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All Journal Indonesian Journal of Medicine Narra J
Budiningsih, Fatichati
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Association between Serum Calcidiol Levels and Cognitive Function in Geriatric Patients Anandhita, Sandy; Budiningsih, Fatichati; Nurrudhin, Arief
Indonesian Journal of Medicine Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (30.085 KB)

Abstract

Background: The role of vitamin D toward cognitive function is as neuroprotective in which vitamin D will increase neurotrophic factor production which contributes to supporting neuron life sustainability, development, and function. The study aims to analyze the association between calcidiol serum level and cognitive functions of geriatric patients.Subjects and Method: A cross-sectional study was conducted at Geriatric Polyclinic of dr. Moewardi Hospital, Surakarta. A sample of 30 geriatric patients was selected randomly. The dependent variable was cognitive functions (MMSE score). The Independent variable was calcidiol serum level. The data were analyzed by Spearman test.Results: There was no difference of calcidiol serum level with MMSE score (OR= 1.00; p= 0.478).Conclusion: There was no difference in calcidiol serum level with MMSE score.Keywords: cognitive functions, calcidiolCorrespondence: Sandy Anandhita. Masters Program in Family Medicine, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta, Central Java. Email: anandhitasandy3@gmail.com. Mobile: 082227940410Indonesian Journal of Medicine (2020), 05(03): 185-190https://doi.org/10.26911/theijmed.2020.05.03.02 
Effects of Moringa oleifera extract on inflammaging markers, muscle mass, and physical endurance in geriatric mice model Budiningsih, Fatichati; Purwanto, Bambang; Wasita, Brian; Poncorini, Eti
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.2052

Abstract

A comprehensive approach to managing frailty is required due to the increasing number of elderly. Physical frailty, associated with inflammatory processes and a loss of muscle mass, can significantly impair health status. The aim of this study was to determine the effect of Moringa oleifera Lam. leaf extract on frailty in geriatric mice model. An experimental study was conducted using a post-test-only control group design using  Mus musculus Balb/C mice aged eight weeks. The animals were divided into five groups: negative control group received intraperitoneal injections of normal saline (0.5 cc/day) for eight weeks, positive control group received D-galactose (150 mg/kg body weight (BW)/day) only, and three treatment groups treated with 150 mg/kg of D-galactose intraperitoneally for eight weeks followed by 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW of M. oleifera leaf extract orally for five weeks. At the end of the study, the blood levels of malondialdehyde (MDA), transforming growth factor-beta (TGF-β) and caspase-3, as well as caspase-3 expression in skeletal muscle, skeletal muscle mass fibrosis, and physical endurance were measured. The results showed that a dose of 400 mg/kg/day of M. oleifera leaf extract had the most significant effect on lowering MDA, TGF-β, and caspase-3 expression in skeletal muscle tissue, skeletal muscle fibrosis, and improved physical endurance compared to other groups (p<0.001). This study highlights that M. oleifera leaf extract reduced frailty in geriatric mice model-induced using D-galactose by reducing inflammaging factors, thereby improving physical endurance.
Correlation Between Analgesic Administration, Depression, and Knee Osteoarthritis Severity in Elderly Gutomo, Arthur Marc; Kusumaningrum, Sulistyani; Budiningsih, Fatichati; Werdiningsih, Yulyani
Indonesian Journal of Medicine Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.3.772

Abstract

Background: Chronic diseases in the elderly, including osteoarthritis (OA), impact quality of life and can lead to depression. Pain caused by knee osteoarthritis may trigger stress and depression, while depression can worsen pain perception and disability. This study aimed to analyze the correlation between analgesic use, depression, and the severity of knee osteoarthritis in elderly patients. Subjects and Method: A cross-sectional study was conducted at Dr. Moewardi Hospital, Surakarta, using medical records of 99 elderly patients diagnosed with primary knee osteoarthritis between January 2018 and January 2024. Analgesic administration data were obtained from prescription records. Depression levels were assessed using the Geriatric Depression Scale (GDS), while the severity of osteoarthritis was evaluated using the Kellgren and Lawrence radiological classification. Data were analyzed using the Spearman correlation test. Results: Analgesic administration was negatively associated with depression (OR= 0.09; 95% CI= 0.03 to 0.32; p<0.001) and severity of knee OA (OR= 1.91; 95% CI= 0.60 to 6.08; p<0.001). Severity of knee OA was positively associated with depression (OR= 0.18; 95% CI= 0.05 to 0.62; p<0.001). Conclusion: Analgesic administration is negatively associated with depression and severity of knee OA. Severity of knee OA is positively associated with depression.
Co-Authors Anandhita, Sandy Bambang Purwanto Brian Wasita Gutomo, Arthur Marc Kusumaningrum, Sulistyani Nurrudhin, Arief Poncorini, Eti Werdiningsih, Yulyani