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All Journal Jurnal Analis Kesehatan INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY
Lendawati, Lendawati
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Health Professions Immunology & microbiology Social Sciences

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Uji Toksisitas dan Aktivitas Antimalaria Melalui Penghambatan Polimerisasi Hem Fraksi Etil Asetat, N-Heksan dan Lendawati, Lendawati; Yuniza, Filia; Hartanti, Hartanti
Jurnal Analis Kesehatan Vol. 12 No. 1 (2023): JURNAL ANALIS KESEHATAN
Publisher : Department of Health Analyst, Politeknik Kesehatan, Kementerian Kesehatan Tanjungkarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jak.v12i1.3831

Abstract

The population at risk of developing malaria in the Asian region is 1.4 billion people. Nine countries are at high risk of developing malaria in the Asian region where the highest proportion is achieved by India 89%, Myanmar 2% and Indonesia 7%. Inhibition of heme polymerization is an initial screening test for antimalarial activity. Bidara leaves (Ziziphus mauritiana L.) were selected based on the content of secondary metabolites containing alkaloids. Plant compounds that have been shown to have heme polymerization inhibitory activity are phenolic compounds such as flavonoids, anthraquinones, tannins, saponins, terpenoids, alkaloids, and glycosides. This study aims to determine the chemical content and inhibition activity of heme polymerization based on the IC50 value of the N Hexane, Ethyl Acetate and ethanol fractions of bidara leaves (Ziziphus mauritiana L.). The research method was carried out using the modified Basilico method. Heme polymerization inhibition activity is expressed in 50% Inhibition Concentration (IC50), which is the extract level that can inhibit heme polymerization up to 50%. IC50 data showed that the lowest average IC50 value of the ethyl acetate fraction was 1.107 mg/mL, which means that the ethyl acetate fraction of bidara leaves with a concentration of 1.107 mg/mL could provide 50% inhibition. Followed by an average IC50 of the N Hexane fraction of 3.052 mg/mL and an average IC50 value of chloroquine diphosphate of 8.059 mg/mL. Meanwhile, the ethanol fraction of bidara leaves has an IC50 value above the positive control, which is 21.815 mg/ml.
Incidence of Hepatitis B Surface Antigen (HBsAg) Infection and Its Relationship with Risk Factors at Janitors at Regional General Hospital dr. M. M. Dunda Limboto Gorontalo Lalangpuling, Indra Elisabet; Dakio, Zumrotul Abidah; Nikma, Nikma; Prihandono, Dwi Setiyo; Lendawati, Lendawati
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 5 No 1 (2023): Step up to strengthen the laboratory system and prepare for patients care
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v5i1.3623

Abstract

Hepatitis B is an inflammatory liver disease caused by the Hepatitis B virus, which can be acute or chronic. The outer membrane protein of Hepatitis B Virus (HBV) is known as Hepatitis B Surface Antigen (HBsAg). Janitors are employees who are tasked with cleaning the hospital environment to keep it clean, because of the the dangers that exist in hospitals, such as disease transmission, can occur if the hospital environment is not kept clean. The purpose of this study was to describe the results and their relationship to risk factors of the Hepatitis B examination on janitors at the Regional General Hospital (RSUD) dr. Mansyoer Mohammad Dunda Limboto Gorontalo. This study used a descriptive method with an accidental sampling technique. The sample in this study amounted to 33 respondents who met the inclusion criteria. Specimen were examined using the rapid test method. The data were presented descriptively and statistically to see the relationship between work and the incidence of Hepatitis B infection. The results obtained were as many as 33 respondents by conducting an HBsAg examination, with the results obtained being 2 reactive people and 31 non-reactive people. The results of statistical tests on the relationship between infection status and age showed a p-value of 0.019 and the relationship between infection status and symptoms showed a p-value of 0.002. The study’s findings revealed that there was a substansial correlation between the respondents’ reported symptoms and their infection status (6% of respondents teste for Hepatitis B).
Co-Authors Dakio, Zumrotul Abidah Filia Yuniza Hartanti Hartanti, Hartanti Lalangpuling, Indra Elisabet Nikma, Nikma Prihandono, Dwi Setiyo