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All Journal JFL : Jurnal Farmasi Lampung Journal of Fundamental and Applied Pharmaceutical Science
Isbiyantoro, Isbiyantoro
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

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ANALISIS DRUG RELATED PROBLEMS (DRPs) PENGGUNAAN ANTIPSIKOTIK PADA PASIEN SKIZOFRENIA DI RUMAH SAKIT JIWA PROVINSI LAMPUNG JANUARI-JUNI 2024: DRUG RELATED PROBLEMS (DRPs) ANALYSIS OF ANTIPSYCHOTIC USE IN SCHIZOPHRENIA PATIENTS AT THE MENTAL HOSPITAL OF LAMPUNG PROVINCE JANUARY-JUNE 2024 Hijrah, Hijrah; Wahyuni, Novita Tri; Isbiyantoro, Isbiyantoro; Sari, Wulan
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2222

Abstract

Schizophrenia is severe mental disorder that affects an individual’s thought, feelings, and behavior. Antipsychotics are the primary treatment for schizophrenia and used for a long preiod of time which increases the risk of Drug Related Problems (DRPs) and cause ineffective therapeutic results.  The purpose of this study was to analyze the incidience of DRPs on the use antipsychotic in scizhoprenia patients at The Mental Hospital Of Lampung Province January-June 2024. This research study is a descriptive study with purposive sampling technique. The number of samples used was 86 samples of schizophrenia in patients at Mental Hospital Of Lampung Province in January-June 2024.  The results showed that the characteristics of schizophrenia patiens based on gender were 77 men (89,5%) and 9 women (10,5%).  Characteristic based on age are26-35 years old 35 people (40,7%).  The Characteristics of the most patients occupations were not working 68 people (79,1%). The most prevalent kind of schizophrenia patients was paranoid schizophrenia as 82 cases (94,2%).  The most prescribed drugs for schizophrenia patients were risperidone 82 prescriptions, chlorpromazine 70 prescriptions, and trihexyphenidyl 86 prescriptions. The incidence of DRPs in the category of inappropriate drug combinations was 86 cases (100%), drug dose too low was 23 cases (27%), drug dose too high 0%, and inapproprate of drug administration was 0%. The conclusion of this study is the precentage of Drug Related Problems (DRPs) in schizophrenia patients at the Mental Hospital Of Lampung Province is 32%.   Keywords : Antipsychotics, DRPs, Schizophrenia
RELATIONSHIP BETWEEN PARENTS' KNOWLEDGE LEVEL OF CHILD PATIENTS WITH ACUTE RESPIRATORY TRACT INFECTION (ARI) AND ANTIBIOTIC USE BEHAVIOR AT TANJUNG BINTANG COMMUNITY HEALTH CENTER IN 2024: Relationship Between Parents Knowledge Level Of Child Patients With Acute Respiratory Infection (ARI) And Antibiotic Use Behavior At Tanjung Bintang Community Health Center In 2024 Isbiyantoro, Isbiyantoro; Wahyuni, Novita Tri; Hijrah, Hijrah; Faliandra, Dinda Renanti
JFL : Jurnal Farmasi Lampung Vol. 14 No. 2 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/akdt3x05

Abstract

Infectious diseases are one of the most common public health problems, especially in developing countries. The causes include age, season, living conditions and existing health problems. One of the infectious diseases is Acute Respiratory Infection or better known as (ARI). Efforts to treat ARI caused by bacteria with the use of antibiotics. This study aims to determine the relationship between the level of knowledge of parents of pediatric patients with acute respiratory infections (ARI) and antibiotic use behavior at the Tanjung Bintang Health Center in 2024. This type of research uses quantitative analytical cross-sectional design, the sampling technique uses the accidental sampling method with a total of 80 respondents. Data analysis in this study used the chi-square test technique. The results of this study obtained the level of parental education of elementary school (52.2%), junior high school education (15.0%) high school-college education (32.5%). Respondents with work as many as (75.5%) and unemployed as many as (25.5%), children aged 5-8 years (61.3%), aged 9-12 years (38.8%), male gender (52.5%) and female (47.5%) and mild ISPA (31.3%), moderate ISPA (63.8) and severe ISPA (5.0%), respondent knowledge level of knowledge level less (26.3%) and good knowledge level (73.8%), parental behavior less (26.3%) and good behavior (73.8%). Based on the chi-square test there is a significant relationship between the level of knowledge and parental behavior towards the use.   Keywords : Antibiotics, Behavior, ISPA, Knowledge
Ethanol Fraction of Seligi Leaves (Phyllanthus buxifolius (Blume) Muell. Arg) as Analgesic in Male White Mice (Mus musculus) Samsuar, Samsuar; Susanti, Laila; Isbiyantoro, Isbiyantoro; Tantia, Ulfa
Journal of Fundamental and Applied Pharmaceutical Science Vol. 7 No. 1 (2026): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v7i1.31474

Abstract

Pain is an uncomfortable sensory and emotional feeling for the sufferer, and pain arises as a sign of tissue damage. There are various types of analgesic drugs used by the community, both traditional and synthetic. One of the plants used as a traditional medicine is Seligi (Phyllanthus buxifolius (Blume) Muell. Arg). The leaves of Seligi are known to contain flavonoid compounds that inhibit prostaglandin biosynthesis, a process that produces pain mediators. The purpose of this study is to examine the analgesic effects of the ethanol fraction of Seligi leaves on mice and to establish the optimal dose for oral analgesia in mice. In this investigation, the Sigmund approach was employed. The test animals were 25 male white mice divided into five groups: the negative control group (carboxymethyl cellulose), the positive control group (mefenamic acid) at a dose of 65 mg/kg body weight, and Groups I, II, and III, which were given the ethanol fraction of celosia leaves orally at doses of 46 mg/kg body weight, 92 mg/kg body weight, and 138 mg/kg body weight. After 15 minutes, the mice were intraperitoneally injected with 1% acetic acid, and their movements were observed and counted every 5 minutes for 1 hour. The research results revealed that Group I provided a protection percentage of 36.63% and an effectiveness percentage of 52.3%. Group II provided a protection percentage of 62.98% and an effectiveness percentage of 85.26%. Group III achieved a protection percentage of 71.1% and an effectiveness percentage of 96.26%, which is nearly comparable to the control group, which achieved a protection percentage of 73.86% and an effectiveness percentage of 100%. The results of the smallest significant difference test showed that the positive controls (doses 1, 2, and 3) were significantly different from the negative control, indicating that these groups exhibited an analgesic effect. At doses 2 and 3, there was no significant difference from the positive control, indicating that these doses are equivalent to the positive control.
Co-Authors Faliandra, Dinda Renanti Hijrah Hijrah Samsuar, Samsuar Susanti, Laila Tantia, Ulfa Wahyuni, Novita Tri Wulan Sari, Wulan