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All Journal MPI (Media Pharmaceutica Indonesiana) Jurnal Pendidikan Kimia (JPKim) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Indonesian Journal of Pharmaceutical and Clinical Research Community Development Journal: Jurnal Pengabdian Masyarakat Journal of Multidisciplinary Applied Natural Science Herbal Medicine Journal Borneo Journal of Pharmacy
Iksen, Iksen
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health

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In vitro test of antibacterial activity causing inhibition of wound healing from ethanol extract of nangka (Artocarpus heterophyllus, Lam.) leaf Esther Siringo-ringo; Indah Yani Tambunan; Mastiur Julianti Butar-butar; Kasta Gurning; Iksen Iksen
Jurnal Pendidikan Kimia (JPKIM) Vol 15, No 1 (2023): April
Publisher : Pascasarjana Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (426.442 KB) | DOI: 10.24114/jpkim.v15i1.42154

Abstract

Nangka (Artocarpus heterophyllus, Lam.)  is a plant that is rich in nutrients and contains phytochemicals that can be used in various fields, especially in the health sector. Traditionally, every part of this plant has been widely used for its anticarcinogenic, antimicrobial, antifungal, anti-inflammatory, wound healing, and hypoglycemic effects. Antibacterials are an important part of drug preparations to accelerate wound healing. Antibiotics inhibit the occurrence of infection and stimulate the process of forming fibroblast cells for wound closure. Bacteria that are often found in wounds and inhibit the acceleration of wound healing are Staphylococcus aureus and Escherichia coli. The purpose of this study was to test the activity of the ethanol extract of nangka leaf (Artocarpus heterophyllus, Lam.) in vitro on E. coli and S. aureus bacteria. The extraction method used was maceration with ethanol solvent and in vitro antibacterial activity testing using the paper disc method, as well as variations in extract concentrations, namely 12.5%, 25%, 50%, 75%, chloramphenicol as a positive control, and 5% DMSO as a negative control. The results showed that the ethanol extract contained various secondary metabolites, namely alkaloids, tannins, saponins, steroids/triterpenoids, and flavonoids. The ethanol extract of nangka leaf (Artocarpus heterophyllus, Lam.) has strong category potential as an antibacterial against E. coli and S. aureus.Keywords: Antibacterials; Escherichia coli; Nangka leaf; Staphylococcus aureus; Wound healing
Molecular docking analysis of six major compounds from sweet basil (Ocimum basilicum L.) extract as potential anti-hypertension therapy Bayu Cakra Buana; Iksen Iksen; Kasta Gurning
Jurnal Pendidikan Kimia (JPKIM) Vol 15, No 2 (2023): August
Publisher : Pascasarjana Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jpkim.v15i2.43617

Abstract

Hypertension is an abnormally high blood pressure condition that is the leading cause of preventable cardiovascular disease, chronic kidney disease, and cognitive impairment. In the case of hypertension, repressing the Angiotensin-Converting Enzyme (ACE) expression has been shown to be an effective method of controlling hypertension by inhibiting the conversion of angiotensin I to angiotensin II. Captopril is the most commonly used ACE inhibitor. It simultaneously inhibits the conversion of angiotensin I to the potent vasoconstrictor angiotensin II and the vasodilator peptide bradykinin. Sweet basil (Ocimum basilicum L.) on the other hand, is used in traditional Indian and Chinese medicine to treat a variety of diseases, including hypertension. The study aimed attempts to investigate the potency of 6 major compounds found in sweet basil (Ocimum basilicum L.) extract, as an anti-hypertension therapy. The analysis demonstrates that Ocimum basilicum L., extract is effective as an anti-hypertension therapy because it contains several compounds that may interact with ACE and inhibit its activity. The molecular docking analysis and drug-likeness prediction indicate that camphor could be a potential drug candidate because it does not violate the Lipinski rule, has a high Gastrointestinal (GI) absorption, a high affinity to interact with ACE, and a similar interaction site to the ACE-Captopril interaction.Keywords: ACE; Holly basil; Hypertension; Molecular docking
STUDI IN SILICO SENYAWA MINYAK ATSIRI KETUMBAR TERHADAP PROTEIN RNA-DEPENDENT RNA POLYMERASE (RdRp) COVID-19 Iksen; Emanrius Lase
Majalah Farmasi dan Farmakologi Vol. 27 No. 4 (2023): MFF SPECIAL ISSUE
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v27i4.30047

Abstract

COVID-19 adalah penyakit akibat infeksi virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).COVID-19 dapat menyebabkan gangguan sistem pernapasan, mulai dari gejala yang ringan seperti flu, hinggainfeksi paru-paru, seperti pneumonia. Sampai sekarang belum ditemukan pengobatan yang sesuai untukpenyakit COVID-19. Daun ketumbar (Coriander sativum L.) mengandung beberapa minyak atsiri yangdiprediksi dapat berfungsi sebagai antivirus. Tujuan penelitian ini adalah untuk mengetahui gambaraninteraksi secara in silico senyawa minyak atsiri dari daun ketumbar terhadap target protein RNA-dependentRNA polymerase (RdRp) pada virus COVID-19. Penelitian ini dilakukan dengan menggunakan software(perangkat lunak) Pyrx dan divisualisasikan dengan software Discovery Studio. Pengunduhan protein RdRPmelalui Protein Data Bank (PDB) dengan kode 6M71. Struktur dua dan tiga dimensi senaywa minyak atsiri dankontrol diunduh dengan menggunakan database PubChem. Hasil penelitian menunjukkan senyawa minyakatsiri daun ketumbar (Coriandrin) memiliki potensi interaksi terbaik antara ligan terhadap RdRp secara in silicodengan nilai energi -6.5 Kcal/mol. Pada penelitian ini dapat disimpulkan bahwa senyawa minyak atisiri daunketumbar mampu terhambat pada protein RdRp secara in silico sehingga berpotensi sebagain anti-COVID-19.
Phytochemical Screening and Anti-Hyperuricemia Activity Test In Vivo of Ethanolic Extract of Shallot (Allium cepa L.) Skin Syahrina Syahrina; Vivi Asfianti; Kasta Gurning; Iksen Iksen
Borneo Journal of Pharmacy Vol. 3 No. 3 (2020): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3i3.1365

Abstract

Uric acid is the final product of purine metabolism that will be excreted through urine, feces, and sweat. Excessive production of uric acid can cause hyperuricemia, known as gout. The skin of shallots (Allium cepa L.) is one of the household wastes that are very rarely used by the community. Ethanol extract of shallot skin (EESS) was tested for phytochemical screening and anti-hyperuricemia activity using potassium oxonate. Mice were divided into five groups (Allopurinol, Na-CMC, EESS 200 mg/kg BW, 300 mg/kg BW, and 400 mg/kg BW) and uric acid levels were observed at 2-hour intervals for six hours. Phytochemical screening shows that EESS has potential compounds in the treatment of gout. Tests to reduce uric acid levels showed that EESS has better potential than allopurinol at concentrations of 300 mg/kg BW and 400 mg/kg BW after six hours of induction in reducing uric acid levels.
Association between Drug-Related Problems and Blood Pressure of Hypertensive Patients Admitted to Universitas Sumatera Utara Hospital Mutiara Siahaan; Azizah Nasution; Wiryanto Wiryanto; Iksen Iksen
Borneo Journal of Pharmacy Vol. 6 No. 1 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i1.3664

Abstract

Patients with hypertension usually experience chronic comorbidities and complications that require complex treatment (polypharmacy), which can further cause drug-related problems (DRPs) and interfere with the required clinical outcomes. This study, by using a case-control prospective cross-sectional, aimed to analyze the association between DRPs and blood pressures (BPs) of hypertensive patients admitted to Universitas Sumatera Utara (USU) hospital from July to September 2021. The incidence of DRPs was analyzed and classified according to the Cipolle classification system and reliable literature. Blood pressures of the patients were classified into controlled and uncontrolled BPs. The association between DRPs and BP was analyzed using the Chi-Square test. Most of the patients (57.5%) were female. Their mean age was 59±9.94 (years). The mean incidence of DRPs experienced by the patients was 1.78±0.79. The most frequently occurred DRPs were drug interactions. There was a significant association between the number of DRPs experienced by the patients and their BPs (p=0.02). DRPs are the contributing factor to the uncontrolled BPs of hypertensive patients.
Identification of Potential COVID-19 Targets and Pathways Derivate from Various Phenolic Compounds from Chives (Allium schoenoprasum) by Using Network Pharmacology Approach Iksen; Buana, Bayu Cakra
MPI (Media Pharmaceutica Indonesiana) Vol. 4 No. 2 (2022): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v4i2.5272

Abstract

With the uncertainty of COVID-19 disease around the world, the discovery and development of novel treatments for COVID-19 becoming an emerging trend. Network pharmacology has been used for determining the potential targets from several diseases. This research mainly focused on the potential of Allium schoenoprasum against COVID-19 based on a network pharmacology approach. The methods consist of target identification of the compounds, target identification related to COVID-19 disease, compound-target interaction network, protein-protein interaction network and gene ontology and pathway enrichment analysis. Fifthy three main targets obtained from the compound-COVID-19 were identified as main targets from the compounds with MMP9, MPO, TLR4, MMP2, CCNB1, AURKB, PLK1, TOP2A, ALOX5, and CD38 becoming the top 10 core targets. Phenolic compounds in Allium schoenoprasum may act as anti-COVID-19 through several inflammatory and immune response pathways. Based on these results, it seems that phenolic compounds in Allium schoenoprasum might act as anti-COVID-19 via network pharmacology approaches.
The Impact of Pharmaceutical Care Implementation on The Incidence of Drug-Related Problem and Clinical Outcome of Hypertension Patients at Puskesmas Lubuk Pakam in 2021 Darmirani, Yosi; Dalimunthe, Aminah; Khairunnisa; Iksen
MPI (Media Pharmaceutica Indonesiana) Vol. 5 No. 1 (2023): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v5i1.5609

Abstract

The role of pharmacists in the implementation of pharmaceutical care has been shown to improve the outcome of therapy in hypertension patients in various countries. This study aimed to implement pharmaceutical care for hypertension patients and determine its impact on the incidence of drug-related problems (DRPs) and clinical outcomes of hypertension patients in Puskesmas Lubuk Pakam. This study used a comparative experimental method before and after the intervention of 73 hypertension patients in March-August 2021. Identification of the of DRPs was using the PCNE V9.00 standard and blood pressure values were obtained from direct examination of patients. Data were analyzed using the Wilcoxon Signed-Rank test. The results showed that the average DRPs incidence was significantly reduced after the intervention (observation, interview, and education) on the hypertension patients. The average blood pressure before intervention was 154.38 ± 16.20 mmHg and after intervention became 144.04 ± 15.94 mmHg (p value = 0.000). Based on the results of the study, it can be concluded that the application of pharmaceutical care can reduce the incidence of DRPs and improve clinical outcomes in hypertension patients in Puskesmas Lubuk Pakam.
Identifikasi Komponen Minyak Atsiri Daun Salam (Syzygium polyanthum (Wight Walp.) dengan GC-MS dan Potensinya Sebagai Antibakteri Sihotang, Santyria; Simanjuntak, Helen Anjelina; Purba, Hermawan; Iksen, Iksen; Sembiring, Mahral Effendi
Herbal Medicine Journal Vol 8 No 1 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i1.137

Abstract

Essential oils, known as volatile oils or essential oils, are oils produced from plants and have the property of easily evaporating at room temperature without undergoing decomposition. The bay leaf plant (Syzygium polyanthum (Wight.) Walp.) is one of the plants that is very often used as an alternative medicine. There is evidence that bay leaves, which contain compounds such as niacin, fiber, tannin, and vitamin C, have the ability to lower serum triglyceride levels. This research aims to determine the essential oil content in bay leaves using the steam distillation method and its potential as an antibacterial. The results of the research show that bay leaves contain essential oils which have antibacterial properties against the bacteria Helicobater pylori and Bacillus cereus. Bay leaf essential oil (Syzygium polyanthum (Wight.) Walp) with varying concentrations of 10%, 30%, 50%, 70% and 100% showed the highest inhibitory zone diameter for Helicobater pylori bacteria, namely at a concentration of 100% with a diameter of 5, 25 mm and in Bacillus cereus bacteria with a diameter of 7.95 mm.
Investigation of Potential Molecular Targets of Zanthoxylum acanthopodium in Ovarian Cancer Using Network Pharmacology Assessments Wijaya, Johanna Fransiska; Chiuman, Linda; Syahputra, Hariyadi Dharmawan; Kaban, Vera Estefania; Razoki, Razoki; Ginting, Chrismis Novalinda; Iksen, Iksen
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.268

Abstract

Ovarian cancer is a serious disease that affects the ovaries, and its early detection is challenging due to vague symptoms often dismissed as minor ailments. Currently, natural sources have gained attention for their potential role in anticancer treatment. This study aimed to utilize network pharmacology to explore the potential targets and mechanisms of Zanthoxylum acanthopodium in the treatment of ovarian cancer. This study utilized the KNApSAcK and Swiss Target Prediction to identify active compounds and target genes. Additionally, ovarian cancer-specific target genes were sourced from the GEO database. To identify possible key target genes, the network interaction between protein-protein using the STRING database and visualized them in Cytoscape. Subsequent analysis using Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enabled us to focus on primary therapeutic targets. Our investigation into Zanthoxylum acanthopodium revealed 10 active compounds that pass Lipinski rule of five and oral bioavailability with acceptable pharmacokinetic profiles, 88 therapeutic targets, and identified 5 hub genes: SRC, CCNB2, MMP9, PTGS2, and PTPRC, which are strongly associated with ovarian cancer progression. Pathway enrichment analysis highlighted several pathways significantly related to the pathogenesis of ovarian cancer. This study elucidates the therapeutic potential and mechanisms of action of Z. acanthopodium as a promising candidate for ovarian cancer treatment. However, further research, including both in vitro and in vivo studies, is necessary to understand its molecular mechanisms comprehensively.
Formulation of Lempuyang Essential Oil Lotion (Zingiber zerumbet (L.) Smith) as a Mosquito Repellent Fahdi, Firdaus; Harahap , Khoirunnisa; Sari , Herviani; Iksen
MPI (Media Pharmaceutica Indonesiana) Vol. 7 No. 1 (2025): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v7i1.7416

Abstract

Mosquito-borne diseases, such as malaria, pose a significant public health threat in Indonesia, with cases increasing to 400,000 in 2023. This study focuses on developing a natural mosquito repellent lotion using lempuyang (Zingiber zerumbet (L.) Smith) essential oil, known for its insecticidal properties, as a sustainable and eco-friendly alternative to synthetic repellents. The objective of this study is to formulate and evaluate a mosquito repellent lotion using lempuyang essential oil at varying concentrations (5%, 10%, and 15%) and assess its physical properties, safety, and repellent efficacy. Lempuyang essential oil was extracted via steam distillation from fresh rhizomes. Lotion formulations were prepared with different oil concentrations and evaluated for organoleptic properties, homogeneity, emulsion type, pH, spreadability, and stability. Skin irritation tests were conducted and mosquito repellent efficacy was tested using Culex sp. mosquitoes in a controlled environment. The essential oil extraction via steam distillation yielded 0.4% oil from fresh lempuyang rhizomes, producing a pale yellowish-white oil. All lotion formulations exhibited desirable organoleptic properties, homogeneity, and spreadability (5–7 cm), with pH levels (6.18–7.46) suitable for skin application. Stability tests confirmed no changes in appearance, color, or odor over four weeks. Irritation tests showed no adverse reactions, confirming the lotion’s safety. The 15% formulation demonstrated the highest mosquito repellent efficacy, providing 82.45% protection, outperforming the 5% and 10% formulations. These results highlight the 15% lempuyang essential oil lotion as a promising, natural, and safe mosquito repellent. Submitted: 23-03-2025, Revised: 16-04-2025, Accepted: 21-04-2025, Published regularly: June 2025
Co-Authors Aminah Dalimunthe Azizah Nasution Bayu Cakra Buana Br. Sitorus, Juniar Alpina Buana, Bayu Cakra Chiuman, Linda Dameria Siahaan Darmirani, Yosi Emanrius Lase Esther Siringo ringo FAHDI, FIRDAUS Ginda Haro Ginting, Chrismis Novalinda Harahap , Khoirunnisa Harahap, Daimah Wirdatus Sanaun Helen Anjelina Simanjuntak Hutabalian, Marshinta Romarta Uly Indah Yani Tambunan Kasta Gurning Kevin kevin Khairunnisa Lydia Br Barus Masfria Mastiur Julianti Mutiara Siahaan Purba, Hermawan Razoki, Razoki Sari , Herviani Sari, Hesti Yola Sembiring, Mahral Effendi Sihotang, Santyria Sipahutar, Dame Meldaria Sipayung, Novitri Adelia Siti Morin Sinaga Syahputra, Hariyadi Dharmawan Syahrina Syahrina Vera Estefania Kaban Vivi Asfianti Wijaya, Johanna Fransiska Wiryanto Yanti Yanti