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All Journal Indonesian Journal of Pharmaceutical Science and Technology Biota Majalah Obat Tradisional Pharmascience JFL : Jurnal Farmasi Lampung JPSCR : Journal of Pharmaceutical Science and Clinical Research Journal of Multidisciplinary Applied Natural Science Jurnal Abdimas Kartika Wijayakusuma Jurnal Inovasi Pembangunan Jurnal Pengabdian Masyarakat Bangsa

Susanti, Laila

Universitas Tulang Bawang

Author-ID : 729319

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Antibacterial Activity From Cucumber (Cucumis sativus .L) Ethanol Extract In Deodorant Roll On Dosage Form Susanti, Laila; Widodo, Subur; Aini, Qurrota; Rahmawati, Dyah
Indonesian Journal of Pharmaceutical Science and Technology Supp 1, No 1 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Body odor of human skin usually occur due to excessive production of sweat glands couples with the presence of bacteria. The active ingredient to prevent body odor are chemicals materials from alum or sodium in order to have negative effects such as skin irritation, Alzheimer disease, prostate and breast cancer. Natural materials technology has been development as an active agent by using cucumber (Cucumis sativus .L). The purpose of this research to conduct a deodorant roll on a stable and qualified physical quality and also develop the use of extract cucumber as an antibacterial Staphylococcus epidermidis. Cucumber extraction has been done by maceration with ethanol 70% for 4 days and then divided into three formulation extract (5%, 10%, and 20% (b/v)). All of the formulations has been tested by zone inhibition, organoleptic, homogenity, pH, viscosity and irritation test. The results given that all of the formulations meet the quality requirements of physical and the best formulation extract 20% able to inhibit bacterial by 26 mm as a largest diameter of the inhibitory zone. In addition the stability of deodorant roll on form were performed accelerated stability test for 35 days at room temperature (28Â°C) and 40Â°C. The test results indicate that the stability of the extract 10% quali ed physical quality during storage at room temperature (28Â°C) and high temperature (40Â°C) for 35 days. While in the extract 20% at high temperature (40oC) physical changes characterized by the deposition. Keyword : cucumber, deodorant roll on, antibacteriaÂ

Antibacterial Activity From Cucumber (Cucumis sativus .L) Ethanol Extract In Deodorant Roll On Dosage Form Laila Susanti; Subur Widodo; Qurrota Aini; Dyah Rahmawati
Indonesian Journal of Pharmaceutical Science and Technology Supp 1, No 1 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Body odor of human skin usually occur due to excessive production of sweat glands couples with the presence of bacteria. The active ingredient to prevent body odor are chemicals materials from alum or sodium in order to have negative effects such as skin irritation, Alzheimer disease, prostate and breast cancer. Natural materials technology has been development as an active agent by using cucumber (Cucumis sativus .L). The purpose of this research to conduct a deodorant roll on a stable and qualified physical quality and also develop the use of extract cucumber as an antibacterial Staphylococcus epidermidis. Cucumber extraction has been done by maceration with ethanol 70% for 4 days and then divided into three formulation extract (5%, 10%, and 20% (b/v)). All of the formulations has been tested by zone inhibition, organoleptic, homogenity, pH, viscosity and irritation test. The results given that all of the formulations meet the quality requirements of physical and the best formulation extract 20% able to inhibit bacterial by 26 mm as a largest diameter of the inhibitory zone. In addition the stability of deodorant roll on form were performed accelerated stability test for 35 days at room temperature (28°C) and 40°C. The test results indicate that the stability of the extract 10% quali ed physical quality during storage at room temperature (28°C) and high temperature (40°C) for 35 days. While in the extract 20% at high temperature (40oC) physical changes characterized by the deposition. Keyword : cucumber, deodorant roll on, antibacteria

Formulation Of Ointment From Extract Combination Of Lemongrass (Cymbopogon nardus L. Rendle), Green Betel Leaf (Piper betle L.) And Natural Zeolite As An Antibacterial Agent Laila Susanti; Subur Widodo; Mashuri Yusuf; Retno Fardila Sari
Biota Vol 6 No 2 (2020): Jurnal Biota 2020
Publisher : Faculty of Science and Technology Universitas Islam Negeri Raden Fatah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/10.19109/Biota.v6i2.6363

Lemongrass (Cymbopogon nardus L. Rendle) and green betel (Piper betle L.) plants are native to Indonesia. Empirically betel leaf can be used as a wound healer, lemongrass leaves are widely used as medicine for insect bites. On the basis of information obtained from various literatures, in this research has been done formulation of ointment from extract combination of lemongrass, green betel leaf and natural zeolite as antibacterial of Staphylococcus aureus. The use of zeolites based on features has a three-dimensional framework structure that is interconnected so that it has a large surface. Based on these reasons, it is believed that zeolites can increase the activity of active substances in ointments. The formulation of ointment extracts of lemongrass leaves-green betel leaves and zeolites with various dosages are KZ (zeolite control), KE (20% -5%), F1 (10% -6% + zeolite), F2 (20% - 5% + zeolite), F3 (30% -4% + zeolite), F4 (20% -0% + zeolite), F5 (0% -5% + zeolite) with a fixed amount of zeolite (2 gr). Evaluation of ointment preparations including organoleptic test, pH, homogeneity, spreading test and adhesion test showed results that met the requirements. The sample was tested for antibacterial activity with positive control (gentamicin 0.1%) showed that all formulas can provide an inhibition zone against staphylococcus aureus, except KZ. Test results were analyzed using One Way Annova with sig (0,000) <p value (0,050) followed by Tukey's further tests. From this explanation it can be concluded that the formulation of ointment from extract combination of lemongrass leaves, green betel leaves and zeolites has antibacterial agent.

Cream Formulation Of Extract Of Maja Leaves (Crescentia cujete) As An Antimicrobial Against Staphylococcus aureus Siti Nurjanah; Yuli Wahyu Tri Mulyani; Laila Susanti; Samsuar Samsuar; Mashuri Yusuf; Meidaliyantisyah Meidaliyantisyah
Biota Vol 7 No 2 (2021): Jurnal Biota 2021
Publisher : Faculty of Science and Technology Universitas Islam Negeri Raden Fatah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/Biota.v7i2.7070

Maja (Crescentia cujete L) is a plant that has medicinal properties for various diseases. Leaves of Maja contain some compounds such which are thought to have the potential to be antibacterial. The purpose of this study was to determine the potential of maja leaf extract in cream dosage form and to prove the presence of Antibacterial activity against Staphylococcus aureus. The cream of Maja leaf extract was made into several formulations; (5, 10, 15 %) The results was the cream of Maja leaf extract was able to inhibit the growth of S. aureus with the largest inhibition zone at a concentration of 15% with an average of 11.52 ± 0.95mm. Cream formulations were evaluated physically; organoleptic was resulting F1 in brownish-green, F2 in brown, and F3 in dark brown. Homogeneity tests show that all formulations were homogeneous. The pH value of all formulations following the cosmetic standard was about 4.5 – 6.5. The standard viscosity value was between 2000 – 4000 cps. The stability test of cream preparations shows no changes in the form of low-temperature storage (4ºC), room temperature, and high temperature (40ºC), so that maja leaf extracts can be formulated in cream preparations and cream formulations

Formulasi Salep Ekstrak Buah Mengkudu (Morinda citrifolia L.) Kombinasi Zeolit Alam Lampung (Zal) Sebagai Penstabil Sediaan Antibakteri Staphylococcus aureus Laila Susanti; Lilik Koernia Wahidah; Pratika Viogenta
Jurnal Pharmascience Vol 7, No 1 (2020): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i1.8086

ABSTRAK Sediaan salep esktrak buah mengkudu telah terbukti sebagai antibakteri, namun esktrak tanaman pada umumnya sangat mudah terdegradasi oleh pH, cahaya dan suhu, oleh karena itu pemanfaatan Zeolit Alam Lampung (ZAL) dengan keistimewaan struktur morfologinya diharapkan mampu mempertahankan kestabilan sediaan salep hingga suhu tinggi. Penelitian ini bertujuan untuk mengetahui potensi ZAL sebagai penstabil sediaan salep dengan menghitung perubahan prosentase zona hambat bakteri pada sediaan salep sebelum dan sesudah dilakukan penyimpanan pada suhu 40oC. Penelitian ini meliputi tiga tahap utama yakni pertama formulasi salep ekstrak buah mengkudu kombinasi Zeolit Alam Lampung (ZAL) dengan variasi konsentrasi ekstrak 10%+ZAL, 15%+ZAL, 30%+ZAL, KZ (Kontrol Zeolit tanpa esktrak) dan KE (Kontrol Ekstrak tanpa zeolit) yang kemudian dilakukan evaluasi sediaan salep. Tahap kedua seluruh sampel dilakukan uji aktivitas antibakteri terhadap bakteri Staphylococcus aureus pada sediaan salep, dan tahap ketiga seluruh sampel disimpan pada suhu 40oC selama 24 jam, kemudian diuji aktivitas antibakteri kembali terhadap bakteri Staphylococcus aureus. Hasil penelitian menunjukkan bahwa seluruh sampel sebelum dilakukan penyimpanan pada suhu 40oC menunjukkan respon zona hambat bakteri yang kuat kecuali KZ. Setelah dilakukan penyimpanan pada suhu 40oC, terjadi penurunan zona hambat pada KE dan Ekstrak 10%+ZAL sebesar 100% dan 36,81%. Hal yang menarik terjadi pada Esktrak 15%+ZAL dan 30%+ZAL, yakni terjadi kenaikan zona hambat sebesar 35,20 % dan 31,32%. Hasil uji statistik menunjukkan nilai Asymp. Sig (0,016) < nilai p (0,01) maka H0 ditolak sehingga dilakukan uji lanjut Tukey yang menunjukkan terjadi perbedaan yang signifikan antar kelompok uji. Dari penjelasan tersebut maka dapat disimpulkan bahwa ZAL mampu meningkatkan kinerja sediaan salep ekstrak buah mengkudu terutama pada konsentrasi 15% dan 30% dalam menghambat bakteri Staphylococcus aureus sehingga sediaan salep esktrak buah mengkudu kombinasi ZAL dapat digunakan sebagai alternatif obat pengganti obat sintetik kimiawi. Kata kunci : Zeolit, Salep, M.citrifolia L, Staphylococcus aureus ABSTRACT Noni extract ointment has been proven to be antibacterial, but plant extracts are generally very easily degraded by pH, light and temperature, therefore the use of Lampung Natural Zeolite (ZAL) with its special morphological structure is expected to be able to maintain the stability of ointment preparations to high temperatures. This study aims to determine the potential of ZAL as a stabilizer for ointment preparations by calculating the change in the percentage of bacterial inhibition zones in ointment preparations before and after storage at 40oC. This study includes three main stages, namely the first formulation of noni extracts from Lampung Natural Zeolite extract (ZAL) with variations in extract concentration of 10% + ZAL, 15% + ZAL, 30% + ZAL, KZ (Zeolite control without extract) and KE (Control Extract without zeolite) which then evaluated the ointment preparation. The second stage of all samples was tested for antibacterial activity against Staphylococcus aureus bacteria in ointment preparations, and the third stage all samples were stored at 40oC for 24 hours, then tested for antibacterial activity against Staphylococcus aureus. The results showed that all samples before storage at 40oC showed a strong inhibitory zone response except KZ. After storage at 40oC, there was a decrease in inhibition zones at KE and Extract 10% + ZAL by 100% and 36.81%. An interesting thing happened at the Extract 15% + ZAL and 30% + ZAL, namely an increase in inhibition zones of 35.20% and 31.32%. Statistical test results indicate the Asymp value. Sig (0.016) >p value (0.01) then H0 is accepted, so Tukey's further tests show that there are significant differences between the test groups. From this explanation it can be concluded that ZAL can improve the performance of noni fruit extract ointment especially at concentrations of 15% and 30% in inhibiting Staphylococcus aureus bacteria so that the ZAL noni extract extract can be used as an alternative drug for chemical synthetic drugs. Keywords : Zeolite, Ointment, M.citrifolia L, Staphylococcus aureus

Uji Formulasi Sediaan Salep Ekstrak Batang Brotowali (Tinospora Crispa L. Miers ) Kombinasi Zeolit Terhadap Bakteri Staphylococcus Aureus dan Pseudomonas Aeruginosa Laila Susanti; Subur Widodo; Syaiful Bahri; Wenny Indriasari
Inovasi Pembangunan : Jurnal Kelitbangan Vol 4 No 03 (2016): November 2016
Publisher : Balitbangda Provinsi Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.591 KB)

Treatment of infected wounds on the skin generally use synthetic chemicals, which when used in the long term lead to negative side effects. Development of herbal medicines have been done as an alternative to synthetic chemicals because of cheap and has no side effects and low toxicity. From this background, the test formulation extract ointment preparation brotowali (Tinospora crispa L. Miers) a combination of zeolite against Staphylococcus aureus and Pseudomonas aeruginosa in vitro. This study aims to get the best formulation of the extract ointment preparation brotowali (Tinospora crispa L. Miers) which has an antibacterial effect against Staphylococcus aureus and Pseudomonas aeruginosa. In this study, the method used discs to observe the growth of bacteria by doing two to three treatments. P1 was the treatment group were given a salve on the market, namely the ointment Gentamicin as a positive control, P2 is the treatment group were given an ointment containing extract brotowali combination of zeolite with base oils, P3 is the treatment group were given ointment without extract brotowali oily base as a negative control. From the research results generated extract ointment brotowali with base oils produced are bactericidal and active substance formulations extract brotowali combination of zeolite that is at 9%v/v.

UJI KADAR NITRIT PADA DAGING BURGER DI KOTA BANDAR LAMPUNG MENGGUNAKAN SPEKTROFOTOMETRI UV-VIS Laila Susanti; Merinda Setyowati; Subur Widodo; Anita Setiawati
JFL : Jurnal Farmasi Lampung Vol. 7 No. 1 (2018): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v7i1.38

Daging merupakan salah satu sumber makanan yang berasal dari hewani dan memiliki cita rasa yang khas serta kandungan gizi yang tinggi. Dari berbagai cara pengolahan daging, daging burger merupakan salah satu produk olahan yang banyak dikonsumsi masyarakat. Sebagai bahan pengawet pada daging burger digunakan nitrit, untuk memperpanjang waktu simpan. Tujuan dari penelitian ini adalah untuk mengetahui kadar nitrit pada daging burger dengan menggunakan Spektrofotometri Uv-Vis. Sebagai pelarut digunakan asam sulfanilat bereaksi dengan asam nitrit membentuk garam diazonium kemudian ditambah pelarut naftilamin membentuk senyawa azo yang berwarna ungu, lalu diukur absorbansinya pada panjang gelombang 531 nm. Hasil penelitian menunjukan kadar rata-rata nitrit pada masing- masing sampel A ,B, C, D, E, F secara berurutan adalah 123,95 mg/kg, 30,14 mg/kg, 195,25 mg/kg, 105,74 mg/kg, 20,85 mg/kg dan 16,14 mg/kg. Dari ke enam sampel, ada 4 sampel yang memiliki kandungan nitrit melebihi ambang batas maksimum penggunaan bahan pengawet pada makanan menurut Peraturan Kepala BPOM RI Nomor 36 Tahun 2013 yaitu sebesar 30 mg/kg untuk produk daging olahan. Hanya sampel C yang memiliki kadar nitrit melebihi batas maksimum persyaratan berdasarkan Permenkes Nomor 1168/Menkes/Per/X/1999, yaitu 125 mg/kg. Kata Kunci : Daging burger, Nitrit, Spektrofotometri UV-Vis

Optimasi Zeolit Alam Lampung (ZAL) Sebagai Penstabil Sediaan Antibakteri Esktrak Buah Mengkudu (Morinda citrifolia L.) Laila Susanti; Lilik Koernia Wahidah; Pratika Viogenta
JFL : Jurnal Farmasi Lampung Vol. 7 No. 2 (2018): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Noni fruit extract has been widely known as an antibacterial, but plant extracts are easily degraded by light, pH and temperature, thus reducing the antibacterial activity, zeolite is added to maintain the stability of the noni extract. This study uses an experimental method that is by comparing the inhibition zones that occur between noni fruit extract and noni + ZAL fruit extract and to test the stability of the preparation, the sample is heated at 40oC and then tested for antibacterial activity again. The statistical test results show the value of Asymp. Sig (0.003)

ANALISIS BIOAUTOGRAFI DAN KARAKTERISASI DENGAN FTIR PADA FRAKSI DAUN LABU SIAM (Sechium edule (jacq).SW) TERHADAP Porphyromonas gingivalis DAN Streptococcus mutans Laila Susanti; Isbiyantoro Isbiyantoro; Septiana Simanjuntak
JFL : Jurnal Farmasi Lampung Vol. 8 No. 1 (2019): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Siamese pumpkin leaves are one of the plants that have antibacterial properties. Compounds that act as antibacterial are flavonoite, tannin, triterpenes, alkaloids, and saponins. The aim of this study was to prove the antibacterial activity of ethanol hexane and chloroform fraction of pumpkin siam leaves and characterize the functional groups of active compounds from pumpkin siam leaves (Sechium edule (jacq). SW) with FTIR spectrophotometers. The extraction process of Siamese Pumpkin leaves was carried out by maceration method using 70% ethanol. The extract was continued with the fractionation process with ethanol, n-hexane and chloroform solvents. Antibacterial activity testing using the well method with a concentration of 100%, positive control chlorhexidi and negative control aquadst. The compound content test used the Thin Layer Chromatography (TLC) method with the stationary phase using silica plate G60 F254 and comparison of the mobile phase of chloroform: methanol: water (2: 5: 3) (v / v). Bioautography test using the contact method, namely the elution TLC plate, was placed on the NA medium containing a bacterial suspension for 3 hours. Antibacterial test results The largest ethanol fraction of pumpkin leaves was at a concentration of 100% with a diameter of inhibition zone of 11.49 mm on P. gingivalis while 16.04 mm in S. mutans. The results of TLC showed the presence of flavonoids with a price of Rf 0.47 and tannin with a price of Rf 0.84. Bioautography results showed a inhibition zone with a price of Rf 0.49 in the bacteria P. gingivalis and S. mutans which are flavonoid compounds. Characterization by FTIR spectrophotometer O-H phenol, C = C aromatic, C-O-C ether, aromatic C-H functional group Keywords: (Sechium edule (jacq) .SW). Porphyromonas Gingivalis, Streptococcus mutans, TLC, Bioautography and FTIR

Ethanol Fraction of Corn Silk (Zea mays L.) to Decrease Uric Acid Levels in Male White Mice Laila Susanti
JFL : Jurnal Farmasi Lampung Vol. 8 No. 2 (2019): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v8i2.145

Corn silk (Zea mayz L.) were empirically used by the community in some regions as traditional remedies for hypertension,kidney stones,diabetes mellitus, urinary tractinfections and gout. This study aimed to determine the effect of corn silk ethanol fraction on decrease uric acid levels in male white mice.corn silk were extracted by macerate used 70% ethanol for 4 days.Urin acid test was performed on male mice induced by beef liver for 7 days.25 mice were grouped into 5 groups, groups dose I, II and III weregiven a fraction at a dose of 27.5 mg / bwBB, 55 mg / bwBB and 110 mg / bwBB, control given Na.CMC 0.5% and as positive controls were given allopurinol dose of 13 mg / bwBB. The five groups were treated orally 1 time a day for 7 days. Decreased uric acid levels were measured and observed on days 7 using an acid (easy touch). The results of ANOVA statistical analysis showed that negative controls gave a significant difference with positive controls, dose I, II and III because the sig value was

Co-Authors Abdiyati, Santi Asfiyatul Affiana, Maulidya Nur Ananta, Nadia Diaz Anita Setiawati Aprilia, Linda Ayu Resa Aulia Agustina, Aulia Cindya Alfi Dyah Rahmawati Fauzi, Fariha Qalbi Ilmillahi Hartono, Adityo Isbiyantoro Isbiyantoro Isbiyantoro Kholida, Nilna Maya Latifah Megasari Latifah Megasari Lilik Koernia Wahidah Luthfiyah, Yosi M. Wahyu Ariawan Mashuri Yusuf Meidaliyantisyah Meidaliyantisyah Merinda Setyowati Mulia, Niken Ayu Dewanti Mulia, Wanda Natasya Dewanti Munadhah, Ummu Khusna Pratiwi, Inda Putri, Alvina Adelia qurrota aini Rahmania, Nayla Rahmawati, Dyah Retno Fardila Sari Riyanti, Deski Rokiban, Akhmad Sa'adah, Isnawaitus Safitri, Andika Samsuar Samsuar Samsuar Samsuar User Samsuar, Samsuar Septiana Simanjuntak Siti Nurjanah Siti Nurjanah Sivitha, Sivitha Suhartina Suhartina, Suhartina Syaiful Bahri Viogenta, Pratika Wenny Indriasari Widiyastuti, Asih Widodo, Subur Yuli Evadianti, Yuli Yuli Wahyu Tri Mulyani Yuli Wahyu Tri Mulyani

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