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All Journal Majalah Kedokteran Sriwijaya Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Perinatology Jurnal RSMH Palembang
Cindy Kesty
Department Of Obstetrics And Gynecology, Faculty Of Medicine, Universitas Sriwijaya / General Hospital Dr. Mohammad Hoesin, Palembang, South Sumatera, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Relationship Between Vitamin D Supplementation and Improvement in Body for Carcinogenesis: A Literature Review Irawan Sastradinata; Rizal Sanif; Cindy Kesty; Siti Hardianti Harahap
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 2 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i2.447

Abstract

Vitamins are probably the best-selling dietary supplements in the United States, in which an estimated 35% of the population take multivitamin and mineral supplements. Data relating microconstituents to carcinogenesis are extremely limited, as explained in the first report. A striking feature of many of the compounds in the three groups mentioned above is their capacity to prevent or retard the occurrence of neoplasia. However, there is a paucity of data concerning the conditions under which inhibition occurs, the mechanisms of inhibition, and the precise impact of these microconstituents on humans. A literature review was conducted in the electronic databases PubMed and Google Scholar using the index terms "carcinogenesis" and "cancer" and "vitamin D" All types of studies were included for this study, such as randomized controlled trials, systematic reviews, literature reviews, and pilot studies published between 2010 and 2021. Articles which not written in English were excluded from the study. This search resulted in 10 papers. Many of the mechanisms proposed for vitamin D and cancer prevention have been studied only in the context of one tissue or one type of cancer and so further studies must be conducted to determine if these mechanisms can be generalized. For example, while higher serum (25(OH)D3) is associated with reduced cancer risk, and CYP27B1 is expressed in non-renal cells, there is no evidence that the low-level expression of CYP27B1 in tissues leads to meaningful local production of 1a,25(OH)2D3 or calcitriol, and that this mediates the protection from cancer provided by high vitamin D status. In conclusion, we suggest that vitamin D compounds to be employed in the treatment of, alone or in combination with other anticancer agents. solar UV-B radiation, acting through the production of vitamin D, is a risk reduction factor for over a dozen forms of cancer.
Cortisol Level Related to Depression in Women with Endometriosis Adnan Abadi; Aria Indrabrata; Iskandar Zulqarnain; Theodorus; Abdullah Sahab; Kemas Yusuf Effendi; Heriyadi Manan; Fatimah Usman; Awan Nurtjahyo; Cindy Kesty
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 6 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i6.537

Abstract

Background: Several main symptoms of endometriosis can lead to physical and psychological stress and also hormonal disturbances as the result of prolonged stress. Cortisol was associated with the onset of depression. This study aimed to determine the relationship between cortisol levels and depression in women with endometriosis at the Department of Obstetrics and Gynecology at Dr. Mohammad Hoesin General Hospital (RSMH) Palembang. Methods: A cross-sectional study was performed at the Reproductive Endocrinology and Infertility outpatient clinic and inpatient ward, Department of Obstetrics and Gynecology at Dr. Mohammad Hoesin General Hospital Palembang, from January to November 2020. There were 74 samples of endometriosis patients who met the inclusion criteria. The blood cortisol level was examined using the ELISA method. The determination of depression level was performed by filling out the Beck Depression Inventory questionnaire. Data were analyzed using SPSS version 22.0. Results: Seventy-four samples met the inclusion criteria. As many as 44 patients (59.5%) without depression, 20 patients (27%) with mild depression, 8 patients (10.8%) with moderate depression, and only 2 patients (2.7%) with severe depression. There were no differences in age, marital status, parity, menstrual cycle, and duration of treatment between endometriosis patients with and without depression (p > 0.05). There was a significant difference in cortisol levels between endometriosis patients with and without depression (p = 0.017). Endometriosis patients with cortisol levels ≤ 7.4 mg/dl were three times more at risk of depression than endometriosis patients with cortisol levels > 7.4 mg/dl. In addition, there was a significant relationship between cortisol level and depression status (OR = 3.023 (95% CI 1.153–7.942; p = 0.041). This study also found a significantly low negative correlation between cortisol levels and BDI scores (r = -0.249; p = 0.032). Conclusion: There was a significant relationship between serum cortisol levels and depression in women with endometriosis. Endometriosis patients with depression had significantly lower cortisol levels than endometriosis patients without depression.
Characteristics of pregnancy with Systemic Lupus Erythematosus (SLE) in Dr. Mohammad Hoesin Hospital, Palembang Nyimas Aliyah Faizatun Muthmainnah; Nuswil Bernolian; Eddy Roflin; Cindy Kesty
Indonesian Journal of Perinatology Vol. 2 No. 1 (2021): Available Online: 1 June 2021
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (319.046 KB) | DOI: 10.51559/inajperinatol.v2i1.10

Abstract

Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease with complex pathogenesis with broad clinical manifestations, more common in women of reproductive age between 15-44 years, so there is an increased incidence in pregnancies. Methods: This study was a descriptive observational study with a cross-sectional design using medical records of patients in Dr. Mohammad Hoesin Hospital Palembang from January 2018-June 2020. Sampling was carried out by total sampling with the presentation of data in tables and narratives. Data processing was performed using SPSS 25. Results: There were 1,039 pregnancies in January 2018-June 2020 with 26 pregnancies with SLE and 8 patients (30.8%) of moderate degree SLE. The demographic characteristics were 26-30 age range (30.8%), high school education status (53.8%), the number of pregnancies 2-3 times (53.8%), the number of primiparous births (46.2%), and the number of miscarriages was never experienced (65.4%). Based on clinical signs and symptoms, malaise (15.4%), malar rash, photosensitivity spots and alopecia (15.4%), inflammatory arthritis (46.2%), lupus nephritis (11.5%), abdominal pain ( 34.6%), lymphadenopathy (3.8%), anemia or lymphopenia (15.4%), and cephalgia (7.7%). Meanwhile, the parameter of diagnosis was lymphopenia (15.4%), eGFR stage 1 (34.6%), proteinuria or proteinuria and cylindruria (11.5%), ANA test (+) (19.2%), anti-dsDNA test (+) (19.2%), and the complement test decreased (7.7%). Pregnancy outcomes were found to have intrauterine growth restriction (IUGR) (19.2%) and preeclampsia and IUGR (11.5%). Conclusion: From the 26 pregnant patients with SLE, most were found with a moderate degree. Most demographic characteristics were age range 26-30 years old, high school education status, number of pregnancies 2-3 times, primipara, and never miscarriage. Characteristics of clinical signs and symptoms most commonly found in patients were malaise, malar rash, photosensitivity spots and alopecia, inflammatory arthritis, and abdominal pain. The diagnosis parameters were lymphopenia, stage 1 eGFR, proteinuria or proteinuria and cylindruria, ANA test (+), and anti-dsDNA test (+). Most pregnancy outcome is intrauterine growth restriction (IUGR).
THE DIAGNOSTIC METHODS OF PLACENTA ACCRETA SPECTRUM DISORDERS Alia Desmalia; Nuswil Bernolian; Abarham Martadiansyah; Theodorus Theodorus; Citra Dewi; Putri Mirani; Peby Maulina Lestari; Cindy Kesty
Majalah Kedokteran Sriwijaya Vol 54, No 3 (2022): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v54i3.19655

Abstract

Placenta Accreta Spectrum Disorder (PASD) is abnormal trophoblast invasion of part or all of the placenta into the myometrium of the uterine wall. Magnetic resonance imaging (MRI) examination is one of the tools that can help diagnosing PASD earlier, so that maternal morbidity and mortality can be reduced. This study aims to determine the prevalence, risk factors of PASD and the accuracy of Placenta Accreta Index Score (PAIS) and MRI, with histopathological examination in diagnosing PASD at dr. Mohammad Hoesin General Hospital (RSMH) Palembang during the 2018–2021. A descriptive study with a survey design on pregnant and intrapartum women with suspected PASD was performed at Department of Obstetrics and Gynecology at RSMH Palembang from 2018 until 2021. There were 72 study subjects who met the inclusion criteria. The relationship between the independent and dependent variables was analyzed using Chi Square and Fisher Exact. The cut-off point of the PAIS scores was analyzed using the Receiver Operating Curve (ROC). The comparison of the diagnostic value of PAIS and MRI scores used the Youden Index. Data was analyzed with SPPS version 22.0 From 72 subjects, 60 subjects (83.3%) were PASD and 12 subjects (16.7%) were not PASD. The risk factors of PASD in this study was surgical history more than once (PR = 4.600 (95% CI 1.261–16.781); p = 0.037). Youden Index values and PAIS accuracy were 0.782 and 0.953 while Youden Index values and MRI accuracy were 0.333 and 0.886. PAIS and MRI could be considered as diagnostic tools for PASD. However, overall, PAIS had a better diagnostic value than MRI.
Co-Authors A. Abadi A. Kurdi Syamsuri Abdullah Sahab Adnan Abadi Alia Desmalia Amir Fauzi Aria Indrabrata Awan Nurtjahyo Benedictus Wicaksono Widodo Benedictus Wicaksono Widodo Chairil Anwar Citra Dewi Eddy Roflin Eka H. Oktharina Fatimah Usman Febi Stevi Aryani Ferry Yusrizal Firmansyah Basir Hartati Hendra S Saputra Heriyadi Manan Irawan Sastradinata Iskandar Zulqarnain Kgs Irawan Satria Arjanggi Kms Yusuf Effendi M. Hatta Ansyori Martadiansyah, Abarham Mufida Muzakkie Murwani Emasrissa Latifah Nuswil Bernolian Nuswil Bernolian Nuswil Bernolian Nuswil Bernolian Nyimas Aliyah Faizatun Muthmainnah Peby Maulina Lestari, Peby Maulina Putri Mirani Putri Mirani Putri Mirani Radiyati Umi Partan Radiyati Umi Partan Ramzi Amin, Ramzi Rizal Sanif Rizani Amran Saputra, Hendra S Selly Rizany Siti Chodijah Siti Hardianti Harahap Siti Nurmaini Theodorus Theodorus Theodorus Theodorus Theodorus Vicela Patricia Virgyna Wim T. Pangemanan Win T. Pangemanan