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Faktor sosio ekonomi demografi terhadap kejadian infeksi kecacingan pada anak Sekolah Dasar Mahmudah, Umi; Dirgahayu, Paramasari; Wasita, Brian
Ilmu Gizi Indonesia Vol 1, No 1 (2017): Agustus
Publisher : Program Studi S-1 Ilmu Gizi

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Abstract

Latar belakang: Infeksi kecacingan merupakan masalah kesehatan masyarakat di negara-negara berkembang seperti Indonesia. Anak sekolah dasar merupakan golongan yang paling berisiko terhadap kejadian infeksi kecacingan. Infeksi ini dipengaruhi oleh beberapa faktor yaitu kondisi sanitasi lingkungan, perilaku personal hygiene,  serta kondisi  sosio  ekonomi demograf daerah sekitar. Kondisi sosio demograf yang berbeda di setiap wilayah mengakibatkan terjadinya infeksi kecacingan yang berbeda–beda. Tujuan: Untuk mengetahui hubungan faktor sosio ekonomi demograf  terhadap  kejadian  infeksi  kecacingan  pada  anak  sekolah  dasar. Metode: Penelitian ini merupakan penelitian observasional dengan rancangan cross sectional, pada populasi anak sekolah dasar kelas 1 sampai kelas 5 dengan jumlah 92 siswa, sedangkan besar sampel penelitian berjumlah 74 siswa di SD Barengan Kecamatan Teras Kabupaten Boyolali dengan teknik pengambilan sampel secara purposive. Data kecacingan pada anak diperoleh dengan pengambilan sampel feses dan diperiksa menggunakan metode  formol ether concentration di Laboratorium Parasitologi  Fakultas  Kedokteran  Universitas  Sebelas Maret.  Data  sosio  ekonomi  demograf diperoleh dengan kuisioner dengan metode wawancara. Analisis data diolah menggunakan chi square. Hasil: Prevalensi kejadian infeksi kecacingan pada anak sekolah dasar di SD Barengan Kecamatan Teras Kabupaten Boyolali adalah 40,21%. Pendidikan ayah (p=0,159) dan pendidikan ibu (p=0,352) tidak berhubungan dengan kejadian infeksi kecacingan. Penghasilan ayah (p=0,330) dan penghasilan ibu (p=1,152) tidak berhubungan dengan kejadian infeksi kecacingan. Kesimpulan:  Pendidikan ayah, pendidikan ibu, penghasilan ayah dan penghasilan ibu tidak berhubungan dengan kejadian infeksi kecacingan.Kata kunci: Sosio; ekonomi; demograf; infeksi kecacingan
Hubungan Kecerdasan Emosional dan Status Anemia terhadap Prestasi Belajar Mahasiswa Tingkat III Akademi Keperawatan Dharma Husada di Kediri Santoso, Puguh; Syamsulhadi, Muchamad; Wasita, Brian
Jurnal Gizi dan Kesehatan Vol 1, No 1 (2014)
Publisher : Program Studi Ilmu Gizi Pascasarjana Universitas Sebelas Maret

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Latar Belakang : Pencapaian tujuan pendidikan tergantung pada proses belajar yang dialami individu. Salah satu faktor internal yang memiliki hubungan dengan prestasi belajar adalah kecerdasan emosi, kondisi fisik yang mengganggu kemampuan belajar, dan anemia. Tujuan untuk menganalisis hubungan kecerdasan emosional dan status anemia terhadap prestasi belajar mahasiswa Tingkat III Akademi Keperawatan Dharma Husada di Kediri.Metode Penelitian : Penelitian ini merupakan penelitian observasional dengan menggunakan rancangan cross sectional. Populasi dalam penelitian ini adalah mahasiswa Tingkat III Tahun 2013/2014 Akademi Keperawatan Dharma Husada di Kediri yang terdiri dari 2 kelas. Melalui teknik Simple Random Sampling diperoleh subjek berjumlah 91 orang. Metode untuk memperoleh datak ecerdasan emosional dengan kuesioner, kadar Hb menggunakan cyanmethemoglobin dan prestasi belajar menggunakan studi dokumentasi. Data di analisis dengan uji bivariat menggunakan regresi linier sederhana, serta multivariat menggunakan regresi linier berganda dengan tingkat kepercayaan 95% (α = 5%).Hasil : Kecerdasan emosional mempunyai hubungan yang signifikan terhadap prestasi belajar mahasiswa Tingkat III  Akademi Keperawatan Dharma Husada di Kediri (p = 0,000). Status anemia tidak mempunyai hubungan yang signifikan terhadap prestasi belajar mahasiswa Tingkat III  Akademi Keperawatan Dharma Husada di Kediri (p = 0,104). Ada hubungan yang signifikan antara kecerdasan emosional dan status anemia secara bersama - sama terhadap prestasi belajar mahasiswa Tingkat III  Akademi Keperawatan Dharma Husada di Kediri (p = 0,000). Kesimpulan : Ada hubungan yang signifikan antara kecerdasan emosional dan status anemia secara bersama – sama terhadap prestasi belajar mahasiswa Tingkat III  Akademi Keperawatan Dharma Husada di Kediri. Sumbangan kecerdasan emosional dan status anemia terhadap prestasi belajar adalah 20%, dengan kontribusi kecerdasan emosional sebesar 17,1% dan status anemia sebesar 2,9%, sedangkan 80%  berhubungan dengan  faktor lain yang tidak dianalisis dalam penelitian ini. Kata Kunci :  Kecerdasan Emosional, Status Anemia,  Prestasi Belajar
PENGARUH PEMBERIAN JUS BUAH NAGA MERAH (Hylocereus polyrhizus) TERHADAP KADAR KOLESTEROL TOTAL TIKUS PUTIH (Rattus norvegicus) JANTAN MODEL HIPERKOLESTEROLEMIA Suryani, Irma; Dirgahayu, Paramasari; Wasita, Brian
Jurnal Gizi dan Kesehatan Vol 1, No 2 (2014)
Publisher : Program Studi Ilmu Gizi Pascasarjana Universitas Sebelas Maret

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Abstract Background : Hyperlipidemia is a major cause of cardiovascular disease because it can lead to narrow of the arteries. Prevalence of diseases caused by hyperlipidemia is still quite high in many countries. Some therapeutic agents of modern medicine has been available, but most of these drug give side effects and the cost is quite high. The content of the red dragon fruit has been studied, which consists of fiber and antioxidants.This study was conducted to determine the effectiveness of antihiperlipidemia red dragon fruit juice compared with atorvastatin.Methods : Experimental with pre and post group randomized controlled design. The 36 samples were divided into six groups randomly: negative control group, positive control group (induction high fat diet for 14 days), group 1(induction high fat diet for 14 days and atorvastatin 10 days), 2, 3 and 4 (induction high fat diet for 14 days and red dragon fruit juice with a variety of doses for 10 days). The levels of lipid profiles of samples were measured before and after the intervention is given. Data were analyzed with SPSS 22.0 for windows. Result : After 14 days of margarine induction, group KP, P1, P2, P3, and P4 showed significant increase (p <0,05) on the average of total cholesterol, as well as in P1 with 0,18 mg of atorvastatin. Conclusion Red dragon fruit juice has the potential antihiperlipidemia comparable to atorvastatin Key words: Red Dragon Fruit, Lipid Profile, Atorvastatin
Sensitivity and specificity of cell block method of transthoracic fine needle aspiration in diagnosis of lung cancer Sutanto, Yusup Subagio; Santi, Nur; Wasita, Brian; Rima, Ana; Kurniawan, Hendra
Universa Medicina Vol. 40 No. 2 (2021)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2021.v40.133-140

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BackgroundLung cancer is still the main cause of cancer deaths. The high lung cancer mortality rate is caused by a diagnosis factor or therapy selection. The cell block cytology technique using fine needle aspiration (FNA) samples can provide immunocytochemical material that plays an important role in the differential diagnosis of lung cancer subtypes and in determining immunotherapy administration. This study aimed to determine the sensitivity and specificity of transthoracic FNA (TTFNA) cell block cytology in comparison with bronchial washing smears and TTFNA smears in diagnosing lung cancer. MethodsThis was a cross-sectional diagnostic study involving 26 subjects. All subjects had undergone bronchial washing and CT scan-guided fine needle aspiration followed by cell block preparation. Both direct FNA smears and cell blocks are useful in the diagnostic work-up of patients. Comparative statistical analysis of TTFNA cell block versus bronchial washing smear and TTFNA smear cytology was carried out using the McNemar test. ResultsLung cancer was found in 15 patients (57.7%) using the TTFNA cell block technique. The sensitivity and specificity of the TTFNA cell block technique were 85.7% and 75%, respectively. There was no difference in the positivity value between TTFNA cell block technique of bronchial wash smear technique, and TTFNA smear on lung cancer diagnosis (p>0.05). ConclusionsTransthoracic fine-needle aspiration in combination with the cell block technique has good sensitivity and specificity. The TTFNA can be used for immunocytochemical examinations in lung cancer diagnosis and therapy. This approach is valuable for providing individualized treatment and prognostic evaluations.
Survival and prognostic factors in pediatric osteosarcoma: A 5-year single-center experience in Central Java, Indonesia Riza, Muhammad; Salimo, Harsono; Wasita, Brian; Idulhaq, Mujaddid; Saputra, Rhyan Darma; Widyaningsih, Vitri; Soestrisno, Soestrisno; Zahidah, Fairuz; Wayanshakty, Janur
Paediatrica Indonesiana Vol. 64 No. 1 (2024): January 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.1.2024.10-6

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Background The advent of chemotherapy with multimodal treatment has improved the survival rate of osteosarcoma. However, the survival rate of patients with osteosarcoma in low- and middle-income countries (LMICs) remains lower than in high-income countries (HICs). Objective To assess prognostic factors associated with survival rate of pediatric patients with osteosarcoma in Moewardi Hospital, Surakarta. Methods This retrospective study was performed in pediatric osteosarcoma patients at Moewardi Hospital, Surakarta from 2018 to 2022. We described patients’ clinical presentations and assessed prognostic factors. Survival rate was calculated using Kaplan–Meier survival analysis. Prognostic factors were analyzed using univariate and multivariate Cox regression methods. Results Of the 82 patients included in the study, 40 (48.8%) were male and 42 (51.2%) were female. Most subjects (75.6%) were diagnosed with osteosarcoma at the age of >10 years, 45 patients (54.9%) had primary tumors in the femur, and 16 patients (19.5%) had limb salvage surgery. The mean event-free survival duration was 13.6 (95%CI 9.7 to 17.5) months. The mean duration of overall survival was 22.7 (95%CI 17.3 to 28.1) months, with a 44.1% survival probability. Type of surgery was a significant prognostic factor (P=0.018), with limb salvage having better survival probability (93.3%) than amputation (19.8%). Conclusion The overall survival rate of osteosarcoma patients at our center is still lower than in other regional centers. Limb salvage surgery was a significant prognostic factor for survival, while gender, location of primary tumor, histological subtype, and metastasis at the time of diagnosis were not.
Total Knee Replacement of Synovial Haemangioma of The Knee Joint in a 44-Year-Old Male: A Case Report Idulhaq, Mujaddid; Saputra, Rhyan Darma; Wasita, Brian; Sabariyah, Lely; Gardjito, Fajar Baskoro; Nursulistyo, Fajar
Indonesian Journal of Cancer Vol 18, No 1 (2024): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i1.911

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Introduction: Synovial hemangioma is a rare illness frequently misdiagnosed, leading to years of inaction. In this study, we aim to discover the consequences of untreated hemangioma of the knee joint. Case Presentation: Our patient was a 44-year-old male who experienced recurring pain in his left knee. The previous year, the patient experienced pain in his left knee while walking, which has subsided with rest. Although he has been performing radiography at multiple hospitals since 2019, no problems have been recorded. We detected a mass after performing magnetic resonance imaging. The T1-weighted sequence + contras near the medial femoral condyle revealed a homogeneous mass with high intensity. We decided to conduct surgical intervention and total knee replacement. Postsurgical, the patient regained symptom-free. Conclusions: Because of the limited radiographic capacity, synovial hemangioma is uncommon and challenging to diagnose on an outpatient basis. Magnetic resonance imaging and angiography are highly beneficial. If intraarticular hemangiomas are not considered, they can cause bony dysplasia and multiple clinical manifestations. Initial total excision can be conducted to decrease the chance of hemarthrosis.
Correlation between circulating fibrosis biomarkers with left atrial function and left atrial volume index in rheumatic mitral stenosis Asrial, An A.; Reviono, Reviono; Soetrisno, Soetrisno; Setianto, Budi Y.; Widyaningsih, Vitri; Nurwati, Ida; Wasita, Brian; Pudjiastuti, Anggit
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.293

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Mitral stenosis is the most common rheumatic heart disease (RHD) disorder worldwide, including in Indonesia. This pathological condition causes left atrial pressure, leading to left atrial fibrosis that affects the structure and function of the left atrial as well as the clinical condition. The aim of this study was to assess the correlation between circulating fibrosis biomarkers with net atrioventricular compliance (Cn) as a parameter of left atrial function, and left atrial volume index (LAVI) as a parameter left atrium structure of changes. A cross-sectional study was conducted at Panti Rahayu Hospital and Permata Bunda Hospital, Purwodadi, Central Java, with a total of 40 RHD patients with severe mitral stenosis. The ELISA was used to measure the levels of carboxy-terminal propeptide of type I procollagen (PICP), matrix metalloproteinase I (MMP-1), tissue inhibitor matrix metalloproteinase 1 (TIMP-1), and transforming growth factor-β1 (TGF-β1). The left atrial function was assessed by measuring Cn, and the LAVI parameters were measured to assess left atrium structure/size. The mean levels of circulating fibrosis biomarkers were as follows: PICP 153.96±89.12 ng/mL; MMP-1 1.44±2.12 ng/mL; MMP-1/TIMP-1 ratio 0.38±0.54 and TGF-β1 2.66±1.96 pg/mL. From the echocardiographic evaluation, the mean Cn was 5.24±1.93 mL/mmHg and the mean LAVI was 152.55±79.36 mL/m2. There were significant correlation between MMP-1 and MMP-1/TIMP-1 ratio with Cn (r=0.345 and r=0.333, respectively; both had p<0.05). PICP and TGF-β1 biomarkers did not significantly correlate with Cn (p>0.05). Meanwhile, none of the biomarkers had a significant correlation with LAVI (p>0.05). This study highlights that MMP-1 and MMP-1/TIMP-1 ratio are potentially to be used as markers to determine the Cn in RHD patients with severe mitral stenosis. However, further studies with a higher sample size are needed to confirm this finding.
Exploring the therapeutic potential of functional foods for diabetes: A bibliometric analysis and scientific mapping Wiyono, Nanang; Yudhani, Ratih D.; Wasita, Brian; Suyatmi, Suyatmi; Wardhani, Lusi O.; Pesik, Riza N.; Yarsa, Kristanto Y.; Rahayu, Rachmi F.
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.382

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The incidence of diabetes is increasingly becoming a global health burden. Meanwhile, in recent years, functional foods have been intensively investigated for diabetes management. These foods provide health benefits due to their bioactive compounds that enhance the metabolism and lower the risk of chronic diseases, such as diabetes. The aim of this study was to explore the keywords, countries/territories, publication numbers, institutions, authors, and journals associated with functional foods for the management of diabetes using a comprehensive bibliometric analysis method. Scopus database was used to compile the information, followed by VOSviewer for comprehensive bibliometric data analysis. A total of 1,226 Scopus articles that met the inclusion criteria were analyzed. The results showed that the greatest expansion in research occurred in 2012, and China was identified as the most productive nation in this field. In addition, Food and Function was found as the most recognized journal in this area, and Singh, R.B. as well as Zengin, G. made the greatest contribution. The bibliometric data also illustrated several mechanisms of functional foods for diabetes management, including antioxidant activity, effect on the gastrointestinal microbiomes, and inhibitor α-amylase. These results underscore the immense potential of functional foods in the diabetes management and provide guidance for future research on this subject.
Aerobic exercise improves spatial memory in a rat model of meningitis Zaidah, Lailatuz; Soetrisno, Soetrisno; Purwanto, Bambang; Kristiyanto, Agus; Wasita, Brian; Widyaningsih, Vitri
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.977

Abstract

Infections of the nervous system, such as acute bacterial meningitis, pose serious health problems that require immediate intervention. In experimental animals, exposure to lipopolysaccharide (LPS) is used to induce meningitis. Aside from drug intervention to reduce inflammation in meningitis, aerobic exercise helps to maintain the regulatory mechanisms of brain homeostasis through anti-inflammatory mechanisms. The aim of this study was to evaluate the effect of aerobic exercise on malondialdehyde (MDA), nuclear factor-kappa B (NF-κB), insulin-like growth factor 1 (IGF-1), endothelial nitric oxide synthase (eNOS), brain-derived neurotrophic factor (BDNF), apoptosis, and spatial memory. A four-week experimental study was conducted using 18 rats, which were randomly divided into three different groups (six rats per group): healthy rats as negative controls (non-meningitis), a treatment group treated with antibiotic treatment (meningitis group), and a third group (aerobic exercise group) treated with antibiotics and aerobic exercise following LPS-induced meningitis. Data were analyzed using a one-way analysis of variance (ANOVA) test, and the comparison between groups used the Bonferroni post-hoc test. The results showed that aerobic exercise significantly reduced MDA (p<0.001), NF-κB (p=0.035), and apoptosis (p=0.020) while increasing the serum levels of IGF-1 (p<0.001), eNOS (p=0.011), and BDNF (p=0.001) levels. Improvement in spatial memory was significant in the aerobic exercise group (p<0.001). This study suggested that aerobic exercise could be a promising adjunct therapy in meningitis management strategies, particularly due to its effect on improving spatial memory. Further clinical trials are needed to confirm these findings for clinical use.
Impacts of Phyllanthus niruri extract on biomarker levels, macrophage count, and lesion area in an endometriotic rat model Wulandari, Eka T.; Soetrisno, Soetrisno; Purwanto, Bambang; Reviono, Reviono; Wasita, Brian; Laqif, Abdurrahman
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1002

Abstract

Endometriosis is a gynecological disorder characterized by chronic inflammation, anatomical changes, prolonged pain, and infertility. On the other hand, Phyllanthus niruri is recognized for its pharmacological effects, which might be beneficial in managing endometriosis. The aim of the study was to investigate the pharmacological effects of P. niruri as a potential therapy for endometriosis by using an animal model. An experimental laboratory study with randomized, controlled trial, pre-test, and post-test design using 40 female Wistar rats (Rattus norvegicus) was conducted at the Integrated Research and Testing Laboratory (LPPT) of Universitas Gadjah Mada, Yogyakarta, Indonesia, from February to June 2023. Endometriosis was induced in female Wistar rats by suturing a 0.5 cm2 flap from the uterine horn to the peritoneal cavity. Changes in serum interleukin 1β (IL-1β), malondialdehyde (MDA), and matrix metalloproteinase 9 (MMP-9), before and after the treatment, were analyzed using enzyme-linked immunosorbent assay. Hematoxylin and eosin (HE) staining were used to evaluate lesion size and macrophage quantity. The results suggested that the P. niruri extract with a dose of 196 mg/200 g body weight (BW) could significantly attenuate serum IL-1β (p=0.004), MMP-9 (p=0.021), and MDA (p=0.021). Rats receiving the P. niruri extract (196 mg/200 g BW) had significantly higher macrophage counts (p=0.003), but similar lesion area (p=0.093) as compared with the negative control. In conclusion, P. niruri demonstrated promising therapeutical effects on endometriosis by modulating IL-1β, MDA, and MMP-9 levels, although the effect was not pronounced on macrophage counts and lesion area.
Co-Authors Adam Fauzi Adi Magna, Adi Adi Prayitno Afdhaliya, Noor Khalwati Agus Kristiyanto Amarduan, Tince Bety Ambar Mudigdo Amilia Yuni Damayanti Ana Rima Anugrah, Tessa Septian Ari Probandari Asrial, An A. Bambang Purwanto Binti Maulina Brahmana, Ivanna Beru Budiningsih, Fatichati Budiyanti Wiboworini Cindikya Saftiari Dewi Cr. Siti Utari Cr. SitiUtari Darmayani, Aritantri David Perdana Dentiko Wasis Aulia Dewi Okta Anggraini Didik Prasetyo Diffah Hanim Dono Indarto Eka Puspita Sari Eka Tri Wulandari, Eka Tri Ellistasari, Endra Yustin ernawati, ammik Eti Poncorini Pamungkasari Fadila, F Gardjito, Fajar Baskoro Gunawan, Timotheus A. Hari Wujoso Harsono Salimo Hermansyah, Muhamad Lukman Herviana, Herviana Ida Nurwati Idulhaq, Mujaddid Irawan, Amelia Tjandra Irma Suryani Jati, Agus Kariosentono, ⁠⁠Harijono Kusumaningrum, Sulistyani Laqif, Abdurrahman LAWEI, THARINA Marintan, Elita Muchamad Syamsulhadi, Muchamad Muhammad Riza Mulianto, ⁠Nurrachmat MULYOTO PANGESTU Muthaminah, Muthaminah Muthmainah Muthmainah Muthmainah Nanang Wiyono Nofia, Yasinta Novan Adi Setyawan Nur Shani Meida Nursulistyo, Fajar Paramasari Dirgahayu Paulus Kusnanto Pesik, Riza N. Poncorini, Eti Primisawitri, Pratiwi Prasetya Pudjiastuti, Anggit puguh santoso, puguh Rachmi Fauziah Rahayu Rahayu, Rachmi F. Rahmah Rahmah Ratih Dewi Yudhani Ratih Puspita Febrinasari Reviono Reviono Risya Cilmiaty, Risya Rita Cempaka Riza Deviana Riza Novierta Pesik Rizma, Amalina Sabariyah, Lely Sahara, Nita Santi, Nur Saputra, Rhyan Darma Senyum Indrakila Setianto, Budi Y. Sholikah, Tri Agusti Siswanto, Febby Gunawan Siti Maesaroh Soestrisno, Soestrisno Soetrisno Soetrisno Soetrisno Sri Lestariningsih Suyatmi Suyatmi Tamaulina Br Sembiring Taufiqurrahman, Surya Tedjo Danudjo Tonang Dwi Ardyanto Tri Harsono Tri Nugraha Susilawati Triyanta Yuli Pramana Uki Retno Budihastuti Umi Mahmudah Vitri Widyaningsih Wardhani, Lusi O. Wardhani, Lusi Oka Wayanshakty, Janur Widhiati, Suci Wulandari, Eka T. Wulansari, Indry Yarsa, Kristanto Y. Yarso, Kristanto Yuli Yudhani, Ratih D. Yudhistira, Muhammad Yurizar Yundari, Yundari yusari Yusup Subagio Yusup Subagio Sutanto Yuyun Yueniwati Zahidah, Fairuz Zahrah, Fathimah Afifah Zaidah, Lailatuz