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Edukasi Pengenalan Obat Kepada Siswa Sekolah Dasar Ani Kristiyani; Sarah Puspita Admaja
J.Abdimas: Community Health Vol 2 No 1 (2021): J.Abdimas: Community Health - Mei 2021
Publisher : LPPM STIKES Guna Bangsa Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30590/jach.v2n1.p28-34.2021

The problem of rational drug use in the community, especially among students, is still minimal. The government by gema cermat or smart community movement to use drugs which in the context of society expects an in knowledge increase, understanding and skills in using drug properly and wisely so that can lead awareness of drugs using in the community. Health education is an effort that is given guidance to someone or students. Presenting counseling is expected to increase knowledge about proper drugs used for students. The method used in educating students is through material presentation, discussion, quizzes, and playing games. Students are given a pre-test and post-test before and after education. Education to increase students' knowledge is shown from the post-test results obtained that have a higher knowledge value than the pre-test.

Efek Polimorfisme Gen Enzim Pemetabolisme Obat terhadap Kadar Rivaroxaban: Sebuah Kajian Naratif Sarah P. Atmaja; Ani Kristiyani; Ellsya A. Rawar
Jurnal Farmasi Klinik Indonesia Vol 11, No 2 (2022)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2022.11.2.164

Rivaroxaban merupakan agen antikoagulan yang mengalami biotransformasi via liver dengan melibatkan peran dari CYP3A4/5 (18%); CYP2J2 (14%) dan sisanya melalui CYP independent hydrolytic cleavage (14%). Polimorfisme yang terjadi pada gen pemetabolisme obat memengaruhi kadar rivaroxaban di dalam tubuh, hal tersebut telah dilaporkan di dalam berbagai macam penelitian. Kajian naratif ini bertujuan untuk mengulas mengenai pengaruh variasi gen enzim pemetabolisme obat pada kadar rivaroxaban di dalam tubuh pasien dari beberapa penelitian yang sudah dilaporkan. Metode yang digunakan adalah kajian naratif dengan cara menelusuri data berbasis Google Scholar dengan kata kunci rivaroxaban, polymorphism, CYP3A4, CYP3A5, dan CYP2J2. Beberapa penelitian menunjukan bahwa polimorfisme gen pemetabolisme tidak memberikan pengaruh yang signifikan terhadap perubahan kadar rivaroxaban di dalam darah, namun masih terdapat beberapa keterbatasan penelitian. Perlu adanya penelitian yang lebih komprehensif dengan melibatkan keseluruhan single nucleotide polymorphism (SNP) yang berperan dalam farmakokinetika rivaroxaban, mengingat rivaroxaban dimetabolisme oleh beberapa isoenzim CYP dan diekskersikan oleh beberapa transporter, sehingga hal tersebut masih membuka kesempatan untuk penelitian lebih lanjut mengenai farmakogenomik rivaroxaban. Kata kunci: CYP3A4, CYP3A5, CYP2J2, polimorfisme, rivaroxaban Effect of Gene Polymorphism in Drug-metabolizing Enzyme on Concentration of Rivaroxaban: A Narrative ReviewAbstractRivaroxaban is an anticoagulant agent that often experience biotransformation in the liver through CYP3A4/5 (18%); CYP2J2 (14%) and CYP independent hydrolytic cleavage (14%). Several studies revealed that Polymorphism in drug-metabolizing enzyme genes can affect the rivaroxaban levels in the body. Therefore, this study aims to review the effect of gene variations of metabolizing enzymes on rivaroxaban concentration in patient’s body. A search using keyword rivaroxaban, polymorphism, CYP3A4, CYP3A5 and CYP2J2 was carried out in Google Scholar. Several studies showed that polymorphisms of metabolizing genes do not have a significant effect on rivaroxaban concentration. There is also a need for comprehensive studies involving all single nucleotide polymorphisms (SNPs) that play a role in the drug’s pharmacokinetics. This is because rivaroxaban is metabolized by several CYP isoenzymes and excreted by different transporters. This still opens the opportunity for further studies on its pharmacogenomic. Keywords: CYP3A4, CYP3A5, CYP2J2, polymorphism, rivaroxaban

The Relationship Between Length of Rehabilitation and Quality of Life for Psychoactive Substance Users in Yogyakarta Ani Kristiyani
Duta Pharma Journal Vol. 2 No. 1 (2022): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (158.114 KB)

The background of this research is the use of psychoactive substances causes complex problems and becomes a threat to the state. Rehabilitation can reduce the risk of relapse of psychoactive substance abuse and the risk of crime, thereby improving quality of life. Understanding rehabilitation with quality of life has a positive impact on users of psychoactive substances. Therefore, it is essential to study the relationship between the length of rehabilitation and the quality of life of users of psychoactive substances. The purpose of this study was to determine the relationship between the size of rehabilitation and the quality of life for users of psychoactive substances. This research method is a non-experimental observational analytic study with a cross-sectional design. The subjects of the study were users of psychoactive substances who were undergoing the rehabilitation process at the Class IIA Narcotics Prison in Yogyakarta. Quality of life was measured by the World Health Organization Quality of Life BREF (WHOQOL-BREF) instrument. The significance level of the statistical test was stated at p<0.05. Data analysis used the Spearman Rank correlation test and multiple linear regression. The results of this study carried out for two months (March to April 2021) obtained a total of 77 subjects using psychoactive substances. The length of rehabilitation has a significant positive correlation with the quality of life, indicated by the value of p = 0.048 (p <0.05) and r = 0.220, which means that the longer the respondent undergoes rehabilitation, the better the quality of his life. This study concludes that there is a significant relationship between the length of repair and quality of life for users of psychoactive substances.

Edukasi Kesehatan dan Manfaat Obat Herbal dalam Mengatasi Menstruasi Bagi Remaja Putri : Health Education and The Benefits of Herbal Medicine in Overcoming Menstruation for Adolescent Women Ani Kristiyani; Aloysia Yossy Kurniawaty; Sarah Puspita Admaja; Yosua Adi Kristariyanto; Shintia Claudia Atiameru; Tabita Rahmavika; Syalomita Chornelia Lahope; Lilya Cecillia Arunde; Naomi Azazya Tatambihe; Angelina Eclesia Zangga Kulla; Lusiana Cindy Putri Laka; Renald Umbu Deta Dapawando
Jurnal Pengabdian Kepada Masyarakat : Kesehatan Vol. 2 No. 3 (2022): september
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) STIKES Notokusumo Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (605.998 KB)

Abstrak: Premenstrual syndrome (PMS) mencakup beragam gejala fisik dan psikologis sehingga menyebabkan banyak remaja putri tidak dapat melakukan aktivitas seperti biasanya. Terdapat beberapa bukti yang mendukung kemanjuran melalui intervensi pengobatan herbal dalam mengendalikan sindrom pramensturasi dan gangguan disforik pramenstruasi. Tujuan pengabdian kepada masyarakat ini adalah memberikan informasi kepada remaja putri mengenai mensturasi dan manfaat obat herbal dalam membantu mengatasi menstruasi melalui penyuluhan. Metode penyuluhan melalui konseling dan pembagian materi edukasi menggunakan media cetak berupa brosur. Hasil dari pengabdian kepada masyarakat menunjukan terdapat peningkatan pengetahuan yang tunjukkan dari hasil pre-test (sebelum) edukasi rata-rata memiliki nilai 79,5 dan nilai post-test (sesudah) edukasi memilik nilai rata-rata 91,6, peningkatan ini sebesar 12,1%. Kesimpulan dan saran: Penyuluhan melalui konseling dan pembagian materi melalui media brosur merupakan cara efektif untuk meningkatkan pengetahuan kesehatan remaja putri mengenai mensturasi dan pengetahuan mengenai manfaat herbal untuk mengatasi menstruasi dan perlu dilaksanakan secara berkelanjutan dengan target sasaran yang lebih banyak lagi. Abstract: Premenstrual syndrome (PMS) includes a variety of physical and psychological symptoms that cause many young women to be unable to carry out their usual activities. There is some evidence supporting the efficacy of herbal medicine interventions in controlling premenstrual syndrome and premenstrual dysphoric disorder. This community service aims to inform young women about menstruation and the benefits of herbal medicine in helping overcome menstruation through counselling. The counselling method is through counselling and the distribution of educational materials using printed media in the form of brochures. The community service results show an increase in knowledge, which shows that the pre-test (before) education results have an average value of 79.5, and the post-test score (after) education has an average value of 91.6; this increase is 12,1%. Conclusions and suggestions: Counseling through counselling and distributing materials through brochures is an effective way to increase young women's health knowledge about menstruation and to learn about the benefits of herbs to treat menstruation and needs to be carried out continuously with more targets.

Penyuluhan Kesehatan Tentang Insomnia : The Health Education About Insomnia Ani Kristiyani; Cresensia Aprilia Belu; Agustinus Jitro Nono; Ika Ismiyarti; Teofilia Alvanes
Jurnal Pengabdian Kepada Masyarakat : Kesehatan Vol. 2 No. 4 (2022): Desember
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) STIKES Notokusumo Yogyakarta

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Abstrak: Tidur merupakan sepertiga dari kehidupan manusia dan menjadi kebutuhan manusia. Berdasarkan National Sleep Foundation (2018), kejadian insomnia di seluruh dunia mencapai 67% dari 1.508 orang di Asia Tenggara dan 7,3% insomnia terjadi pada mahasiswa. Di Indonesia angka prevalensi insomnia sekitar 67%, sedangkan sebanyak 55,8 % insomnia ringan dan 23,3 % mengalami insomnia sedang. Salah satu cara mengatasi insomnia dapat dilakukan melalui edukasi untuk meningkatkan pengetahuan tentang insomnia kepada masyarakat. Metode penyuluhan kesehatan mengatasi insomnia ini dilakukan melalui seminar secara online. Tahapan kegiatan diawali dengan pre-test lalu dilakukan pemaparan materi, diskusi, tanya jawab, kemudian diakhir kegiatan peserta diminta mengisi kembali post-test. Tingkat pengetahuan diukur berdasarkan hasil pre-test dan post-test. Tujuan kegiatan pengabdian kepada masyarakat ini yakni untuk meningkatkan pengetahuan mengenai insomnia dan memberikan informasi pengobatan insomnia secara farmakologi dan non-farmakologi dengan sasaran mahasiswa. Kegiatan pengabdian kepada masyarakat ini berhasil meningkatkan pengetahuan mahasiswa mengenai insomnia yang ditunjukkan dari hasil rerata peningkatan pengetahuan yang signifikan antara pre-test (57,75) dan post-test (80) dengan nilai P-Value < 0,05. Abstract: Sleep is a third of human life and a human need. Based on the National Sleep Foundation (2018), the incidence of insomnia worldwide reaches 67% of 1,508 people in Southeast Asia and 7.3% of insomnia occurs in college students. In Indonesia, the prevalence of insomnia is around 67%, while 55.8% of mild insomnia and 23.3% have moderate insomnia. One way to overcome insomnia can be done through education to increase knowledge about insomnia to the public. This method of health counseling to overcome insomnia is carried out through online seminars. The stages of the activity began with a pre-test and then carried out material presentation, discussion, question and answer, then at the end of the activity the participants were asked to fill out the post-test. The level of knowledge is based on the pre-test and post-test outcome measures. The purpose of this community service is to increase knowledge about insomnia and provide information on pharmacological and non-pharmacological insomnia treatment with student targets. This community service activity succeeded in increasing students' knowledge about insomnia, as indicated by the results of a significant increase in mean knowledge between pre-test (57,75) and post-test (80) with P-Value <0.05.

PENETAPAN KADAR FLAVONOID TOTAL DAN FENOLIK TOTAL SERTA UJI PENGHAMBATAN DENATURASI PROTEIN DALAM SEDUHAN TEH BUNGA TELANG (Clitoria ternatea L.) Ellsya Rawar; Ani Kristiyani; Intan Selvyanti Waruwu
Majalah Farmasi dan Farmakologi Vol. 27 No. 2 (2023): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v27i2.26250

Inflamasi merupakan bentuk respon perlindungan tubuh terhadap kerusakan sel atau jaringan tubuh. Inflamasi dapat menyebabkan terjadinya denaturasi protein. Senyawa flavonoid dan fenolik yang dikandung dalam tanaman memiliki aktivitas anti-inflamasi. Bunga telang (Clitoria ternatea L.) mengandung senyawa flavonoid dan fenolik. Bunga telang telah dimanfaatkan oleh masyarakat Indonesia sebagai minuman kesehatan dalam bentuk teh. Tujuan penelitian ini adalah menentukan kadar fenolik total dan flavonoid total serta uji aktivitas penghambatan denaturasi protein dalam seduhan teh bunga telang. Metode penelitian meliputi pembuatan seduhan teh bunga telang, penentuan kandungan fenolik total dan flavonoid total, serta uji penghambatan denaturasi protein secara spektrofotometri UV-Vis. Pembuatan serbuk teh bunga telang dilakukan dengan pengeringan kelopak bunga telang dengan solar dryer, penyerbukan dengan blender, dan penyaringan dengan ayakan 42 mesh. Seduhan teh bunga telang dibuat dengan cara melarutkan serbuk teh dalam akuades panas dengan suhu 70 °C dan didiamkan selama 10 menit. Metode kolorimetri dengan reagen AlCl3 pada panjang gelombang 440 nm digunakan untuk menentukan kandungan flavonoid total. Reagen Folin-Ciocalteu secara spektrofotometri UV-Vis dengan penjang gelombang 770 nm digunakan untuk menentukan kandungan fenolik total. Uji penghambatan denaturasi protein secara dilakukan dengan menggunakan Bovine Serum Albumin sebagai protein yang didenaturasi dengan pemanasan pada 72 °C selama 5 menit dalam waterbath. Di dalam seduhan teh bunga telang, terdapat kandungan flavonoid total sebesar 3,24±0,0759 EK (mg/g sampel) dan fenolik total sebesar 2,60±0,0153 GAE (mg/g sampel). Nilai IC50 natrium diklofenak sebesar 3,37 ppm lebih kecil daripada nilai IC50 seduhan teh bunga telang sebesar 184,10 ppm. Seduhan teh bunga telang dengan konsentrasi 140 ppm memiliki presentase penghambatan denaturasi protein lebih dari 20%.

EFEKTIVITAS EKSTRAK DAUN KEMANGI (Ocimum sanctum L.) TERHADAP BAKTERI Staphylococcus aureus Ani Kristiyani; Pilar Tesalonika Wahyukurnia; Aloysia Yossy Kurniawaty; Yosua Adi Kristariyanto
Duta Pharma Journal Vol. 3 No. 1 (2023): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/djp.v3i1.2382

Telah ditemukan beberapa antibiotik yang berasal dari tumbuhan, salah satunya daun kemangi. Ekstrak daun kemangi (Ocimum sanctum L.) memiliki kandungan senyawa metabolit sekunder yang memiliki manfaat sebagai antibakteri yaitu flavonoid, tannin, fenol dan minyak atsiri. Bakteri yang diujikan dalam artikel yaitu bakteri Staphylococcus aureus. Bakteri Staphylococcus aureus menyebabkan penyakit pada kulit seperti mastitis, dermatitis. Tujuan review artikel ini adalah untuk mengetahui aktivitas antibakteri dari ekstrak daun kemangi terhadap bakteri Staphylococcus aureus. Metode yang digunakan review artikel adalah pencarian jurnal dari tahun 2011-2021 dengan bahasa Indonesia menggunakan google scholar serta sesuai kriteria inklusi dan ekslusi yang ditentukan. Hasil pencarian jurnal diperoleh sejumlah 9 jurnal, dan disimpulkan bahwa ekstrak daun kemangi memiliki aktivitas antibakteri terhadap bakteri Staphylococcus aureus.

HUBUNGAN KUALITAS HIDUP FAMILY CAREGIVER DENGAN DURASI SAKIT PASIEN SKIZOFRENIA DI RSJ GHRASIA Ani Kristiyani; Envan Widya Chrisnawan
JURNAL FARMASI DAN KESEHATAN INDONESIA Vol. 1 No. 1 (2021): Jurnal Farmasi dan Kesehatan Indonesia
Publisher : Universitas Kristen Immanuel

Show Abstract | Download Original | Original Source | Check in Google Scholar

Kualitas hidup family caregiver dilaporkan sebagai prediktor dalam pemulihan fungsional pasien skizofrenia. Penurunan kualitas hidup family caregiver secara signifikan menyebabkan rendahnya komitmen perawatan pasien sehingga dapat memperpanjang durasi sakit. Dengan demikian, kualitas hidup caregiver perlu menjadi perhatian utama bagi tenaga kesehatan profesional. Tujuan penelitian ini adalah mengetahui hubungan kualitas hidup family caregiver dengan durasi sakit pasien Skizofrenia di RSJ Ghrasia. Penelitian ini merupakan penelitian deskriptif analitik dengan rancangan cross-sectional. Subyek penelitian ini adalah pasien skizofrenia di bagian rawat jalan psikiatri RSJ Ghrasia. Kualitas hidup dinilai dengan instrumen WHOQOL-BREF. Analisis statistik dilakukan dengan menggunakan uji korelasi Pearson. Tingkat kemaknaan uji statistik dinyatakan pada p<0,05. Subyek penelitian ini adalah 55 pasien skizofrenia dan 55 caregiver. Hasil penelitian ini menunjukkan tidak ada hubungan antara quality of life family caregiver pasien skizofrenia dengan durasi sakit.

The Genetic Polymorphisms of CYP3A4*1G and CYP3A5*3 in Javanese Indonesian Population: The Genetic Polymorphisms of CYP3A4*1G and CYP3A5*3 in Javanese Indonesian Atmaja, Sarah; Ellsya Angeline Rawar; Ani Kristiyani; Dwi Aris Agung Nugrahaningsih; Ahmad Hamim Sadewa; Christine Patramurti
Journal of Tropical Life Science Vol. 14 No. 1 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.01.06

Polymorphisms of CYP3A4*1G and CYP3A5*3 affect the pharmacokinetic profile of various drugs, e.g., fentanyl, tacrolimus, diltiazem, simvastatin. Tetra-primer amplification refractory mutation system-polymerase chain (ARMS-PCR) is a simple and economical method for SNP determination. The polymorphisms in the CYP3A4*1G and CYP3A5*3 genes have not yet been examined using this method in Javanese Indonesian. Our aim was to determine the frequency of polymorphisms in the CYP3A4*1G and CYP3A5*3 genes in Indonesian Javanese using the ARMS-PCR method. Eighty-six patients at the Kalasan Community Health Centre in Yogyakarta, Indonesia, were chosen based on the inclusion criteria, which is Javanese ancestry. They gave their informed consent to blood collection by completing a form. Genetic variants were detected using Tetra-primer amplification refractory mutation system-polymerase chain (ARMS-PCR). The chi-square test was used to determine genotype deviations from Hardy-Weinberg equilibrium, with a significant threshold of 0.05. For homozygous wild types, CYP3A4 *1/*1 dominated overall among study participants (73.35%), whereas for CYP3A5*3/*3, homozygous mutants were more prevalent (83.72%). Hardy-Weinberg equilibrium is consistent with genotype frequencies (p > 0.005). One participant carried a homozygous mutation for both CYP3A4*1G and CYP3A5*3, while the other 49 subjects were heterozygous for CYP3A4*1G and homozygous mutant for CYP3A5*3, which is the highest number of SNP combinations. The findings of the current investigation demonstrate that the population has the highest proportion of homozygous CYP3A4*1G wild-types (CYP3A4*1/*1) and homozygous mutants for CYP3A5*3 (CYP3A5*3/*3)

The Genetic Polymorphisms of CYP3A4*1G and CYP3A5*3 in Javanese Indonesian Population: The Genetic Polymorphisms of CYP3A4*1G and CYP3A5*3 in Javanese Indonesian Atmaja, Sarah; Ellsya Angeline Rawar; Ani Kristiyani; Dwi Aris Agung Nugrahaningsih; Ahmad Hamim Sadewa; Christine Patramurti
Journal of Tropical Life Science Vol. 14 No. 1 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.01.06

Polymorphisms of CYP3A4*1G and CYP3A5*3 affect the pharmacokinetic profile of various drugs, e.g., fentanyl, tacrolimus, diltiazem, simvastatin. Tetra-primer amplification refractory mutation system-polymerase chain (ARMS-PCR) is a simple and economical method for SNP determination. The polymorphisms in the CYP3A4*1G and CYP3A5*3 genes have not yet been examined using this method in Javanese Indonesian. Our aim was to determine the frequency of polymorphisms in the CYP3A4*1G and CYP3A5*3 genes in Indonesian Javanese using the ARMS-PCR method. Eighty-six patients at the Kalasan Community Health Centre in Yogyakarta, Indonesia, were chosen based on the inclusion criteria, which is Javanese ancestry. They gave their informed consent to blood collection by completing a form. Genetic variants were detected using Tetra-primer amplification refractory mutation system-polymerase chain (ARMS-PCR). The chi-square test was used to determine genotype deviations from Hardy-Weinberg equilibrium, with a significant threshold of 0.05. For homozygous wild types, CYP3A4 *1/*1 dominated overall among study participants (73.35%), whereas for CYP3A5*3/*3, homozygous mutants were more prevalent (83.72%). Hardy-Weinberg equilibrium is consistent with genotype frequencies (p > 0.005). One participant carried a homozygous mutation for both CYP3A4*1G and CYP3A5*3, while the other 49 subjects were heterozygous for CYP3A4*1G and homozygous mutant for CYP3A5*3, which is the highest number of SNP combinations. The findings of the current investigation demonstrate that the population has the highest proportion of homozygous CYP3A4*1G wild-types (CYP3A4*1/*1) and homozygous mutants for CYP3A5*3 (CYP3A5*3/*3)

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