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WORKSHOP FORMULATION OF LIQUID SOAP PREPARATIONS OF CITRUS LEAF EXTRACT PURUT (CITRUS HYSTRIX) AS AN ANTISEPTIC AGAINST STAPHYLOCOCCUS AUREUS BACTERIA: WORKSHOP FORMULATION OF LIQUID SOAP PREPARATIONS OF CITRUS LEAF EXTRACT PURUT (CITRUS HYSTRIX) AS AN ANTISEPTIC AGAINST STAPHYLOCOCCUS AUREUS BACTERIA pratiwi, asti; Siahaan, Safrika Juliana; Pranata, Chandra; Darmirani, Yosi
JURNAL PENGMAS KESTRA (JPK) Vol. 2 No. 2 (2022): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Kaffir lime leaves contain compounds such as flavonoids, saponins, and tannins. Staphylococcus aureus is a pathogenic bacterium associated with virulence. Pharmaceutical preparations used to maintain healthy skin are soaps. The purpose of this study was to determine the inhibitory power of the Liquid Soap Preparation Formulation of Kaffir lime Leaf Extract as an Antiseptic Against Staphylococcus aureus Bacteria. The study was carried out by making ethanol extract of purut orange leaves formulated with liquid soap preparations, then an inhibitory test was carried out on Staphylococcus aureus bacteria that had been bred 3 times with concentrations of 20%, 40%, and 60% and positive and negative controls were carried out. The results of the analysis showed that the formulation of liquid soap preparations of ethanol extract of purut orange leaves with a concentration of 60% has the strongest power against the growth of Staphylococcus aureus bacteria. In conclusion, the concentration of the formulation of liquid soap preparations of ethanol extract of purut orange leaves is directly proportional to the magnitude of the diameter of the inhibitory zone.

Socialization of The Effectiveness Test of Antifungi Formulation of Garlic (Allium Sativum L.) Ethanol Extract Mouth on The Growth of Candida Albicans Pranata, Chandra; Darmirani, Yosi; Pratiwi, Asti; Sumitra, Jhoti
JURNAL PENGMAS KESTRA (JPK) Vol. 3 No. 2 (2023): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jpk.v3i2.1975

Garlic plants (Allium sativum L.) can be found in almost all parts of Indonesia, including in Lubuk Pakam, Deli Serdang. The content contained in the ethanol extract of garlic has various secondary metabolites with a role as an antifungal, namely tannins, saponins, flavonoids, and alkaloids. As utilization and information to the public that garlic ethanol extract is made into mouthwash formulations. This article reports on outreach activities to the people of Lubuk Pakam, to be precise in Lubuk Pakam Pekan sub-district about the potential use of natural garlic mouthwash formulations. Testing the antifungal activity of mouthwash preparations was produced by showing the average diameter of inhibition in the form of F1 (12.3 mm), F2 (17.3 mm), F3 (18.5 mm) and F4 (21.6 mm). This means that the higher the concentration, the better the inhibition of garlic ethanol extract in inhibiting fungal growth.

FORMULASI SEDIAAN LOTION EKSTRAK ETANOL BIJI KOPI ROBUSTA (Coffea cenephora) Wati, Erda; cahya, uci dwi; Darmirani, Yosi
Jurnal FARMASIMED (JFM) Vol 3 No 2 (2021): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i2.570

Bean robusta coffee contains polyphenol compounds which are useful as antioxidants. Antioxidants can inactivate the development of oxidation reactions, by preventing the formation of free radicals. Robusta coffee bean plant (Coffea canephora) is an ingredient that can be formulated into lotion preparations. Cosmetic lotion aims to remove dead skin cells, brighten the skin and soften the skin. This research is to make lotion preparations from robusta coffee bean extract (Coffea Canephora) . This research uses pure experiment. Robusta coffee beans are extracted by maceration process. The lotion formulation is made with variations of robusta coffee bean powder (Coffea Canephora) with a concentration of 2%, 3%, and 4%. The characteristic test includes organoleptic test, homogeneity test, Ph test, and irritation test. The purpose of this study was to determine the lotion formulation for robusta coffee bean extract (Coffea Canephora). The results of the lotion test had a homogeneous concentration of 2%, 3% and 4%, light brown to blackish brown, with a distinctive smell of coffee. The ph lotion test had a PH of 5 in all formulations on the blank had a PH of 6. The irritation test on the lotion preparation showed no erythema and edema in 5 volunteers. From all the tests carried out, the lotion formulation has good characteristics.

UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN TALAS (Colococasia Esculenta L.) TERHADAP BAKTERI Escherichia coli Pranata, Chandra; Tarihoran, Sartika Noviani; Darmirani, Yosi
Jurnal FARMASIMED (JFM) Vol 4 No 1 (2021): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v4i1.793

Salah satu tanaman yang sering dijadikan obat adalah daun Talas (Colocasia esculanta L.). Daun talas memiliki kandungan senyawa flavonoid, alkaloid, saponin dan tannin yang memiliki kemampuan untuk menghambat pertumbuhan bakteri. Eschericia coli adalah salah satu jenis bakteri yang dapat menyebabkan infeksi pada pencernaan. Salah satu tujuan penelitian ini untuk mengetahui aktivitas antibakteri daun talas dengan konsentrasi yang paling efektif dalam menghambat bakteri Eschericia coli. Penelitian ini adalah penelitian eksperimental murni. Daun talas aktivitas antibakteri dilakukan dengan metode difusi cakram. Penelitian dilakukan dengan 3 variasi konsentrasi yang berbeda. Hasil penelitian menunjukkan bahwa ada aktivitas antibakteri pada setiap konsentrasi. Kesimpulan pemberian aktivitas daun talas dengan konsentrasi 15%, 25%, dan 35% memberikan daya hambat pertumbuhan bakteri paling efektif dengan kosentrasi 25%, 35% yang termasuk dalam kategori kuat. Saran diharapkan kepada peneliti selanjutnya dapat melakukan uji terhadap bakteri lain dan membuat formulasi dari ekstrak daun talas.

Implementation of Pharmaceutical Care or Hypertension Patients in Communty Health Center of Lubuk Pakamdeli Serdang Darmirani, Yosi; Dalimunthe, Aminah; Khairunnisa, Khairunnisa
Journal La Medihealtico Vol. 5 No. 3 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i3.1447

The objective of this research was to provide pharmaceutical care to patients with Hypertension and assess its effects on the occurrence of drug-related problems (DRPs), clinical outcomes, adherence levels, and quality of life of Hypertension patients at Puskesmas (Community Health Center) Lubuk Pakam. This research used a comparative experimental approach using a prospective cohort study design to assess the effects of an intervention on 73 individuals with Hypertension between March and August 2021. The PCNE V9.00 instrument was used to identify the occurrence of Drug-Related Problems (DRPs). Adherence level data was collected through the MMAS-8 questionnaire. Random blood glucose (RBG) data and Blood Pressure values were obtained by directly examining patients. The EQ-5D-3L questionnaire was used to gather data on the quality of life. The data were analyzed using the Wilcoxon Signed-Rank test and Friedman test in the SPSS V22.0 software. The findings indicated that the average occurrence of drug-related problems (DRPs) before to the intervention was 1.436 ± 0.502, however after the intervention, it decreased to 0.282 ± 0.456 (α <0.05). The mean blood pressure before to the intervention was 278.58 ± 75.278 mmHg, whereas after the intervention it decreased to 179.68 ± 14.008 mmHg (α <0.05). There was a substantial rise in the mean adherence score before to the intervention, from 5.00 ± 0.89 to 8.48 ± 0.77 (α<0.05). Similarly, the average quality of life score increased from 0.878 ± 0.176 to 1 ± 0.09 after the intervention (α<0.05).

The Impact of Pharmaceutical Care Implementation on The Incidence of Drug-Related Problem and Clinical Outcome of Hypertension Patients at Puskesmas Lubuk Pakam in 2021 Darmirani, Yosi; Dalimunthe, Aminah; Khairunnisa; Iksen
MPI (Media Pharmaceutica Indonesiana) Vol. 5 No. 1 (2023): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v5i1.5609

The role of pharmacists in the implementation of pharmaceutical care has been shown to improve the outcome of therapy in hypertension patients in various countries. This study aimed to implement pharmaceutical care for hypertension patients and determine its impact on the incidence of drug-related problems (DRPs) and clinical outcomes of hypertension patients in Puskesmas Lubuk Pakam. This study used a comparative experimental method before and after the intervention of 73 hypertension patients in March-August 2021. Identification of the of DRPs was using the PCNE V9.00 standard and blood pressure values were obtained from direct examination of patients. Data were analyzed using the Wilcoxon Signed-Rank test. The results showed that the average DRPs incidence was significantly reduced after the intervention (observation, interview, and education) on the hypertension patients. The average blood pressure before intervention was 154.38 ± 16.20 mmHg and after intervention became 144.04 ± 15.94 mmHg (p value = 0.000). Based on the results of the study, it can be concluded that the application of pharmaceutical care can reduce the incidence of DRPs and improve clinical outcomes in hypertension patients in Puskesmas Lubuk Pakam.

Test of the Anti-Inflammatory Effectiveness of Ethanol Extract of Cat's Whiskers Leaves (Orthisiphon Aristatus) on Paw Edema in Male Mice (Mus Musculus) Pranata, Chandra; Darmirani, Yosi; Limbing, Reida
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2289

Cat's whisker leaves contain secondary metabolite compounds, flavonoids and essential oils. The chemical compounds contained in cat's whisker leaves have antioxidant, antibacterial, anti-inflammatory and antifungal properties. Flavonoids are known to function as anti-inflammatories by inhibiting pro-inflammatory enzymes, namely by blocking cyclooxygenase or lipoxygenase, can influence cellular signaling pathways such as NF-kB which can inhibit the migration of inflammatory cells to areas of inflammation. Objective: to test the anti-inflammatory effectiveness of ethanol extract of cat's whisker leaves in-vivo. Method: Anti-inflammatory effectiveness testing was carried out on male mice (Mus musculus) by inducing edema on the soles of their feet using 0.1 ml of 1% carrageenan. This research was an experimental study with 5 treatments and 5 replications. The parameters observed were edema volume, edema percentage, and edema inhibition percentage. Edema volume measurements were taken every 60 minutes for 6 hours. The results of measuring the volume of edema were used to calculate the percentage of edema, which was then used to calculate the percentage of edema inhibition. Data on the percentage of edema inhibition were statistically analyzed using the One Way ANOVA test. Result: the results of statistical tests showed significant differences in data on the percentage of edema inhibition and the percentage of edema between treatment groups showing p<0.05. From the results of the percentage of edema inhibition, it shows that cat's whisker leaf extract with a concentration of 15% has the best anti-inflammatory effect, namely inhibition of 88.42% is the concentration with the optimum dose.

Socialization of the Benefits of Cat's Whiskers Leaf Extract (Orthisiphon Aristatus) in Healing Wounds Pranata, Chandra; Darmirani, Yosi
JURNAL PENGMAS KESTRA (JPK) Vol. 4 No. 2 (2024): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jpk.v4i2.2431

Inflammation or wounds are a response to disruption of body tissue due to physical, chemical, or biological factors. Wounds often occur in the layers of the skin, muscles, tissues, and organs of the body. Wounds cause various conditions such as pain, bleeding, and swelling. Cat's whiskers leaves contain flavonoid, polyphenol, and terpenoid compounds that can be useful as antioxidants, antibacterials, and anti-wound agents. The purpose of this socialization is to increase public knowledge about plants around them that can be used for health, such as treating wounds using cat's whiskers leaves. The Community Service activity was carried out through a socialization attended by 25 participants who were residents around the Lubuk Pakam sub-district. The material that was socialized was about the benefits of cat's whiskers leaves in healing wounds, chemical compound content, and the process of extracting cat's whiskers leaves. The level of knowledge of participants was measured based on the pre-test and post-test scores filled in by the Community Service participants to assess the success of the implementation of this socialization activity. The results showed that cat's whiskers leaves can be used as an anti-wound medicine because they are rich in secondary metabolites such as flavonoids, polyphenols, and terpenoids. The process of extracting cat's whiskers leaves can be done through soaking or boiling techniques. After the PkM material was socialized, there was an increase in participant knowledge into the good and very good knowledge categories with percentages of 52% and 28% respectively, where previously knowledge was more dominant in the less and sufficient categories with percentages of 48% and 40%. This PkM activity provides benefits to the community in the form of new knowledge about the benefits of cat's whiskers leaves which can act as an anti-wound medicine.

Physics test of water in refill drinking water in Tanjung Morawa Sub-district, Deli Serdang District Prahesti, Ajeng; Darmirani, Yosi; Suprianto
Medistra Medical Journal (MMJ) Vol 2 No 2 (2025): Medistra Medical Journal (MMJ)
Publisher : Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/mmj.v2i2.2375

Introduction: Humans use water to fulfill various daily needs. Each individual's water needs vary from one location to another and at each level of demand. The higher the standard of living in a place, the greater the need for water. Objective: This study aims to examine the quality of water in several depots in Tanjung Morawa District. Method: The method used in this study is a gravimetric method in which the parameters measured determine the quality of water, namely TDS (Total Dissolved Solid) and TSS (Total Suspended Solid). Then measure the pH using a universal pH indicator, litmus paper and a pH meter. As well as the measurement of taste and turbidity. Result: The results of this study indicated that 8 out of 9 samples of TDS levels had levels higher than the maximum 2010 PERMENKES quality standard, namely 500 mg/L. TSS (Total Suspend Solid) is still lower when compared to the maximum standard content of refill drinking water stipulated by SNI (Indonesian National Standard) for clean water, which is 50 mg/L. The pH level is within normal limits, there is a sweet taste in drinking water and at turbidity levels clear drinking water has particles and is clear without particles.

Community Education on the Effects of Cigarette Smoke on Lung Tissue and the Preventive Role of Green Apple (Malus domestica) Juice Pranata, Chandra; Darmirani, Yosi; Pratiwi, Asti
JURNAL PENGMAS KESTRA (JPK) Vol. 5 No. 1 (2025): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/fm823d94

Cigarette smoke contains a large number of oxidants or free radicals, along with approximately 4,700 harmful chemical substances. An increase in free radical levels in the body can trigger the formation of Reactive Oxygen Species (ROS), which contributes to oxidative stress, especially when there is an imbalance between oxidants and antioxidants. During this process, oxygen (O?) may leak and convert into superoxide radicals (O??), which can stimulate The synthesis of pro-inflammatory mediators like interleukin-6 (IL-6). In this research aims To assess the impact of cigarette smoke exposure on the histological structure of lung tissue in laboratory rats. A Community Service Activity (PkM) involving 70 residents of Pantai Labu Subdistrict Aimed at promoting public awareness regarding the importance of adopting a safe and healthy lifestyle. During the activity, participants received education regarding The damaging influence of cigarette smoke on the body, particularly on, as well as potential of green apple juice as a natural alternative to support lung health. The educational materials included information on the safety and stability of green apple juice consumption, and the importance of maintaining an appropriate acidity level (pH) that aligns with lung health. Through pre-test and post-test assessments, there was a 50% and 30% increase in participants' knowledge, respectively, indicating that the program was effective in improving public understanding of the dangers of cigarette smoke on lung health. In addition, green apple juice was introduced as a promising natural alternative to support the histopathological repair of organs. The PkM team also encouraged the community to adopt a healthier lifestyle, be more selective, and remain cautious about exposure to cigarette smoke in their environment.

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