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All Journal Jurnal Biologi Tropis Biosaintifika: Journal of Biology & Biology Education Organisms: Journal of Biosciences
Alifiyah, Na'ilah Insani
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Veterinary

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Potential of Red Okra Extract (Abelmoschus esculentus L. Moench) to Restore Kidney Damage due to Sodium Nitrite Wahyuningsih, Sri Puji Astuti; Fachrisa, Amalia; Nisa’, Nabilatun; Kusuma, Baskara Wiku Adi; Shoukat, Nadia; Ahmar, Rasyidah Fauzia; Alifiyah, Na'ilah Insani
Biosaintifika: Journal of Biology & Biology Education Vol 13, No 1 (2021): April 2021
Publisher : Department of Biology, Faculty of Mathematics and Sciences, Semarang State University . Ro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v13i1.28141

Abstract

Sodium nitrite (NaNO2) found in vegetables, drinking water, and cured meats, can damage tissue because it is an oxidant. Plant phytochemicals such as quercetin are antioxidants. This study aimed to determine the potential of red okra pods ethanol extract (ROE) to repair kidney damage in mice (Mus musculus) induced by NaNO2. The red okra pods were extracted three times with saturated ethanol. The experiment used 36 male BALB/c mice aged 6-8 weeks and body weight of about 28 g. There are six research groups, namely, normal control, negative control (exposure to NaNO2 50 mg/kg BW), treatment of exposure to NaNO2 and administration of ROE at doses of 25, 50, 75, and 100 mg/kg BW. Sodium nitrite and ROE were given daily for 23 days by gavage. On day 24, the serum was isolated. Blood urea nitrogen (BUN) and creatinine (Cre) levels are measured to assess kidney function, as well as measuring the oxidant malondialdehyde (MDA) and the antioxidant enzyme of superoxide dismutase (SOD). The kidneys were made histological preparations and analyzed on the proximal convoluted tubule (PCT).  All data were statistically analyzed (α=0.05). This study indicated that the administration of ROE at a 100 mg/kg BW dose is the most optimal in repairing damage to the PCT with increased normal cells and reduced necrosis. Besides, it degraded BUN, Cre, and MDA levels in the serum of mice exposed to NaNO2 compared to the other treatments. All doses of ROE promoted the SOD level. ROE restore kidney tissue, especially on PCT to normal. Kidney damage due to exposure to NaNO2 preservatives can be reduced by administering ROE. ROE prevents kidney damage through an increase in antioxidant enzymes. ROE can be used as a food ingredient as a source of antioxidants, thereby reducing the impact of oxidant compounds.
Phytochemical Constituents, Nutritional Composition, and Pharmacological Potentials of Mangifera foetida: A Comprehensive Review Alifiyah, Na'ilah Insani; Aryanto, Arie; Zikriyani, Hikmah
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.9167

Abstract

Mangifera foetida, commonly referred to as bacang, is a tropical fruit tree of the Anacardiaceae family widely used in traditional medicine throughout Southeast Asia for a variety of therapeutic purposes. Recent scientific studies have validated many of these ethnomedicinal uses by uncovering a diverse phytochemical composition alongside notable pharmacological activities. This review synthesizes current knowledge on the nutritional content, bioactive compounds, and pharmacological effects of M. foetida, with particular focus on its antioxidant, antimicrobial, cytotoxic, antidiabetic, and anti-inflammatory properties. Key secondary metabolites, including mangiferin, phenolic compounds, flavonoids, and essential oils, are believed to underpin its therapeutic efficacy. Moreover, the fruit and other plant parts provide considerable nutritional benefits, supplying essential vitamins, minerals, and dietary fiber. Despite these promising findings, further investigations are needed to clarify underlying mechanisms, improve extraction techniques, and evaluate clinical effectiveness. This review seeks to establish a comprehensive reference to support future research and facilitate the development of M. foetida-derived nutraceuticals and pharmaceuticals.
Earthworm Cultivation (Lumbricus rubellus) Using Cattle Manure Waste in Pangalengan District, Bandung Regency Aryanto, Arie; Alifiyah, Na'ilah Insani; Zikriyani, Hikmah
ORGANISMS: JOURNAL OF BIOSCIENCES Vol. 5 No. 1 (2025): Organisms: Journal of Biosciences
Publisher : Pusat HKI, Paten, dan Publikasi Ilmiah Universitas Islam Negeri Raden Intan Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24042/es4z7c38

Abstract

This high level of organic waste poses significant environmental risks if left unmanaged. Therefore, there is a need for waste management strategies that are simple, cost-effective, and environmentally sustainable. One such approach is vermiculture the cultivation of earthworms to convert organic waste into nutrient-rich vermicompost. Integrating Effective Microorganisms (EM4) and tomato waste into cattle manure feed has the potential to enhance nutrient bioavailability through microbial fermentation, which in turn supports earthworm metabolism and growth. This study aims to evaluate the productivity of Lumbricus rubellus and the efficiency of vermicompost production under different feed formulations. The experiment was conducted using a completely randomized design (CRD) with four feed treatments: cow manure (P1), cow manure + EM4 (P2), cow manure + tomato waste (P3), and cow manure + tomato waste + EM4 (P4), with three replications per treatment. The observed parameters included earthworm weight, earthworm length, vermicompost production, and proximate analysis of earthworm biomass. This study also assesses the impact of these feed combinations on the growth performance of L. rubellus and the resulting vermicompost yield, within the agroclimatic conditions of Pangalengan. Additionally, the nutritional composition of the harvested earthworm biomass is evaluated to explore its potential as a supplementary protein source for livestock feed contributing to sustainable and circular agricultural practices in dairy farming systems.
Co-Authors Ahmar, Rasyidah Fauzia Arie Aryanto, Arie Fachrisa, Amalia Kusuma, Baskara Wiku Adi Nisa’, Nabilatun Shoukat, Nadia Sri Puji Astuti Wahyuningsih, Sri Puji Astuti Zikriyani, Hikmah