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All Journal Jurnal Penelitian Inovatif Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
Murti, Bayu Tri
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Education Engineering Environmental Science Health Professions Public Health Social Sciences

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THE IN VITRO AND IN VIVO EFFECTS OF Persea Americana ETHANOL EXTRACT AS AN ANTIHYPERTENSIVE AND ANTIOXIDANT IN PREDNISONE-INDUCED RATS Elisa, Novi; Dian Advistasari, Yustisia; Sari, Wulan Kartika; Pratiwi, Mustika Endah; Tobi, Claudius Hendraman Boli; Murti, Bayu Tri; Putri, Athika Darumas
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 2 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.6583

Abstract

Hypertension impacts the quantity of free radicals within the body. This study aimed to investigate the effect of antihypertension based on free radical levels in the predni-sone-induced rats, focusing on evaluating specific anti-hypertensive fraction of avoca-do leaves. The study's methods conducting GC-MS, anti-hypertensive, and assessing malondialdehyde levels and catalase enzyme. Systolic blood pressure measurements indicated that the positive control (131 ± 3 mmHg) and ethyl acetate fraction (136 ± 4 mmHg) were statistically similar, significantly different from the negative control group. Diastolic blood pressure measurements showed a blood pressure decreasing in posi-tive control (105 ± 7) that similar statistically with ethyl acetate fraction (104 ± 6), and significantly difference with negative control group. Malondialdehyde levels were nota-bly elevated in both the positive control (37.79 ± 5.47) and ethyl acetate fraction (38.01 ± 5.47) compared to the negative control (-9.07 ± 10.10), indicating increased free rad-ical. Catalase activity demonstrated significant differences, with the positive control (44.06 ± 5.44) and ethyl acetate fraction (44.05 ± 5.45) showing similar levels, both substantially higher than the negative control (13.90 ± 21.50). In summary, this study indentificates several flavonoid compounds that promising anti-hypertension effect from ethyl acetate fraction of avocado leaves extract.
Evaluasi Aktivitas Antioksidan Ekstrak dan Fraksi Daun Mint (Mentha Piperita L.) Menggunakan Metode DPPH In Vitro Saridewi, Ida; Murti, Bayu Tri; Wulansari, Endang Dwi
Jurnal Penelitian Inovatif Vol 5 No 2 (2025): JUPIN Mei 2025
Publisher : CV Firmos

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54082/jupin.1381

Abstract

Penyakit degeneratif seperti diabetes mellitus, kardiovaskular, penuaan dini hingga kanker merupakan dampak dari radikal bebas. Menurut Kementrian Kesehatan tahun 2018, pasien dengan penyakit degeneratif di Indonesia selalu mengalami peningkatan dari tahun ke tahun yakni sebanyak 13,3% pada lima tahun terakhir. Daun mint (Mentha piperita L.) merupakan salah satu jenis bahan teh herbal yang memiliki aktivitas antioksidan yang dapat menangkal radikal bebas. Penelitian ini bertujuan untuk mengevaluasi aktivitas antioksidan dari fraksi daun mint (Mentha piperita L.) menggunakan metode 2,2-diphenyl-1-picrylhydrazyl (DPPH). Metode pembuatan ekstrak menggunakan metode remaserasi selama tiga hari dengan pelarut etanol 96%, fraksinasi menggunakan metode partisi cair-cair dengan pelarut n-heksana, etil asetat dan air, skrining fitokimia dan uji aktivitas antioksidan. Data hasil penelitian diperoleh bahwa vitamin c sebagai kontrol positif memiliki aktivitas antioksidan dengan nilai IC50 sebesar 23,33 µg/mL dengan kategori sangat kuat, ekstrak memiliki aktivitas antioksidan dengan nilai IC50 sebesar 411,23 µg/mL dengan kategori sangat lemah, fraksi n-heksana memiliki aktivitas antioksidan dengan nilai IC50 sebesar 527,45 µg/mL dengan kategori sangat lemah, fraksi etil asetat memiliki aktivitas antioksidan nilai IC50 105,60 µg/mL kategori sedang, dan fraksi air memiliki aktivitas antioksidan nilai IC50 219,20 µg/mL kategori sangat lemah. Fraksi yang memiliki aktivitas antioksidan terkuat berdasarkan nilai IC50 adalah fraksi etil asetat.
THE IN VITRO AND IN VIVO EFFECTS OF Persea Americana ETHANOL EXTRACT AS AN ANTIHYPERTENSIVE AND ANTIOXIDANT IN PREDNISONE-INDUCED RATS Elisa, Novi; Dian Advistasari, Yustisia; Sari, Wulan Kartika; Pratiwi, Mustika Endah; Tobi, Claudius Hendraman Boli; Murti, Bayu Tri; Putri, Athika Darumas
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 2 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.6583

Abstract

Hypertension impacts the quantity of free radicals within the body. This study aimed to investigate the effect of antihypertension based on free radical levels in the predni-sone-induced rats, focusing on evaluating specific anti-hypertensive fraction of avoca-do leaves. The study's methods conducting GC-MS, anti-hypertensive, and assessing malondialdehyde levels and catalase enzyme. Systolic blood pressure measurements indicated that the positive control (131 ± 3 mmHg) and ethyl acetate fraction (136 ± 4 mmHg) were statistically similar, significantly different from the negative control group. Diastolic blood pressure measurements showed a blood pressure decreasing in posi-tive control (105 ± 7) that similar statistically with ethyl acetate fraction (104 ± 6), and significantly difference with negative control group. Malondialdehyde levels were nota-bly elevated in both the positive control (37.79 ± 5.47) and ethyl acetate fraction (38.01 ± 5.47) compared to the negative control (-9.07 ± 10.10), indicating increased free rad-ical. Catalase activity demonstrated significant differences, with the positive control (44.06 ± 5.44) and ethyl acetate fraction (44.05 ± 5.45) showing similar levels, both substantially higher than the negative control (13.90 ± 21.50). In summary, this study indentificates several flavonoid compounds that promising anti-hypertension effect from ethyl acetate fraction of avocado leaves extract.
Co-Authors Claudius Hendraman B. Tobi Dian Advistasari, Yustisia Elisa, Novi Mustika Endah Pratiwi Putri, Athika Darumas Sari, Wulan Kartika Saridewi, Ida Wulan Kartika Sari