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All Journal Medicinus : Jurnal Kedokteran Majalah Patologi Indonesia
Tjahjadi, Hartono
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Health Professions Medicine & Pharmacology Public Health

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Profil Klinikopatologik Metastasis Kelenjar Getah Bening pada Karsinoma Ovarium di Departemen Patologi Anatomik FKUI/RSCM 2016-2018 Hayati, Amal; Tjahjadi, Hartono
Majalah Patologi Indonesia Vol. 32 No. 1, Januari 2023
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v32i1.569

Abstract

Background Ovarian cancer is one of the most common malignancies in women. In Indonesia, this incidence is the third highest after breast and cervical cancer. The prognosis for ovarian carcinoma is generally poor. Ovarian cancer patients have low survival rate since most of them diagnosed at advanced stage. The tumor spread to retroperitoneum lymph nodes is important to evaluate considering that metastasis to lymph nodes will upstage the tumor to stage III. Tumor histological type, grade and CA 125 serum level considered as risk factors for lymph node metastases. Methods This study was a cross-sectional descriptive study to determine the profile of lymph node metastases in ovarian carcinoma at the Anatomical Pathology Department FKUI-RSCM for 3 years. The assessment criteria included demographic, clinical, and histopathological features of tumor mass and retroperitoneum lymph nodes. Results Analysis of demographic data in 54 cases of ovarian carcinoma found 47 patients (87%) aged ≥40 years. Unilateral tumors found in 42 cases (77.8%) and bilateral tumors found in 12 cases (22.2%). Patients generally diagnosed at stage III as many as 17 cases (31.4%). Elevated levels of tumor marker CA 125 (≥35 u/ml) found in 41 cases (76%). A total of 19 cases of ovarian carcinoma had spread to lymph nodes, with 8 cases (42%) of which were serous carcinomas. Lymph node metastases found in 16 cases (80%) of high-grade ovarian carcinoma and 12 cases (60%) of advance-staged tumors. Macrometastatic tumor deposit patterns found in 180 lymph nodes and micrometastases found in 10 lymph nodes. Two subjects diagnosed for lymph node metastases only from micrometastasis deposit in lymph nodes. Conclusion Lymph node metastases in ovarian carcinoma are more frequently found in serous carcinoma, high grade carcinoma, and cases with elevated CA125 serum level. Lymph nodes evaluation should be conducted carefully to detect micrometastasis deposit.
The Profile of P63 Expression and Epstein-Barr-Encoded RNA (EBER) Distribution in Primary Central Nervous System Lymphoma: A Retrospective Bi-Center Study Kristiani, Erna; Marisca, Stephanie; Suharyani, Sally; Dermawan, Kevin; Widodo, Stephanie T.; Ham, Maria F.; Harahap, Agnes S.; Susanto, Eka; Tjahjadi, Hartono; July, Julius
Medicinus Vol. 14 No. 2 (2025): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v14i2.9545

Abstract

Background : Primary central nervous system lymphoma (PCNSL) is a type of lymphoma occurring around 0.5 – 1.2% of all intracranial neoplasms. However, recent epidemiological research shows a threefold increase in the number of cases. The Epstein-Barr virus (EBV) and PCNSL are both associated with the condition of immunosuppression or immunodeficiency, which often found to have a significant relationship with each other. Moreover, the TP63 mutation is associated with a poor prognosis. Methods : This is a descriptive study to assess the expression of TP63 and EBER on PCNSL, and present the characteristics of the disease. The study was conducted on 25 cases from two health centers with the most cases of brain tumors in Indonesia, Siloam Hospital Lippo Village and Cipto Mangunkusumo Hospital (CMH) from 2014 to 2018, the P63 expression and EBER-1 examinations were done by 4 pathologists. A total of 25 patients, 13 (52%) patients were male, ranging from age 30 – 79, with average 57,6 years old, located mostly in the frontal lobe in 8 patients (30.9%). Result : From the research results obtained positive P63 results in 20 cases (80%), while the EBER test was negative for all 25 patients. Further analysis with software SPSS 25 proving that P63 expression is not associated with germinal center B-cell type (GCB) or non-GCB type (p-value 0,87). Neither, P63 have any association with Ki67 with p-value of 1.00. Conclusions : This study concludes that there is a possibility that PCNSL cases in Indonesia are not associated with Epstein-Barr virus infection, but most of the cases will have a poor prognosis as indicated by P63 expression.
Profil Klinikopatologik Karsinoma Payudara Invasif Metastasis Jauh di Departemen Patologi Anatomik FKUI/RSCM Tahun 2019 Kurnianingrum, Laurencia Leny; Tjahjadi, Hartono
Majalah Patologi Indonesia Vol. 31 No. 1, Januari 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i1.489

Abstract

BackgroundInvasive breast carcinoma (IBC) is the highest incidence and is the leading cause of malignancy-related death in women in theworld. Bones are the most common sites of IBC metastases. This study aims to provide clinical and histological characteristic datain cases of distant metastastic IBC in the Anatomical Pathology Department, Faculty of Medicine, Universitas Indonesia, Dr. CiptoMangunkusumo General Hospital (PA-FKUI/RSCM).MethodsThis is descriptive research with cross-sectional design, using secondary data from the archives of PA-FKUI/RSCM, starting fromJanuary 1, 2019 to December 31, 2019.ResultsDistant metastases of IBC was found 65.2% as bone metastases, 46.1% as pulmonary metastases, 26.1% as liver metastases, and8.7% as brain metastases. The largest age group was 40-59 years, median age was 49 years with range 27-78 years. The mostcommon of the classification of primary tumor size was 54.8% T4, and 87% unilateral cases. Most histologic subtypes were 90.4%cases no special type, then lobular and mucinous subtypes. Lymphovascular invasion was 24.3% cases. The most commonmolecular subtype was luminal B Luminal and mostly as bone metastases and triple negative breast cancer (TNBC) in lungmetastases. The greatest histological grade was grade 2.ConclusionBone was the most common IBC metastatic. The most common of the classification of primary tumor size was T4 and histologicsubtype was no special. Luminal B was the most common molecular subtypes and the highest was bone metastases.
Deteksi Mikrometastasis pada Bulky Kelenjar Getah Bening Karsinoma Serviks Stadium IA-IIB Menggunakan Sitokeratin AE1/AE3 Angeline, Reni; Tjahjadi, Hartono; Wuyung, Puspita Eka
Majalah Patologi Indonesia Vol. 29 No. 3, September 2020
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v29i3.441

Abstract

BackgroundCervical uterine carcinoma is a primary malignant disease of the uterine cervix. The presence or absence of metastasis in lymphnodes does not alter the stage but affects recurrence, survival, and therapy. Immunohistochemistry stains of the AE1/AE3cytokeratin can assist in the diagnosis and determine the small focus of carcinoma metastasis. In this study, we analyzedimmunohistochemistry cytokeratin AE1/AE3 could determine micrometastasis in bulky lymph nodes negative.MethodsThis study used cross-sectional design. The sample consisted of 52 cases of stage IA-IIB cervical carcinoma performed by radicalhysterectomy and lymphadenectomy accompanied by negative bulky lymph nodes at the Department of Anatomical PathologyFaculty of Medicine University of Indonesia/Cipto Mangunkusumo Hospital (FKUI/RSCM) from January 2011 to June 2017. Allcases stained by immunohistochemistry cytokeratin AE1/AE3.ResultsBulky Lymph Nodes Cervical Carcinoma stage IA-IIB, histopathologic diagnose of non keratinized squamous cell carcinoma,moderate differentiation degree, no lymphovascular invasion and deepest invasion >5.0 mm. Immunohistochemistry staining ofAE1/AE3 cytokeratin showed no micrometastasis in all cases.ConclusionThe immunohistochemistry staining of AE1/AE3 cytokeratin used in Bulky Lymph Nodes Cervical Carcinoma stage IA-IIB could notdetected micrometastasis in all cases.
Co-Authors Amal Hayati, Amal Angeline, Reni Dermawan, Kevin Harahap, Agnes S. Julius July Kristiani, Erna Kurnianingrum, Laurencia Leny Maria F. Ham Marisca, Stephanie Puspita Eka Wuyung Suharyani, Sally Susanto, Eka Widodo, Stephanie T.