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All Journal Journal of Food and Pharmaceutical Science Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Cendekia Journal of Pharmacy Golden Ratio of Auditing Research Journal of Food and Pharmaceutical Sciences Jurnal Bioteknologi & Biosains Indonesia
Sari, Wulan Kartika
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Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Immunology & microbiology Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Optimization of Propylene Glycol and Na CMC in Gel Serum Preparations of Chicken Bone Collagen Antioxidant (Gallus gallus domesticus) Saputri, Dian; Cahyani, Intan Martha; Kristantri, Rika Sebtiana; Pebriani, Tris Harni; Sari, Wulan Kartika
Journal of Food and Pharmaceutical Sciences Vol 13, No 3 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.19932

Abstract

One important component found in the dermis layer of the skin is collagen. A decrease in collagen levels can result in reduced skin thickness and strength, loss of elasticity, and decreased skin hydration. Chicken bones serve as a valuable alternative source for the commercial production of collagen, which can be used in easily applicable pharmaceutical preparations, such as gel serum. Antioxidant gel serum preparations are developed by optimizing chicken bone collagen gel serum combined with Na CMC (0-2%) and propylene glycol (8-10%) using the Simplex Lattice Design method, so it is obtained 8 consecutive runs, the comparison is R1 and R3 (1% : 9%), R2 and R8 (2% : 8%), R4 (0,5% : 9,5%), R5 (1,5% : 8,5%) R6 and R7 (0% : 10%). The results indicate that the optimal formula consists of 1.984% Na CMC and 8.016% propylene glycol, yielding a pH of 4.50, a viscosity of 1700 cps, adhesion of 1.72 seconds, spreadability of 6.15 cm, and an IC50 of 57,36 ppm. Validation tests using the T-test demonstrated no significant difference between the observation and prediction results, confirming that the obtained formula was valid.
POLA PERESEPAN ANTIBIOTIK UNTUK PENGOBATAN INFEKSI SALURAN PERNAFASAN ATAS (ISPA) DI KLINIK X KOTA SEMARANG Sari, Wulan Kartika; Advistasari, Yustisia Dian; Elisa, Novi
Cendekia Journal of Pharmacy Vol 8, No 1 (2024): Cendekia Journal of Pharmacy
Publisher : Institut Teknologi Kesehatan Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v8i1.275

Abstract

Infeksi Saluran Pernafasan Atas (ISPA) merupakan 10 penyakit terbanyak di Indonesia. Penyakit ISPA diawali dengan gejala demam, batuk selama kurang lebih jangka waktu 2 minggu, pilek atau hidung tersumbat dan sakit tenggorokan. Penyebab ISPA dapat berasal dari berbagai mikroorganisme yakni bakteri dan virus. Beberapa faktor yang mempengaruhi penyebaran infeksi saluran pernafasan atas diantaranya faktor lingkungan, perilaku masyarakat yang kurang baik terhadap hygne dan sanitasi diri, keluarga, dapat pula dari kurangnya asupan makanan yang bergizi serta menurunnya imunitas tubuh  Penelitian ini dilakukan secara retrospektif dengan periode pengambilan data Januari hingga Juni 2023 yang bertempat di Klinik X di Kota Semarang, Jawa Tengah dengan periode pengambilan data Januari hingga Juni 2023. Subyek penelitian yang sesuai dengan kriteria inklusi sebanyak 3945 pasien. Karakteristik pasien dalam penelitian kemudian dikategorikan berdasarkan jenis kelamin diperoleh hasil  laki laki 46,24% dan perempuan 53,76%, perempuan lebih sigap, tanggap, cekatan serta memiliki kepekaan, kepedulian, perhatian yang lebih terhadap kesehatan dan lingkungan sekitarnya. Pasien dengan penderita ISPA banyak terjadi pada retang usia secara berturut turut 0 -12 th (34,63%), 13-25 th (15,59%), 26-38 th (17,79%), 39-51th (20,51%) dan 52-60 th (11,48%). Usia 0 sampai 12 tahun memiliki persentase tertinggi hal ini dikarenakan penyakit ISPA berhubungan dengan adanya kemampuan imunitas tubuh terhadap serangan bakteri atau virus. Bentuk sediaan antibiotik yang banyak diresepkan oleh dokter yakni syrup (12,09%), pulveres (21,88%), tablet (66.03%). Antibiotik yang banyak diresepkan oleh dokter yakni amoxycillin (54,90%), kloramfenikol (25,63%), thiamphenicol (8,04%), ciprofloxacin (10,70%) dan sefadroxil 0,74%). Pemilihan amoxycillin dalam terapi ISPA dikarenakan amoxycillin memiliki mekanisme kerja dalam kondisi tertentu sebagai bakteriostatik dapat pula bersifat bakterisid yakni dengan cara merusak dinding sel pada bakteri yang mengandung mucoprotein kompleks terhadap mikroba. Berdasarkan hasil penelitian diperoleh hasil bahwa pada klinik X penyakit ISPA banyak terjadi pada pasien perempuan dan antibiotik yang paling banyak diresepkan adalah amoxycillin tablet 500 mg.
A Qualitative Study on the Use of Data Analytics in Auditing Sari, Wulan Kartika
Golden Ratio of Auditing Research Vol. 4 No. 1 (2024): July - January
Publisher : Manunggal Halim Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52970/grar.v4i1.387

Abstract

This qualitative study investigates the utilization of data analytics in auditing, aiming to provide insights into its applications, benefits, challenges, and implications. Through a systematic literature review, the research explores the multifaceted aspects of data analytics integration in auditing practices. The research design encompasses a systematic review methodology, involving the identification, selection, and synthesis of relevant studies from academic databases and scholarly sources. Thematic analysis is employed to analyze the selected literature and identify key themes, patterns, and relationships. The findings reveal a wide range of applications of data analytics in auditing, including anomaly detection, predictive modeling, and text mining. Additionally, the study identifies several benefits associated with the use of data analytics, such as improved audit quality, enhanced risk detection capabilities, and greater efficiency in audit processes. However, the integration of data analytics also presents challenges, including data quality issues, technological limitations, skill gaps among auditors, and ethical considerations. Addressing these challenges requires investments in technology infrastructure, training programs, and organizational culture conducive to data-driven decision-making. The research contributes to the existing body of knowledge by offering valuable insights and recommendations for audit practitioners, policymakers, and educators
Optimization of Propylene Glycol and Na CMC in Gel Serum Preparations of Chicken Bone Collagen Antioxidant (Gallus gallus domesticus) Saputri, Dian; Cahyani, Intan Martha; Kristantri, Rika Sebtiana; Pebriani, Tris Harni; Sari, Wulan Kartika
Journal of Food and Pharmaceutical Sciences Vol 13, No 3 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.19932

Abstract

One important component found in the dermis layer of the skin is collagen. A decrease in collagen levels can result in reduced skin thickness and strength, loss of elasticity, and decreased skin hydration. Chicken bones serve as a valuable alternative source for the commercial production of collagen, which can be used in easily applicable pharmaceutical preparations, such as gel serum. Antioxidant gel serum preparations are developed by optimizing chicken bone collagen gel serum combined with Na CMC (0-2%) and propylene glycol (8-10%) using the Simplex Lattice Design method, so it is obtained 8 consecutive runs, the comparison is R1 and R3 (1% : 9%), R2 and R8 (2% : 8%), R4 (0,5% : 9,5%), R5 (1,5% : 8,5%) R6 and R7 (0% : 10%). The results indicate that the optimal formula consists of 1.984% Na CMC and 8.016% propylene glycol, yielding a pH of 4.50, a viscosity of 1700 cps, adhesion of 1.72 seconds, spreadability of 6.15 cm, and an IC50 of 57,36 ppm. Validation tests using the T-test demonstrated no significant difference between the observation and prediction results, confirming that the obtained formula was valid.
THE IN VITRO AND IN VIVO EFFECTS OF Persea Americana ETHANOL EXTRACT AS AN ANTIHYPERTENSIVE AND ANTIOXIDANT IN PREDNISONE-INDUCED RATS Elisa, Novi; Dian Advistasari, Yustisia; Sari, Wulan Kartika; Pratiwi, Mustika Endah; Tobi, Claudius Hendraman Boli; Murti, Bayu Tri; Putri, Athika Darumas
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 2 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.6583

Abstract

Hypertension impacts the quantity of free radicals within the body. This study aimed to investigate the effect of antihypertension based on free radical levels in the predni-sone-induced rats, focusing on evaluating specific anti-hypertensive fraction of avoca-do leaves. The study's methods conducting GC-MS, anti-hypertensive, and assessing malondialdehyde levels and catalase enzyme. Systolic blood pressure measurements indicated that the positive control (131 ± 3 mmHg) and ethyl acetate fraction (136 ± 4 mmHg) were statistically similar, significantly different from the negative control group. Diastolic blood pressure measurements showed a blood pressure decreasing in posi-tive control (105 ± 7) that similar statistically with ethyl acetate fraction (104 ± 6), and significantly difference with negative control group. Malondialdehyde levels were nota-bly elevated in both the positive control (37.79 ± 5.47) and ethyl acetate fraction (38.01 ± 5.47) compared to the negative control (-9.07 ± 10.10), indicating increased free rad-ical. Catalase activity demonstrated significant differences, with the positive control (44.06 ± 5.44) and ethyl acetate fraction (44.05 ± 5.45) showing similar levels, both substantially higher than the negative control (13.90 ± 21.50). In summary, this study indentificates several flavonoid compounds that promising anti-hypertension effect from ethyl acetate fraction of avocado leaves extract.
Pemanfaatan Limbah Tembakau Sebagai Pestisida Alami Di Kecamatan Selo Kabupaten Boyolali Herlyanti, Kyky; Prahasiwi, Masitoh Suryaning; Sulistyowati, Etty; Nugraheni, Bekti; Sari, Wulan Kartika
Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Vol 9, No 1 (2026): Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstormin
Publisher : Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/japhb.v9i1.9862

Abstract

Penggunaan pestisida sintetis dalam pertanian berpotensi mencemari lingkungan dan mengganggu keseimbangan mikroorganisme tanah, sehingga diperlukan alternatif pestisida yang lebih aman dan ramah lingkungan. Salah satu alternatif yang dapat dikembangkan adalah pestisida nabati berbahan metabolit sekunder tanaman, seperti nikotin.Pestisida merupakan senyawa kimia yang sering digunakan pada lahan pertanian namun, penggunaan pestisida memiliki risiko mencemari lingkungan dan lahan pertanian. Cemaran pestisida dalam tanah dapat mengganggu keseimbangan jamur alami pada tanah. Oleh karena itu, perlu dikembangkan alternatif pestisida khususnya dari bahan alam yang cukup aman dan ramah lingkungan. Salah satu metabolit sekunder tanaman yang mampu berfungsi sebagai pestisida adalah senyawa nikotin.  Nikotin berperan sebagai agonis reseptor asetilkolin nikotinik dan efektif terhadap beberapa hama penting, antara lain kutu hijau, Plutella xylostella, ulat grayak, dan larva Aedes aegypti. Senyawa tersebut dapat digunakan sebagai pestisida karena merupakan agonis reseptor asetilkolin nikotinik. Tembakau mengandung nikotin yang cukup tinggi. Meskipun demikian, daunnya memiliki nilai ekonomi yang tinggi sehingga perlu dikembangkan pestisida nabati dari bagian lain dari tembakau seperti batang. Nikotin efektif terhadap kutu hijau, Plutella xylostella, ulat grayak, dan larva Aedes aegypti. Tanaman tembakau banyak dibudidayakan masyarakat Kecamatan Selo Kabupaten Boyolali. Daun tembakau mempunyai nilai ekonomis tinggi pada industri rokok namun limbah tembakau belum dimanfaatkan dengan baik. Kegiatan dilakukan secara langsung dalam bentuk sosialisasi dan demonstrasi pembuatan pestisida nabati dari tanaman tembakau. Hasil kegiatan menunjukkan meningkatnya pemahaman petani mengenai konsep dan manfaat pestisida nabati serta munculnya minat untuk menerapkan pestisida tembakau sebagai alternatif pengendalian hama. Secara keseluruhan, kegiatan ini menunjukkan bahwa pemanfaatan limbah tembakau berpotensi mendukung kemandirian petani dalam penyediaan pestisida ramah lingkungan dan berkelanjutan.
Co-Authors Advistasari, Yustisia Dian Bekti Nugraheni Claudius Hendraman B. Tobi Dian Advistasari, Yustisia Elisa, Novi Etty Sulistyowati Intan Martha Cahyani, Intan Martha Kristantri, Rika Sebtiana Kyky Herlyanti, Kyky Murti, Bayu Tri Mustika Endah Pratiwi Pebriani, Tris Harni Prahasiwi, Masitoh Suryaning Putri, Athika Darumas SAPUTRI, DIAN