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All Journal Jurnal Riset Kesehatan Poltekkes Depkes Bandung Majalah Kedokteran Neurosains Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan Jurnal Penelitian Pendidikan, Psikologi Dan Kesehatan (J-P3K) Molucca Medica Jurnal Kedokteran Meditek Folia Medica Indonesiana
Astari, Riezky Valentina
Fakultas Kedokteran, Universitas Riau
Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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HUBUNGAN NILAI NATRIUM SERUM DENGAN LUARAN FUNGSIONAL PADA PASIEN CEDERA KEPALA Riezky Valentina Astari,* Jimmy Eko Budi Hartono,** Dody Priambada***
NEURONA Vol 33 No 1 Desember 2015
Publisher : Neurona Majalah Kedokteran Neuro Sains

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Abstract

INTRODUCTION SODIUM LEVEL DISTURBANCE IS COMMON AFTER TRAUMATIC BRAIN INJURY AND MAY CAUSE SERIOUS COMPLICATIONS AND POOR OUTCOME INCLUDING DEATH SODIUM PLAY A ROLE IN CYTOTOXIC PROCESS AND REPERFUSION PATHWAY IN SECONDARY BRAIN DAMAGE SERUM SODIUM LEVEL AND ITS RELATIONSHIP WITH OUTCOME IN BRAIN INJURY IS SCARCELY STUDIED
PERBANDINGAN PROFIL GLUKOSA DARAH PASIEN STROKE ISKEMIK DAN STROKE HEMORAGIK DI RSUP FATMAWATI TAHUN 2018 Husna, Intan Rahma; Astari, Riezky Valentina; Rizkianti, Tuty
Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan Vol 5, No 1 (2021): Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan
Publisher : Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jmstkik.v5i1.8217

Abstract

Stroke is the death of brain cells due to lack of blood flow and oxygen to the brain by blockage or rupture of an artery. Stress hyperglycemia in acute stroke may worsen the clinical outcome and the prognosis of stroke. The purpose of this study is to find out and compare blood glucose profile between ischemic stroke and hemorrhagic stroke. This is an observational analytic cross-sectional research using consecutive sampling. Data was obtained through medical record from January to December 2018 in RSUP Fatmawati with each group of stroke consisting of 74 samples. Data was processed using SPSS 2017. Mann-Whitney test shows a significant difference in random blood glucose levels between ischemic stroke and hemorrhagic stroke (p = 0.024), with the median value of random blood glucose level during ischemic stroke is 115.50 mg / dL and hemorrhagic stroke is 136.50 mg / dL. The results also shows a significant difference in fasting blood glucose levels between ischemic stroke and hemorrhagic stroke (p = 0.042), with the median value of fasting blood glucose level for ischemic stroke is 116.50 mg / dL and hemorrhagic stroke is 125.50 mg / dL. A significant difference is also seen in 2 hours post-prandial glucose level between ischemic stroke and hemorrhagic stroke (p = 0.028), with the median value of 2 hours post-prandial glucose level of  ischemic stroke is 130 mg / dL and hemorrhagic stroke is 147.50 mg / dL. Keywords: Ischemic Stroke; Hemorrhagic Stroke; Random Blood Glucose; Fasting Blood Glucose; 2 Hour Post-Prandial Blood Glucose AbstrakStroke adalah kematian sel-sel otak akibat hilangnya pasokan darah dan oksigen ke otak karena adanya  hambatan atau ruptur arteri yang menuju otak. Pada stroke fase akut dapat terjadi hiperglikemia reaktif yang dapat memperburuk  keluaran klinis dan prognosis stroke. Penelitian ini dilakukan untuk mengetahui dan membandingkan profil glukosa darah antara stroke iskemik dan stroke hemoragik. Penelitian ini bersifat analitik observasional dengan desain potong lintang dan pemilihan sampel consecutive sampling. Data didapat dari rekam medis periode Januari-Desember 2018 di RSUP Fatmawati dengan masing-masing kelompok stroke sebanyak 74 sampel. Pengolahan data dilakukan dengan program SPSS tahun 2017. Uji Mann-Whitney menunjukkan adanya perbedaan bermakna kadar Glukosa Darah Sewaktu antara stroke iskemik dengan stroke hemoragik (p = 0,024), dengan nilai median Glukosa Darah Sewaktu stroke iskemik adalah 115,50 mg/dL dan stroke hemoragik adalah 136,50 mg/dL. Hasil juga menunjukkan adanya perbedaan bermakna kadar Glukosa Darah Puasa antara stroke iskemik dan stroke hemoragik (p = 0,042), dengan nilai median Glukosa Darah Puasa stroke iskemik adalah 116,50 mg/dL dan stroke hemoragik adalah 125,50 mg/dL, serta adanya perbedaan bermakna kadar Glukosa Darah 2 Jam Post-Prandial antara stroke iskemik dan stroke hemoragik (p = 0,028), dengan nilai median Glukosa Darah 2 Jam Post-Prandial stroke iskemik adalah 130 mg/dL dan stroke hemoragik adalah 147,50 mg/dL.
Gambaran Klinis Terapi Tension Type Headache dengan Akupunktur Medis di RSPAD Gatot Soebroto Tahun 2022-2024 Hermawan, Puthema Alfaridzky; Saleh, Arman Yurisaldi; Dandanah, Maulidya Ayudika; Astari, Riezky Valentina
JURNAL PENELITIAN PENDIDIKAN, PSIKOLOGI DAN KESEHATAN (J-P3K) Vol 5, No 3 (2024): J-P3K DESEMBER
Publisher : Yayasan Mata Pena Madani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51849/j-p3k.v5i3.565

Abstract

Penelitian ini bertujuan untuk mengidentifikasi karakteristik klinis pasien tension type headache (TTH) yang menjalani terapi akupunktur medis di RSPAD Gatot Soebroto. Dengan menggunakan desain penelitian deskriptif cross-sectional, data dikumpulkan dari rekam medis pasien periode 2022-2023. Sebanyak 25 pasien dipilih secara purposive sampling berdasarkan kriteria inklusi, yaitu telah menjalani enam sesi terapi akupunktur lengkap. Hasil penelitian menunjukkan bahwa pasien usia 35–45 tahun merupakan kelompok dominan (56%), mengindikasikan tingginya prevalensi TTH pada usia produktif akibat tekanan kerja dan sosial. Mayoritas pasien adalah perempuan (56%), yang dikaitkan dengan faktor hormonal dan tanggung jawab sosial. Sebagian besar pasien memiliki IMT normal (60%), mendukung penelitian sebelumnya yang menyatakan bahwa IMT tidak berkorelasi langsung dengan prevalensi TTH. Selain itu, sebanyak 60% pasien memiliki kadar kolesterol abnormal (200 mg/dL), yang berpotensi memicu TTH melalui gangguan vaskular. Kesimpulan penelitian ini menekankan pentingnya pengelolaan stres dan kadar kolesterol sebagai upaya pencegahan TTH. Terapi akupunktur medis menjadi alternatif pengobatan efektif yang dapat dipertimbangkan untuk kasus TTH kronis. Penelitian ini memberikan wawasan klinis berharga untuk pengembangan terapi dan pencegahan TTH.
DAMPAK INFEKSI COVID-19 TERHADAP SIKLUS MENSTRUASI PADA PENYINTAS COVID-19 Maulida, Ika; Bustamam, Nurfitri; Astari, Riezky Valentina; Lardo, Soroy
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 16 No 1 (2024): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/juriskesbdg.v16i1.2397

Abstract

The study results of 2020 reported that as many as 16% of COVID-19 survivors experience changes in their menstrual cycles. This study aimed to describe the menstruation cycle among COVID-19 survivors at The Faculty of Medicine, University Pembangunan Nasional “Veteran” Jakarta. This is an analytical study using a retrospective design. The sample size consisted of 32 subjects who met the criteria of being confirmed with COVID-19 within the past year, aged 18-24 years, normoweight, unmarried, and without a history of illness or the use of hormonal contraception that affects the menstrual cycle. Data was collected using a questionnaire. The results of the univariate analysis indicate that out of the subjects, 18 (56.3%) had received three doses of vaccination, 21 (65.6%) had received the first and second doses of the Sinovac vaccine, 31 (96.9%) experienced mild symptoms (home isolation) during the COVID-19 infection, and 9 (28.1%) had been infected with COVID-19 twice. Changes in menstrual cycles experienced by subjects 0-6 months after being infected with COVID-19 included two subjects with prolonged cycles, three subjects with shortened cycles, one subject with decreased menstrual blood volume, one subject with increased menstrual duration, five subjects experiencing menstrual pain, and two subjects experiencing bleeding between two cycles. A total of 8 subjects reported that these changes in menstrual cycles were recurring. The Chi-square exact test result indicates there was a relationship between the frequency of COVID-19 infection and the number of menstrual cycle changes (p = 0.022).
HUBUNGAN ANTARA TIME WINDOW DAN JUMLAH SESI TERAPI OKSIGEN HIPERBARIK DENGAN DERAJAT KEKUATAN MOTORIK PASIEN PASCASTROKE ISKEMIK DI RS AL DR. MINTOHARDJO Pratama, Muhammad Rafli; Savitri, Pritha Maya; Setyaningsih, Yuni; Astari, Riezky Valentina
Molucca Medica Vol 18 No 1 (2025): VOLUME 18, NOMOR 1, APRIL 2025
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/molmed.2025.v18.i1.38

Abstract

Stroke adalah gangguan neurologis yang diakibatkan karena kekurangan suplai darah ke bagian-bagian otak. Stroke iskemik terjadi sekitar 62,4% dari semua jenis stroke. Saat ini, Terapi Oksigen Hiperbarik (TOHB), yaitu pasien bernapas dengan 100% oksigen bersamaan dengan peningkatan tekanan atmosfer, dapat menjadi pilihan terapi dan bisa dilakukan setelah onset stroke iskemik untuk mendapatkan efek penyembuhan, salah satunya perbaikan motorik pasien stroke. Hasil yang dicapai bergantung pada periode dari onset terjadinya stroke hingga dilakukan tata laksana (time window) dan jumlah sesi terapi. Tujuan penelitian untuk mengetahui hubungan antara time window dan jumlah sesi terapi oksigen hiperbarik dengan derajat kekuatan motorik pasien pascastroke iskemik di Rumah Sakit Angkatan Laut Dr. Mintohardjo. Desain yang digunakan adalah potong lintang dengan metode total sampling. Terdapat 30 sampel yang dipilih berdasarkan kriteria inklusi. Sampel dianalisis dengan uji fisher exact. Hasil analisis bivariat menunjukkan p=0,011 untuk hubungan antara jumlah sesi terapi TOHB dengan derajat kekuatan motorik (RR=2,100; 95% Cl: 1,341 – 3,289) dan p=0,140 untuk hubungan antara time window TOHB dengan derajat kekuatan motorik. Kesimpulan yang diajukan yaitu jumlah sesi TOHB memengaruhi secara signifikan terhadap perubahan derajat kekuatan motorik dan meskipun pasien melakukan TOHB dalam rentang waktu tertentu setelah onset terjadinya stroke, tidak berpengaruh secara signifikan terhadap perubahan derajat kekuatan motorik. Disarankan untuk penelitian selanjutnya agar memperbanyak jumlah sampel dan mempertimbangkan faktor lain yang dapat memengaruhi hasil terapi.
Hubungan Fungsi Ginjal dengan Kejadian Demensia Vaskular di RSPAD Gatot Soebroto 2023-2024 Afralia, Aqila Fayza; Astari, Riezky Valentina; Saleh, Arman Yurisaldi; Dandanah, Maulidya Ayudika
Jurnal Kedokteran Meditek Vol 31 No 4 (2025): JULI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i4.3541

Abstract

Introduction: Vascular dementia is the second most common type of dementia in the world, following Alzheimer's dementia. One of the primary risk factors for vascular dementia is hypertension. Prolonged hypertension can impair kidney function, as indicated by the glomerular filtration rate (GFR). A decreased GFR can lead to vascular complications, such as endothelial dysfunction, which may result in brain tissue infarction and contribute to the development of vascular dementia in the future. Purpose: The purpose of this research is to examine the relationship between kidney function, measured through GFR values, and the incidence of vascular dementia at Gatot Soebroto Army Hospital during the 2023-2024 period. Methods :  This study employed a cross-sectional design and conducted a bivariate test using the Chi-square method with a sample of 47 individuals. The research utilized a total sampling technique. Results: Among the 47 patients, 35 (74.5%) were diagnosed with vascular dementia, while 12 (25.5%) had different types of dementia. The majority of patients, 31 (66%), exhibited a mild decrease in GFR values. The analysis revealed a relationship between kidney function and the incidence of vascular dementia, with a p-value of 0.596. Conclusion:  There was no significant relationship found between kidney function, as indicated by GFR values, and the incidence of vascular dementia. Future researchers can study larger populations.
CD4 Count and Central Nervous System Infection among HIV/AIDS Patients in an Indonesian Presidential Hospital from 2020 to 2022 Ramadina, Annisa Azzahra; Astari, Riezky Valentina; Yusmaini, Hany; Saleh, Arman Yurisaldi
Folia Medica Indonesiana Vol. 60, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: 1. There were insufficient data on the correlation between CD4 count and central nervous system infection as well as the risk magnitude of the infection for HIV/AIDS patients in Indonesia. 2. This study revealed a significant correlation between CD4 count and the incidence of central nervous system infection in HIV/AIDS patients, showing an increased risk with a low CD4 count. 3. The findings suggest that CD4 count is a vital parameter in determining therapy and evaluating the presence of opportunistic infections in HIV/AIDS patients. Abstract People living with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), referred to as PLWHA, have a high rate of mortality and morbidity due to opportunistic central nervous system infections. The infections are attributed to the immune deficiency caused by HIV exposure to the immune system's cluster of differentiation 4 (CD4) cells. This allows the central nervous system, the most vital body system, to acquire an opportunistic infection. The purpose of this study was to determine the existence and magnitude of a risk by examining the correlation between CD4 count and the incidence of central nervous system infection among HIV/AIDS patients. This analytical cross-sectional study utilized a simple random sampling technique on the population of HIV/AIDS patients, which consisted of 80 medical records from January 2020 to December 2022. This study was conducted at Gatot Soebroto Presidential Hospital, also known as Gatot Soebroto Central Army Hospital, in Jakarta, Indonesia. The data analysis was performed using Fisher's exact test (p<0.05) and the prevalence odds ratio (POR). The results showed that 16.3% of the patients suffered a central nervous system infection, which consisted of cerebral toxoplasmosis (76.9%) and brain abscess (23.1%). The bivariate analysis suggested a significant correlation between CD4 count and the incidence of central nervous system infection, with an 11.5-fold increased risk for HIV/AIDS patients who had a CD4 count of <200 cells/mm3 (p=0.000; OR=11.5; 95% CI=2.9–43.8). This study concludes that CD4 count is correlated with the incidence of central nervous system infection, indicating a higher risk for HIV/AIDS patients with a low CD4 count.
Vascular Dementia Patients Characteristics With a History of Stroke in a National Brain Center Hospital Jakarta, Indonesia Hanifah, Afifah Kusuma; Astari, Riezky Valentina; Muktamiroh, Hikmah; Saleh, Arman Yurisaldi
Folia Medica Indonesiana Vol. 58, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: • Characteristics of vascular dementia patients with a history of stroke was aimed. • The most characteristics of vascular dementia patients with stroke history are men, post-ischemic stroke, hypertension grade 1, and lesions in the basal ganglia. Abstract: Stroke patients increase each year. Stroke is a cerebrovascular disorder caused by disruption of cerebral blood flow, which could reason vascular lesions within the mind parenchyma to be a threat to significant disorders. One of them is vascular dementia. Each affected person is prone to growing dementia after a stroke in three to five instances. Thisstudy aimed to decide the traits of patients with vascular dementia with a record of stroke. This study used a descriptive retrospective approach with a cross-sectional method. The samples were obtained from the total sampling technique. The sample of the study was vascular dementia patients with a stroke record at the National Brain Center Hospital Prof. Dr. dr. Mahar Mardjono Jakarta in the period of 2020 through the inclusion standards with 191 samples. This study found that the majority of patients were males as many as 129 (67.5%), age group of 55-64 were 67 patients (35.1%), post-ischemic strokes were 164 patients (85.9%), grade 1 hypertension as many as 70 patients (36.6%), and basal ganglia as many as 76 patients (29.23%). Characteristics of vascular dementia patients with the maximum stroke records in men, aged 55-64 years, post-ischemic stroke, grade 1 hypertension, and a majority of the lesions within the basal ganglia.
The Effect of Antinociceptive Flavonoid on Leea Indica Leaves for Orofacial Pain of Adult Zebra Fish (Danio Rerio) Daya, Mei Putra; Saleh, Arman Yurisaldi; Astari, Riezky Valentina
Folia Medica Indonesiana Vol. 57, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Pain affects millions of people and is one of the most frequent complaints in the medical office. Pain involves various behavioral and emotional aspects. When it is persistent, it can become debilitating, impairing occupational performance, and producing negative impacts for the economy and public health costs. In general, commercial drugs can improve chronic pain patients' quality of life which can result in adverse reactions. Therefore, the search for new capsules as an opportunity remedy for ache is a challenge. Pain occurs due to stimuli from pain receptors called nociceptors. One pain known in the medical world is orofacial, defined as pain that occurs in soft and hard tissue in the head, face, and neck area. This study determined the antinociceptive effect of flavonoids isolated from the Leea Indica plant, on orofacial pain in zebrafish (Danio rerio) as a test model for behavior or locomotor activity. To study the orofacial pain of zebrafish induced with glutamate, this study was a true experiment. The parameter used was the number of times the fish crossed the line between the caudran from the glass petri dish during 0-5 minutes and 15-30 minutes. The Anova one-way test showed that there were differences in locomotors activity measured from 0-5 minutes and 15-30 minutes by giving flavonoids that could affect zebrafish locomotors activity or an increase in zebrafish locomotors activity. The antinociceptive effect of flavonoids was similar to tramadol. The flavonoids from Leea Indica had an antinociceptive effect on orofacial pain in adult zebrafish. The flavonoid dose of 2.5 mg/ml was a dose that had a significant difference in all treatment groups.
Characteristics of Aphasia in Ischemic Stroke Patients at a National Brain Center in Indonesia Danardhono, Rasya Hapsari; Saleh, Arman Yurisaldi; Theresa, Ria Maria; Astari, Riezky Valentina
Folia Medica Indonesiana Vol. 59, No. 4
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: 1. This study was the first study identifying the characteristics of aphasia among ischemic stroke patients during COVID-19 pandemic at a national brain center in Indonesia. 2. This study provides additional data for future studies to conduct a comparison between the pre- and post-pandemic incidence of aphasia. Abstract Different types of aphasia may occur due to lesions in various brain regions following ischemic strokes. Global aphasia was the most prevalent type of aphasia before the COVID-19 pandemic. However, stroke incidence and mortality rose during the pandemic. This study aimed to identify the types, clinical and radiological features, and management of aphasia in ischemic stroke cases during the pandemic. This study was a descriptive study with a cross-sectional design. The total sampling technique was used for the sampling process. The research samples were ischemic stroke subjects with aphasia who were diagnosed between January 1 and December 31, 2021, at the National Brain Center Prof. Dr. dr. Mahar Mardjono Hospital, Jakarta, Indonesia. The statistical analysis was performed using IBM SPSS Statistics for Mac, Version 25.0 (IBM Corp., Armonk, N.Y., USA). The results of this study showed that 162 aphasic subjects had suffered from ischemic strokes. The age range of the subjects was 34–87 years old. The majority of the subjects were male (59.9%) and aged 55–65 years (37.0%). The three most common risk factors were hypertension (90.1%), diabetes mellitus (50.0%), and dyslipidemia (75.9%). Motor aphasia (33.3%) and global aphasia (43.8%) were the most prevalent types of aphasia among the subjects. The parietal lobe was the main location of the causative lesions, as demonstrated by 38 global aphasic subjects and 47 motor aphasic subjects. The therapies administered to the subjects consisted of speech therapy (85.2%), antiplatelet therapy (98.1%), anticoagulants (19.1%), recombinant tissue plasminogen activator (rTPA) (1.2%), and neuroprotectors (3.0%). This study concluded that global aphasia was the most common type of aphasia among ischemic stroke patients during the pandemic, with the parietal lobe as the primary location of the causative lesions.
Co-Authors Afralia, Aqila Fayza Arman Yurisaldi Saleh Danardhono, Rasya Hapsari Dandanah, Maulidya Ayudika Daya, Mei Putra Hanifah, Afifah Kusuma Hany Yusmaini Hermawan, Puthema Alfaridzky Husna, Intan Rahma Maulida, Ika Nurfitri Bustamam Pratama, Muhammad Rafli Pritha Maya Savitri Ramadina, Annisa Azzahra Ria Maria Theresa Rizkianti, Tuty Setyaningsih, Yuni Soroy Lardo