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Handini, Mitra
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Journal : Muhammadiyah Medical Journal

 1 
Protective Effect of Combination Black Seed Oil (Nigella sativa) and Honey on the Duodenum of Rats Exposed to Cisplatin Wasilah, Khusnul; Ilmiawan, Muhammad In’am; Handini, Mitra
Muhammadiyah Medical Journal Vol 4, No 1 (2023): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.4.1.8-14

Abstract

Background: Cisplatin (CP) is an anticancer agent with various side effects, including duodenal mucosal damage. It is well known that black seed oil (BSO) and honey (H) are rich in antioxidants and have a mucosal protective effect. Purposes: To determine the protective effect of the BSO and H combination on the histopathology of duodenal rats given CP exposure. Methods: Randomized post-test-only control group design was used in this study. A total of 30 rats were divided into ten groups, namely the control group (K), treatment groups (P1-P8), and cisplatin group (C). The treatment groups were given BSO and H orally for 21 days, and CP was given intraperitoneally on day 18 to the treatment and cisplatin groups. On day 22, the duodenal tissue was taken for preparation and histopathological assessment. Data analysis using IBM SPSS v.24 and Compusyn program. Result: There were significant differences in the duodenal mucosa damage scores of the P1-P8 group compared to the C group (p0.05). The combination index of P7 exerted a synergism effect (CI 1). Conclusion: The combination of BSO and H exerted a protective effect on the histopathological of rats’ duodenal tissue induced with CP, and the combination of BSO 2 mL/KgBW and H 3.7 mL/KgBW exerted a synergism effect.
Protective Effect of Combination Commercial Black Seed Oil (Nigella sativa) and Honey Against Cisplatin-Induced Hepatotoxicity in Rats Siddiq, Andri Muhrim; Ilmiawan, Muhammad In'am; Handini, Mitra
Muhammadiyah Medical Journal Vol 1, No 2 (2020): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (568.669 KB) | DOI: 10.24853/mmj.1.2.43-48

Abstract

Background: The chemotherapeutic use of cisplatin (CP) is restricted because of its hepatotoxicity induced by oxidative stress. Malondialdehyde (MDA) is a secondary product of lipid peroxidation as a biomarker of oxidative stress. Individual administration of black seed oil (BSO) or honey (H) demonstrated hepatoprotective effect in rats. Interaction of both substances when administrated as combination can be evaluated using combination index (CI) to quantitatively depict synergism (CI1), additive (CI=1) and antagonism effect (CI1). Objective: to know the combination effect of BSO and honey on rat liver tissue given CP exposure. Methods: This study used 30 rats were divided into 10 groups. Normal group (N); Negative control group (NC); P1-P4 groups were administerated BSO (1 and 2 mL/kg) and honey (3.7 and 7.4 mL/kg); P5-P8 groups were combination of BSO and H. P1-P8 groups were given BSO and honey orally for 21 days. On the 18th day, NC and P1-P8 groups were given CP 8 mg/kg intraperitoneally, while the N group was given NaCl 0.9% 1 mL/kg intraperitoneally. Result: Malondialdehyde (MDA) levels were found to be lower in P1-P8 groups compared to negative control group and P6 and P7 groups have levels equivalent to MDA levels of normal control group (p 0.05). Conclusion: Combination of BSO and honey provides a protective effect on cisplatin-induced rat liver tissue damage indicated by reduced MDA levels, but all combination group showed antagonism effect.
Co-Authors ., Nevita Abror Irsan Agustina Arundina Triharja Tejoyuwono, Agustina Arundina Triharja Alex Alex Desni Yuniarni Ery Hermawati Febrianti, Fatayatun Nur Ilmiawan, Muhammad In'am Ilmiawan, Muhammad In’am Mahyarudin, Mahyarudin Nashruddin, Raisah Hulaimah Nurfarihah, Eva Pasaribu, Putri Sondang Putranda, Muhammad Afia Akbar Ramadhina, Saffana Fadhilla Safitri, Maisara Sejati, Makmur Siddiq, Andri Muhrim Uswatun Hasanah Wasilah, Khusnul