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All Journal Jurnal Pengabdian kepada Masyarakat Nusantara Narra J Jurnal Riset Ilmiah
Tofrizal, Alimuddin
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Exploring the promising therapeutic benefits of iodine and radioiodine in breast cancer cell lines Elliyanti, Aisyah; Hafizhah, Nurul; Salsabila, Dhianisa; Susilo, Veronica Y.; Setiyowati, Sri; Tofrizal, Alimuddin; Kurniawati, Yulia; Irrahmah, Miftah
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1078

Abstract

Iodine has an anti-proliferative effect on cancer cells; however, its effects have not been explored adequately. The aim of this study was to evaluate the therapeutic potential of iodine and radioiodine by assessing their effects on the viability of various breast cancer cell lines: MCF7, SKBR3, and MDA-MB231. The viability of cells was measured in treated cells exposed to six doses of iodine (5, 10, 20, 40, 60, 80 µM) and two doses of radioiodine (3.7×104 and 3.7×105 Bq). A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and modified clonogenic assays were used to assess cell viability. Exposure to 80 µM of iodine significantly reduced the viability of all cell types. The cells were then exposed to a 50% inhibitory concentration (IC50) dose. When the cells were exposed to the IC50 dose of iodine, the MCF7 cell viability was reduced by 42.6±0.14% (IC50 dose 12.88 µM), 40.2±0.08% for SKBR3 (IC50 dose 11.03 µM) and 47.0±0.02% for MDA-MB231 (IC50 dose 14.09 µM). All cells were also exposed to 3.7×104 Bq and 3.7×105 Bq radioiodine. Both doses significantly reduced the cell viability of MCF7 and SKBR3 cells compared to the unexposed control cells (all had p<0.05), while MDA-MB231 cell viability only reduced significantly after 3.7×105 Bq of radioiodine exposure compared to the unexposed control cells (p<0.05). This study highlighted that iodine had a toxic effect on breast cancer cells, and radioiodine enhanced the toxicity to breast cancer cells. The types of cancer cells and doses of iodine and radioiodine influenced the effect. These findings suggest that iodine and radioiodine hold promise as therapeutic agents for breast cancer, similar to their established use in thyroid disease treatment. However, further in vivo studies are important to provide more evidence.
Deteksi Dini Risiko Metabolik melalui Skrining pada Ibu PKK Kampung Wisata Bukit Nobita Maliza, Rita; Santoso, Putra; Nofrita, Nofrita; Idris, Muhammad; Novarino, Wilson; Janra, Muhammad Nazri; Pratama Elisa, Tasya Putri; Ashrifurrahman, Ashrifurrahman; Sinurat, Arthauly Yopita; Tofrizal, Alimuddin; Arya, Bramadi; Yerizel, Eti
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 6 No. 2 (2025): Jurnal Pengabdian kepada Masyarakat Nusantara Edisi April - Juni
Publisher : Lembaga Dongan Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55338/jpkmn.v6i2.6174

Abstract

Penyakit tidak menular seperti diabetes melitus, hiperkolesterolemia, dan hiperurisemia merupakan tantangan utama kesehatan masyarakat di Indonesia, terutama karena rendahnya deteksi dini di tingkat komunitas. Pengabdian masyarakat ini bertujuan mendeskripsikan hasil deteksi dini risiko penyakit metabolik melalui skrining gula darah, kolesterol, dan asam urat pada Ibu PKK di Kampung Wisata Bukit Nobita, serta memberikan rekomendasi upaya promotif dan preventif. Kegiatan dilakukan melalui observasi, koordinasi, penyuluhan, dan pemeriksaan kesehatan pada 15 anggota PKK, dilanjutkan evaluasi pengetahuan dan kepuasan peserta. Hasil menunjukkan mayoritas peserta memiliki lingkar pinggang di atas normal, kadar gula darah, kolesterol, dan asam urat melebihi batas normal, serta beberapa kasus tekanan darah tinggi, yang menandakan tingginya risiko sindrom metabolik di komunitas ini. Kegiatan ini meningkatkan pengetahuan peserta tentang status kesehatan dan pentingnya perubahan gaya hidup sehat. Temuan ini menegaskan perlunya skrining rutin dan edukasi berkelanjutan di komunitas, serta kolaborasi dengan fasilitas kesehatan untuk menurunkan risiko penyakit tidak menular. Hasil pengabdian ini penting sebagai dasar intervensi kesehatan masyarakat berbasis komunitas di masa mendatang.
PENGARUH PEMBERIAN PARE (MOMORDICA CHARANTIA) TERHADAP PERUBAHAN HISTOPATOLOGIS PADA USUS TIKUS YANG TERINFEKSI ESCHERICHIA COLI Putri, Sabrina Herfika; Tofrizal, Alimuddin; Sy, Elmatris; Asri, Aswiyanti; Rita, Rauza Sukma; Putra, Syandrez Prima
SINERGI : Jurnal Riset Ilmiah Vol. 3 No. 4 (2026): SINERGI : Jurnal Riset Ilmiah, April 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v3i4.2469

Abstract

Bitter melon (Momordica charantia) has been empirically proven for antimicrobial properties that can be used as an alternative medicine, while the changes that occur in Escherichia coli-infected mouse intestine after administering bitter melon have not been widely studied. The aim of this study was to determine the effect of Momordica charantia administration on histopathology of intestine of E. coli infected mice. This research was post-test control randomized group study involving 20 mice’s small intestine paraffin blocks which were divided into 4 groups consisted of control and different dosage of bitter melon juice, observed subsequently under a microscope to measure the of the small intestine lining and assess inflammation using modified Barthel Mandja scoring. This study found significant changes the height of mucosa and villi of mice small intestine after administration of 100 grams of bitter melon juice and the muscle layer and crypts after administration of 200 grams of bitter melon juice. The Barthel Manja score showed decrease of inflammation degree among P2 group, while increased inflammation degree found in P3 group. It can be concluded that administration of bitter melon juice has the potential to improve the intestinal histopathology of mice infected with Escherichia coli.
Co-Authors Aisyah Elliyanti Ashrifurrahman, Ashrifurrahman Aswiyanti Asri Bramadi Arya Elmatris Sy Eti Yerizel Hafizhah, Nurul Irrahmah, Miftah Janra, Muhammad Nazri Maliza, Rita Muhammad Idris Nofrita Nofrita Pratama Elisa, Tasya Putri Putra Santoso Putri, Sabrina Herfika Raden Mohamad Herdian Bhakti Rauza Sukma Rita Salsabila, Dhianisa Sinurat, Arthauly Yopita Sri Setiyowati Susilo, Veronica Y. Syandrez Prima Putra Wilson Novarino