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The Synthesis of Y-zeolite-modified CaCO3-ZnO Nanocomposites as an Antibacterial Agent Artissiani, Maysa; Widiarti, Nuni; Wahyuni, Sri; Widhihastuti, Endah; Ni'ma, Neli Syahida
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 1, May 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i1.36246

The ability of inorganic antibacterial agents like metal oxides and nanoscale inorganic materials to inhibit bacterial growth rates has yet to receive much research attention. In this study, CaCO3-ZnO/Y-zeolite nanocomposites were created utilizing coprecipitation and impregnation techniques with Ca(CH3COO)2, Zn(CH3COO)2 2H2O, Y-zeolite precursors. Physical and chemical characteristics of nanocomposites have been investigated using XRD, FTIR, and SEM-EDX characterizations. The agar-well diffusion method tested the substance for antibacterial activity against gram-positive and gram-negative bacteria. Nanocomposites have a crystal size range of 35.46-36.53 nm and a crystallinity of 35-37 %, according to the results of XRD analysis. The carbonate groups are visible in FTIR data at wave numbers 1433, 875, and 712 cm-1. The Zn-O absorption band was verified at wave numbers 600-400 cm-1. The Y-zeolite absorption bands at wave numbers 1012-997 cm-1 and 745-746 cm-1 were confirmed. The particle morphology is cube-shaped with irregular sizes. The EDX result showed that the composition consists of 35.92 % calcium, 1.68 % zinc, 44.81 % oxygen, and 13.79 % carbon as elements. With the addition of 2.5 % Y-zeolite, the antibacterial activity of nanocomposites showed the best results, with an inhibition zone diameter of 7.62 mm against Escherichia coli and 6.56 mm against Staphylococcus aureus bacteria.

SOSIALISASI DAN DETEKSI DINI PENCEGAHAN HIPERKOLESTEROLEMIA SERTA PENGEMBANGAN PRODUK ROSELLA BAGI MASYARAKAT DESA BINAAN JATIREJO Widhihastuti, Endah; Rakainsa, Senda Kartika; Christijanti , Wulan
GERVASI: Jurnal Pengabdian kepada Masyarakat Vol. 8 No. 2 (2024): GERVASI: Jurnal Pengabdian Kepada Masyarakat
Publisher : LPPM IKIP PGRI Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31571/gervasi.v8i2.7007

Penelitian ini bertujuan untuk meningkatkan kesadaran dan pengetahuan masyarakat Jatirejo mengenai pencegahan hiperkolesterolemia melalui pemanfaatan Tanaman Obat Keluarga (TOGA) serta memberikan keterampilan pengolahan produk selai bunga rosella. Program pengabdian yang dilakukan meliputi sosialisasi, pelatihan pengolahan selai rosella, dan deteksi dini penyakit degeneratif. Hasil menunjukkan peningkatan pengetahuan masyarakat tentang penyakit degeneratif dan potensi pengembangan produk olahan dari rosella. Kondisi kesehatan masyarakat tergolong baik dimana terdapat 50% masyarakat Jatirejo memiliki tekanan darah normal, 93,3% memiliki gula darah normal, serta 76,67 memiliki kolesterol normal. Akan tetapi 62,5% responden laki laki dan 45,45% pada wanita memiliki kadar asam urat tinggi. Dampak dari kegiatan Pengabdian kepada Masyarakat ini adalah terpantaunya kondisi kesehatan Masyarakat Jatirejo, mengurangi resiko penyakit hiperkolesterolemia dengan peningkatan pengetahuan penyakit hiperkolesterolemia, serta keterampilan pengelolaan produk selai Rosella untuk peningkatan perekonomian warga.

Improved recommender system using Neural Network Collaborative Filtering (NNCF) for E-commerce cosmetic product Subhan, Subhan; Syarif, Deny Lukman; Widhihastuti, Endah; Rakainsa, Senda Kartika; Sam'an, Muhammad; Ifriza, Yahya Nur
SINERGI Vol 29, No 1 (2025)
Publisher : Universitas Mercu Buana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22441/sinergi.2025.1.014

This study presents an enhanced recommender system tailored for e-commerce platforms specializing in cosmetic products. Traditional recommender systems often need help providing accurate and personalized recommendations due to the complexity and subjectivity inherent in cosmetic preferences. In e-commerce, personalized product recommendations are crucial to improving user engagement and driving sales. This paper presents an innovative approach to enhance recommendation systems by leveraging neural network collaborative filtering techniques for the cosmetic product domain. The proposed method integrates neural networks into collaborative filtering, namely neural network collaborative filtering with improved preprocessing step. To validate the effectiveness of our proposed system, extensive experiments were conducted using real-world e-commerce cosmetic datasets "eCommerce Event History in Cosmetics Shop". Additionally, we evaluate the system's performance using historical e-commerce event data in cosmetics stores, demonstrating the system's effectiveness with mean reciprocal ratings (MRR) and normalized discount cumulative gain (NDCG). Evaluation Metrics of MRR and NDCG in this study got 0.56 and 0.60, respectively, with a split of the data: 70% train data, 15% validation data, and 15% test data. This study obtained better evaluation metrics than the previous study, which had an MRR of 0.31 and NDGC of 0.32. Furthermore, this model exhibits robustness against data sparsity and cold-start problems commonly encountered in e-commerce platforms. This research advances knowledge of recommendation systems and paves the way for more personalized and efficient online shopping experiences.

Analysis of Hydroquinone in Face Whitening Cream Circulating in Semarang City Using UV-Vis Spectrophotometry Method SIRAIT, Ernessa Indah Rotua; Widhihastuti, Endah
Journal of Science and Technology Research for Pharmacy Vol 3 No 1 (2023)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar

The Food and Drug Supervisory Agency of the Republic of Indonesia issued a regulation that hydroquinone with levels above two percent is a class of strong drugs that can only be given with a doctor's prescription. However, reality shows that many manufacturers misuse hydroquinone as an over-the-counter cream with a content of more than 2%. This study aims to determine the validity of the UV-Vis spectrophotometric method for hydroquinone analysis, to test the hydroquinone content and levels in whitening creams sold in Semarang, and to ascertain whether these levels comply with BPOM regulations. A total of 10 samples of facial whitening creams obtained from cosmetic shops located in North Semarang, East Semarang, West Semarang, Central Semarang and South Semarang were subjected to qualitative tests and quantitative tests. Method validation test was carried out to ensure the validity of the results obtained. The validation parameters used are linearity, LOD and LOQ, precision and accuracy. The results showed that the UV-Vis spectrophotometric method was valid for hydroquinone analysis in samples of facial whitening cream for all tested parameters. The linear regression equation obtained is y=0,0132x+0,0655 with r=0,9986 and R2=0,9973; the maximum wavelength is 294 nm, high precision with %RSD obtained by 0,84%, the LOD and LOQ values were 2,5 µg/ml and 8,3 µg/ml, and the accuracy value was 100,211%. Then a qualitative test was carried out on each sample of facial whitening cream by comparing the spectrum between each sample and the standard spectrum of hydroquinone to identify the presence or absence of hydroquinone. The results of samples A, G, H, and J were not identified as containing hydroquinone, while samples B, C, D, E, F, and I were identified to contain hydroquinone. The quantitative test was carried out by determining the levels of hydroquinone in a sample of facial whitening cream using a linear regression equation. The hydroquinone content in the sample A, G, H, and J could not be determined because they were not detected by the spectrophotometer used. Hydroquinone levels in creams B, C, D, E, F, and I each have a value of 0.84%; 4.77%; 0.74%; 2.27%; 4.75%; and 1.39%.

Formulation and Sunscreen Activity of Cream Preparation from Iler Leaves Extract (Coleus scutellarioides (L.) Benth) Widhihastuti, Endah; Larasati, Dhatu Sekar; Priatmoko, Sigit; Rakainsa, Senda Kartika
Indonesian Journal of Chemical Science Vol. 13 No. 1 (2024)
Publisher : Prodi Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v13i1.3583

Paparan sinar ultraviolet memiliki efek positif seperti membantu produksi vitamin D, tetapi jika terlalu berlebihan dapat menyebabkan inflamasi akut, eritema, hiperpigmentasi, penuaan dini, dan kanker kulit. Oleh karena itu, diperlukan perlindungan tambahan yaitu tabir surya untuk menyerap atau memantulkan sinar UV. Penelitian ini bertujuan untuk menguji potensi ekstrak etanol dari daun iler (Coleus scutellarioides (L.) Benth) sebagai tabir surya dan memformulasikannya menjadi krim. Penelitian ini dilakukan dengan mengekstraksi simplisia daun iler dengan metode maserasi dan pelarut etanol 96%. Uji fitokimia dilakukan pada ekstrak untuk menentukan kandungan metabolit sekunder. Ekstrak dengan berbagai konsentrasi diuji aktivitas tabir surya dengan menentukan nilai SPF, %Te, dan %Tp. Hasil penelitian menunjukkan bahwa ekstrak daun iler dengan nilai SPF terbaik adalah pada konsentrasi 0,3% dengan nilai SPF 29 yang berada dalam kategori tabir surya dengan perlindungan ultra. Formula krim F1 dengan kandungan asam stearat 17% dan trietanolamin 2% paling memenuhi evaluasi persiapan krim dengan nilai SPF 5 yang tergolong sedang, serta nilai %Te dan % Tp berturut 0,26359 dan 0,38828 yang tergolong sunblock.

The Synthesis of Y-zeolite-modified CaCO3-ZnO Nanocomposites as an Antibacterial Agent Artissiani, Maysa; Widiarti, Nuni; Wahyuni, Sri; Widhihastuti, Endah; Ni'ma, Neli Syahida
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 1, May 2024
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i1.36246

The ability of inorganic antibacterial agents like metal oxides and nanoscale inorganic materials to inhibit bacterial growth rates has yet to receive much research attention. In this study, CaCO3-ZnO/Y-zeolite nanocomposites were created utilizing coprecipitation and impregnation techniques with Ca(CH3COO)2, Zn(CH3COO)2 2H2O, Y-zeolite precursors. Physical and chemical characteristics of nanocomposites have been investigated using XRD, FTIR, and SEM-EDX characterizations. The agar-well diffusion method tested the substance for antibacterial activity against gram-positive and gram-negative bacteria. Nanocomposites have a crystal size range of 35.46-36.53 nm and a crystallinity of 35-37 %, according to the results of XRD analysis. The carbonate groups are visible in FTIR data at wave numbers 1433, 875, and 712 cm-1. The Zn-O absorption band was verified at wave numbers 600-400 cm-1. The Y-zeolite absorption bands at wave numbers 1012-997 cm-1 and 745-746 cm-1 were confirmed. The particle morphology is cube-shaped with irregular sizes. The EDX result showed that the composition consists of 35.92 % calcium, 1.68 % zinc, 44.81 % oxygen, and 13.79 % carbon as elements. With the addition of 2.5 % Y-zeolite, the antibacterial activity of nanocomposites showed the best results, with an inhibition zone diameter of 7.62 mm against Escherichia coli and 6.56 mm against Staphylococcus aureus bacteria.

Analysis study of Methampyrone in jamu pegal linu circulating in Semarang City using Fourier Transform Infrared (FTIR) Spectrophotometry and UV-Vis Spectrophotometry Ameliyana; Endah Widhihastuti
Journal of Science and Technology Research for Pharmacy Vol. 4 No. 2 (2024): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v4i2.9954

Traditional medicine (jamu) has been widely known as an alternative medicine because its side effects are mild, easy to obtain, and cheaper than synthetic medicines. One of the herbal medicines used as a pain reliever in Indonesia is called Jamu Pegal linu. Analgesic drugs are often added illegally to herbal remedies to treat aches and pains. Methampyrone is an example of a medicinal chemical that can most likely be added to jamu pegal linu. The National Food and Drug Administration reported the discovery of contamination in the form of medicinal chemicals. The distribution of herbal medicines containing medicinal chemicals that are dangerous to the public is prohibited based on Minister of Health Regulation no. 007 of 2012. This study aims to determine the content and levels of the medicinal chemical methampyrone in jamu pegal linu in Semarang City. In this study, jamu pegal linu sold in Semarang City will be analyzed for the medicinal chemical content of methampyrone. This research is an experimental study to qualitatively and quantitatively analyze the medicinal chemicals of the drug methampyrone in jamu pegal linu. The qualitative analysis method uses FTIR to identify functional groups. The quantitative analysis method uses UV-Vis Spectrophotometry which has been validated to determine the levels of methampyrone contained in jamu pegal linu. The results of qualitative analysis tests using FTIR show that methampyrone contains functional groups such as C=O (amide), C=C (aromatic), C-H, O=S=O, C-O, S=O, and C-H out-of-plane. The readings from the fifth samples (A, B, N, I, and L) were positive for methampyrone due to the presence of these functional groups, which are characteristic of methampyrone. Validation of the analytical method using UV-Vis Spectrophotometry demonstrates its suitability for quantifying methampyrone levels in jamu pegal linu. The method validation parameters include a correlation coefficient (R2) of 0.9997; limit of detection (LOD) of 0.275966 mg/L; limit of quantification (LOQ) of 0.9198867 mg/L; precision expressed as % RSD of 0.1444%; and accuracy indicated by %recovery of 82,7544%; 84,005%; and 85,721%. The results from the validated analysis method reveal the presence of methampyrone in jamu pegal linu across the five samples (A, B, N, I, and L), with concentrations in each sample measured at 3,594 ± 0,002%; 1,507 ± 0,003%; 1,386 ± 0,003%; 2,900 ± 0,003%; and 31,870 ± 0,028%.

Identification And Determination of Levels the Drug Chemical Sibutramin Hydrochloride in Body Slimming Herbs Circulating in the City of Salatiga Prisma Detty Nuryana; Endah Widhihastuti
Journal of Science and Technology Research for Pharmacy Vol. 4 No. 2 (2024): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v4i2.9977

Background: Sibutramine hydrochloride is strictly prohibited from being present in weight loss herbal medicines according to the regulations of the Indonesian National Agency of Drug and Food Control (Badan POM RI) No.KH.00.01.43. However, due to increasing competition, many traditional medicine producers seek greater profits by adding sibutramine hydrochloride (SH) to their products. Aim: This study aimed to establish the validity of the UV-VIS spectrophotometer method for analyzing sibutramine hydrochloride and to test the levels and content of sibutramine hydrochloride in weight loss herbal medicine samples sold in Salatiga City. Materials and Methods: A total of 8 samples of weight loss capsules obtained from traditional medicine stores in Salatiga City were subjected to qualitative and quantitative tests. Validation parameters included linearity, limit of detection (LoD), limit of quantification (LoQ), precision, and accuracy. Results: The study revealed a linear regression equation of y=0.0397x + 0.046 with r=0.9975 and r^2=0.9950, with a maximum wavelength of 223 nm. The LOD was 1.01 mg/L and LOQ was 3.37 mg/L. Precision, expressed as % RSD, was 0.147%, and percent recoveries (% recovery) were 98.263%, 89.337%, and 91.703%. Qualitative tests on each sample compared spectra and maximum wavelengths with standard sibutramine hydrochloride spectra, identifying samples A, B, C, E, and F as negative for sibutramine hydrochloride, while samples D, G, and H tested positive. Quantitative analysis determined sibutramine hydrochloride concentrations in weight loss herbal medicines using linear regression equations. The concentrations in samples D, G, and H were 6.0117 mg/L, 6.7254 mg/L, and 6.0117 mg/L, respectively. The percentage content of sibutramine hydrochloride in samples D, G, and H was 3.00%, 3.36%, and 3.00%, respectively. Conclusion: The UV-VIS spectrophotometer method is validated for analyzing sibutramine hydrochloride in weight loss herbal medicines across all tested parameters. Samples A, B, C, E, and F were found negative for sibutramine hydrochloride, whereas samples D, G, and H tested positive.

Validation Study of the Method of Analysis of Fe (II) Levels in Blood Addition Tablet Preparations by Wet Destruction and Dry Destruction Methods by UV-Vis Spectrophotometry Nurul Fajar Agustina; Endah Widhihastuti
Journal of Science and Technology Research for Pharmacy Vol. 4 No. 2 (2024): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v4i2.10006

Iron is one of the micro minerals needed in the human body. One effort to meet iron needs can be done by consuming blood supplement tablets that contain iron. The iron content contained in blood supplement tablets needs to be known by carrying out quality testing to ensure that the preparation contains the specified ingredients and quantities. The UV-Vis spectrophotometer is an alternative method for determining iron levels because it has lower operating costs and is simpler but has high sensitivity. Determining the iron content to be analyzed requires a complexing agent to form colored compounds. The complexing compound often used in this research is phenantorline. The requirement for metal analysis using a UV-Vis Spectrophotometer is that the sample must be in solution form so a digestion process needs to be carried out. Destruction is divided into two, namely dry and wet destruction. This study aims to compare two digestion methods that are commonly used, namely wet digestion and dry digestion in determining Fe (II) levels in blood supplement tablets. In this research, method validation will also be carried out which aims to show that the testing procedures used obtain the expected results consistently and continuously. Validation of analytical methods carried out includes linearity test parameters, detection limit tests, quantitation limit tests, accuracy tests and precision tests. . Linearity is indicated by R2 of 0.9986; detection limit of 1.10 mg/L; quantitation limit of 3.62 mg/L; accuracy of dry digestion and wet digestion between 80-120%; and precision of dry digestion and wet digestion as indicated by an RSD percentage below 2%. Quantitative test results showed that the percentage levels of blood added tablet samples from wet digestion and dry digestion were 91.52% respectively; 100.09%; 96.15%; 100.96%; 100.67%. and 93.39%; 108.29%; 99.47%; 93.47%; and 92.57%.

Antibacterical Activity Test of Suji Leaf Fraction (Dracaena angustifolis (Medik.) Roxb) against the Growth of Staphylococcus Epidermidis Acne-Causing Bacteria Erika Wuryaningsih; Endah Widhihastuti
Journal of Science and Technology Research for Pharmacy Vol. 4 No. 2 (2024): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v4i2.10175

The suji plants is a plant that has benefits as an antibacterial, one of which is the leaves. Suji leaves contain chemical compounds such as flavonoids, alkaloids, saponins, steroids, terpenoids, and tannins. The compounds can function as antibacterials. The study aims to determine the value of the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of suji leaf fractions against Streptococcus epidermidis bacteria. The antibacterial test method used is liquid dilution and solid dilution. The results obtained were the most active fraction that was able to inhibit Staphylococcus epidermidis was the n-hexane fraction with a KHM value of 6.25% and KBM 12.5%. The results obtained show that the N-Hexane fraction of suji leaves which is the most active fraction in inhibiting bacterial growth is not as good as clindamycin and ethanol extract in inhibiting Staphylococcus epidermidis bacteria, where ethanol extract has a KBM value of 6.25%. Meanwhile, clindamycin which is a positive control has been able to inhibit and kill the growth of Staphylococcus epidermidis bacteria at a concentration of 0.1%. The results of KBM values obtained from the most active samples are ethanol extract > n-hexane fraction > ethyl acetate fraction > ethyl acetate insoluble fraction. Bioautography KLT results show that the compounds responsible for antibacterial activity are thought to be flavonoids, steroids, and triterpenoids.

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