Article Per Year (5 Year)
p-Index From 2020 - 2025
0.444
P-Index
This Author published in this journals
All Journal Jurnal Farmasi Jurnal Bioteknologi & Biosains Indonesia (JBBI)
Dian Advistasari, Yustisia
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
THE IN VITRO AND IN VIVO EFFECTS OF Persea Americana ETHANOL EXTRACT AS AN ANTIHYPERTENSIVE AND ANTIOXIDANT IN PREDNISONE-INDUCED RATS Elisa, Novi; Dian Advistasari, Yustisia; Sari, Wulan Kartika; Pratiwi, Mustika Endah; Tobi, Claudius Hendraman Boli; Murti, Bayu Tri; Putri, Athika Darumas
Jurnal Bioteknologi dan Biosains Indonesia Vol. 11 No. 2 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jbbi.11.2.6583

Abstract

Hypertension impacts the quantity of free radicals within the body. This study aimed to investigate the effect of antihypertension based on free radical levels in the predni-sone-induced rats, focusing on evaluating specific anti-hypertensive fraction of avoca-do leaves. The study's methods conducting GC-MS, anti-hypertensive, and assessing malondialdehyde levels and catalase enzyme. Systolic blood pressure measurements indicated that the positive control (131 ± 3 mmHg) and ethyl acetate fraction (136 ± 4 mmHg) were statistically similar, significantly different from the negative control group. Diastolic blood pressure measurements showed a blood pressure decreasing in posi-tive control (105 ± 7) that similar statistically with ethyl acetate fraction (104 ± 6), and significantly difference with negative control group. Malondialdehyde levels were nota-bly elevated in both the positive control (37.79 ± 5.47) and ethyl acetate fraction (38.01 ± 5.47) compared to the negative control (-9.07 ± 10.10), indicating increased free rad-ical. Catalase activity demonstrated significant differences, with the positive control (44.06 ± 5.44) and ethyl acetate fraction (44.05 ± 5.45) showing similar levels, both substantially higher than the negative control (13.90 ± 21.50). In summary, this study indentificates several flavonoid compounds that promising anti-hypertension effect from ethyl acetate fraction of avocado leaves extract.
Sintesis Oktil Sinamat dengan Metode Sonokimia dan Potensinya sebagai Antikolesterol Verdia Mutiara, Erlita; Wildan, Achmad; Dian Advistasari, Yustisia; Indriyanti, Erwin
Jurnal Farmasi (Journal of Pharmacy) Vol. 11 No. 1 (2022): Jurnal Farmasi (Journal of Pharmacy), April 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/5wasds29

Abstract

Cinnamic acid derivatives play a very important role in the synthesis of other important compounds and as precursors for the synthesis of cinnamic esters. Cinnamate esters have diverse bioactivity. This group has antioxidant, hepatoprotective, anti-inflammatory, anxiolytic, insect repellent, antidiabetic and anticholesterol activities. Octyl cinnamate is a cinnamic acid derivative which is thought to be efficacious as a cholesterol lowering agent. Cholesterol has been known as the main cause of the process of atherosclerosis, namely the process of calcification and hardening of the arteries. As a result of this process the blood vessels, especially coronary arteries become narrow and block blood flow. Octylcinnamate has been successfully synthesized from the esterification reaction between cinnamic acid and n-octanol with a concentrated sulfuric acid catalyst. The sonochemical method is one of the methods developed in this synthesis process because it is very easy to do, efficient, with high yields, short time and environmentally friendly. From the results of the synthesis, identification of compounds was carried out through melting point and FTIR spectrophotometry. Based on the interpretation of data from FTIR that the synthesis product was n-octyl cinnamate. The synthesis was carried out at 600C with a sonication time of 7 hours. The anticholesterol activity of the optimally synthesized n-octyl cinnamate compound at a concentration of 5 ppm was 55.42%.
Co-Authors Achmad Wildan Claudius Hendraman B. Tobi Elisa, Novi Indriyanti, Erwin Murti, Bayu Tri Mustika Endah Pratiwi Putri, Athika Darumas Verdia Mutiara, Erlita Wulan Kartika Sari