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All Journal Folia Medica Indonesiana The Indonesian Biomedical Journal Jurnal Kesehatan Calvaria Medical Journal
Titut Harnanik
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Hyperbaric Oxygen Effects on Contrast and Macular Light Sensitivity in Dry Type Age-Related Macular Degeneration Patients Indriani Kartika Dewi; Moestidjab Moestidjab; Titut Harnanik
Folia Medica Indonesiana Vol. 57 No. 1 (2021): March
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.465 KB) | DOI: 10.20473/fmi.v57i1.9310

Abstract

This study was to compare the effectiveness of hyperbaric oxygen therapy (HBOT) on contrast and macular light sensitivity improvement in dry type age-related macular degeneration (AMD) patients. The subjects were eyes that had been diagnosed with dry type AMD which met inclusion criteria. The subjects were divided into two groups. The first group was given antioxidants and HBOT. The second group was given only antioxidants. Contrast and macular light sensitivity test were done using MARS contrast sensitivity chart and Humphrey Field Analyzer-3 for three times, pre-therapy, day-1 and 14 post- therapy. This study found that 25 eyes were included for analysis, 14 subjects in first group, and 11 subjects in second group. Statistical analysis results showed that there were significant increase on contrast sensitivity in intervention group between one-day post-therapy with pre-therapy, P = 0.003 (P <0.05), and between 14-days post-therapy with pre-therapy, P = 0,015 (P <0.05). From pre- and post-analysis, there were no significant difference found on contrast sensitivity in control group and macular light sensitivity in intervention group. In control group, there were significant increase on superotemporal, superonasal, and inferonasal area between one-day post-therapy and pra-therapy with P = 0.004, P = 0.013 and P = 0.008 (P <0.05), respectively, and there was significant decrease on inferonasal area between 14-days post-therapy and one-day post-therapy, P = 0.003 (P <0.05). In conclusion, patients with AMD who were subjected to HBOT achieved improvement in contrast sensitivity in cases considered as having low prognosis. HBOT should be considered as promising intervention for AMD management adjuvant and further research are needed to find optimal dosage.
Hyperbaric Oxygen Ameliorates The Expression of Tumor Growth Factor-β and Malondialdehyde in Pristane-induced Lupus Nephritis Mice Model Soetjipto Soetjipto; Indri Dwi Murbani; Titut Harnanik
The Indonesian Biomedical Journal Vol 15, No 1 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i1.2084

Abstract

BACKGROUND: Lupus nephritis (LN) is associated with chronic renal failure and a high mortality rate. Tumor growth factor-β (TGF-β) plays a basic part in keeping up immune homeostasis, meanwhile extensive oxidation of the lipid membrane in LN causes the arrangement of malondialdehyde (MDA). Up to date, the mechanism of hyperbaric oxygen (HBO) therapy in LN has not been elucidated well. Hence this study was conducted to assess the impact of HBO therapy on TGF-β and MDA expression in the pristane-induced LN mice model.METHODS: Thirty-two mice aged 8-12 old weeks were isolated into 4 groups: normal saline-injected mice (group 1); pristane-injected mice (group 2); as well as pristane-injected followed by HBO-exposured with 2.4 (group 3) and 1.5 (group 4) atmosphere absolute (ATA) pressure. Pristane were injected intraperitoneal to initiate LN. Two months after pristane injection, the mice were placed within 24 hours in the special cage for metabolic examination to determined that pristane-induced LN mice model was successfully formed and marked by the occurring proteinuria. Oxidative stress was assessed by examining MDA, while systemic inflammation was assessed by examining by TGF-β. MDA and TGF-β serum were measured by enzyme-linked immunosorbent assay (ELISA).RESULTS: A significantly lower (p<0.050) MDA expression was found in group 3 in comparison with group 2. The results also showed that TGF-β level was significantly increased (p<0.050) in group 3 compared to group 2.CONCLUSION: HBO therapy ameliorates inflammation in LN by diminishing MDA and expanding TGF-β levels through activating antioxidants.KEYWORDS: lupus nephritis, hyperbaric oxygen, malondialdehyde, tumor growth factor-β
Prevalensi Terjadinya Komplikasi pada Ibu Hamil dengan Infeksi Covid-19 Post Sectio Caesarea Utami, Nadila Rizqi; Herdiyantini, Mita; Budiarti, Retno; Harnanik, Titut
Jurnal Kesehatan Vol 13 No 1 (2024): Jurnal Kesehatan
Publisher : STIKES Ngesti Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46815/jk.v13i1.187

Abstract

Pregnancy is a period of fetal growth and development accompanied by physiological and immunological changes in the mother, making her more susceptible to infections, including COVID-19. Pregnancy accompanied by COVID-19 infection increases the risk of complications for pregnant women. This study aims to determine the prevalence of post-Caesarean section complications in pregnant women with COVID-19. The sampling method employed purposive sampling by observing medical record data at Dr. Ramelan Surabaya Hospital during the period from March 2020 to March 2023. Out of a total of 100 samples, there were 58 confirmed cases of COVID-19, with 8 cases (32.0%) of cardiovascular complications, consisting of 6 cases (75.0%) of PPH complications, and 2 cases (25.0%) of surgical wound infection complications. The prevalence of respiratory system complications included 13 cases (52.0%), with 9 cases (69.2%) of pneumonia complications and 4 cases (30.8%) of Acute Respiratory Distress Syndrome complications. One case (4.0%) of sepsis and 3 cases (12.0%) of maternal death complications were identified. The results of the data analysis using the Contingency Coefficient test showed a p-value of 0.001 (p < α), indicating a significant relationship between COVID-19 infection and an increased prevalence of complications in pregnant women. In conclusion, the study found 25 cases (43.1%) of post-Caesarean section complications in pregnant women with COVID-19, indicating an increased prevalence of complications in pregnant women with COVID-19 post-Caesarean section.
Pendekatan Terapi Hyperbaric Oxygen Therapy pada Pasien dengan Polycystic Ovary Syndrome Nurdianto, Arif Rahman; Harnanik, Titut; Setiawan, Fery
Calvaria Medical Journal Vol 2 No 2 (2024): Edisi Desember 2024
Publisher : Institute for Research and Community Services (LPPM) of University of Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/cmj.v2i2.168

Abstract

Background: Polycystic Ovary Syndrome (PCOS) is an endocrine disorder affecting around 5-10% of women of reproductive age. Symptoms of PCOS include menstrual irregularities, infertility, and elevated androgen levels. Various therapies have been explored to address these issues, one of which is Hyperbaric Oxygen Therapy (HBOT), known for its ability to enhance tissue healing, reduce inflammation, and improve hormonal balance. However, the effects of HBOT on PCOS patients require further investigation. Objective: This study aims to explore the effectiveness of Hyperbaric Oxygen Therapy in reducing PCOS symptoms and improving patients' quality of life. Method: This research employs a literature review methodology, collecting data from various relevant articles and journals on Hyperbaric Oxygen Therapy in PCOS patients. The sources were selected based on strict inclusion criteria, focusing on studies that examine the physiological and hormonal effects of HBOT on PCOS patients. Results: The reviewed studies suggest that HBOT shows potential in reducing PCOS symptoms, particularly in regulating menstrual cycles and lowering androgen levels. Other positive effects include improved insulin sensitivity and ovarian health. However, further research with larger sample sizes and long-term follow-ups is necessary to provide more consistent results. Conclusion: Hyperbaric Oxygen Therapy could be a potential adjunctive treatment for PCOS patients, though more research is needed to confirm its long-term benefits and underlying mechanisms
The Penyakit Dekompresi Tipe II pada Penyelam Rekreasi: Sebuah Laporan Kasus dan Penanganan dengan Terapi Oksigen Hiperbarik: - Devi, Anita; Nurdianto, Arif Rahman; Himawan, Achmad Nurdin; Rini, Anis Dwi Anita; Hisnindarsyah, Hisnindarsyah; Harnanik, Titut; Pratiknya, Djatiwidodo Edi
Calvaria Medical Journal Vol 3 No 1 (2025): Edisi Juni 2025
Publisher : Institute for Research and Community Services (LPPM) of University of Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/cmj.v3i1.191

Abstract

Latar Belakang: Menyelam SCUBA adalah rekreasi populer namun berisiko, salah satunya adalah Penyakit Dekompresi (DCS) yang disebabkan pembentukan gelembung gas inert akibat penurunan tekanan lingkungan. DCS dapat bermanifestasi ringan hingga berat, termasuk gejala neurologis. Penanganan cepat sangat penting. Tujuan: Melaporkan kasus Penyakit Dekompresi Tipe II pada penyelam rekreasi dan penanganannya dengan Terapi Oksigen Hiperbarik (TOHB). Presentasi Kasus: Dilaporkan kasus laki-laki 70 tahun dengan gejala pusing berputar, vertigo, gangguan keseimbangan, mual, muntah, parestesia, dan nyeri sendi setelah dua kali penyelaman. Pemeriksaan fisik menunjukkan Romberg test positif. Manajemen awal dengan oksigen normobarik dan obat simptomatik hanya memberikan sedikit perbaikan. Hasil: Pasien menjalani dua sesi TOHB (menggunakan Tabel 6 dan Tabel 5 US Navy). Setelah terapi, gejala pasien membaik signifikan, termasuk hilangnya pusing, mual, muntah, parestesia, dan nyeri sendi. Romberg test kembali negatif. Kesimpulan: Terapi Oksigen Hiperbarik adalah terapi standar emas yang efektif dalam meredakan gejala Penyakit Dekompresi Tipe II pada penyelam rekreasi.
Co-Authors Devi, Anita Fery Setiawan Herdiyantini, Mita Himawan, Achmad Nurdin Hisnindarsyah, Hisnindarsyah Indri Dwi Murbani Indriani Kartika Dewi Moestidjab Moestidjab Nurdianto, Arif Rahman Pratiknya, Djatiwidodo Edi Retno Budiarti Rini, Anis Dwi Anita Soetjipto Soetjipto Utami, Nadila Rizqi