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All Journal Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Info Kesehatan
Serang, Yithro
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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UJI EFEK ANTIDIARE EKSTRAK ETANOL KULIT BUAH PISANG AMBON (Musa acuminata Colla) TERHADAP MENCIT JANTAN (Mus Musculus L.) YANG DIINDUKSI MINYAK JARAK (Oleum Ricini) Serang, Yithro; Wijayanti, Maria Widya Riska
Jurnal Farmasi & Sains Indonesia Vol 5 No 2 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no2p20-25

Abstract

Utilization of plants as a treatment for diarrhea is an alternative to traditional medicine. Ambon banana peel is one of the plants that can be used as an antidiarrheal because it contains flavonoid compounds, tannins and saponins. This study aimed to determine the antidiarrheal effect of the ethanol extract of Ambon banana peel on male mice induced by Oleum Ricini and to determine the dose of ethanol extract of Ambon banana peel that gave the best antidiarrheal effect. Ambon banana peel was extracted by maceration method. The research method used was a laboratory experimental study using 25 male mice which were divided into 5 groups, namely the negative control group (given CMC Na 1%), the positive control group (given Loperamide HCl 2 mg), the treatment group with ethanol extract of Ambon banana peel. with varying doses of 300 mg/KgBW, 600 mg/KgBW and 900 mg/KgBW. The antidiarrheal effect was observed every 30 minutes for 4 hours with the parameters used were diarrhea frequency, stool weight and stool consistency. Based on the results of the study, the ethanol extract of Ambon banana peel at a dose of 900 mg/KgBW showed diarrhea frequency and stool weight results which were almost the same as the Loperamide HCl treatment group. The results of statistical analysis using ANOVA obtained p<0.05, this indicates that there is a significant difference. The ethanol extract of Ambon banana peel at a dose of 900 mg/KgBW had the best antidiarrheal effect compared to the ethanolic extract of Ambon banana peel at a dose of 300 mg/KgBW and a dose of 600 mg/KgBW.
The Total Cholesterol And Body Weight Lowering Effect Of Wild Poinsettia Infusion (Euphorbia heterophylla L.) On The High Fat – Diet Induced Rats Novembrina, Metrikana; Wahyuni, Tri; Anggrahini, Siti Nur Muthia; Toyo, Eleonora Maryeta; Serang, Yithro
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p144-148

Abstract

Obesity is one of the risk factors which can lead to cardiovascular diseases such as hypertension, diabetes melitus and end stage renal failure. As a tropical archipelago, Indonesia has abundant potential of medicinal plantsuch as Wild Poinsettia (Euphorbia heterophilla L.), which is used by the locals as anherbal drinking to treat obesity. This research aimed to study the effectivenes of Wild poinsettia infusion in lowering total cholesterol level and body weight on the high fat – diet induced wistar male rats. The study used an experimental method with controlled post-test only design. As many as 30 high fat-diet induced male wistar rats were devided into six groups : normal control, negative control given 0,5% cmc Na as placebo, positive control given 27 mg/kgBB gemfibrozil and those given 1.25g/kgBW, 2.5g/kgBW and 5 g/kgBW Wild poinsettia infusion respectively. Prior to the treatment, the total cholesterol level of all groups were measured by using NESCO GCU®cholesterol test kit. After the treatment, the cholesterol levels were remeasured. The body weight of all testing animal was measured every week. Data was then collected and analyzed by using anava to evaluate the difference of total cholesterol level and body weight among the testing groups. According to data analysis’s results, it showed that the bodyweight and the total cholesterol level of all testing groups were significantly different (p < 0,05). Based on the results it was concluded that the Wild poinsettia infusion given to the high fat-diet induced rats can lower their total cholesterol level as well as the body weight. Keywords: high fat-diet induced rats, wild poinsettia infusion, obesity.
HUBUNGAN POLIFARMASI DAN TEMUAN POTENSI INTERAKSI OBAT PADA PERESEPAN PASIEN ANAK DI APOTEK BUKIT SARI SEMARANG TAHUN 2021 Dariyati, Nita; Suwarni, Sri; Pitarisa, Agustina Putri; Serang, Yithro; Leki, Karol Giovani Battista
Jurnal Farmasi & Sains Indonesia Vol 5 No 2 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no2p14-19

Abstract

Polypharmacy is still frequent and very common in pediatric prescribing. Polypharmacy can increase the potential for drug interactions. Most of which have a detrimental impact on patient therapy. Drug interactions are considered clinically important when they result in increased toxicity or reduced therapeutic effectiveness. This study aims to determine the relationship between polypharmacy and the potential for drug interactions in the prescription of pediatric patients at Bukit Sari Pharmacy Semarang for the 2021 period. This research is a type of quantitative descriptive analysis research. Research data were obtained retrospectively in the period January - December 2021 which is based on the prescription data of pediatric patients at Bukit Sari Pharmacy Semarang for the 2021 period. The sampling technique used proportional random sampling method where samples were taken from pediatric patient prescriptions that met the inclusion criteria. Of the 270 prescription sheets analyzed, 160 prescription sheets experienced polypharmacy. Percentage of drug interaction events drug interaction was 36.7%. Statistical analysis using the Spearmans Test obtained a p value
Evaluation of Antioxidant Activity in Solanum Ferox (Through DPPH and FRAP Assays) Leki, Karol Giovani Battista; Febrianto, Yahya; Serang, Yithro
JURNAL INFO KESEHATAN Vol 23 No 2 (2025): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol23.Iss2.1743

Abstract

The antioxidant properties of natural compounds have garnered significant attention for their potential therapeutic applications. Solanum ferox, a plant traditionally used in several countries for medicinal purposes, has been identified as possessing potential antioxidant properties. However, the extent and efficacy of its antioxidant capacity have not been thoroughly examined, creating a gap in understanding its effectiveness compared to established antioxidants like ascorbic acid. This study aims to evaluate the antioxidant capacity of Solanum ferox using DPPH and FRAP assays across concentrations ranging from 20 to 100 µg/µl, with ascorbic acid serving as a standard reference. The DPPH assay measured the scavenging activity of both samples to assess their radical-quenching properties, while the FRAP assay evaluated their reducing power. Findings indicate that ascorbic acid exhibits significantly higher scavenging activity than Solanum ferox across all concentrations, with consistent activity ranging between 88.4% and 90.88% in the DPPH assay and from 45.16% to 83.89% in the FRAP assay. In contrast, Solanum ferox shows a gradual but much lower increase in activity, from 6.8% to 35.5% in the DPPH assay and from 10.59% to 33.82% in the FRAP assay, suggesting limited antioxidant potential. The study contributes to the understanding of the antioxidant properties of Solanum ferox, highlighting its limited efficacy compared to ascorbic acid and suggesting that further research is needed to explore its potential at higher concentrations or through alternative methods. These insights provide a foundational basis for future studies investigating Solanum ferox as a potential natural antioxidant source.   
Co-Authors Anggrahini, Siti Nur Muthia Dariyati, Nita Eleonora Maryeta Toyo Leki, Karol Giovani Battista Novembrina, Metrikana Pitarisa, Agustina Putri Sri Suwarni tri wahyuni Wijayanti, Maria Widya Riska Yahya Febrianto