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All Journal MNJ (Malang Neurology Journal) Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Nugraha, Boya
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Health Professions Neuroscience Public Health

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EFFICACY AND SAFETY OF DULOXETINE IN THE TREATMENT OF CHEMOTHERAPY INDUCED PERIPHERAL NEUROPATHY: A SYSTEMATIC REVIEW AND META-ANALYSIS Widyadharma, I Putu Eka; Vania Rau, Chiquita Putri; Pinzon, Rizaldy Taslim; Y, Yudiyanta; Indrayani, Agung Wiwiek; Purwata, Thomas Eko; Nugraha, Boya
MNJ (Malang Neurology Journal) Vol. 7 No. 1 (2021): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2021.007.01.10

Abstract

Background: One of the adverse effects of chemotherapy in the neurological field is chemotherapy-induced peripheral neuropathy (CIPN), it was an adverse effect caused by many chemotherapeutic regimens and a major cause of continuous pain in patients who survived cancer. When the symptoms get worse, survivor’s quality of life is declining and they are often having problems with mental health, insomnia, cognitive functioning, fatigue, physical functioning, and pain. So far the choice of therapy for CIPN is still limited. Now, there was no drug approved to treat pain due to CIPN. Duloxetine are a SNRI (serotonin norepinephrine reuptake inhibitor), which it’s useful in CIPN are highly supported by evidence.Methods: We conducted a systemactic-computer based literature search on January 4, 2019 in PubMed database for article published between 2013 and 2018. We searched for a literature related with used a duloxetine for management of chemotherapy induced peripheral neuropathy.Results: From the 4 studies that included in this review, the total participants are 478 patients with neuropathic pain and already get a chemotherapy regiment. From the meta-analysis showed one study had no effect, two studies had small effect, and one study had medium effect.Conclusion: Duloxetine is a great option for the treatment of CIPN in especially reducing neuropathic pain.  
INDUSTRIAL REVOLUTION 4.0 IN NEUROREHABILITATION: THE IMPLEMENTATION OF VIRTUAL REALITY FOR NEUROLOGICAL DISORDERS Widyadharma, I Putu Eka; Limalvin, Nicholas Prathama; Dharmatika, I Made Pramana; G, Gayathridayawasi; Indrayani, Ida Ayu Sri; Nugraha, Boya
MNJ (Malang Neurology Journal) Vol. 7 No. 2 (2021): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2021.007.02.9

Abstract

Industrial revolution 4.0 has changed the health industry. Medical treatments derived from the latest technologies are expected to improve health and economic status. The rapid development of technology has influenced the learning and clinical practice of medicine. Virtual Reality (VR) is one of the latest technologies that is currently being implemented as a treatment for neurological disorders. This article seeks to give an overview of the development of VR implementation in neurorehabilitation. The data source of this article is research and studies published in NCBI, PubMed, Cochrane, and other relevant online databases. From this article, it is found that VR can be used as a pain reliever and motor function rehabilitation for patients with balance and gait deficits. VR is used to distract patients’ attention to pain for a short time period. VR also improves motor function recovery in stroke patients. Cybersickness is usually reported as a side effect of using VR and it depends on each individual. The implementation of VR for patients with neurological disorders has showed advantages in reducing pain and improving motor function but still need further research about applicability and authorization of virtual reality in the world of medicine.
The Influence and Feasibility of Therapeutic Exercise Videos at Home on the Functional Status of Post-COVID-19 Hospitalization Wahyuni, Luh Karunia; Harini, Melinda; Sunarjo, Peggy; Ramadhany, Mellisya; Fitriana, Ika; Hidemi, Octaviany; Wijayanti, Indri; Nugraha, Boya; Tedjasukmana, Deddy; Tamin, Tirza Z
Kesmas Vol. 18, No. 5
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The COVID-19 pandemic pushed physicians to modify conventional practices to reduce the exposure and risk of infection among patients and health workers. Telemedicine is one of the safest methods, and telerehabilitation could prevent the sequelae of COVID-19. A quasi-experimental study with randomized sampling without masking/blinding was conducted. The study was conducted from August 2021 to March 2022 at Hospital A in Pekanbaru, Hospital B in Jayapura, and Hospital C in Jakarta, Indonesia. A total of 27 patients were recruited and divided into control and intervention groups. The control group was given conventional education on therapeutic exercise at home, while the intervention group was shown educational videos about therapeutic exercise at home. The comparison of all functional outcomes between the two groups after the intervention showed a significant difference. The intervention group improved more than the control group, except for the fatigue severity scale. Most of the responses showed that this video was feasible and useful and did not need to be supervised by health workers. Therapeutic exercise educational videos can be an option to deliver rehabilitation programs for post-COVID-19 hospitalized patients.
Co-Authors Agung Wiwiek Indrayani fitriana, ika G, Gayathridayawasi Harini, Melinda Hidemi, Octaviany I Made Pramana Dharmatika I Putu Eka Widyadharma Ida Ayu Sri Indrayani Limalvin, Nicholas Prathama Luh Karunia Wahyuni, Luh Karunia Ramadhany, Mellisya Rizaldy Pinzon Sunarjo, Peggy Tedjasukmana, Deddy Thomas Eko Purwata Tirza Z Tamin Vania Rau, Chiquita Putri Wijayanti, Indri Y, Yudiyanta