1.017–2.455; p = 0.042), dialysis vintage (RR 1.850; 95% CI 1.208–2.834; p = 0.005), and depression (RR 2.165; 95% CI 1.542–3.039; p < 0.001) were obtained. The logistic regression model shows a significant relationship between moderate PDF and severe malnutrition inflammation score, mild to moderate depression, and dialysis vintage exceeding 12 months. Conclusion. Our findings underscore a significant association between depression, dialysis vintage, and malnutrition inflammation score (MIS) with moderate PDF in CKD-HD patients.
Co-Authors A. Kasim, Vivien Novarina Abdi Dzul Ikram Hasanuddin Dyah Purnamasari E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Endang Susalit Evy Yunihastuti Ikhwan Rinaldi Maruhum B.H. Marbun Mulyadi, Jesica Nanang Roswita Paramata Nunuk Mardiana, Nunuk Pringgodigdo Nugroho, Pringgodigdo Rudy Hidayat Soeli, Yuniar M. Sune, Ziah Anisa Wardoyo, Elizabeth Y Yuniar M. Soeli Ziah Anisa Sune