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All Journal Journal of Islamic Pharmacy Majalah Kesehatan FKUB Journal of Islamic Medicine
Umami, Zahra
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

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AKTIVITAS ANTITUSIF KOMBINASI EKSTRAK ETANOL JAHE MERAH (Zingiber officinale var. rubrum) DAN DAUN UNGU (Graptophyllum pictum) PADA MARMUT (Cavia porcellus) Umami, Zahra; Muti'ah, Roihatul; Annisa, Rahmi
Majalah Kesehatan FKUB Vol 7, No 4 (2020): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.majalahkesehatan.2020.007.04.1

Abstract

Batuk sebagai sebuah sistem perlindungan dengan cara mengeluarkan benda asing pada saluran pernapasan manusia yang bisa menyebabkan infeksi. Perlu dilakukan penelitian terhadap pemanfaatan tanaman sebagai obat yang digunakan untuk mengatasi batuk. Hal tersebut dikarenakan tanaman obat memiliki efek samping minim daripada obat buatan. Jahe merah (Zingiber officinale var. rubrum) serta daun ungu (Graptophylum pictum) telah dimanfaatkan penggunaannya dengan cara tradisional dalam mengatasi batuk. Tujuan penelitian ini yaitu mendapatkan pengetahuan mengenai aktivitas antitusif serta perbandingan optimal kombinasi dari ekstrak etanol 96% jahe merah serta ekstrak etanol 96% daun ungu. Uji aktivitas antitusif dilakukan dengan menilai persentase supresi batuk melalui induksi larutan asam sitrat 7,5% pada hewan coba marmut betina sebanyak 28 ekor dibagikan menjadi tujuh kelompok perlakuan di antaranya perlakuan dengan pemberian CMC-Na (kontrol negatif), kodein 10 mg/kg BB (kontrol positif), dosis tunggal 250 mg/kg BB dari ekstrak etanol 96% jahe merah serta daun ungu, dosis kombinasi ekstrak etanol 96% jahe merah serta daun ungu dengan perbandingan kombinasi 1:1, 0,5:1 dan 1:0,5 selama 5 hari. Penelitian menunjukkan hasil bahwa ekstrak etanol 96% jahe merah serta daun ungu pada dosis tunggal maupun kombinasinya memiliki aktivitas antitusif yang mampu meningkatkan supresi batuk melalui hewan percobaan yaitu marmut. Perbandingan hasil kombinasi ekstrak etanol 96% jahe merah serta ekstrak etanol 96% daun ungu yang optimal adalah 1:0,5 dengan persentase supresi batuk sebesar 73,00 %. 
mec Genes in Methicillin Resistant Staphylococcus aureus Umami, Zahra; Warni, Asri Indahning; Wahyuni, Dewi
Journal of Islamic Pharmacy Vol 8, No 2 (2023): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v8i2.24060

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) manifests antibiotic resistance, especially for the β-lactams antibiotic group. MRSA bacteria are a common cause of infection in humans. The antibiotic resistance characteristic comes from the mecA, mecB, and mecC genes in the bacterial chromosome. mecA is the most common gene found in MRSA. Therefore, it is essential to know the role of the mecA gene in antibiotic resistance. This paper searched the literature about MRSA bacteria, the mec gene, and their relationship to cause resistance. The results showed that the mec gene found in MRSA bacteria causes antibiotic resistance in penicillin groups. Methicillin-resistant Staphylococcus aureus (MRSA) manifests antibiotic resistance, especially for the β-lactams antibiotic group. MRSA bacteria are a common cause of infection in humans. The antibiotic resistance characteristic comes from the mecA, mecB, and mecC genes in the bacterial chromosome. mecA is the most common gene found in MRSA. Therefore, it is essential to know the role of the mecA gene in antibiotic resistance. This paper searched literature about MRSA bacteria, the mec gene, and their relationship to cause resistance. The results showed that the mec gene found in MRSA bacteria causes antibiotic resistance in penicillin groups.
Peran Vitamin D Terhadap Kanker: Sebuah Tinjauan Literatur Umami, Zahra; Suharjono, Suharjono
Journal of Islamic Medicine Vol 8, No 2 (2024): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2024
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v8i2.26058

Abstract

Vitamin D is a potent steroid hormone precursor that regulates a broad spectrum of physiological processes in the body. Besides its general role in bone metabolism, vitamin D plays an important role in the prevention and treatment of many diseases such as cancer. The aim of this literature review is to examine in more depth the role of vitamin D as an anticancer. There are studies that reveal biological mechanisms mediated by vitamin D in regulating cancer cells, such as cell renewal, cell proliferation, cell differentiation, cell transformation, and cell death. Other studies have also revealed a link between the immune system and the anti-neoplastic effects of vitamin D. Research shows that low levels of vitamin D in circulation are associated with an increased risk of cancer. The use of supplementation alone or in combination with immunotherapy or other chemotherapy may promote better clinical outcomes. These promising results still require further development and research through novel approaches targeting vitamin D signaling and metabolic systems to improve cancer therapeutic outcomes.
Co-Authors Dewi Wahyuni Muti'ah, Roihatul Rahmi Annisa Suharjono, Suharjono Warni, Asri Indahning