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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) PROFICIO: Jurnal Pengabdian Masyarakat Borneo Journal of Pharmacy
Prasetya, Rahmad Aji
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Social Sciences Other

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In Vitro Evaluation of Cholesterol-Reducing Ability of Chitosan from Mangrove Crab (Scylla serrata) Shell Solid Dispersion using PVP K-30 as a Carrier: Uji In Vitro Penurunan Kadar Kolesterol Sistem Dispersi Padat Kitosan dari Cangkang Kepiting Bakau (Scylla serrata) Menggunakan PVP K-30 Sebagai Pembawa Imtihani, Hilya Nur; Permatasari, Silfiana Nisa; Prasetya, Rahmad Aji
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 2 (2021): (October 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i2.15597

Abstract

Background: Chitosan is a compound that can be synthesized from nature which can reduce the total serum cholesterol levels between 5.8−42.6% and decrease LDL (Low-Density Lipoprotein) between 15.1-35.1%. One of the natural resources containing chitosan derivative compounds is the shell of mud crab. Chitosan is insoluble in water but soluble in acidic solutions such as acetic acid. With such chitosan solubility, it is necessary to increase the solubility by making a solid dispersion system so that drug absorption can be faster. Objectives: The aims of this study is to determine the potential of chitosan solid dispersion system for reducing cholesterol. Material and Methods: The reduction of cholesterol levels was carried out by in vitro tests using UV-Vis spectrophotometer at a wavelength of 405 nm with Lieberman-Burchad reagent. The positive control used was simvastatin. There are 4 formulas, namely SD1, PM1, SD2, and PM2. This solid dispersion system uses polyvinyl pyrrolidone K-30 (PVP K-30) as carrier. Results: The characterization of chitosan has fulfilled all the characterization requirements that is organoleptic (shape and color) was creamy white, moisture content was 2.15%, ash content was 1.14%, ninhydrin test was positive purple, and deacetylation degree was 70.57%. The results of in vitro evaluation were obtained a dark green solution. The reducing percentage in cholesterol levels are SD1: 18.44%; PM1 : 18.11%; SD2 : 29.57%; and PM2 :12.01%. Simvastatin as a positive control has a percentage reduction in cholesterol levels of 30.07%. Conclusion: Chitosan has an activity as anticholesterol agent. SD2 (Solid Dispersion Chitosan: PVP K-30 = 1:2) has the higher percentage than other formulas for reducing cholesterol level comparable with the positive control.
Formulation and Evaluation of Soursop (Annona muricata) Leaf Extract Nanoemulgel Against Propionibacterium acnes Ikramina, Nabila; Rehana, Rehana; Prasetya, Rahmad Aji; Kurniawan, Dhadhang Wahyu
Borneo Journal of Pharmacy Vol. 7 No. 4 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i4.5977

Abstract

Annona muricata (soursop) leaves are rich in antimicrobial compounds such as flavonoids, alkaloids, tannins, saponins, and phenols. This study aimed to develop a nanoemulgel formulation incorporating A. muricata leaf ethanol extract to enhance its efficacy against Propionibacterium acnes, a bacterium associated with acne vulgaris. Four nanoemulgel formulations containing varying concentrations of the extract (0%, 0.5%, 0.7%, and 1%) were prepared and evaluated for their physical properties (organoleptic, homogeneity, pH, spreadability, and viscosity) and stability through freeze-thaw cycles. The formulation with the highest extract concentration (Formula III) was selected for further characterization (particle size, morphology, and zeta potential) and antimicrobial testing against P. acnes. All formulations met the established physical property and stability criteria. Formula III exhibited a particle size of 20.5 nm and a zeta potential of 9.8 mV, indicating a stable nanoemulsion with well-dispersed particles. Antimicrobial testing revealed that Formula III demonstrated a strong inhibitory effect against P. acnes, with an average inhibition zone of 19.00 mm. These findings suggest that A. muricata leaf extract-loaded nanoemulgel has the potential to be a promising topical formulation for acne treatment. Further research is warranted to optimize the formulation and evaluate its efficacy in clinical settings.
PENINGKATAN HIGIENITAS DAN KUALITAS PRODUK OLAHAN SUSU SAPI BAGI KELOMPOK MASYARAKAT DUSUN BRAU, KOTA BATU Wardana, Andika Pramudya; Suyatno; Taufikurohmah, Titik; Wikandari, Prima Retno; Ramadhania, Nurina Rizka; Prasetya, Rahmad Aji
Jurnal Pengabdian Masyarakat FKIP UTP Vol 7 No 1 (2026): PROFICIO : Jurnal Abdimas FKIP UTP
Publisher : FKIP UNIVERSITAS TUNAS PEMBANGUNAN SURAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36728/jpf.v7i1.5689

Abstract

Dusun Brau di Kota Batu, Jawa Timur, merupakan salah satu sentra produksi susu sapi yang menghadapi tantangan dalam pengolahan produk turunan seperti keju, terutama pada aspek higienitas dan kualitas produk. Permasalahan utama terletak pada keterbatasan pengetahuan masyarakat mengenai sanitasi pangan dan standar mutu berdasarkan Standar Nasional Indonesia (SNI 8896:2020). Untuk itu diberikan pelatihan partisipatif yang dirancang melalui pemaparan teori, praktik langsung pembuatan keju, pengemasan, pelabelan, serta penyusunan rencana bisnis. Evaluasi dilakukan dengan membandingkan nilai prates dan pascates 13 peserta menggunakan analisis statistik (Shapiro-Wilk dan Wilcoxon). Hasil menunjukkan adanya peningkatan skor rata-rata dari 70,77 (prates) menjadi 83,08 (pascates), meskipun secara statistik tidak signifikan (p=0,2656). Meskipun demikian, peserta menunjukkan peningkatan pemahaman dalam penerapan prinsip higienitas, sanitasi produksi, serta pemenuhan standar mutu produk olahan susu. Temuan ini menegaskan bahwa pelatihan aplikatif dan partisipatif mampu meningkatkan keterampilan teknis maupun kesadaran kualitas, sehingga mendukung peningkatan daya saing produk olahan susu sapi di tingkat lokal maupun nasional.
Co-Authors Dhadhang Wahyu Kurniawan Ikramina, Nabila Imtihani, Hilya Nur Permatasari, Silfiana Nisa Prima Retno Wikandari Ramadhania, Nurina Rizka Rehana, Rehana SUYATNO Titik Taufikurohmah Wardana, Andika Pramudya