The COVID-19 pandemic has had a significant impact on the mental health of health workers, including Post Traumatic Stress Disorder (PTSD), which negatively affects their quality of life. This study aims to determine the prevalence of PTSD, quality of life, and the relationship between PTSD and quality of life in health workers who are COVID-19 survivors at Prof. Dr. I.G.N.G. Ngoerah General Hospital. This analytical observational study used a cross-sectional design with the PCL-5 and WHOQOL-BREF questionnaires in 188 health workers from July to October 2022. The results showed a prevalence of PTSD of 10.1%. The overall quality of life was mostly in the good category (62.8%), but there were respondents with very poor (0.5%) and poor (3.2%) quality of life. In the physical health domain, the quality of life was mostly in the moderate category (61.7%), while the psychological, social relationships, and environmental domains showed variations in moderate to good quality of life with several respondents in the very poor category (0.5%). Analysis showed a trend towards worse overall quality of life in subjects with GSPT compared to those without (P<0.002). In conclusion, there is a significant relationship between GSPT and overall quality of life, although it does not apply to each domain of quality of life specifically. GSPT can reduce the overall quality of life of COVID-19 survivor health workers. ABSTRAKPandemi COVID-19 memberikan dampak signifikan terhadap kesehatan mental tenaga kesehatan, termasuk Gangguan Stres Pasca Trauma (GSPT), yang memengaruhi kualitas hidup mereka secara negatif. Penelitian ini bertujuan untuk mengetahui prevalensi GSPT, kualitas hidup, serta hubungan antara GSPT dan kualitas hidup pada tenaga kesehatan penyintas COVID-19 di RSUP Prof. Dr. I.G.N.G. Ngoerah. Penelitian observasional analitik ini menggunakan desain potong lintang dengan kuesioner PCL-5 dan WHOQOL-BREF pada 188 tenaga kesehatan dalam periode Juli hingga Oktober 2022. Hasil penelitian menunjukkan prevalensi GSPT sebesar 10,1%. Kualitas hidup keseluruhan terbanyak berada pada kategori baik (62,8%), tetapi terdapat responden dengan kualitas hidup sangat buruk (0,5%) dan buruk (3,2%). Dalam domain kesehatan fisik, kualitas hidup terbanyak berada pada kategori sedang (61,7%), sedangkan domain psikologis, hubungan sosial, dan lingkungan menunjukkan variasi kualitas hidup sedang hingga baik dengan beberapa responden pada kategori sangat buruk (0,5%). Analisis menunjukkan kecenderungan kualitas hidup keseluruhan yang lebih buruk pada subjek dengan GSPT dibandingkan yang tidak (P<0,002). Kesimpulan, terdapat hubungan signifikan antara GSPT dan kualitas hidup keseluruhan, meskipun tidak berlaku pada masing-masing domain kualitas hidup secara spesifik. GSPT dapat menurunkan kualitas hidup tenaga kesehatan penyintas COVID-19 secara keseluruhan.