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All Journal Jurnal Kesehatan Gigi JURNAL SKALA HUSADA: THE JOURNAL OF HEALTH Odonto dental journal
Setyaningsih, Sari
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Examining the Impact of Porphyromonas gingivalis Infection on Ovarian Health: A Reduction in Primordial Follicles in a Female Periodontitis Model Meilawaty, Zahara; Galau, Argha Sirna; Permatasari, Sabania Dinar; Setyaningsih, Sari; Astuti, Pudji; Setiawatie, Ernie Maduratna; Hendarto, Hendy; Suci Dharmayanti, Agustin Wulan
Jurnal Kesehatan Gigi Vol. 12 No. 1 (2025): Juni 2025
Publisher : Jurusan Kesehatan Gigi, Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkg.v12i1.12547

Abstract

Periodontitis is a chronic inflammation of the periodontal tissues caused by periodontal pathogens, such as Porphyromonas gingivalis (P. gingivalis). P. gingivalis possesses several virulence factors that enable it to invade and spread through the bloodstream to other organs, including the ovaries. It triggers inflammation, which may impact the number of primordial follicles. The aim of this study was to assess the effects of P. gingivalis infection on the number of primordial follicles in the ovaries. This study was a laboratory experiment with a post-test control group design. The rats were divided into control and periodontitis groups. The periodontitis group consisted of rats induced with P. gingivalis in their sulcus gingiva of the first mandible molar every three days for 19 days. Therefore, control groups were without P. gingivalis induction. Seven days after the last induction of P. gingivalis, the rats were euthanized, and their ovarian tissues were collected for histological preparation. The primordial follicles were counted under 400x magnification. The results indicated that the treatment group had a significantly lower number of primordial follicles (2.2 ± 2.61) compared to the control group (12.4 ± 2.41). The study concludes that P. gingivalis infection led to a reduction in the number of ovarian primordial follicles in periodontitis models.
Toothbrush design appropriate for pre-elderly: The relationship of toothbrush bristles number to oral hygiene Suhartini, Suhartini; Hamzah, Zahreni; Setyaningsih, Sari; Prijatmoko, Dwi; Harmono, Happy; Arina, Yuliana Mahdiyah Daat; Prihatiningrum, Berlian
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.%p

Abstract

Background: The increase in the elderly population leads to a decline in their health and affects the productivity and quality of life. Preventive measures must be taken to improve oral hygiene for the elderly starting from the pre-elderly group so that later it will form healthy and productive elderly. One of the efforts to improve dental hygiene and health is through mechanical tooth cleaning with a toothbrush. However, currently, there is no toothbrush design that is suitable for the condition of the pre-elderly oral cavity. Therefore, it is necessary to analyze the design of the number of toothbrush bristles as initial research to obtain an appropriate toothbrush design for the elderly. Method:The study was conducted on 30 participants using a toothbrush with a number of toothbrush bristles paths: with 4 paths, 3 paths, and 2 paths. The effectiveness of tooth brushing hygiene was measured through the debris index before using a toothbrush and after brushing. Result: The results of the Kruskal Wallis test showed a significance value of 0.01 (p
Uji Aktivitas Antibakteri Ekstrak Daun Secang terhadap Pertumbuhan Bakteri Streptococcus mutans Agustini, Ni Putu Eka; Burhannuddin, Burhannuddin; Sudarmanto, I Gede; Setyaningsih, Sari
Jurnal Skala Husada : The Journal of Health Vol 20, No 1 (2023): Jurnal Skala Husada: The Journal of Health
Publisher : Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/jsh:tjoh.v20i1.2474

Abstract

Streptococcus mutans merupakan salah satu bakteri yang dapat menyebabkan terjadinya infeksi gigi dan mulut. Daun secang memiliki senyawa antibakteri seperti flavonoid, fenol, tanin, dan saponin. Penelitian ini bertujuan untuk mengetahui perbedaan diameter zona hambat pertumbuhan Streptococcus mutans pada berbagai konsentrasi ekstrak daun secang dan menentukan konsentrasi efektif. Penelitian ini merupakan true experiment dengan desain penelitian rancangan acak lengkap, menggunakan metode difusi cakram Kirby-Bauer pada empat konsentrasi (20%, 40%, 60% dan 80%) kontrol kerja (kloramfenikol 30 mcg) dan kontrol negatif (etanol 96%). Hasil penelitian menunjukkan, ekstrak daun secang mampu menghambat Streptococcus mutans dengan diameter zona hambat 20% (11.55 mm), 40% (13.02 mm), 60% (13.02 mm), 80% (16.57 mm), dan kontrol negatif (0 mm). Uji Kruskal Wallis didapatkan nilai p (0.000) α (0,05) yang artinya bahwa ada perbedaan nilai diameter zona hambat pertumbuhan bakteri Streptococcus mutans pada berbagai variasi konsentrasi ekstrak etanol daun secang. Simpulan penelitian ini adalah ada aktivitas antibakteri ekstrak etanol daun secang terhadap pertumbuhan bakteri Streptococcus mutans.
Co-Authors Agustin Wulan Suci Dharmayanti Agustini, Ni Putu Eka Arina, Yuliana Mahdiyah Daat Burhannuddin Dwi Prijatmoko Ernie Maduratna Setiawatie Galau, Argha Sirna Happy Harmono Hendy Hendarto Permatasari, Sabania Dinar Prihatiningrum, Berlian PUDJI ASTUTI Sudarmanto, I Gede Suhartini Suhartini Zahara Meilawaty Zahreni Hamzah