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All Journal Bali Dermatology and Venereology Journal PAEDAGOGY : Jurnal Ilmu Pendidikan dan Psikologi HEALTHY: Jurnal Inovasi Riset Ilmu Kesehatan
Kosim, Hartono
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Biochemistry, Genetics & Molecular Biology Languange, Linguistic, Communication & Media Medicine & Pharmacology Social Sciences Other

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Buschke-Lowenstein tumour (BLT)/giant condyloma acuminatum (GCA): an immunopathogenesis insight Christopher, Paulus Mario; Kosim, Hartono; Wijaya, Ratna Sari; Suhardi, Silvi; Wijayadi, Linda Julianti
Bali Dermatology and Venereology Journal Vol 3, No 1 (2020)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v%vi%i.27

Abstract

Buschke Lowenstein tumor (BLT)/giant condyloma acuminatum is a rare variant of a sexually transmitted infection caused by human papillomavirus (HPV) type 6 and 11. HPV has its viral factors that exist to avoid immune surveillance and control through 1) infecting only the basal layer of the epithelium, 2) downregulation of host immunity, 3) suppression of proinflammatory proteins essential for viral clearance. The incidence of BLT/GCA is estimated to be 0.1% in the general population, with males having 2.7 times increased risk than females. A BLT/GCA is characterized by verrucous tumor or palpable cauliflower-likemass, exophytic growth, flesh-colored, and uneven surface. The definitive diagnosis of BLT/GCA is typical morphology along with histopathological examination, and/or viral serotyping. Treatment of BLT/GCA requires a multidisciplinary approach, determined based on age, the extent of the lesion, organ involvement, and organ location.
Update on scrofuloderma Marianto, Marianto; Kosim, Hartono; Agung Mahariski, Pande; Christopher, Paulus Mario
Bali Dermatology and Venereology Journal Vol 2, No 2 (2019)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v2i2.20

Abstract

Tuberculosis is one of the most significant diseases which causes death worldwide. TB infection is assumed to infect the lungs only from a general perspective. In fact, TB infection also causes lesions on the skin. Scrofuloderma, as one of the most common types of cutaneous tuberculosis, often misdiagnosed and managed improperly due to its similarity with abscess. In addition, there were still no national and international guidelines for scrofuloderma. This review to give insights and review about an update in the basic principle of scrofuloderma and management.
PERAN TERAPI SPIRITUAL (LOGOTERAPI DAN ALCOHOLIC ANONYMUS ) PADA PASIEN GANGGUAN MENTAL DAN PERILAKU AKIBAT PENGGUNAAN ZAT MULTIPEL (ALKOHOL DAN NIKOTIN) ARYANI, LUH NYOMAN ALIT; KOSIM, HARTONO
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 3 No. 3 (2024)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v3i2.3438

Abstract

Rehabilitation is a recovery process for patients with drug use disorders, either in the short or long term, which aims to change their behavior so that they are ready to return to society. Drug users also need to be saved so they can return to living a healthy and productive life. One approach given is spiritual therapy. The aim of this case report is to evaluate the effectiveness of spiritual interventions that can improve the quality of life and improve existing symptoms in addiction patients. Spiritual therapy was analyzed for its effect on general symptoms and improvement of perception and motivation in these patients. The patient is male, 59 years old, Dutch citizen, no religion, married status, last degree, experiences discomfort and restlessness, it is very difficult to be fully conscious, when he wants to walk the patient is very easy to fall, vomit and has levator pain ani. With spiritual approaches, namely logotherapy and alcoholic anonymus, which are added to standard treatment, patients become calm and no longer hopeless and the motivation appears to continue treatment and psychotherapy. Currently, the patient is much better and can begin to carry out activities and work as before. ABSTRAKRehabilitasi adalah suatu proses pemulihan pasien gangguan penggunaan NAPZA baik dalam jangka waktu pendek ataupun panjang yang bertujuan mengubah perilaku mereka agar siap kembali ke masyarakat. Pengguna narkoba juga perlu diselamatkan agar dapat kembali menjalani hidup dalam keadaan sehat dan produktif. Salah satu pendekatan yang diberikan adalah dengan terapi spiritual. Tujuan dari laporan kasus ini adalah untuk mengevaluasi efektivitas intervensi spiritual yang dapat meningkatkan kualitas hidup dan memperbaiki gejala yang ada pada pasien adiksi. Terapi spiritual dianalisis pengaruhnya terhadap gejala umum dan perbaikan persepsi dan motivasi pada pasien ini. Pasien laki-laki, 59 tahun warga negara Belanda, tidak beragama, status menikah, pendidikan terakhir sarjana, mengalami rasa tidak nyaman dan gelisah, sulit sekali untuk bisa sadar sepenuhnya. Ketika dia berjalan, pasien sangat mudah untuk terjatuh, ada muntah dan memiliki sakit levator ani. Dengan pendekatan spiritual yaitu logoterapi dan alcoholic anonymus yang ditambahkan pada pengobatan standar, pasien menjadi tenang dan tidak putus asa lagi serta motivasinya muncul untuk melanjutkan pengobatan dan psikoterapi. Saat ini pasien sudah jauh lebih baik serta mulai bisa beraktivitas dan bekerja seperti semula.
GANGGUAN CAMPURAN CEMAS DAN DEPRESI PADA PASIEN PEMFIGUS FOLIACEUS: LAPORAN KASUS DENGAN PENDEKATAN PSIKIATRI LIAISON Kosim, Hartono; Wardani, Ida Aju Kusuma; Ariani, Ni Ketut Putri; Mahardika, I Komang Ana
PAEDAGOGY : Jurnal Ilmu Pendidikan dan Psikologi Vol. 5 No. 1 (2025)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia (P4I)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/paedagogy.v5i1.5120

Abstract

Pemphigus foliaceus is a chronic autoimmune disease that attacks the superficial layers of the epidermis, causing painful and aesthetically disturbing skin lesions. In addition to physical impacts, this disease can also trigger psychological disorders such as mixed anxiety and depressive disorders, which are often unrecognized by medical personnel. This report discusses the case of a 45-year-old female patient with active pemphigus foliaceus, who presented with complaints of excessive anxiety, depressed mood, insomnia, and decreased social function. The diagnosis was made as mixed anxiety and depressive disorder (F41.2, PPDGJ III). The Consultation-Liaison Psychiatry (CLP) approach was applied, including pharmacological interventions in the form of selective serotonin reuptake inhibitors (SSRIs) and benzodiazepines, as well as non-pharmacological interventions such as supportive psychotherapy, relaxation techniques, and psychoeducation. The CLP approach emphasizes collaboration between dermatologists and psychiatrists for comprehensive treatment. This multidisciplinary management has been proven effective in improving the clinical prognosis and quality of life of patients with dermatological and psychiatric comorbidities. Early detection and integration of mental health services are essential for optimal therapy outcomes. ABSTRAKPemfigus foliaceus merupakan penyakit autoimun kronis yang menyerang lapisan superfisial epidermis, menyebabkan lesi kulit yang nyeri dan mengganggu penampilan. Selain dampak fisik, penyakit ini juga dapat memicu gangguan psikologis seperti gangguan campuran cemas dan depresi, yang sering tidak dikenali oleh tenaga medis. Laporan ini membahas kasus seorang pasien perempuan berusia 45 tahun dengan pemfigus foliaceus aktif, yang datang dengan keluhan cemas berlebihan, suasana hati depresif, insomnia, serta penurunan fungsi sosial. Diagnosis ditegakkan sebagai gangguan campuran cemas dan depresi (F41.2, PPDGJ III). Pendekatan Consultation-Liaison Psychiatry (CLP) diterapkan, mencakup intervensi farmakologis berupa selective serotonin reuptake inhibitor (SSRI) dan benzodiazepin, serta intervensi nonfarmakologis seperti psikoterapi suportif, teknik relaksasi, dan psikoedukasi. Pendekatan CLP menekankan kolaborasi antara spesialis dermatologi dan psikiatri untuk penanganan komprehensif. Penatalaksanaan multidisipliner ini terbukti efektif dalam meningkatkan prognosis klinis dan kualitas hidup pasien dengan komorbiditas dermatologis dan psikiatris. Deteksi dini dan integrasi layanan kesehatan jiwa sangat penting untuk hasil terapi yang optimal.
“SEARCH FOR NMDAR-A” DALAM DIAGNOSIS PSIKOTIK AUTOIMUN: SERIAL KASUS ENSEFALITIS NMDAR Kosim, Hartono; Surya, Michael; Wahyuni, Anak Ayu Sri
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 5 No. 2 (2026)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v5i2.10391

Abstract

ABSTRACT Anti-NMDAR encephalitis is an autoimmune disorder of the central nervous system that often presents initially with psychiatric symptoms, leading to a high risk of misdiagnosis as functional psychotic disorders. This study aims to evaluate the role of the “Search For NMDAR-A” approach in the early identification of autoimmune psychosis in acute psychotic episodes. The study employed a case series design involving 10 patients collected from November 2023 to June 2024 in the Department of Psychiatry. Evaluation was conducted through clinical psychiatric assessment, longitudinal observation, and cerebrospinal fluid (CSF) examination. Data were analyzed using qualitative descriptive analysis to identify key clinical patterns. The results indicate a dominant combination of symptoms, including sleep disturbances, agitation, and psychosis, with some cases accompanied by catatonia and cognitive impairment. The main finding highlights a consistent pattern of early symptoms accompanied by CSF abnormalities (elevated protein and pleocytosis) as indicators of suspected autoimmune psychosis. The “Search For NMDAR-A” approach shows potential as an initial clinical screening tool prior to definitive antibody testing. Conclusion: This approach is effective in enhancing clinicians’ awareness for the early detection of autoimmune psychosis. The novelty of this study lies in the systematic application of a mnemonic approach within psychiatric clinical practice. ABSTRAK Ensefalitis anti-NMDAR merupakan gangguan autoimun sistem saraf pusat yang sering diawali gejala psikiatri sehingga berisiko tinggi disalahdiagnosis sebagai gangguan psikotik fungsional. Penelitian ini bertujuan mengevaluasi peran pendekatan “Search For NMDAR-A” dalam identifikasi dini psikosis autoimun pada episode psikotik akut. Desain penelitian berupa serial kasus terhadap 10 pasien yang dikumpulkan pada November 2023–Juni 2024 di Departemen Psikiatri. Evaluasi dilakukan melalui asesmen klinis, observasi longitudinal, dan pemeriksaan cairan serebrospinal (CSF). Data dianalisis secara deskriptif kualitatif untuk mengidentifikasi pola klinis utama. Hasil menunjukkan kombinasi gejala dominan berupa gangguan tidur, agitasi, dan psikosis, dengan sebagian kasus disertai katatonia dan gangguan kognitif. Temuan utama adalah konsistensi pola gejala awal yang disertai abnormalitas CSF (peningkatan protein dan pleositosis) sebagai indikator kecurigaan psikosis autoimun. Pendekatan “Search For NMDAR-A” berpotensi sebagai alat skrining awal sebelum uji antibodi definitif. Simpulan: Pendekatan ini efektif meningkatkan kewaspadaan klinisi dalam deteksi dini psikosis autoimun. Kebaruan penelitian terletak pada penerapan sistematis mnemonic dalam praktik psikiatri.
RIWAYAT TRAUMA MASA KANAK SEBAGAI FAKTOR RISIKO ORIENTASI SEKSUAL PADA KAUM LESBIAN, GAY, BISEXUAL, TRANSGENDER, QUEER+ (LGBTQ): SEBUAH TINJAUAN SISTEMATIKA Torrys, Yesyurun Sekundus; Kosim, Hartono; Diniari, Ni Ketut Sri
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 5 No. 2 (2026)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v5i2.10417

Abstract

ABSTRACT The development of sexuality and gender issues has shown increasing complexity, particularly in understanding the experiences of LGBTQ+ individuals. Sexual orientation is an important component of identity formation that can be influenced by childhood experiences. This study aims to identify and analyze risk factors of childhood trauma among LGBTQ+ individuals based on recent empirical evidence. The study employed a systematic review method following PRISMA guidelines, drawing from PubMed, Cochrane Library, and Embase databases within the last ten years.A total of 8 studies meeting the inclusion criteria were analyzed, involving 336,042 participants. The results indicate that LGBTQ+ individuals have a higher risk of experiencing childhood trauma compared to heterosexual-cisgender groups, with risk estimates ranging from 1.4 to 3.11. The main finding highlights a consistent increase in the risk of various forms of trauma among LGBTQ+ individuals, particularly sexual abuse, domestic violence, and exposure to family members with mental disorders. These findings confirm that childhood trauma is a significant risk factor contributing to mental health vulnerability among LGBTQ+ individuals. Implications suggest the need for more inclusive and evidence-based mental health services to minimize long-term impacts and improve the quality of life of LGBTQ+ individuals. ABSTRAK Perkembangan isu seksualitas dan gender menunjukkan kompleksitas yang semakin meningkat, khususnya dalam memahami pengalaman individu LGBTQ+. Orientasi seksual merupakan bagian penting dari pembentukan identitas diri yang dapat dipengaruhi oleh pengalaman masa kanak. Penelitian ini bertujuan untuk mengidentifikasi dan menganalisis faktor risiko trauma masa kanak pada kelompok LGBTQ+ berdasarkan bukti empiris terkini. Studi ini menggunakan metode tinjauan sistematis dengan mengacu pada pedoman PRISMA dan bersumber dari database PubMed, Cochrane Library, dan Embase dalam kurun waktu 10 tahun terakhir. Sebanyak 8 studi yang memenuhi kriteria inklusi dianalisis dengan total 336.042 partisipan. Hasil menunjukkan bahwa kelompok LGBTQ+ memiliki risiko lebih tinggi mengalami trauma masa kanak dibandingkan kelompok heteroseksual-cisgender, dengan rentang risiko antara 1,4 hingga 3,11. Temuan utama menunjukkan adanya peningkatan risiko yang konsisten pada kelompok LGBTQ+ terhadap berbagai bentuk trauma, terutama kekerasan seksual, kekerasan dalam rumah tangga, serta paparan gangguan mental dalam keluarga. Temuan ini menegaskan bahwa trauma masa kanak merupakan faktor risiko signifikan yang berkontribusi terhadap kerentanan kesehatan mental pada kelompok LGBTQ+. Implikasinya, diperlukan pendekatan layanan kesehatan mental yang lebih inklusif dan berbasis bukti untuk meminimalkan dampak jangka panjang serta meningkatkan kualitas hidup individu LGBTQ+.
Co-Authors Agung Mahariski, Pande Anak Ayu Sri Wahyuni, Anak Ayu Sri Ariani, Ni Ketut Putri Christopher, Paulus Mario Luh Nyoman Alit Aryani, Luh Nyoman Alit MAHARDIKA, I KOMANG ANA Marianto Marianto Ni Ketut Sri Diniari, Ni Ketut Sri Silvi Suhardi, Silvi Surya, Michael Torrys, Yesyurun Sekundus Wardani, Ida Aju Kusuma Wijaya, Ratna Sari Wijayadi, Linda Julianti