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All Journal Medical Journal of Indonesia Jurnal Penyakit Dalam Indonesia
Endang Susalit
Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta.
Medicine & Pharmacology

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Survival Kidney Transplantation from Related and Emotionally Related Living Donors in Cipto Mangunkusumo Hospital 2010-2015 Susilowati, Utami; Sutrisna, Bambang; Marbun, Maruhum Bonar H; Susalit, Endang
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 2
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Clinical Features and Quality of Life in End Stage Renal DiseasePatients Undergoing Hemodialysis Twice A Week Compared toThrice A Week Imelda, Fitri; Susalit, Endang; Marbun, M Bonar M
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 3
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Introduction. National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NFK-KDOQI) recommends thrice weekly hemodialysis (HD) However, in Indonesia, most patients are given HD twice a week. Therefore it is necessary to investigate the clinical features and quality of life in End Stage Renal Disease (ESRD) patients undergoing twice-weekly HD. This study aimed to identify the clinical features and the quality of life in ESRD patients undergoing hemodialysis twice a week. Methods. A cross-sectional study was conducted in ESRD patients undergoing twice-weekly HD and thrice-weekly HD at Cipto Mangunkusumo Hospital and some private hospitals in Jakarta. Blood samples were obtained for laboratory examination. Meanwhile, quality of life were assessed by using Kidney Disease Quality of Life (KDQOL-SF 36). Results. A total of 80 subjects were included in this study, most of them were male and over 50 years old. Some clinical features were significantly higher in twice-weekly HD patients compared to thrice-weekly HD patients. Those features were Interdialytic Weight Gain (IDWG) (mean 4.91% (SD 1.52) and 3.82% (SD 1.28); p= 0.002); albumin (mean 4.05 mg/dl (SD 0.26) and 3.86 mg/dl (SD 0.48); p= 0.027); transferrin saturation (median 25.5% (range 12.0 to 274.0) and 21.95% (5.8 to 84.2); p= 0.004); phosphate level (mean 5.82 mg/dl (SD 1.68) and 5.82 mg/dl (SD 1.68); p= 0.026. Meanwhile, Total Iron Binding Capacity (TIBC) was significantly higher in thrice-weekly HD patients (mean 235.20 μg/dl (SD 55.72) and 273.73 μg/dl (SD 58.29 SB); p= 0.004). Approximately, 68% of twice-weekly HD reached Kt/V >1.8 and 93.3% of thrice-weekly HD reached Kt/V >1.2. Quality of life between the two groups was not significant either on Physical Componet Score (PCS) (p= 0.227), Mental Component Score (MCS) (p= 0.247), and Kidney Disease Component Score (KDCS) (p= 0.889). Conclusions. There are statistically significant differences between clinical features of twice-weekly HD and thrice-weekly HD on examination of IDWG, albumin, transferrin saturation, and phosphate levels which are higher in twice-weekly HD. Whereas, TIBC is higher in thrice-weekly HD group. Meanwhile, the patients quality of life in both groups showed no statistically significant differences.
The Association between Elevated Levels of Erythropoietin andEndothelial Progenitor Cell with Improvement of EndothelialFunction in Renal Failure Patients 3 Months after KidneyTransplantation Armelia, Linda; Susalit, Endang; HM, Maruhum Bonar; Shatri, Hamzah
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 2
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Introduction. Endothelial progenitor cell (EPC) is considered possible to reduce asymmetric dimethylarginine (ADMA) levels, which is a marker of improved endothelial function. However, clinically, there is still a debate about the role of EPC. This study was conducted to determine the correlation of elevated levels of erythropoietin (Epo) and the number of EPC CD34 + and CD133 + with improvement of endothelial function in renal failure patients 3 months after kidney transplantation. Methods. A cross-sectional study was conducted in prior and 3 months after kidney transplantation of renal failure patients who underwent a kidney transplant in Cipto Mangunkusumo hospital. The study included 21 subjects who enrolled from July 2013 to February 2014. Blood samples prior and 3 months after kidney transplantation were collected to evaluate the level of Epo, numbers of EPC CD34+ and CD133+ and level of assymetric dimethylarginine (ADMA). Statistical analysis was performed using Pearson or Spearman correlation test. Results. Results of this study showed that prior to kidney transplantation, level of Epo was increased but not statistically significant (p>0.05). The EPC numbers of CD34+ and CD133+ were significantly increased (p0.05). There was no association between the elevated level of Epo and the numbers of EPC CD34+ and CD133+ with the improvement of endothelial function three months after kidney transplantation. Conclusions. In three months after kidney transplantation, there is an elevated level of Epo, the numbers of EPC CD34+ and CD133+ and decrease level of ADMA. However, there was no association between the elevated level of Epo and the numbers of EPC CD34+ and CD133+ with the improvement of endothelial function in patients 3 months after kidney transplantation.
The Role of Hydration and N-Acetyl Cysteine Combination in 48Hours Contrast-Induced Nephropaty after Percutaneous CoronaryIntervention in Stage Three Chronic Kidney Disease Patients Simatupang, Lydia D; Susalit, Endang; Wijaya, Ika Prasetya
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 3
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Introduction. Contrast Induced Nephropathy (CIN) after percutaneous coronary intervention (PCI) is common in stage 3 chronic kidney disease (CKD) patients. While there is no cure for CIN and some cases are fatal for the kidney or even life, it is preventable. Eventhough controversial, hydration and N-Acetyl Cysteine (NAC) are modalities to prevent CIN. Not having a certain guideline to prevent CIN in Integrated Cardiac Services (ICS) Cipto Mangunkusumo Hospital for PCI patients generates interest to study it. Methods. A prospective cohort is conducted to evaluate plasma creatinine before and 48 hours after PCI, meanwhile recording whom is given combined hydration and NAC and which not. Results. 43,4% of stage 3 CKD patients are given hydration and NAC, and incidence of CIN occurred in 5.26% patients all belonging to the non hydration and NAC group. Attributable risk is 100% means CIN can be prevented with hydration and NAC. Conclusions. Hydation and NAC is indicated to be protective against CIN in stage 3 CKD patients undergoing PCI.
Perbedaan Pola Sirkadian Tekanan Darah pada Pasien Penyakit Ginjal Kronik Pra dan PascaTransplantasi Ginjal Di RSCM Tambunan, Marihot; Susalit, Endang; Dharmeizar, Dharmeizar; Rumende, Cleopas Martin
Jurnal Penyakit Dalam Indonesia Vol. 2, No. 4
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Pendahuluan: Meningkatnya tekanan darah (TD) 24 jam dan nondipper merupakan faktor risiko morbiditas dan mortalitas kardiovaskular. Prevalensi hipertensi dan nondipper pada Penyakit Ginjal Kronik Stadium 5 dalam Terapi Dialisis (PGK 5D) masih sangat tinggi. Transplantasi ginjal akan memperbaiki TD dan nondipper. Namun demikian, satu bulan pasca transplantasi ginjal, kebutuhan dosis obat imunosupresan masih cukup tinggi yang dapat mengakibatkan hambatan penurunan TD. Perlu dilakukan studi untuk mengetahui seberapa dini perubahan pola sikardian, sehingga dapat dijadikan pertimbangan penatalaksanaan hipertensi yang lebih tepat pada pasien PGK 5D pra dan pasca transplantasi ginjal. Metode: Studi Pre experimental dengan before and after design dilakukan pada 15 pasien PGK 5D/ Pra Transplantasi Ginjal berusia 18–60 tahun di Rumah Sakit dr. Cipto Mangunkusumo (RSCM) Jakarta pada Oktober-Desember 2014. Dilakukan pengumpulan urin 24 jam, pemeriksaan LFG dan pengukuran TD 24 jam dengan 24 hrs ABPM pada pra dan satu bulan pasca transplantasi ginjal. Hasil: Terdapat 12 subjek nondipper dan 3 subjek dipper pada pasien PGK Pra Transplantasi Ginjal. Satu bulan pasca transplantasi ginjal, seluruh subjek (15 orang) memperlihatkan keadaan nondipper. Uji McNemar tidak dapat dilakukan karena seluruh subjek PGK satu bulan pasca transplantasi ginjal nondipper (homogen). Penurunan rerata TD sistolik 24 jam pasien PGK satu bulan pasca transplantasi ginjal tidak bermakna (p >0,05), namun demikian penurunan rerata TD diastolik 24 jam bermakna (p <0,05). Simpulan: Berdasarkan hasil studi, dapat disimpulkan bahwa belum terdapat perbaikan nondipper pada pasien satu bulan Pasca Transplantasi Ginjal.
Development of kidney transplantation as a healthcare development model to achieve Indonesia Emas 2045 Rasyid, Nur; Susalit, Endang; Rodjani, Arry
Medical Journal of Indonesia Vol. 32 No. 3 (2023): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.com.237171

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Co-Authors Abdul Aziz Rani Agus Rizal Ardy Hariandy Hamid, Agus Rizal Ardy Hariandy Aida Lydia, Aida Alfarissi, Fekhaza Ari Fahrial Syam Arry Rodjani Bambang Sutrisna C. Martin Rumende, C. Martin Chaidir A. Mochtar Cleopas Martin Rumende Cosphiadi Irawan Dharmeizar Dharmeizar Djulzasri Albar E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Erni Sulistiawati Fitri Imelda, Fitri Hotmen Sijabat Ika Prasetya Wijaya Irfan Wahyudi Linda Armelia Lydia D Simatupang Marbun, M Bonar M Marcellus Simadibrata Marihot Tambunan, Marihot Maruhum B.H. Marbun Maruhum Bonar HM, Maruhum Bonar Muchtaruddin Mansyur Nur Rasyid Nuryati Chairani Pringgodigdo Nugroho, Pringgodigdo Radja P. Sidabutar Sahala Panggabean Soeroto, Adhitama A. Susilowati, Utami Vidhia Umami, Vidhia